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Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： Jihong Kim Sung Min Wi Jong-Guk Ahn Sangjun Son Hee Young Lim Yeonsu park hye Ji Eun Jong Bae park Hyunseob Lim Sangyeon Pak A-Rang Jang Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

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Epimedium koreanum Nakai and its main constituent icariin suppress lipid accumulation during adipocyte differentiation of 3T3-L1 preadipocytes

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Chinese Journal of Natural Medicines 2016年第9期14卷 671-676页

作者： HAN Yunk-Yung SONG Mi-Young HWANG Min-Sub HWANG Ji-hye park Yong-Ki JUNG Hyo-Won 无 Korean Medicine R&D Center College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea department of rehabilitation medicine of korean medicine college of korean medicinedongguk universityGyeongju 38066Republic of Korea Department of Acupuncture&Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea Department of Herbology College of Korean MedicineDongguk UniversityGyeongju 38066Republic of Korea

Obesity is associated with a number of metabolic abnormalities such as type 2 diabetes and has become a major health problem worldwide. In the present study, we investigated the effects of Epimedium koreanum Nakai(Herba Epimedii, HE) and its main constituent icariin on the adipocyte differentiation in 3T3-L1 preadipocytes. HE extract and icariin significantly reduced lipid accumulation and suppressed the expressions of PPARγ, C/EBPα, and SREBP-1c in 3T3-L1 adipocytes. They also inhibited fatty acid synthase(FAS), acyl-Co A synthase(ACS1), and perilipin. Moreover, HE extract and icariin markedly increased the phosphorylation of AMPK. These results indicated that HE extract and icariin can inhibit the adipocyte differentiation through downregulation of the adipogenic transcription factors, suggesting that HE containing icariin may be used as a potential therapeutic agent in the treatment and prevention of obesity.

关键词： Epimedium koreanum Nakai Herba Epimedii Icariin 3T3-L1 cells Obesity

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Distraction ligamentotaxis for complex proximal interphalangeal joint fracture dislocations:a clinical study and themodified pins rubber band traction system revisited

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Burns & Trauma 2018年第3期6卷 234-241页

作者： Cheng Hean Lo Simone H.Nothdurft hye-Sung park Eldho Paul James Leong Department of Plastic and Reconstructive Surgery Monash Health(Dandenong Hospital)135 David StDandenongVictoria 3175Australia Monash Health(Dandenong Hospital) 135 David StDandenongVictoria 3175Australia Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria 3004Australia Department of Surgery Monash UniversityWellington RoadClaytonVictoria 3800Australia

Background:The purpose of this study is to present our experience with the modified pins and rubber band traction system, discuss problems encountered, and make recommendations to optimize outcomes. Methods:Data was collected prospectively from November 2013 to March 2017 at a tertiary referral hospital in Melbourne, Australia. Patients with closed complex proximal interphalangeal joint fracture dislocations that were considered unsuitable for other surgical options were included in the study. Patients underwent dynamic skeletal distraction using the modified (Deshmukh) pins rubber band traction system. Outcomes were measured using the Nominal Rating Scale for pain;Disabilities of the Arm, Shoulder, and Hand (DASH) score;active and passive range of motion;patient rating scale;and complications. Results:Twenty patients underwent the procedure, and 19 were included in analyses. At the final follow-up assessment, an average of 62° and 77° was achieved for proximal interphalangeal joint active and passive range of motion, respectively. Pain levels were low (median score of 0 at rest and 1 ranging, out of 10). Four patients suffered minor pin site infections. Conclusion:Distraction ligamentotaxis is a useful part of the armamentarium, especially in the absence of more suitable procedures. It is important to select appropriate patients, educate, and ensure adherence to postoperative therapy. Employing the Deshmukh frame modification streamlines the theatre processes, and removal of wires at approximately 4 weeks minimizes risk of pin site infection.

关键词： Intra-articular fracture dislocations Proximal interphalangeal Pins rubber band distraction Ligamentotaxis

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Skin whitening and anti-corrugation activities of glycoprotein fractions from liquid extracts of boiled sea cucumber

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 980-984页

作者： So Jung Kim So Yun park Sun-Mee Hong Eun-hye Kwon Taek-Kyun Lee Gyeongbuk Institute for Marine Bio-Industry South Sea Environment Research Department Korea Institute of Ocean Science and Technology

Objective: To determine skin whitening and wrinkle improvement efficacy, glycoprotein fractions were extracted from liquid extracts of boiled sea cucumber and their effects on tyrosine and elastase inhibitory activities were assayed. Methods: Fractions above and below 50 k Da(>50 kD a and 50 kDa enhanced tyrosinase and elastase inhibitory activities by 50.84% and 28.78%, respectively. Correlations of the >50 kD a concentration with tyrosinase inhibitory(R^2=0.968) and elastase inhibitory(R2=0.983) efficacy were significant. Conclusions: >50 kD a glycoprotein fraction isolated from liquid extracts of boiled sea cucumber, which can serve as a functional cosmetic ingredient for whitening and wrinkle improvement of skin.

关键词： Sea cucumber Glycoprotein Cytotoxicity Tyrosinase Elastase

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Ethanol extract of Chondracanthus tenellus(Harvey)Hommersand attenuates lipopolysaccharide-induced inflammatory and oxidative response by blocking the NF-κB,MAPKs,and PI3K/Akt signaling pathways

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Asian Pacific Journal of Tropical Biomedicine 2021年第10期11卷 450-459页

作者： Da hye Kwon Cheol park hyesook Lee Su Hyun Hong Gi-Young Kim Hee-Jae Cha Suhkmann Kim Heui-Soo Kim hye-Jin Hwang Yung Hyun Choi Anti-Aging Research Center Dong-eui UniversityBusan 47340Republic of Korea Department of Biochemistry College of Korean MedicineDong-eui UniversityBusan 47227Republic of Korea Division of Basic Sciences College of Liberal StudiesDong-eui UniversityBusan 47340Republic of Korea Department of Marine Life Sciences School of Marine Biomedical SciencesJeju National UniversityJeju 63243Republic of Korea Department of Parasitology and Genetics College of MedicineKosin UniversityBusan 49104Republic of Korea Department of Chemistry College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Biological Sciences College of Natural SciencesPusan National UniversityBusan 46241Republic of Korea Department of Food and Nutrition College of NursingHealthcare Sciences&Human EcologyDong-eui UniversityBusan 47340Republic of Korea

Objective:To investigate whether the ethanol extract of Chondracanthus tenellus(Harvey)Hommersand,a type of red algae,could exhibit anti-inflammatory potential in lipopolysaccharide(LPS)-stimulated ***:The ethanol extract of Chondracanthus tenellus was applied to 100 ng/mL LPS-stimulated RAW 264.7 cells,and cell viability,phagocytic ability,levels of pro-inflammatory factors,and the production of reactive oxygen species were *** identify the underlying mechanism of the ethanol extract of Chondracanthus tenellus,the expression of inflammation-regulated genes was ***:The ethanol extract of Chondracanthus tenellus had no cytotoxic effect at concentrations below 300μg/mL,and reduced the LPS-induced production of inflammatory mediators including nitric oxide(NO)and prostaglandin ***,the extract markedly suppressed the expression of inducible NO synthase and cyclooxygenase-2,as well as the production of reactive oxygen *** LPS-induced up-regulation of pro-inflammatory cytokines was attenuated by treatment with the ethanol extract of Chondracanthus tenellus,reducing their extracellular *** Chondracanthus tenellus extract also inhibited LPS-mediated activation of nuclear factor-kappa B(NF-κB).In addition,the phosphorylation of mitogen activated protein kinases(MAPKs)and phosphatidylinositol 3 kinase(PI3K)/Akt was markedly increased by LPS,which was significantly abolished by the Chondracanthus tenellus ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimulated RAW 264.7 *** ***:Our findings indicate that the ethanol extract of Chondracanthus tenellus exhibited potential anti-inflammatory and antioxidant effects through downregulating the NF-κB,MAPKs,and PI3K/Akt signaling pathways in LPS stimu

关键词： Chondracanthus tenellus Inflammation ROS NF-κB RAW 264.7 cells

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A computational study of the chemokine receptor CXCR1 bound with interleukin-8

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Chinese Physics B 2018年第3期27卷 534-543页

作者： Yang Wang Cecylia Severin Lupala Ting Wang Xuanxuan Li Ji-hye Yun Jae-hyun park Zeyu Jin Weontae Lee Leihan Tan Haiguang Liu Complex Systems Division Beijing Computational Science Research Center Beijing 100193 China Genome Center University of California Davis 451 East Health Science Drive Davis CA 95616 USA Department of Engineering physics Tsinghua University Beijing 100086 China Department of Biochemistry College of Life Science ＆ Biotechnology Yonsei University Seou103722 South Korea Department of Physics and Institute of Computational and Theoretical Studies Hong Kong Baptist University Hong Kong China

CXCR1 is a G-protein coupled receptor, transducing signals from chemokines, in particular the interleukin-8 （1L8） molecules. This study combines homology modeling and molecular dynamics simulation methods to study the structure of CXCRI-IL8 complex. By using CXCR4-vMIP-II crystallography structure as the homologous template, CXCRI-IL8 complex structure was constructed, and then refined using all-atom molecular dynamics simulations. Through extensive simulations, CXCRI-IL8 binding poses were investigated in detail. Furthermore, the role of the N-terminal of CXCR1 receptor was studied by comparing four complex models differing in the N-terminal sequences. The results indicate that the receptor N-terminal affects the binding of IL8 significantly. With a shorter N-terminal domain, the binding of IL8 to CXCR1 becomes unstable. The homology modeling and simulations also reveal the key receptor-ligand residues involved in the electrostatic interactions known to be vital for complex formation.

关键词： CXCRI-IL8 complex homology modeling ligand binding molecular dynamics

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Co-administration of ursodeoxycholic acid with rosuvastatin/ezetimibe in a non-alcoholic fatty liver disease model

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Gastroenterology Report 2022年第1期10卷 440-450页

作者： Sang Hyun Seo Da Hyun Lee Yu Seol Lee Kyung Joo Cho hye Jung park hye Won Lee Beom Kyung Kim Jun Yong park Do Young Kim Sang Hoon Ahn Soo Han Bae Seung Up Kim Department of Internal Medicine Graduate School of Medicine ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Yonsei Liver Center Severance HospitalSeoulRepublic of Korea Severance Biomedical Science Institute Graduate School of Medical ScienceBrain Korea 21 ProjectYonsei University College of MedicineSeoulRepublic of Korea Severance Biomedical Science Institute Yonsei Biomedical Research InstituteYonsei University College of MedicineSeoulRepublic of Korea Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoulRepublic of Korea

Background Ursodeoxycholic acid(UDCA),statins,and ezetimibe(EZE)have demonstrated beneficial effects against nonalcoholic fatty liver disease(NAFLD).We investigated the efficacy of the combination of UDCA and the mix of rosuvastatin(RSV)/EZE in the treatment of *** NAFLD mouse models were developed by injecting thioacetamide,fasting,and high-carbohydrate refeeding,highfat diet,and choline-deficient L-amino acid-defined high-fat diet(CDAHFD).Low-dose UDCA(L-UDCA;15 mg/kg)or highdose UDCA(H-UDCA;30 mg/kg)was administered with RSV/*** also employed an in vitro model of NAFLD developed using palmitic acid-treated Hepa1c1c7 *** Co-administration of RSV/EZE with UDCA significantly decreased the collagen accumulation,serum alanine aminotransferase(ALT)levels,and mRNA levels of fibrosis-related markers than those observed in the vehicle group in thioacetamide-treated mice(all P<0.01).In addition,in the group fasted and refed with a high-carbohydrate diet,UDCA/RSV/EZE treatment decreased the number of apoptotic cells and serum ALT levels compared with those observed in the vehicle group(all P<0.05).Subsequently,H-UDCA/RSV/EZE treatment decreased the number of ballooned hepatocytes and stearoyl-CoA desaturase 1(SCD-1)mRNA levels(P=0.027)in the liver of high-fat diet-fed mice compared with those observed in the vehicle *** the CDAHFD-fed mouse model,UDCA/RSV/EZE significantly attenuated collagen accumulation and fibrosis-related markers compared to those observed in the vehicle group(all P<0.05).In addition,UDCA/RSV/EZE treatment significantly restored cell survival and decreased the protein levels of apoptosis-related markers compared to RSV/EZE treatment in palmitic acid-treated Hepa1c1c7 cells(all P<0.05).Conclusion Combination therapy involving UDCA and RSV/EZE may be a novel strategy for potent inhibition of NAFLD progression.

关键词： non-alcoholic fatty liver disease non-alcoholic steatohepatitis ursodeoxycholic acid rosuvastatin ezetimibe

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Asymptomatic lymphangioma involving the spleen and retroperitoneum in adults

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World Journal of Gastroenterology 2009年第44期15卷 5620-5623页

作者： sook Hee Chung Young sook park Yun Ju Jo Seong Hwan Kim Dae Won Jun Byoung Kwan Son Jun Young Jung Dae Hyun Baek Dong Hee Kim Yoon Young Jung Won Mi Lee Department of Internal Medicine Eulji General Hospital Eulji University School of MedicineSeoul 139-711South Korea Department of General Surgery Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Radiology Eulji General HospitalEulji University School of MedicineSeoul 139-711 South Korea Department of Pathology Eulji General Hospital Eulji University School of MedicineSeoul 139-711 South Korea

Lymphangioma, a benign neoplasm of the lymphatic system, is common in children but rare in adults. Its clinical manifestations include abdominal pain, nausea, vomiting and a palpable mass. However, abdominal sonography or abdominal computed tomography （CT） scan can also incidentally reveal lymphangioma. A larger or symptomatic lymphangioma is treated with total resection to prevent recurrence, infection, torsion and enlargement. Although lymphangioma rarely becomes malignant, its prognosis is generally good. We report a cystic lymphangioma of the spleen and retroperitoneum, which was incidentally found in a 56-year-old man who was hospitalized due to a colon mass. Physical examination showed no specific findings. Abdominal CT revealed a 5.7 cm, non-enhanced multilobulated cystic mass with multiple sepia in the spleen and a 10 cm lobulated cystic mass in the paraaortic area. Splenectomy and retroperitoneal resection of the cystic mass were conducted. The endothelium of splenic and retroperitoneal cyst was immunohistochemically stained with D2-40 antibody. The patient was finally diagnosed with splenic cystic and retroperitoneal cavernous lymphangioma.

关键词： Lymphangioma Retroperitoneum Spleen

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Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie＇s plaque

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Asian Journal of Andrology 2015年第3期17卷 487-492页

作者： Min Ji Choi Kang-Moon Song Jin-Mi park Mi-hye Kwon Ki-Dong Kwon Soo-Hwan park Dong-Soo Ryu Ji-Kan Ryu Jun-Kyu Suh Department of Urology National Research Center for Sexual Medicine Inha University School of Medicine Incheon 400-711 Korea Department of Urology Changwon Samsung Medical Center Changwon 630-522 Korea Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon 400-711 Korea

Transforming growth factor-β1 （TGF-β1） has been identified as one of the most important fibrogenic cytokines associated with Peyronie＇s disease （PD）. The mothers against decapentaplegic homolog 7 （SMAD7） is an inhibitory Smad protein that blocks TGF-J3 signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 （a positive cell cycle regulator） and induced the expression of poly （ADP-ribose） polymerase 1, which is known to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the blocking of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

关键词： cell culture decapentaplegic homolog 7 fibrosis Peyronie's disease transforming growth factor-beta

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Development of dilated cardiomyopathy with a long latent period followed by viral fulminant myocarditis:A case report

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World Journal of Clinical Cases 2022年第36期10卷 13451-13457页

作者： Seung Do Lee Hyo Jin Lee hye Ree Kim Min Gyu Kang Kyehwan Kim Jeong Rang park Division of Cardiology Department of Internal MedicineGyeongsang National University School of Medicine and Gyeongsang National University HospitalJinju 52727South Korea

BACKGROUND The clinical course of acute myocarditis ranges from the occurrence of a few symptoms to the development of fatal fulminant ***,fulminant myocarditis causes clinical deterioration very rapidly and *** long-term prognosis of myocarditis is varied,and it fully recovers without leaving any special ***,even after recovery,heart failure may occur and eventually progress to dilated cardiomyopathy(DCM),which causes serious left ventricular *** the case of follow-up observation,no clear guidelines have been *** SUMMARY We report the case of a 21-year-old woman who presented with *** became hemodynamically unstable and showed sustained fatal arrhythmias with decreased heart *** was clinically diagnosed with fulminant myocarditis based on her echocardiogram and cardiac magnetic resonance *** 2 d,she was readmitted to the emergency department under cardiopulmonary resuscitation and received mechanical ventilation and extracorporeal membrane *** implantable cardioverter defibrillator was inserted for secondary *** recovered and was *** to being hospitalized for sudden cardiac function decline and arrhythmia,she had been well for 7 years without any *** was finally diagnosed with dilated *** DCM may develop unexpectedly in patients who have been cured of acute fulminant myocarditis and have been stable with a long period of ***,they should be carefully and regularly observed clinically throughout long-term follow-up.

关键词： Myocarditis Fulminant Dilated cardiomyopathy Outcome Remission Case report

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