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Colonoscopy evaluation after short-term anti-tuberculosis treatment in nonspecific ulcers on the ileocecal area

World Journal of Gastroenterology 2008年第32期14卷 5051-5058页

作者： Young sook Park Dae Won Jun Seong Hwan kim Han Hyo Lee Yun Ju Jo Moon Hee Song Nam In kim Jun Seok Lee Department of Internal Medicine Eulji University School of Medicine Eulji Medical Center

AIM: To evaluate the eff icacy of colonoscopy follow-up after short-term anti-tuberculosis treatment in patients with nonspecific ulcers on ileocecal areas being suspicious of tuberculous colitis. METHODS: We prospectively analyzed the colonoscopic fi ndings before and after short term anti- tuberculosis treatment in 18 patients with nonspecifi c ulcers on the ileocecal area and compared them with 7 patients of confi rmed tuberculous colitis by acid-fast bacilli or caseating granuloma on colonic biopsy. RESULTS: Mean duration for short-term follow- up was 107.3 d with combined chemotherapy containing isoniazid, rifampicin, ethambutol and pyrazinamide. Seven patients with tuberculous colitis showed complete healing of active ulcers after short- term medication. After short-term anti-tuberculosis treatment, follow-up colonoscopy findings devided 18 patients with nonspecific ulcers into two groups by ulcer state. One is the "suspicious tuberculous colitis group" showing healing of ulcers and erosions and another is the "suspicious inflammatory bowel disease group" showing active ulcers with or without aggravation of the lesion. Finally, all 9 of the "suspicious tuberculous colitis group" were diagnosed as tuberculous colitis showing no recurrence of ulcers after termination of 9 mo of anti-tuberculosis medication. Patients of the "suspicious inflammatorybowel disease group" were f inally diagnosed as Crohn's disease or nonspecifi c colonic ulcers during long-term follow up. CONCLUSION: Follow-up colonoscopy shows a healing stage ulcer or scarring change without an active ulcer with just 2 mo to 3 mo of medication in patients with tuberculous colitis. Colonoscopy follow-up after short term anti-tuberculosis trial in patients with nonspecif ic ulcers on the ileocecal area is valuable in making early differential diagnosis of tuberculous colitis.

关键词： Colonoscopy Short-term Anti-tuberculosis medication Tuberculous colitis Ileocecal ulcer

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World Journal of Gastroenterology 2014年第45期20卷 17120-17126页

作者： sook Hee Chung Soo Jung Park Hye Sun Lee Sung Pil Hong Jae Hee Cheon Tae Ⅱ kim Won Ho kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Internal Medicine and institute of Gastroenterology Ajou University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To investigate differences of clinical characteristics and disease courses between familial and sporadic inflammatory bowel disease (IBD) patients.

关键词： Inflammatory bowel disease Family history Crohn’ s disease Ulcerative colitis Clinical characteristics

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The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis

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Bone Research 2021年第3期9卷 323-335页

作者： Sun-Ju Yi You-Jee Jang Hye-Jung kim Kyubin Lee Hyerim Lee Yeojin kim Junil kim Seon Young Hwang Jin sook Song Hitoshi Okada Jae-Il Park Kyuho Kang Kyunghwan kim Department of Biological Sciences and Biotechnology Chungbuk National UniversityCheongjuChungbukRepublic of Korea Korea Basic Science Institute Gwangju Center at Chonnam National UniversityGwangjuRepublic of Korea New Drug Development Center KBIO Osong Medical Innovation FoundationCheongjuChungbukRepublic of Korea Data Convergence Drug Research Center Therapeutics&Biotechnology DivisionKorea Research Institute of Chemical TechnologyDaejeonRepublic of Korea Department of Biochemistry Kindai University Faculty of MedicineOsakasayamaOsakaJapan

Bone undergoes a constant and continuous remodeling process that is tightly regulated by the coordinated and sequential actions of bone-resorbing osteoclasts and bone-forming *** studies have shown that histone demethylases are implicated in osteoblastogenesis;however,little is known about the role of histone demethylases in osteoclast ***,we identified KDM4B as an epigenetic regulator of osteoclast *** of KDM4B significantly blocked the formation of tartrate-resistant acid phosphatase-positive multinucleated *** with myeloid-specific conditional knockout of KDM4B showed an osteopetrotic phenotype due to osteoclast *** analysis revealed that KDM4B physically and functionally associates with CCAR1 and MED1 in a *** genome-wide chromatin immunoprecipitation(ChIP)-sequencing,we revealed that the KDM4B–CCAR1–MED1 complex is localized to the promoters of several osteoclast-related genes upon receptor activator of NF-κB ligand *** demonstrated that the KDM4B–CCAR1–MED1 signaling axis induces changes in chromatin structure(euchromatinization)near the promoters of osteoclast-related genes through H3K9 demethylation,leading to NF-κB p65 recruitment via a direct interaction between KDM4B and ***,small molecule inhibition of KDM4B activity impeded bone loss in an ovariectomized mouse *** together,our findings establish KDM4B as a critical regulator of osteoclastogenesis,providing a potential therapeutic target for osteoporosis.

关键词： formation. critical MED1

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Diabetic factors associated with gastrointestinal symptoms in patients with type 2 diabetes

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World Journal of Gastroenterology 2010年第14期16卷 1782-1787页

作者： Jeong Hwan kim Hyung Seok Park Soon Young Ko Sung Noh Hong In-Kyung Sung Chan Sub Shim Kee-Ho Song Dong-Lim kim sook Kyung kim Jeeyoung Oh Department of Internal Medicine Digestive Disease Center Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Medical Immunology Center Institute of Biomedical Science and Technology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Internal Medicine Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea Department of Neurology Konkuk University School of Medicine Konkuk University Medical Center Seoul 143-729 South Korea

AIM: To determine whether gastrointestinal (GI) symptoms are more frequent in type 2 diabetic patients and to examine which diabetic factors are associated with the symptoms. METHODS: Consecutive subjects with diabetes and age-/gender-matched normal controls were recruited for this study. GI symptoms were assessed using a structured questionnaire divided into two GI symptomcategories (upper and lower GI symptoms), and consisting of 11 individual symptoms. In the diabetic patient group, diabetic complications including peripheral neuropathy, nephropathy and retinopathy, glycosylated hemoglobin (HbA1c) level and diabetes duration were evaluated. RESULTS: Among the total 190 diabetic patients and 190 controls enrolled, 137 (72%) of the diabetic patients and 116 (62%) of the controls had GI symptoms. In the diabetic patient group, 83 (43%) had upper GI symptoms and 110 (58%) lower GI symptoms; in the control group, 59 (31%) had upper GI symptoms and 104 (55%) lower GI symptoms. This difference between the two groups was significant for only the upper GI symptoms (P = 0.02). Among the diabetic factors, the HbA1c level was the only independent risk factor for upper GI symptoms in the multiple logistic regression analysis (odds ratio = 2.01, 95% confidence interval: 1.02-3.95). CONCLUSION: Type 2 diabetes was associated with an increased prevalence of upper GI symptoms and these symptoms appeared to be independently linked to poor glycemic control, as measured by the HbA1c levels.

关键词： Diabetes HbA1c Upper gastrointestinal symptoms

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Growth of single crystals in the (Na_(1/2)Bi_(1/2))TiO_(3)-(Sr_(1-x)Ca_(x))TiO_(3) system by solid state crystal growth

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Journal of Advanced Ceramics 2021年第5期10卷 973-990页

作者： Phan Gia LE Huyen Tran TRAN Jong-sook LEE John G.FISHER Hwang-Pill kim Wook JO Won-Jin MOONC School of Materials Science and Engineering Chonnam National University77 Yongbong-roBuk-guGwangju 61186Republic of Korea School of Materials Science and Engineering Ulsan National Institute of Science and Technology50 UNIST-gilEonyang-eupUlju-gunUlsan 44919Republic of Korea Korea Basic Science Institute Gwangju Center77 Yongbong-roBuk-guGwangju 61186Republic of Korea

Ceramics based on(Na_(1/2)B_(1/2))TiO_(3) are promising candidates for actuator applications because of large strains generated by an electric field-induced phase *** example,the(1-x)(Na_(1/2)Bi_(1/2))TiO_(3)-xSrTiO_(3) system exhibits a morphotropic phase boundary at x=0.2-0.3,leading to high values of inverse piezoelectric constant d_(33),which can be further improved by the use of single *** our previous work,single crystals of (Na_(1/2)B_(1/2))TiO_(3)-SrTiO_(3) and (Na_(1/2)Bi_(1/2))TiO_(3)-TiO_(3) were grown by the solid state crystal growth *** in the(Nai/2Bi/2)TiO3-SrTiO3 system was sluggish whereas the (Na_(1/2)B_(1/2))TiO_(3)-CaTiO_(3) single crystals grew *** the present work,0.8(Na_(1/2)Bi_(1/2))Ti0_(3)-0.2(Sr_(1-x)Ca_(x))Ti0_(3) single crystals(with x=0.0,0.1,0.2,0.3,0.4)were produced by the solid state crystal growth technique in an attempt to improve crystal growth *** dependence of mean matrix grain size,single crystal growth distance,and electrical properties on the Ca concentration was investigated in *** investigations indicated that at x=0.3 the matrix grain growth was suppressed and the driving force for single crystal growth was *** Sr with Ca increased the shoulder temperature T_(s) and temperature of maximum relative permittivity T_(max),causing a decrease in inverse piezoelectric properties and a change from normal to incipient ferroelectric behavior.

关键词： (Na_(1/2)Bi_(1/2))TiO_(3) lead-free piezoelectric single crystal microstructure electrical properties

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Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model

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Asian Pacific Journal of Tropical Medicine 2018年第12期11卷 653-658页

作者： Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim kim Kyung Hyeon kim Jong Tae kim Won Hee Choi Seung Hee Jang Min Jeung kim Ji hyang Wee Yeon Ki kim Bao Le Interdisciplinary Program of Biomodulation Myongji UniversityYonginGyeonggi 17058Republic of Korea Center for Nutraceutical and Pharmaceutical Materials Myongji UniversityYonginGyeonggi 17058Republic of Korea Teazen Co. B-606 Acrotower230 Sinim-daeroDongan-guAnyang-siGyeonggi-do 14067Republic of Korea Department of Food Science&Biotechnology Shin Ansan UniversityAnsanGyeonggi 15435Republic of Korea' Division of Bioscience and Bioinformatics Myongji UniversityYonginGyeonggi 17058Republic of Korea Department of Biotechnology Chonnam National UniversityYeosuChonnam 59626Republic of Korea

Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer.

关键词： Immune system enhancement Cyclophosphamide Cornus officinalis Sieb Et Zucc Eriobotrya japonica Lindley Olive leaves

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Stereotactic body radiotherapy for isolated paraaortic lymph node recurrence from colorectal cancer

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World Journal of Gastroenterology 2009年第48期15卷 6091-6095页

作者： Mi-sook kim Chul Koo Cho Kwang Mo Yang Dong Han Lee Sun Mi Moon Young Joo Shin Department of RadiationOncology and Surgery Korea Institute of Radiological & Medical Sciences

AIM： To evaluate the efficacy and complications of stereotactic body radiotherapy in localized paraaortic lymph node recurrence from colorectal cancer. METHODS： From 2003 to 2009, 7 patients with paraaortic lymph node recurrence （1-3 lesions） from colorectal cancer were treated with stereotactic body radiotherapy. Total gross tumor volumes ranged from 4 to 40 mL. The doses were escalated from 36 Gy/patient to 51 Gy/patient and were delivered in 3 fractions. RESULTS： One and 3 year overall survival rates were 100% and 71.4%, respectively, and median survival was 37 mo. Grade IV intestinal obstruction was reported in 1 of 7 patients. This patient received 48 Gy in 3 fractions with a maximum point dose to the intestine of 53 Gy and V45Gy = 3.6 mL. However, 6 patients received an intestinal maximum point dose of 〈 51 Gy and V45Gy of 〈 1 mL, and did not develop any severe complications. CONCLUSION： This pilot study suggests selected paraaortic lymph node recurrence （1-3 closed lesions） that failed to respond to chemotherapy can be potentially salvaged by stereotactic body radiotherapy.

关键词： Stereotactic body radiotherapy Paraaortic lymph node recurrence Colorectal cancer

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Pancreatic pseudocyst filled with semisolid lipids mimicking solid mass on endoscopic ultrasound

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World Journal of Gastroenterology 2010年第8期16卷 1034-1038页

作者： Sang-Woo Cha Sae Hee kim hyang Ie Lee Yun Jung Lee Hyeon Woong Yang Sung Hee Jung Anna kim Min Koo Lee Hyun Young Han Dong Wook Kang Division of Gastroenterology Department of Internal Medicine Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Surgery Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Radiology Eulji University College of Medicine Eulji University Hospital Division of Gastroenterology Department of Pathology Eulji University College of Medicine Eulji University Hospital

Pancreatic pseudocysts,which account for 70%-90% of pancreatic cystic lesions,characteristically are non-epithelially lined cystic cavities that are contiguous with the pancreas. Pancreatic pseudocysts can be caused by acute,chronic or traumatic pancreatitis and should be differentiated from other pancreatic diseases with cystic appearances,especially cystic neoplasms. We report a unique case of a pancreatic pseudocyst filled with semisolid lipids,which appeared by endoscopic ultrasound as a solid mass,and was therefore resected.

关键词： Pancreatic pseudocyst Lipids Endosonog-raphy

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Dieckol isolated from Eisenia bicyclis extract suppresses RANKL-induced osteoclastogenesis in murine RAW 264.7 cells

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Asian Pacific Journal of Tropical Biomedicine 2022年第6期12卷 262-269页

作者： Su-Hyeon Cho Tae-Hyung Kwon Hoibin Jeong Jin sook kim Song-Rae kim Myeong Seon Jeong SeonJu Park Miri Choi Jung-Hee Woo Juhee Ahn Kil-Nam kim Chuncheon Center Korea Basic Science InstituteChuncheon 24341Republic of Korea Department of Medical Biomaterials Engineering College of Biomedical SciencesKangwon National UniversityChuncheon 24341Republic of Korea Department of Research and Development Chuncheon Bio-industry FoundationChuncheonRepublic of Korea Marine Industry Research Institute for East se rim Uljin-gunGyeongsangbuk-doRepublic of Korea Department of Bio-analysis Science University of Science&TechnologyDaejeon34113Republic of Korea

Objective:To demonstrate the effect of dieckol from Eisenia bicyclis on osteoclastogenesis using RAW 264.7 ***:Murine macrophage RAW 264.7 cells were subjected to dieckol treatment,followed by treatment with receptor activator of nuclear factor kappa-B ligand(RANKL)to induce ***-resistant acid phosphatase(TRAP)activity was examined using a TRAP activity *** blotting analysis was conducted to examine the level of osteoclast-related factors,including TRAP and calcitonin receptor(CTR),transcriptional factors,including c-Fos,c-Jun,and nuclear factor of activated T cells cytoplasmic 1(NFATc1),nuclear factor kappa-B(NF-κB),extracellular signal-regulated kinase(ERK),and c-Jun N-terminal kinase(JNK).Immunofluorescence staining was conducted to examine the expression of c-Fos,c-Jun,and ***:Among the four phlorotannin compounds present in Eisenia bicyclis,dieckol significantly hindered osteoclast differentiation and expression of RANKL-induced TRAP and *** addition,dieckol downregulated the expression levels of c-Fos,c-Jun,NFATc1,ERK,and JNK,and suppressed NF-κB ***:Dieckol can suppress RANKL-induced ***,it has therapeutic potential in treating osteoclastogenesis-associated diseases.

关键词： Eisenia bicyclis Dieckol Osteoclasts ERK JNK NF-κB RANKL TRAP Calcitonin receptor NFATc1 RAW 264.7 cell

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The Emergence of Technical Communication in South Korea

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China Standardization 2010年第2期55卷 30-34页

作者： Yang sook kim Hansem EZUserGuides the Korea Technical Communication Association(KTCA)

Europe is a large market for Korean companies, and at the same time, I believe Koreais an attractive market for European ***, we've seen the activities oftekom in the Far *** tekom's efforts, we have been able to moni... 详细信息

关键词：通信技术韩国欧洲企业发展趋势吸引力市场

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