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Current perspectives on dengue episode in Malaysia

Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 386-392页

作者： Ee Leen Pang hwei-san loh School of Biosciences.Faculty of Science.The University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

To Prevalence of dengue transmission has been alarmed by an estimate of 390 million infections per *** encroachment,ecological disruption and poor sanitation are all contributory factors of increased *** however arises from the fact that dengue virus inherently exists as four different *** infection is often manifested in the more severe form,such that antibody-dependent enhancement(ADE) could aggravate ailment by allowing pre-existing antibodies to form complexes with infecting viruses as means of ***,increased viraemic litter and suppression of antiviral response are *** concerns are thus expressed in regards to escalating trend of hospitalisation and mortality *** Malaysia,situation is exacerbated by improper clinical management and pending vector control *** a preparedness strategy against the potential deadly dengue pandemic,the call for development of a durable and costeffective dengue vaccine against all infecting serotypes is *** though several vaccine candidates are currently being evaluated in clinical trials,uncertainties in regards to serotypes interference,incomplete protection and dose adequacy have been *** of sole reliance on outsourcing,production of local vaccine should be considered in coherent to government's efforts to combat against dengue.

关键词： Dengue Antibody-dependent enhancement Pandemic Vaccine Malaysia

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Towards development of a universal dengue vaccine-how close are we?

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 209-218页

作者： Ee Leen Pang hwei-san loh School of Biosciences Faculty of ScienceThe University of Nottingham Malaysia Campus Biotechnology Research Centre The University of Nottingham Malaysia Campus

Dengue has been ranked as one of the top emerging diseases in Asia and Latin *** epidemiological data may not even reflect the true burden of disease due to underreported *** control programmes have failed to contain the disease and worst of all,no specific treatment is available at the ***,this pushes the demand for a dengue vaccine as a long-term protective *** there are numerous vaccine candidates ahead,they could be held back by different aspects in promoting vaccine *** for developing nations,logistics and cost are the major hurdles that need to be addressed in order to provide a quick yet affordable medical *** an alternative,plantbased vaccine production system is able to offer an attractive prospect given to its advantages of biocontainment warranty,low operation cost,rapid scalability and logistics *** that have embarked on this scope are laid out and reviewed in terms of the feasibility of plant system to serve as a biofactory for dengue vaccine.

关键词： Dengue vaccine Protective efficacy Developing countries Plant molecular pharming

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MOSFET DRAIN ENGINEERING FOR LOW-POWER APPLICATIONS

MOSFET DRAIN ENGINEERING FOR LOW-POWER APPLICATIONS

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1995 4th International Conference on Solid-State and Integrated Circuit Technology

作者： Felix Fujishiro Lily Ding Ed Nowak Ying·Tsong loh Compass Design Automation. 1865 Lundy Avenue San Jose CA 95131 USA VLSI Technology Inc.. 1109 McKay Drive San Jose CA 95131 USA VLSI Technology Inc.. 1109 McKay Drive San Jose CA 95131 USA VLSI Technology Inc.. 1109 McKay Drive San Jose CA 95131 USA

＜正＞ The lightly doped drain （LDD） transistor structure has been used for several sub-micron process generations to improve hot-carrier immunity for 5-volt applications. The principal challenge for LDD design is to optimize current-drive capability, thus improving circuit performance, while maintaining acceptable hot-carrier lifetime. The challenge for deep sub-micron devices remains the same, but some of the design constraints have changed. Reduction of the supply voltage Vdd inherently improves the hot-carrier lifetime, thus potentially allowing greater latitude in MOS device design. In this paper, the current-drive capability of MOSFETs with various drain structures is studied for 3.3-volt applications.

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Nature:骨髓微环境发生突变可导致造血干细胞异常

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现代生物医学进展 2016年第35期16卷 I0003-I0004页

作者： Lei Dong, Wen-Mei Yu, Hong Zheng, Melinda Pauly, Muxiang Zhou Cheng-Kui Qu Mignon L. loh Silvia T. Bunting Gang Huang Hal E. Broxmeyer David T. Scadden Department of Pediatrics Division of Hematology/Oncology Aflac Cancer and Blood Disorders Center Children’s Healthcare of Atlanta Emory University School of Medicine Atlanta Georgia 30322 USA Department of Pediatrics Division of Pediatric Hematology-Oncology University of California at San Francisco San Francisco California 94122 USA Department of Pathology Children’s Healthcare of Atlanta Emory University Atlanta Georgia 30322 USA Division of Experimental Hematology and Cancer Biology Cincinnati Children&#x27 s Hospital University of Cincinnati Cincinnati Ohio 45229 USA Department of Microbiology and Immunology Indiana University School of Medicine Indianapolis Indiana 46202 USA Center for Regenerative Medicine and MGH Cancer Center Massachusetts General Hospital Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute Harvard University Boston Massachusetts 02114 USA

白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病，来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身... 详细信息

白血病骨髓微环境中支持血液发育的某些DNA突变可以驱动周围造血干细胞形成白血病，来自艾默里大学温希普癌症研究所和亚特兰大儿童健康中心的研究人员在国际学术期刊Nature上公布了他们的最新研究进展。许多致癌突变都作用于细胞自身。让细胞自身生长更快。相比之下，努南综合征小鼠模型上可以观察到间接的邻近细胞效应，努南综合征是一种能够增加白血病患病风险的遗传紊乱。

关键词：造血干细胞 DNA突变微环境骨髓异常可导国际学术期刊白血病

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先天性皮肤白血病及白血病进展

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世界核心医学期刊文摘（皮肤病学分册） 2006年第4期2卷 11-12页

作者： Zhang I.H. Zane L.T. Braun B.S. M.L. loh 李政霄 Department of Pediatrics University of California San Francisco San Francisco CA 94143- 0519 United States Dr.

We describe a newborn infant who was born with a purpuric rash and subcutaneous nodules. Skin biopsies demonstrated acute myeloid leukemia. Cytogenetic studies revealed an 11q23 rearrangement. Initial bone marrow and cerebrospinal fluid examination did not demonstrate medullary or meningeal disease. Chemotherapy was initiated on the basis of the abnormal cytogenetic findings in the skin biopsy. Intensive chemotherapy was, given but the infant s leukemia progressed. The patient died of refractory leukemia and secondary fungal disease. This case report supports the observation that leukemia cutis with an 11q23 rearrangement should be treated aggressively.

关键词：皮肤白血病脑膜病急性髓性白血病继发性真菌感染染色体基因细胞遗传学研究皮肤活检活检标本

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复合疫苗佐剂促进蛋白抗原通过交叉提呈和交叉致敏诱生CD8^+CTL反应的研究

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中国生物制品学杂志 2012年第9期25卷 1085-1090页

作者：王美菊刘颖罗兴杨春亭于三科许洪林西北农林科技大学动物医学院陕西杨凌712100 北京生物制品研究所有限责任公司第一研究室北京100024

目的研究CpG寡聚脱氧核苷酸(CpG-oligodeoxynucleotides,CpG-ODN)与A(loh)3或Montanide ISA720等组成的复合佐剂在小鼠体内促进蛋白抗原通过交叉提呈和交叉致敏诱生CD8+CTL反应的能力。方法以鸡卵清蛋白(Ovalbumin,OVA)为抗原,分别以CpG X1、A(l OH)(3即Alum)、Montanide ISA720、CpG X1+Alum和CpG X1+Montanide ISA720为疫苗佐剂,分别于0和4周经肌肉注射免疫C57BL/6小鼠,体积均为100μl,分别含20μg OVA、20μg CpG X1、74μl Montanide ISA720和/或100μg Alum。通过胞内细胞因子染色和体内CTL杀伤试验评价不同佐剂对细胞免疫应答的影响,通过表达OVA的黑色素瘤和李斯特菌攻击模型评价不同佐剂在免疫预防和免疫治疗中的作用。结果与OVA组相比,A(loh)3本身不能有效诱生小鼠的细胞免疫应答;CpG X1或Montanide ISA720单独使用能够在一定程度上增强抗原特异性CD8+T细胞的IFNγ分泌和CTL活性,但不增强抗原特异性CD4+T细胞反应。两种复合佐剂具有比单佐剂更强的细胞免疫佐剂效应,其中CpG X1+MontanideISA720只能增强抗原特异性CD4+和CD8+T细胞的IFNγ分泌,而CpG X1+Alum不仅能够增强抗原特异性CD4+和CD8+T细胞的IFNγ分泌,还能够增强CD8+CTL的杀伤活性。在黑色素瘤和李斯特菌攻击模型中,CpG X1+Alum佐剂显示出良好的预防和治疗效果。结论 CpG X1与A(loh)3组成的复合佐剂能够有效促进蛋白抗原通过交叉提呈和交叉致敏诱生功能性CD8+CTL反应。

关键词：佐剂蛋白抗原交叉提呈交叉致敏 CD8+CTL反应

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