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Managing type 2 diabetes:targeting a microbial enzyme as a novel treatment option

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Signal Transduction and Targeted Therapy 2024年第1期9卷 3-5页

作者： Anikó Keller-Pintér tamás Korcsmáros Tibor Vellai Department of Biochemistry Albert Szent-Györgyi Medical SchoolUniversity of SzegedSzeged6720Hungary Department of Metabolism Digestion and ReproductionImperial College LondonLondonW120NNUK Quadram Institute Bioscience Norwich Research ParkNorwichNR47UQUK Department of Genetics Eötvös Loránd University(ELTE)Budapest1117Hungary Hungarian Research Network HUN-REN-ELTE Genetics Research Group Budapest1117Hungary

In a recent Science article,Wang and colleagues showed that the dipeptidyl peptidase 4(DPP4)enzyme produced by the gut microbiota can interfere with the effect of host glucagon-like peptide-1(GLP-1)involved in stimulating insulin secretion,and the specific inhibitor of microbial DPP4(mDPP4),combined with clinical inhibitors of host DPP4 isoenzymes,further promotes blood glucose homeostasis.1 These results point out why certain patients respond inadequately to an antidiabetic medication.

关键词： homeostasis stimulating clinical

Regenerated polymer optical fiber Bragg gratings with thermal treatment for high temperature measurements

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Photonics Research 2022年第4期10卷 1011-1021页

作者： Dinusha Serandi Gunawardena Xin Cheng Jingxian Cui Geraldi Edbert Linyue Lu Yuk Ting Ho hwa-yaw tam Department of Electrical Engineering The Hong Kong Polytechnic UniversityKowloonHong KongChina Photonics Research Institute The Hong Kong Polytechnic UniversityKowloonHong KongChina

We report for the first time, to the best of our knowledge, regenerated polymer optical fiber Bragg gratings(RPOFBGs) in ZEONEX-based polymer optical fibers(POFs). The regeneration temperature can be adjusted using a heat treatment process on the POF before FBG inscription, enabling a scalable improvement of the thermal stability of the RPOFBGs. Thermal sustainability of the RPOFBGs at high temperature conditions was investigated for their prolonged use in diverse environments. Furthermore, these RPOFBGs can withstand strain levels up to 2.8% while maintaining a good linearity, even at temperature of 110℃. The RPOFBGs are capable of short-term operation at elevated temperatures of up to 132℃, which is the standard temperature for steam sterilization with at least a 4 min exposure period. The distinction in the morphologies of the two grades of ZEONEX(E48R and 480R, ZEON Corp.) used to fabricate the optical fiber together with the characteristics of UV irradiated and regenerated gratings is explained using micro-Raman spectroscopy. Collectively, these findings provide new heights for long-term operation of POF Bragg gratings(POFBGs) at elevated temperature environments and would be applicable to a wide range of disciplines.

关键词： POF fiber optical

A deep neural network based surrogate model for damage identification in full-scale structures with incomplete noisy measurements

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 393-410页

作者： Tram BUI-NGOC Duy-Khuong LY tam T TRUONG Chanachai THONGCHOM T.NGUYEN-THOI Laboratory for Computational Mechanics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Mechanical-Electrical and Computer Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Faculty of Civil Engineering School of TechnologyVan Lang UniversityHo Chi Minh City 70000Vietnam Department of Computer Science Aarhus UniversityAarhus 8000Denmark Thammasat University research unit in structural and foundation engineering Department of Civil EngineeringThammasat UniversityPathumthani 12120Thailand Laboratory for Applied and Industrial Mathematics Institute for Computational Science and Artificial IntelligenceVan Lang UniversityHo Chi Minh City 70000Vietnam Thammasat School of Engineering Thammasat UniversityPathumthani 12120Thailand

The paper introduces a novel approach for detecting structural damage in full-scale structures using surrogate models generated from incomplete modal data and deep neural networks(DNNs).A significant challenge in this field is the limited availability of measurement data for full-scale structures,which is addressed in this paper by generating data sets using a reduced finite element(FE)model constructed by SAP2000 software and the MATLAB programming loop.The surrogate models are trained using response data obtained from the monitored structure through a limited number of measurement devices.The proposed approach involves training a single surrogate model that can quickly predict the location and severity of damage for all potential scenarios.To achieve the most generalized surrogate model,the study explores different types of layers and hyperparameters of the training algorithm and employs state-of-the-art techniques to avoid overfitting and to accelerate the training process.The approach’s effectiveness,efficiency,and applicability are demonstrated by two numerical examples.The study also verifies the robustness of the proposed approach on data sets with sparse and noisy measured data.Overall,the proposed approach is a promising alternative to traditional approaches that rely on FE model updating and optimization algorithms,which can be computationally intensive.This approach also shows potential for broader applications in structural damage detection.

关键词： vibration-based damage detection deep neural network full-scale structures finite element model updating noisy incomplete modal data

Tungsten-based nanocatalysts with different structures for visible light responsive photocatalytic degradation of bisphenol A

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Journal of Environmental Sciences 2024年第5期139卷 569-588页

作者： Hai Bang Truong Thi Thu Loan Doan Nguyen Tien Hoang Nguyen Van tam Minh Kim Nguyen Le Gia Trung Jin Seog Gwag Nguyen Tien Tran Optical Materials Research Group Science and Technology Advanced InstituteVan Lang UniversityHo Chi Minh CityViet Nam Faculty of Applied Technology School of TechnologyVan Lang UniversityHo Chi Minh CityViet Nam The University of Da Nang University of Science and Technology54 Nguyen Luong BangDa NangViet Nam The University of Da Nang University of Science and Education459 Ton Duc Thang St.Lien ChieuDa Nang 550000Viet Nam Institute of Veterinary Science and Technology 31ha zoneTrau QuyGia LamHa Noi 12400Viet Nam Department of Physics Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea Center for Advanced Chemistry Institute of Research and DevelopmentDuy Tan University03 Quang TrungDa Nang 550000Viet Nam Faculty of Natural Sciences Duy Tan University03 Quang TrungDa Nang 550000Viet Nam

Environmental pollution,such as water contamination,is a critical issue that must be absolutely addressed.Here,three different morphologies of tungsten-based photocatalysts(WO_(3)nanorods,WO_(3)/WS_(2)nanobricks,WO_(3)/WS_(2)nanorods)are made using a simple hydrothermal method by changing the solvents(H_(2)O,DMF,aqueous HCl solution).The as-prepared nanocatalysts have excellent thermal stability,large porosity,and high hydrophilicity.The results show all materials have good photocatalytic activity in aqueous media,with WO_(3)/WS_(2)nanorods(NRs)having the best activity in the photodegradation of bisphenol A(BPA)under visible-light irradiation.This may originate from increased migration of charge carriers and effective prevention of electron–hole recombination in WO_(3)/WS_(2)NRs,whereby this photocatalyst is able to generate more reactive·OH and·O_(2)^(–)species,leading to greater photocatalytic activity.About 99.6% of BPA is photodegraded within 60 min when using 1.5 g/L WO_(3)/WS_(2)NRs and 5.0 mg/L BPA at pH 7.0.Additionally,the optimal conditions(pH,catalyst dosage,initial BPA concentration)for WO_(3)/WS_(2)NRs are also elaborately investigated.These rod-like heterostructures are expressed as potential catalysts with excellent photostability,efficient reusability,and highly active effectivity in different types of water.In particular,the removal efficiency of BPA by WO_(3)/WS_(2)NRs reduces by only 1.5% after five recycling runs and even reaches 89.1%in contaminated lake water.This study provides promising insights for the nearly complete removal of BPA from wastewater or different water resources,which is advantageous to various applications in environmental remediation.

关键词： Photodegradation Bisphenol A Tungsten-based nanocatalyst Structure Nanorod

Ultra-fast polymer optical fibre Bragg grating inscription for medical devices

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Light(Science & Applications) 2017年第1期6卷 104-113页

作者： Julien Bonefacino hwa-yaw tam Tom S Glen Xin Cheng Chi-Fung Jeff Pun Jian Wang Po-Heng Lee Ming-Leung Vincent Tse Steven T Boles Photonics Research Centre Department of Electrical EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Division of Urban Environment Department of Civil and Environmental EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina

We report the extraordinary result of rapid fibre Bragg grating inscription in doped polymer optical fibres based on polymethyl methacrylate in only 7 ms,which is two orders of magnitude faster than the inscription times previously reported.This was achieved using a new dopant material,diphenyl disulphide,which was found to enable a fast,positive refractive index change using a low ultraviolet dose.These changes were investigated and found to arise from photodissociation of the diphenyl disulphide molecule and subsequent molecular reorganization.We demonstrate that gratings inscribed in these fibres can exhibit at least a 15 times higher sensitivity than silica glass fibre,despite their quick inscription times.As a demonstration of the sensitivity,we selected a highly stringent situation,namely,the monitoring of a human heartbeat and respiratory functions.These findings could permit the inscription of fibre Bragg gratings during the fibre drawing process for mass production,allowing costeffective,single-use,in vivo sensors among other potential uses.

关键词： bio-sensing fibre Bragg grating photosensitive dopant polymer optical fibre

Broad-spectrum ginsentides are principal bioactives in unraveling the cure-all effects of ginseng

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Acta Pharmaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamaprasad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang James P.tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of Pharmacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Department of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Department of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is complex and involves multiple physiological systems.Panax ginsengs,reputed for their broad-spectrum“cure-all”effect,are widely prescribed to treat stress and related illnesses.However,the identity of ginseng’s“cure-all”medicinal compounds that relieve stress remains unresolved.Here,we identify ginsentides as the principal bioactives that coordinate multiple systems to restore homeostasis in response to stress.Ginsentides are disulfide-rich,cell-penetrating and proteolytic-stable microproteins.Using affinity-enrichment mass spectrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly purified or synthetic ginsentides promote vasorelaxation by producing nitric oxide through endothelial cells via intracellular PI3K/Akt signaling pathway,alleviate a1-adrenergic receptor overactivity by reversing phenylephrine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit P2Y12 receptors to reduce platelet aggregation.Orally administered ginsentides were effective in animal models to reduce ADP-induced platelet aggregation,to prevent collagen and adrenalineinduced pulmonary thrombosis as well as anti-stress behavior of tail suspension and forced swimming tests in mice.Together,these results strongly suggest that ginsentides are the principal panacea compounds of ginsengs because of their ability to target multiple extra-and intra-cellular proteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich peptides Microproteins Cure-all Stress Homeostasis

A Novel Temperature-Compensated, Intensity-Modulated Fiber Bragg Grating Sensor System

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Journal of Electronic Science and Technology of China 2008年第4期6卷 434-437页

作者： Xin-Yong Dong hwa-yaw tam Key Laboratory of Zhejiang Province on ModemMeasurement Technology and Instrument and College of Optical ＆Electronic Technology China Jiliang University Hangzhou 310018China Photonics Research Centre and Department of Electrical Engineering The Hong Kong Polytechnic University Hong Kong

An intensity-modulated, fiber Bragg grating （FBG） sensor system based on radio-frequency （RF） signal measurement is presented. The RF signal is generated at a photodetector by two modulated optical signals reflected from the sensing FBG and a reference one. Bragg wavelength shift of the sensing FBG changes intensity of the RF signal by changing phase difference between the two optical signals, with temperature effect being compensated automatically by the reference FBG, Strain measurement with a maximum sensitivity of -0.34 μV/με has been achieved.

关键词： Optical fiber sensing fiber Bragg gratings intensity-modulated strain.

Rectangular single-mode polymer optical fiber for femtosecond laser inscription of FBGs

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Photonics Research 2021年第10期9卷 1931-1938页

作者： JITENDRA NARAYAN DASH XIN CHENG DINUSHA SERANDI GUNAWARDENA hwa-yaw tam Photonics Research Centre Department of Electrical EngineeringThe Hong Kong Polytechnic UniversityKowloonHong KongChina

In this study,a novel rectangular polymer single-mode optical fiber for femtosecond(fs)laser-inscribed fiber Bragg gratings(FBGs)is proposed and demonstrated.The cylindrical geometry of the widely used circular fiber elongates the fs laser beam along the fiber axis,resulting in reduced laser intensity and requiring index-matching oil immersion during FBG inscription.However,the flat geometry and negligible surface roughness of the featured fiber significantly diminish this lensing distortion and eliminate the need for oil immersion,thereby resulting in optimal focusing of the laser beam,permitting direct and efficient inscription of FBGs within the optical fiber.The core and cladding of the rectangular fiber were fabricated using two different grades of ZEONEX,a cyclo olefin polymer,which have slightly different refractive indices.The similar glass transition temperature for core and cladding simplifies the fiber drawing process,and a rectangular single-mode optical fiber with dimensions of 213μm×160μm and core diameter of 9.4μm was fabricated using an in-house fiber drawing facility.A second harmonic(520 nm)fs laser beam was used to successfully inscribe a 2-mm-long FBG in the rectangular fiber within a few seconds with a point-by-point technique.The inscription of a single FBG leads to the excitation of higher order FBG peaks at 866.8 and 1511.3 nm,corresponding to widely used wavelength bands in fiber optic sensing.The strain and temperature sensitivities of the FBG were measured to be 7.31 nm=%ε(0.731pm∕με)and 10 pm/℃,and 12.95 nm∕%ε(1.29 pm∕με)and 15 pm/℃at 866.8 nm and 1511.3 nm,respectively.

关键词： fiber mode rectangular

Assessing the Performance of a Dynamical Downscaling Simulation Driven by a Bias-Corrected CMIP6 Dataset for Asian Climate

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Advances in Atmospheric Sciences 2024年第5期41卷 974-988页

作者： Zhongfeng XU Ying HAN Meng-Zhuo ZHANG Chi-Yung tam Zong-Liang YANG Ahmed M.EL KENAWY Congbin FU Institute of Atmospheric Physics Chinese Academy of SciencesBeijing 100029China School of Atmospheric Sciences Nanjing UniversityNanjing 210093China Earth System Science Programme The Chinese University of Hong KongHong KongChina Department of Geological Sciences Jackson School of GeosciencesThe University of Texas at AustinAustinTexasUSA Instituto Pirenaico de Ecología Consejo Superior de Investigaciones Científicas(CSIC)Campus de Aula Dei1005Zaragoza 50059Spain Department of Geography Mansoura UniversityMansoura 35516Egypt

In this study,we aim to assess dynamical downscaling simulations by utilizing a novel bias-corrected global climate model(GCM)data to drive a regional climate model(RCM)over the Asia-western North Pacific region.Three simulations were conducted with a 25-km grid spacing for the period 1980–2014.The first simulation(WRF_ERA5)was driven by the European Centre for Medium-Range Weather Forecasts Reanalysis 5(ERA5)dataset and served as the validation dataset.The original GCM dataset(MPI-ESM1-2-HR model)was used to drive the second simulation(WRF_GCM),while the third simulation(WRF_GCMbc)was driven by the bias-corrected GCM dataset.The bias-corrected GCM data has an ERA5-based mean and interannual variance and long-term trends derived from the ensemble mean of 18 CMIP6 models.Results demonstrate that the WRF_GCMbc significantly reduced the root-mean-square errors(RMSEs)of the climatological mean of downscaled variables,including temperature,precipitation,snow,wind,relative humidity,and planetary boundary layer height by 50%–90%compared to the WRF_GCM.Similarly,the RMSEs of interannual-tointerdecadal variances of downscaled variables were reduced by 30%–60%.Furthermore,the WRF_GCMbc better captured the annual cycle of the monsoon circulation and intraseasonal and day-to-day variabilities.The leading empirical orthogonal function(EOF)shows a monopole precipitation mode in the WRF_GCM.In contrast,the WRF_GCMbc successfully reproduced the observed tri-pole mode of summer precipitation over eastern China.This improvement could be attributed to a better-simulated location of the western North Pacific subtropical high in the WRF_GCMbc after GCM bias correction.

关键词： bias correction multi-model ensemble mean dynamical downscaling interannual variability day-to-day variability validation