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p53和bcl-2蛋白在非肿瘤性、癌前性及肿瘤性高度增殖角化性皮损中的表达分析

世界核心医学期刊文摘（皮肤病学分册） 2005年第3期1卷 25-25页

作者： hussein M.R. Al-Badaiwy Z.h. Guirguis M.N. 马慧群 Department of Path.logy Faculties of Medicine Assuit and South Valley Universities Assuit Egypt Dr.

Background: Th. h.perproliferative keratinocytic lesions encompass a wide ran ge of non-tumorigenic, pretumorigenic, and tumorigenic conditions. Th. aim of th.s work was to examine th. expression patterns of apoptosis-linked molecules (bcl-2 and p53) in th.se lesions. Meth.ds: Immunoperoxidase staining meth.ds were applied to analyze p53 and bcl- 2 protein expression in a total of 66 case s, including 12 squamous cell carcinomas (both.in situ and invasive SCC), 11 act inic keratoses(AK), 13 psoriasis vulgaris(PV), eigh. verruca vulgaris(VV), six c h.onic dermatitis(CD), five seborrh.ic keratosis(SK), four lich.n planus(LP),th. ee epidermodysplasia verruciformis (EDV), two condyloma acuminata(CA),two lich.n simplex ch.onicus (LSC), and 10 specimens from normal skin. Results: As compare d to normal skin (0.70 ± 0.26), th. bcl- 2 average weigh.ed scores in th. non -tumorigenic (0.76 ± 0.16), pretumorigenic (1.45 ± 0.28), and tumorigenic lesions (2.83 ± 0.50 and 2.92 ± 0.50 for in situ and invasive SCC, respectiv ely) sh.wed significant up-regulation (P = 0.001). In th. non-tumorigenic lesions, th. bcl- 2 expression values decreased in th. following order: SK > EDV > CD > LP > CA > PV > VV (1.40 ± 0. 24 > 1.33 ± 0.67 > 0.83 ± 0.40 > 0.67 ± 0.21 > 0.50 ± 0.20 > 0.46 ± 0. 22 > 0.13 ± 0.01, respectively). As compared to normal skin (1.10 ± 0.23), t h. p53 average weigh.ed scores in th. non-tumorigenic (1.86 ± 0.18), pretumo rigenic (3.64 ± 0.53), and tumorigenic lesions (5.00 ± 1.00 and 5.08 ± 0.8 6 for in situ and invasive SCC, respectively) sh.wed significant up-regulation (P = 0.021). In th. non-tumorigenic lesions, p53 average weigh.ed scores decr eased in th. following order: SK > PV > CA > LP > CD > VV > EDV (3.20 ± 0.49 > 2.38 ± 0.27 > 2.0 ± 0.0 > 1.83 ± 0.48 > 1.0 ± 0.37 > 1.0 ± 0.33 > 1.0 ± 0.0, respectively). Th.re was a positive correlation between bcl- 2 and p5 3 protein expression in normal skin (r=0.966, P=0.0001), non-tumorigenic (r=0. 775, P= 0.0001), pretu

关键词：非肿瘤性 bcl-2蛋白角化性 p53 凋亡相关分子寻常型银屑病脂溢性角化病表皮发育不全侵袭性癌前病变

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Triple-Band Metamaterial Inspired Antenna for Future Terah.rtz(Th.)Applications

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Computers, Materials & Continua 2022年第7期72卷 1071-1087页

作者： Adel Y.I.Ash.ap S.Alamri S.h.Dah.an Z.Z.Abidin M.Inam Abbasi h.da A.Majid M.R.Kamarudin Y.A.Al-Gumaei M.h.sh.m Dah.i Center for Applied Electromagnetic(EMCenter) Faculty of Electrical and Electronic EngineeringUniversiti Tun Hussein Onn Malaysia(UTHM)Batu Pahat86400JohorMalaysia Faculty of Engineering Electrical Engineering Dep. Al Baha UniversityAlaqiq65799Al-BahaSaudi Arabia Advanced Telecommunication Research.Center(ATRC) Faculty of Electrical and Electronic EngineeringUniversiti Tun Hussein Onn Malaysia(UTHM)Batu Pahat86400JohorMalaysia Faculty of Electrical and Electronic Engineering Tech.ology Universiti Teknikal Malaysia MelakaHang Tua Jaya76100Durian TunggalMelakaMalaysia Department of Math.matics Physicsand Electrical EngineeringNorthumbria UniversityNE18ST Newcastle Upon TyneUK Department of Electronic Engineering Dawood University of Engineering and TechnologyKarachi74800Pakistan

For future h.alth.are in th. terah.rtz(Th.)band,a triple-band microstrip planar antenna integrated with.metamaterial(MTM)based on a polyimide substrate is *** frequencies of operation are 500,600,and 880 *** triple-band capability is accomplish.d by etch.ng metamaterial on th. patch.with.ut affecting th. overall antenna *** of a partial ground plane,a full ground plane is used as a buffer to sh.eld th. body from back radiation emitted by th. *** overall dimension of th. proposed antenna is 484×484μm^(2).Th. antenna’s performance is investigated based on different crucial factors,and excellent results are *** gain for th. frequencies 500,600,880Gh. is 6.41,6.77,10.1 dB,respectively wh.le th. efficiency for th. same frequencies is 90%,95%,96%,*** research.h.s been conducted by mounting th. presented antenna on a single ph.ntom layer with.varying dielectric *** results sh.w th.t th. design works equally well with.and with.ut th. ph.ntom model,in contrast to a partially ground antenna,wh.se performance is influenced by th. presence of th. ph.ntom *** a result,th. presented antenna could be h.lpful for future h.alth.are applications in th. Th. band.

关键词： Th. metamaterial triple-band wireless body area networks(WBAN)

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Th. Drainage Exch.nge of Stormwater Potential in Flat Area Problems

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Journal of Environmental Science and Engineering 2010年第10期4卷 1-8页

作者： S. Musa N.A. Zakaria S.h. Lai D. Tjah.anto River Engineering and Urban Drainage Research.Centre （REDAC） Universiti Sains Malaysia Engineering Campus Seberang Perai Selatan Seri Ampangan Nibong Tebal 14300 Penang Malaysia Faculty of Civil and Environmental Engineering Universiti Tun Hussein Onn Malaysia Parit Raja Batu Pahat Johor 86400 Malaysia

Groundwater as an alternative source still does not contribute to th. water supply in area of Parit Raja because of th. limitation of water availability in th. ground. Th.s lacking of groundwater could be caused by th. circumstance th.t th. top layer of soil is dominated by compacted clay around 2 meters in wh.ch.its permeability is small, so th. water is difficult to infiltrate th. ground. Th. rech.rge well tech.ique was designed based on th. flat area problems, layer of real condition, flow water table and low infiltration rate. Resistivity soundings were made at existing wells to assess th. subsurface layers. Beside th.t, th. past records on floods event, sub surface and surface studies were collected around study area as a preliminary studies. It was presented th.t th. study area promised good prospects to increase th. capability of groundwater and contribute to th. drainage system by reducing th. volume of rainfall runoff using th. rech.rge well tech.ique.

关键词： Groundwater rech.rge well water supply drainage system

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Saturation beh.vior of a one-pump fiber optical parametric amplifier in th. presence of th. fourth.order dispersion coefficient and dispersion fluctuation

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Ch.nese Optics Letters 2019年第11期17卷 11-16页

作者： N.Oth.an K.G.Tay N.S.Moh. Sh.h.R.Talib h.Pakarzadeh.N.A.Ch.lan Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn Malaysia86400 Batu PahatJohorMalaysia Faculty of Engineering Tech.ology Universiti Tun Hussein Onn Malaysia84600 PagohJohorMalaysia Department of Ph.sics Shiraz University of TechnologyShirazIran

Th. influence of th. fourth.order dispersion coefficient on th. beh.vior of parametric gain and saturation power of a one-pump fiber optical parametric amplifier over a signal wavelength.span in th. presence of fiber random dispersion fluctuations was investigated. Th. output signal power for th. parametric gain calculation was obtained by numerically solving th. th.ee-coupled amplitude equations. Based on th. calculations of th. parametric gain over a variation of th. signal wavelength. it is found th.t th. saturation power beh.vior is dependent on th. beh.vior of parametric gain. Th. manipulations of signal wavelength.and th. fourth.order dispersion coefficient ch.nged th. ph.se-match.ng condition, th.reby affecting th. resulting parametric gain and saturation power.

关键词： parametric dispersion coefficient

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Safety and immunogenicity of a mosaic vaccine booster against Omicron and oth.r SARS-CoV-2 variants:a randomized ph.se 2 trial

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Signal Transduction and Targeted Th.rapy 2023年第2期8卷 672-682页

作者： Nawal Al Kaabi Yun Kai Yang Yu Liang Ke Xu Xue Feng Zh.ng Yun Kang Yu Qin Jin Jun Wei h.u Jing Zh.ng Tian Yang Salah.hussein Moh.med Saif ElDein Ze h.a Lei h.o Zh.ng Sh.ai Sh.o Zh.o Ming Liu Ning Liu Xiang Zh.ng Ji Guo Su Sen Sen Yang Xiangfeng Cong Yao Tan Wenwen Lei Xue Jun Gao Zh.wei Jiang h.i Wang Meng Li h.nadi Mekki Mekki Walid Zah.r Sally Mah.oud Xue Zh.ng Ch.ng Qu Dan Ying Liu Jing Zh.ng Mengjie Yang Islam Eltantawy Peng Xiao Fu Jie Sh.n Jin Juan Wu Zi Bo h.n Li Fang Du Fang Tang Sh. Ch.n Zh. Jing Ma Fan Zh.ng Ya Nan h.u Xin Yu Li Xin Li Zh.o Nian Wang Jin Liang Yin Xiao Yan Mao Jin Zh.ng Liang Qu Yun Tao Zh.ng Xiao Ming Yang Guizh.n Wu Qi Ming Li Sh.ikh.Kh.lifa Medical City SEHAAbu DhabiUAE College of Medicine and h.alth.Sciences Khalifa UniversityAbu DhabiUAE Ch.na National Biotec Group Company Limited BeijingChina Th. Sixth.Laboratory National Vaccine and Serum Institute(NVSI)BeijingChina National Engineering Center for New Vaccine Research BeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention(China CDC)BeijingChina Clinical Medicine Office National Vaccine and Serum Institute(NVSI)BeijingChina Lanzh.u Institute of Biological Products Company Limited LanzhouChina Beijing Key Tech.Statistical Consulting Co. LtdBeijingChina Beijing Institute of Biological Products Company Limited BeijingChina Union 71 Abu DhabiUAE G42 h.alth.are Abu DhabiUAE

An ongoing randomized,double-blind,controlled ph.se 2 trial was conducted to evaluate th. safety and immunogenicity of a mosaic-type recombinant vaccine candidate,named NVSI-06-09,as a booster dose in subjects aged 18 years and older from th. United Arab Emirates(UAE),wh. h.d administered two or th.ee doses of inactivated vaccine BBIBP-CorV at least 6 month. prior to *** participants were randomly assigned with.1:1 to receive a booster dose of NVSI-06-09 or *** primary outcomes were immunogenicity and safety against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)Omicron variant,and th. exploratory outcome was cross-immunogenicity against oth.r circulating *** May 25 and 30,2022,516 adults received booster vaccination with.260 in NVSI-06-09 group and 256 in BBIBP-CorV *** results sh.wed a similar safety profile between two booster groups,with.low incidence of adverse reactions of grade 1 or *** immunogenicity,by day 14 post-booster,th. fold rises in neutralizing antibody geometric mean titers(GMTs)from baseline elicited by NVSI-06-09 were remarkably h.gh.r th.n th.se by BBIBP-CorV against th. prototype strain(19.67 vs 4.47-fold),Omicron BA.1.1(42.35 vs 3.78-fold),BA.2(25.09 vs 2.91-fold),BA.4(22.42 vs 2.69-fold),and BA.5 variants(27.06 vs 4.73-fold).Similarly,th. neutralizing GMTs boosted by NVSI-06-09 against Beta and Delta variants were also 6.60-fold and 7.17-fold h.gh.r th.n th.se by *** findings indicated th.t a booster dose of NVSI-06-09 was well-tolerated and elicited broad-spectrum neutralizing responses against divergent SARS-CoV-2 variants,including Omicron and its sub-lineages.

关键词： ph.se neutral spectrum

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Titanium dioxide-based Q-switch.d dual wavelength.in th. 1 micron region

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Ch.nese Optics Letters 2016年第9期14卷 48-52页

作者： h.Ah.ad M.A.M.Salim Z.A.Ali M.F.Ismail K.Th.mbiratnam A.A.Latif N.Nayan S.W.h.run Ph.tonics Research.Centre(PRC) University of Malaya Department of Ph.sics University Putra Malaysia Faculty of Electrical and Electronic Engineering Universiti Tun Hussein Onn Malaysia

In th.s work a passively Q-switch.d dual-wavelength.ytterbium-doped fiber laser using a titanium dioxide-based saturable absorber is proposed and proven. Th. system also utilizes a side-polish.d fiber in a ring cavity configuration to obtain th. desired pulse train. A stable dual-wavelength.pulse output is obtained at 1034.7and 1039.0 nm, with.a maximum pulse energy of 2.0 n J, and a sh.rtest pulse width.of 3.2 μs. Th. generated pulse train is stable, and h.s a pulse repetition rate from 31.2 to 64.5 kh..

关键词： Titanium dioxide-based Q-switch.d dual wavelength.in th. 1 micron region

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污水灌溉在沙土中所造成的铅、镉、锌和硼的潜在污染

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灌溉排水 1995年第2期14卷 50-52页

作者： EL－h.,AS 邵孝修河海大学

污水灌溉在沙土中所造成的铅、镉、锌和硼的潜在污染Ａ．Ｓ．ＥＬ—ＨＡＳＳＡＮＩＮ《Ｗａｒｅｒ，Ａｉｒ，ａｎｄｓｏｌｌＰｏｌｌｕｔｉｏｎ｝６６：２３９－２４９（１９９３）［英文］对埃及ＡｂｕＲａｗａｓｈ和ＥｌｇａｂａｌＥ... 详细信息

污水灌溉在沙土中所造成的铅、镉、锌和硼的潜在污染Ａ．Ｓ．ＥＬ—ＨＡＳＳＡＮＩＮ《Ｗａｒｅｒ，Ａｉｒ，ａｎｄｓｏｌｌＰｏｌｌｕｔｉｏｎ｝６６：２３９－２４９（１９９３）［英文］对埃及ＡｂｕＲａｗａｓｈ和ＥｌｇａｂａｌＥｌ－Ａｓｆａｒ两地污灌６７年后Ｐｈ...

关键词：污水灌溉沙土铅镉锌硼污染

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单纯超声引导下经股静脉封堵筛孔型房间隔缺损的疗效评价

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中国胸心血管外科临床杂志 2019年第9期26卷 889-894页

作者：孙保程端李波贺贵宝王海峰阿哈提伊力亚斯盛唏李金鹏萨达姆·胡赛因俞国军詹树生张玲新疆心脑血管病医院心外科乌鲁木齐830011 新疆心脑血管病医院超声科乌鲁木齐830011

目的介绍超声引导下经皮由股静脉入路应用多孔筛状房间隔封堵器(amplatzer cribriform occluder,ACO)及房间隔缺损封堵器(atrial septal defect occluder,ASDO)封堵筛孔型房间隔缺损(atrial septal defect,ASD)的经验,评估其可行性、有效性及安全性。方法回顾性分析我院 2015 年 12 月至 2018 年 5 月 48 例在超声引导下经股静脉封堵筛孔型 ASD 患者的临床资料,其中男 17 例、女 31 例,年龄 10 个月至51 岁,平均年龄(11.50±13.86)岁,体重 6~79(27.00±20.14)kg。48 例筛孔型 ASD 患者中 12 例为双孔型,13 例为房间隔膨胀瘤并缺损,23 例为多孔型 ASD。所有患者均在经胸超声心动图(transth.racic ech.cardiograph.,TTE)或经食管超声心动图(transesoph.geal ech.cardiograph.,TEE)引导下完成筛孔型 ASD 的封堵。术后次日复查超声、心电图及胸部 X 线片以评价疗效。结果 48 例筛孔型 ASD 患者共使用 49 枚封堵器,1 例置入 2 枚封堵器,其余置入 1 枚封堵器。ASDO 29 枚,ACO 20 枚,ASDO 大小为 8~26 mm,ACO 大小为 18~34 mm。术中 TTE/TEE 检查显示 48 例均完全封堵成功,13 例在释放推送杆前可见细束分流,释放推送杆后 9 例有细束分流,术后 24 h.复查 8 例有细束分流,1 年后复查 3 例微量分流。所有随访患者封堵器位置形态良好,右心不同程度缩小,胸部 X 线片显示肺血不同程度减少,术后心电图未见心律失常。结论单纯超声引导下经股静脉入路选用 ACO 及 ASDO 封堵筛孔型 ASD,是一种安全有效的方法。

关键词：超声心动图股静脉房间隔缺损房间隔缺损封堵器

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肩关节镜

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中国骨科临床与基础研究杂志 2017年第5期 298-298页

作者： Elkousy h.Edwards TB

ISBN-10:0323529011ISBN-13:978-0323529013Elsevier出版社2018年4月出版3版397页本书由hussein Eldousy和*** Edwards两位肩关节镜领域资深专家撰写,全方位介绍肩关节镜常规和复杂技术,清晰描述每种术式的标准入路、常见解剖变异和并... 详细信息

ISBN-10:0323529011ISBN-13:978-0323529013Elsevier出版社2018年4月出版3版397页本书由hussein Eldousy和*** Edwards两位肩关节镜领域资深专家撰写,全方位介绍肩关节镜常规和复杂技术,清晰描述每种术式的标准入路、常见解剖变异和并发症等,同时为术者提供直观的课堂式教学,引领读者熟悉手术的每一个步骤。本书以简洁扼要的语言阐述了肩关节解剖学特点、适应证和禁忌证、非手术疗法、术

关键词：肩关节镜

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