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Anti-inflammatory and anti-apoptotic effects of N-acetylcysteine in diabetic rat corneal epithelium

International Journal of Ophthalmology(English edition) 2021年第12期14卷 1805-1812页

作者： Sae-Byeok Hwang Jin Hyoung Park Ji-yun Park Soon-Suk Kang Ho Seok Chung hun Lee Jae Yong Kim hungwon Tchah Research Institute of Miso Eye Clinic Gyeonggi-do 13640Republic of Korea Biomedical Research Center Asan Institute for Life ScienceAsan Medical CenterSeoul 05505Republic of Korea Miso Eye Clinic Gyeonggi-do 13640Republic of Korea Department of Ophthalmology University of Ulsan College of MedicineSeoul 05505Republic of Korea Research Institute for Biomacromolecules University of Ulsan College of MedicineSeoul 05505Republic of Korea Department of Ophthalmology Dankook University HospitalDankook University College of MedicineCheonan 31116Republic of Korea

AIM:To characterize the anti-inflammatory and antiapoptotic effects of N-acetylcysteine(NAC)in streptozotocin(STZ)-induced diabetic rat corneal epithelium and human corneal epithelial cells(HCECs)exposed to a high-glucose ***:HCECs were incubated in 0,5,50 mmol/L glucose medium,or 50 mmol/L glucose medium with NAC for *** was induced in rats by intraperitoneal injection of 65 mg/kg STZ and some of these rats were topically administered NAC to corneas with 3 mice per *** characterized receptor for advanced glycation end-products(RAGE)expression using immunofluorescence,and interleukin(IL)-1βand cleaved caspase-3(CCAP-3)expression using *** tumor necrosis factor(TNF)-αconcentration was measured by ELISA and cleaved poly-ADP ribose polymerase(PARP)concentration was quantified by Western *** cells were detected using TUNEL assay and annexin V and propidium iodide ***:Diabetic rats had higher expression of RAGE(2.46±0.13 fold),IL-1β,and CCAP-3 in apoptotic cells of their corneas than control *** expression of RAGE(1.83±0.11 fold),IL-1β,and CCAP-3,and the number of apoptotic cells,were reduced by topical NAC *** incubated in 50 mmol/L glucose medium showed high concentrations of TNF-α(310±2.00 pg/mL)and cleaved PARP(7.43±0.56 fold),and more extensive apoptosis than cells in 50 mmol/L glucose ***,the addition of NAC reduced the concentrations of TNF-α(153.67±2.31 pg/mL)and cleaved PARP(5.55±0.31 fold)and the number of apoptotic ***:NAC inhibits inflammation and apoptosis in the corneas of diabetic rats and HCECs maintained in a high-glucose environment.

关键词： N-acetylcysteine apoptosis inflammation diabetes corneal epithelium rat

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基于非线性约束的局部投影降噪

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电子与信息学报 2009年第2期31卷 400-404页

作者：韩敏刘云侠大连理工大学电子与信息工程学院大连116023

基于相空间重构理论,该文提出了一种改进的混沌时序降噪方法。首先利用递归图对实际观测的时间序列进行混沌特性分析,然后将非线性约束条件引入局部投影方法之中,并在局部邻域内进行奇异谱(SSA)分析,利用代表吸引子的主分量来重构时间... 详细信息

基于相空间重构理论,该文提出了一种改进的混沌时序降噪方法。首先利用递归图对实际观测的时间序列进行混沌特性分析,然后将非线性约束条件引入局部投影方法之中,并在局部邻域内进行奇异谱(SSA)分析,利用代表吸引子的主分量来重构时间序列。该算法克服了传统局部投影方法不能充分刻画系统内在非线性关系的问题,减小了重构误差,提高了系统的信噪比。通过对Lorenz模型和太阳黑子混沌时间序列进行仿真分析,证实了该文算法对实际观测混沌时序降噪的有效性。

关键词：混沌时间序列局部投影非线性约束奇异谱分析递归图

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Simultaneous multiple coronary arteries thrombosis in patients with STEMI

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Journal of Geriatric Cardiology 2018年第3期15卷 241-243页

作者： Seunghwan Kim Sang-Hoon Seol Dong-Hee Park yun-Seok Song Dong-Kie Kim Ki-hun Kim Doo-Il Kim Pil-Sang Song Department of Internal Medicine Haeundae Paik Hospital lnje University college of Medicine Busan Republic of Korea Department of Internal Medicine Se-Jong General Hospital Incheon Republic of Korea

Simultaneous thrombosis affecting more than one coronary artery has been reported to occur in about 4.8% of the cases at the time primary percutaneous coronary intervention （PCI）. Simultaneous multiple coronary arteries throm-bosis is uncommon and can lead to a fatal outcome. Careful attention should be given to identification of abnormal ECG and coronary angiography （CAG） results. The affected ves- sel should be opened timely and efficiently in an effort to save the myocardium and reduce serious complications such as congestive heart failure, ventricular arrhythmia, cardiogenic shock, or sudden cardiac death.

关键词： Multiple Simultaneous STEMI Thrombosis

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Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam hun Park Hyeonkyeong Kim Jiseon Shin Jungseok Choi Sungmin Park Ji-yun Moon Kwanbyung Chae Jeil Jung Jae-Hyun Lee Youngdong Yoo Ji-Yong Park Kwang Jun Ahn Dong-Il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji hun Park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-yun Sun Jong Woong Park Jae Ho Shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve ***,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time ***,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was *** this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the *** using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic *** sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated *** and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were ***,muscle function recovery was improved in rats treated with *** together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

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Wireless Power Generation Strategy Using EAP Actuated Energy Harvester for Marine Information Acquisition

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Wireless Sensor Network 2011年第9期3卷 313-317页

作者： So-Nam yun Eun-A Jeong Hwang-hun Jeong Ky-yun Lee 不详

The energy of a radio wave is reduced through the dispersion, the refraction and the absorption because the medium transferring the vibration of a radio wave is the seawater. In the end the reduced energy of a radio wave causes the reduced transmitting length for communication, the long postponed communication and the frequent error. The subsea communication for the marine environment monitoring which must overcome the weak points of the RF wave and the most practical method for the marine sensor network realization is to use the acoustic wave method, but the energy consumption rate of the acoustic wave communication method is about 100 times greater than the one of the RF wave method. So, the power supply of the sensor node in the marine sensor network system is the most important interest field. In this study, the sample which consists of an acrylic elastomer(VHB4905 film from 3M), conductible carbon grease(from MG chemical) and electric wire for the basic study of an energy harvesting strategy and technique using EAP actuator was fabricated, and the conductible carbon grease was used for an electrode. The characteristics of the fabricated sample were analyzed through the experiment. We also mixed carbon grease with aluminum powder for conductibility improvement, and the effect of the mixed electrode was confirmed through the conductivity measurement.

关键词： Electroactive Polymer Energy Harvester Electric Conductivity Wireless Power Generation Marine Information Acquisition

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ETPTA复合PVDF-HFP基聚合物固态电解质膜的制备与性能研究

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广西科技大学学报 2024年第2期35卷 111-117页

作者：浑前坤贠淑宏卢炫安史雪利王玉莹沈鹏程梁兴华广西科技大学机械与汽车工程学院广西柳州545616

固态电池因其优异的性能备受关注,但是与传统的液态电池相比,离子传输能力偏弱,原因是固-固界面离子传输困难。本文制备了以聚偏氟乙烯-六氟丙烯(PVDF-HFP)为基的固态电解质膜,并探究PVDF-HFP和增塑剂乙氧基化三羟甲基丙烷三丙烯酸酯(ET... 详细信息

固态电池因其优异的性能备受关注,但是与传统的液态电池相比,离子传输能力偏弱,原因是固-固界面离子传输困难。本文制备了以聚偏氟乙烯-六氟丙烯(PVDF-HFP)为基的固态电解质膜,并探究PVDF-HFP和增塑剂乙氧基化三羟甲基丙烷三丙烯酸酯(ETPTA)质量比为1.0∶0.3、1.0∶0.4、1.0∶0.5时对电解质膜离子传输的影响,并组装成以磷酸铁锂为正极、锂片为负极的固态电池,研究其电化学性能。研究发现:当PVDF-HFP和ETPT质量比为1.0∶0.4时,锂离子迁移数达0.89,电化学窗口可达4 V,离子电导率达到8×10^(-5)S/cm,表现出良好的稳定性。将质量比为1.0∶0.4的电解质膜装配成固态电池,经过激活之后,首先在0.1C的倍率下进行测试,首圈充电比容量为133 m A·h/g,首圈放电比容量为129 m A·h/g,在20圈循环测试后,放电比容量也能保持在120 mA·h/g以上,容量保持率为92%。

关键词： ETPTA PVDF-HFP 固态电解质膜性能研究离子电导率

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PVDF-HFP与LATP不同配比对固态电解质膜的影响

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广西科技大学学报 2024年第4期35卷 123-129页

作者：贠淑宏史雪利浑前坤卢炫安王玉莹沈鹏程梁兴华广西汽车零部件与整车技术重点实验室(广西科技大学) 广西柳州545616

液态电解质锂离子电池因其潜在的安全性问题,发展新的固态电解质锂离子电池是目前所研究的热点。磷酸铝钛锂(Li_(1.5)Al_(0.5)Ti_(1.5)(PO_(4))_(3),LATP)是一种NASICON型陶瓷材料,由于其空气稳定性和较好的Li^(+)导电性而备受关注。然... 详细信息

液态电解质锂离子电池因其潜在的安全性问题,发展新的固态电解质锂离子电池是目前所研究的热点。磷酸铝钛锂(Li_(1.5)Al_(0.5)Ti_(1.5)(PO_(4))_(3),LATP)是一种NASICON型陶瓷材料,由于其空气稳定性和较好的Li^(+)导电性而备受关注。然而,为了达到良好的离子导电性并降低晶界阻抗,LATP需要950℃以上的高温来实现致密化,这对于大规模应用来说耗时且昂贵。本文使用简单的溶液浇铸法,通过将LATP嵌入共聚物PVDF-HFP(聚偏氟乙烯-六氟丙烯)基体,合成新的复合固态电解质膜。在此基础上,以磷酸铁锂(LiFePO_(4))为正极,使用PVDF-HFP/LATP复合固态电解质膜进行电池组装。在室温下,利用X射线衍射仪(X-ray diffractometer,XRD)、扫描电子显微镜(scanning electron microscope,SEM)对不同质量比的固态电解质膜进行物理特性研究,并进行相关电化学测试。结果表明,PVDF-HFP/LATP质量比为5∶1的复合固态电解质膜,其LATP的NASICON型晶体结构得到了很好的保持;制备的聚合物固态电解质膜具有阻燃性;组装的半电池在常温条件下锂离子迁移数达到0.70。全电池在20次充放电循环下,放电比容量保持率为85%。

关键词： Li_(1.5)Al_(0.5)Ti_(1.5)(PO_(4))_(3) PVDF-HFP 复合固态电解质膜锂离子迁移数

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Newly developed autoimmune cholangitis without relapse of autoimmune pancreatitis after discontinuing prednisolone

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World Journal of Gastroenterology 2012年第41期18卷 5990-5993页

作者： Ji hun Kim Jae Hyuck Chang Sung Min Nam Mi Jeong Lee Il Ho Maeng Jin Young Park yun Sun Im Tae Ho Kim Chang Whan Kim Sok Won Han Department of Internal Medicine College of MedicineThe Catholic University of KoreaSeoul 137-701South Korea

A 57-year-old man presented with a 2-wk history of painless jaundice and weight Iossl He had a large ill- defined enhancing mass-like lesion in the uncinate pro- cess of the pancreas with stricture of the distal common bile duct. Aspiration cytology of the pancreatic mass demonstrated inflammatory cells without evidence of malignancy. Total serum immunoglobulin G level was slightly elevated, but IgG4 level was normal. After the 2-wk 40 mg prednisolone trial, the patient＇s symptoms and bilirubin level improved significantly. A follow-up computed tomography （CT） scan showed a dramatic resolution of the pancreatic lesion. A low dose steroid was continued. After six months he self-discontinued prednisolone for 3 wk, and was presented with jaundice again. ACT scan showed newly developed intrahepatic biliary dilatation and marked concentric wall thickening of the common hepatic duct and the proximal common bile duct without pancreatic aggravation. The patient＇ s IgG4 level was elevated to 2.51 g/L. Prednisolone was started again, after which his serum bilirubin level became normal and the thickening of the bile duct was resolved. This case suggests that autoimmune pancre- atitis can progress to other organs that are not involved at the initial diagnosis, even with sustained pancreatic remission.

关键词： Autoimmune disease Pancreatitis Cholan-gitis Prednisolone

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Structural Resistance of SRC Column-Steel Beam Joint Developed for Innovative Construction of Buildings

Structural Resistance of SRC Column-Steel Beam Joint Develop...

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第六届国际低合金高强度钢会议

作者： Seo Soo-yeon yun Hyun-Do Kim Seung-hun (Dept.of Architectural Engineering Chungju National UniversityChungjuKorea Dept.of Architectural Engineering Chungnam National UniversityDaejeonKorea Dept.of Architectural Engineering Hanbat National UniversityDaejeonKorea

＜正＞This paper presents an experimental study investigating factors influencing the effective width of steel reinforced concrete（SRC）column-steel beam joints of building in order to calculate its resisting *** 1/2 scaled interior SRC column-steel beam joint specimens were made with considering parameters such as beam flange width, beam depth and SRC column *** directional increasing moment was applied to the joint by acting forces to each ends of beam and the structural behavior of joint was *** previous design method suggested by Deierlein was reviewed and a modified equation was proposed from the analysis of test *** result indicated that the equation to calculate the effective width in Deierlein’s design method didn’t consider effectively the influence caused by the variation of beam depth so that a modified equation was suggested and the validation of it was confirmed in this paper.

关键词： SRC column-steel beam joint effective width flange width beam depth

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