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NIR-II live imaging study on the degradation pattern of collagen in the mouse model

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Regenerative Biomaterials 2023年第1期10卷 271-279页

作者： huizhu li Xinxian Meng Huaixuan Sheng Sijia Feng Yuzhou Chen Dandan Sheng liman Sai Yueming Wang Mo Chen Yan Wo Shaoqing Feng Hossein Baharvand Yanglai Gao Yunxia li Jun Chen Department of Sports Medicine Sports Medicine Institute of Fudan UniversityHuashan HospitalFudan UniversityShanghai 200040China Department of Plastic and Reconstructive Surgery School of MedicineShanghai Jiao Tong UniversityShanghai Ninth People’s HospitalShanghai 200011China Department of Physics Shanghai Normal UniversityShanghai 200234China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Stem Cells and Developmental Biology Cell Science Research CenterRoyan Institute for Stem Cell Biology and TechnologyACECRTehran ***Iran Department of Developmental Biology School of Basic Sciences and Advanced Technologies in BiologyUniversity of Science and CultureTehran ***Iran Hexi College ZhangyeGansu 73400China

The degradation of collagen in different body parts is a critical point for designing collagen-based biomedical ***,three kinds of collagens labeled by second near-infrared(NIR-II)quantum dots(QDs),including collagen with low crosslinking degree(LC),middle crosslinking degree(MC)and high crosslinking degree(HC),were injected into the subcutaneous tissue,muscle and joints of the mouse model,respectively,in order to investigate the in vivo degradation pattern of collagen by NIR-II live *** results of NIR-II imaging indicated that all tested collagens could be fully degraded after 35 days in the subcutaneous tissue,muscle and joints of the mouse ***,the average degradation rate of subcutaneous tissue(k=0.13)and muscle(k=0.23)was slower than that of the joints(shoulder:k=0.42,knee:k=0.55).Specifically,the degradation rate of HC(k=0.13)was slower than LC(k=0.30)in muscle,while HC showed the fastest degradation rate in the shoulder and knee *** summary,NIR-II imaging could precisely identify the in vivo degradation rate of ***,the degradation rate of collagen was more closely related to the implanted body parts rather than the crosslinking degree of collagen,which was slower in the subcutaneous tissue and muscle compared to the joints in the mouse model.

关键词： collagen degradation rate NIR-II live imaging in vivo crosslinking degree

Special report on relationship between wind farms and power grids

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Engineering Sciences 2009年第2期7卷 13-17页

作者： Dai huizhu Wang Weisheng li Hanxiang China Electric Power Research Institute （CEPRI） Beijing 100085 China

The installed capacity of a large scale wind power plant will be up to a number of hundreds MW, and the wind power is transmitted to load centers through long distance transmission lines with 220 kV, 500 kV, or 750 kV. Therefore, it is necessary not only considering the power transmission line between a wind power plant and the first connection node of the power network, but also the power network among the group of those wind power plants in a wind power base, the integration network from the base to the existed grids, as well as the distribution and consumption of the wind power generation by loads. Meanwhile, the impact of wind power stochastic fluctuation on power systems must be studied. In recent years, wind power prediction technology has been studied by the utilities and wind power plants. As a matter of fact, some European countries have used this prediction technology as a tool in national power dispatch centers and wind power companies.

关键词： wind farms (wind power plants) power grids wind power integration wind power prediction

In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu huizhu li liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage *** this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their *** delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)*** Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with *** results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

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Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun huizhu li Fuchun Chen Nguyen Thi Kim Thanh Yunxia li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and *** in a decline in skeletal muscle ***,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related *** to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle ***,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФ*** fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse *** is found that the implanted M2MФaccumulated at the injury site for two ***,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 ***,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle *** results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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国外所藏五件镶嵌铜牌饰的初步认识

华夏考古 2007年第1期 88-93页

作者：王青李慧竹山东大学东方考古研究中心山东济南市250100 山东大学博物馆山东济南市250100

本文讨论的是五件现存国外的镶嵌铜牌饰的分期与年代。根据作者的观点,这些铜牌饰应属二里头文化时期,大多是在20世纪50年代以前出土并流散国外的,到20世纪90年代重新为中国学术界所知,但仅限于文字描述。2002年,作者在访英期间留意收... 详细信息

本文讨论的是五件现存国外的镶嵌铜牌饰的分期与年代。根据作者的观点,这些铜牌饰应属二里头文化时期,大多是在20世纪50年代以前出土并流散国外的,到20世纪90年代重新为中国学术界所知,但仅限于文字描述。2002年,作者在访英期间留意收集了这五件铜牌饰的图片和线图资料,这是对这些牌饰的再发现,也是研究中国文明起源和早期发展的珍贵新资料。

关键词：镶嵌铜牌饰国外藏品二里头文化考古学

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车辆蠕行控制策略研究

汽车工程 2018年第12期40卷 1447-1453页

作者：马彪昌和李和言李慧珠朱礼安北京理工大学机械与车辆学院北京100081 北京电动车辆协同创新中心北京100081 江麓机电集团公司湘潭411100

针对车辆蠕行过程中车速波动及摩擦副易烧蚀问题,本文中对干式摩擦副的摩擦特性进行了分析,确定了其热安全边界;建立了车辆传动系统模型,考虑蠕行起步及蠕行过程中离合器摩擦副摩擦因数变化,以3km/h为蠕行目标车速,得到了满足冲击度要... 详细信息

针对车辆蠕行过程中车速波动及摩擦副易烧蚀问题,本文中对干式摩擦副的摩擦特性进行了分析,确定了其热安全边界;建立了车辆传动系统模型,考虑蠕行起步及蠕行过程中离合器摩擦副摩擦因数变化,以3km/h为蠕行目标车速,得到了满足冲击度要求、相对于目标车速无超调且起步时间最优的蠕行起步控制策略;以实际车速与目标车速偏差极小为控制目标,通过PID调节离合器压紧力使车辆蠕行过程中能保持车速稳定;制订了车辆蠕行控制策略,避免蠕行过程中离合器烧蚀。

关键词：车辆传动蠕行起步控制策略

高管股权激励与大股东掏空抑制研究:大股东异质特征和制度情境的调节效应

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管理工程学报 2020年第3期34卷 20-31页

作者：刘井建李惠竹张冬妮付杰大连理工大学经济管理学院辽宁大连116024

在引入合谋薪酬的委托代理模型中,探究高管股权激励对大股东掏空的作用机制,通过数值模拟与规范分析,从收入效应、风险效应以及身份转换效应三个层面阐释高管股权激励对大股东掏空的影响路径,并以我国沪深A股2009年至2013年实施股权激... 详细信息

在引入合谋薪酬的委托代理模型中,探究高管股权激励对大股东掏空的作用机制,通过数值模拟与规范分析,从收入效应、风险效应以及身份转换效应三个层面阐释高管股权激励对大股东掏空的影响路径,并以我国沪深A股2009年至2013年实施股权激励计划的上市公司为研究对象,运用面板回归分析发现:高管股权激励存在抑制大股东掏空程度的作用;在股权集中度低、控股层级高和两权分离度大,以及市场化程度低、国有性质和集团控股的公司中,高管股权激励对大股东掏空的抑制作用显著,成为有助于投资者保护的内部治理机制;准自然实验的PSM-DID方法稳健性检验也支持了研究假设,并且高管股权激励对大股东掏空在滞后两年的抑制效应显著。研究揭示了高管股权激励对大股东掏空的抑制作用及情境差异,这为从公司内外部治理机制提出抑制大股东掏空的政策提供了启示。

关键词：高管股权激励掏空大股东异质准自然实验

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换挡离合器摩擦元件周向间歇接触温度场研究

汽车工程 2018年第9期40卷 1068-1075页

作者：李和言李明阳马彪杜秋李慧珠于亮北京理工大学机械与车辆学院北京100081 北京电动车辆协同创新中心北京100081

考虑温度和滑摩速度对摩擦因数的影响,建立了宏观维度下换挡离合器摩擦元件周向间歇接触温度场迭代计算模型,研究了与花键齿数相对应的间歇接触对温度场和摩擦因数的影响,并通过温度测量实验对模型进行了验证。结果表明:间歇接触会导致... 详细信息

考虑温度和滑摩速度对摩擦因数的影响,建立了宏观维度下换挡离合器摩擦元件周向间歇接触温度场迭代计算模型,研究了与花键齿数相对应的间歇接触对温度场和摩擦因数的影响,并通过温度测量实验对模型进行了验证。结果表明:间歇接触会导致对偶片表面出现高温区,高温区分布与花键齿数相对应,对偶片表面最高温度与平均温度均随花键齿数增加而降低,对偶片温升与花键齿数和滑摩时间呈非线性相关。相同滑摩条件下,不同花键齿数对应的摩擦因数随滑摩时间增加而逐渐增大至同一最大值,在摩擦因数达到最大值前,花键齿数较少的对偶片对应的摩擦因数较大。换挡工况下,花键齿数较少的摩擦元件较快进入干摩擦状态,在较短时间内便可达到较大的摩擦因数;车辆蠕行等离合器长时滑摩工况下,花键齿数较多的摩擦元件局部温升较小,具有较好的热安全性。

关键词：换挡离合器对偶片间歇接触温度场摩擦因数

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秦冶重工热风阀与德国热风阀节能效果对比

冶金信息导刊 2017年第3期54卷 45-50页

作者：李会珠秦皇岛秦冶重工有限公司河北秦皇岛066318

结合有限元技术以及数值计算，对德国节能热风阀与秦冶重工传统热风阀在结构、节能效果方面作了对比，提出了节能措施。

关键词：热风阀有限元分析结构节能