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SWIR FluorescenceImaging In Vivo Monitoring and Evaluating Implanted M2 Macrophages in Skeletal Muscle Regeneration

Engineering 2024年第2期33卷 283-294页

作者： Mo Chen Yuzhou Chen Sijia Feng Shixian Dong Luyi Sun huizhu li Fuchun Chen Nguyen Thi Kim Thanh Yunxia li Shiyi Chen You Wang Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiaotong UniversityShanghai 200127China Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Key Laboratory of Infrared System Detection&Imaging Technology Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK Healthcare Biomagnetic and Nanomaterials Laboratories University College LondonLondon W1S 4BSUK

Skeletal muscle has a robust regeneration ability that is impaired by severe injury,disease,and aging.resulting in a decline in skeletal muscle function.Therefore,improving skeletal muscle regeneration is a key challenge in treating skeletal muscle-related disorders.Owing to their significant role in tissue regeneration,implantation of M2 macrophages(M2MФ)has great potential for improving skeletal muscle regeneration.Here,we present a short-wave infrared(SWIR)fluorescence imaging technique to obtain more in vivo information for an in-depth evaluation of the skeletal muscle regeneration effect after M2MФtransplantation.SWIR fluorescence imaging was employed to track implanted M2MФin the injured skeletal muscle of mouse models.It is found that the implanted M2MФaccumulated at the injury site for two weeks.Then,SWIR fluorescence imaging of blood vessels showed that M2MФimplantation could improve the relative perfusion ratio on day 5(1.09±0.09 vs 0.85±0.05;p=0.01)and day 9(1.38±0.16 vs 0.95±0.03;p=0.01)post-injury,as well as augment the degree of skeletal muscle regencration on day 13 post-injury.Finally,multiple linear regression analyses determined that post-injury time and relative perfusion ratio could be used as predictive indicators to evaluate skeletal muscle regeneration.These results provide more in vivo details about M2MФin skeletal muscle regeneration and confirm that M2MФcould promote angiogenesis and improve the degree of skeletal muscle repair,which will guide the research and development of M2MФimplantation to improve skeletal muscle regeneration.

关键词： In vivo Short-wave infrared Skeletal muscle Macrophage Regeneration

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In vivo real-time monitoring delayed administration of M2 macrophages to enhance healing of tendon by NIR-II fluorescence imaging

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Nano Research 2024年第5期17卷 4379-4390页

作者： Yuzhou Chen Mo Chen Chengxuan Yu huizhu li liman Sai Nguyen T.K.Thanh Yueming Wang Yan Wo Jian Zhang Xing Yang Evgenii L.Guryev Andrei V.Zvyagin Hao De Min Tang Shiyi Chen Yunxia li Yuefeng Hao Sijia Feng Jun Chen Sports Medicine Institute of Fudan University Department of Sports MedicineHuashan HospitalFudan UniversityShanghai 200040China Department of Orthopedic Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Bone and Joint Surgery Department of OrthopedicsRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China Department of Physics Shanghai Normal UniversityShanghai 200234China Biophysics Group Department of Physics and AstronomyUniversity College LondonLondon WC1E 6BTUK UCL Healthcare Biomagnetic and Nanomaterials Laboratories London W1S 4BSUK Department of Anatomy and Physiology School of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Orthopedics Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhou 215500China Institute of Biology and Biomedicine Lobachevsky State University of Nizhny NovgorodNizhny Novgorod 603950Russia Mathematical Institute University of OxfordOxford OX26GGUK Institute of Natural Sciences School of MathematicsShanghai Jiao Tong UniversityShanghai 200240China

The administration time is a critical but long-neglected point in cell therapy based on macrophages because the incorrect time of macrophage administration could result in diverse outcomes regarding the same macrophage therapy.In this work,the second near-infrared(NIR-II)fluorescence imaging in vivo tracking of M2 macrophages during a pro-healing therapy in the mice model of rotator cuff injury revealed that the behavior of administrated macrophages was influenced by the timing of their administration.The delayed cell therapy(DCT)group had a longer retention time of injected M2 macrophages in the repairing tissue than that in the immediate cell therapy(ICT)group.Both Keller-Segel model and histological analysis further demonstrated that DCT altered the chemotaxis of M2 macrophages and improved the healing outcome of the repaired structure in comparison with ICT.Our results offer a possible explanation of previous conflicting results on reparative cell therapy and provoke reconsideration of the timing of these therapies.

关键词： macrophage cell therapy NIR-II in vivo imaging delayed therapy tendon healing

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Numerical Simulation Study on Wear of Spur Gears under Dynamic Conditions

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Journal of Beijing Institute of Technology 2019年第1期28卷 146-154页

作者： Changsong Zheng Zhouli Zhang Chunping He Weipeng Lou huizhu li Qiu Du School of Mechanical Engineering Beijing Institute of Technology Collaborative Innovation Center of Electric Vehicle in Beijing Jianglu Machinery & Electronics Group Corporation

A numerical simulation model is proposed to predict the wear depth of gears,where Archard's wear equation and a nonlinear dynamic model are combined to establish a wear calculation model under dynamic conditions.The dynamic meshing force,determined by the non-linear dynamic model,and the sliding coefficient are used by Archard's wear equation to calculate the surface wear.Then the dynamic meshing force and sliding coefficient would be recalculated according to the surface wear state.After repeated iterations,the simulation results show that the peak and fluctuation of the meshing force increase first,then decrease,and eventually maintain stability during the process of wear.As for the distribution of wear depth,its fluctuation also increases first and then declines.Finally,the distribution of wear depth becomes V-shaped.Comparing the trends of the two factors,it is clear that the meshing force and wear depth are closely related.Moreover,the wear rate maintains a higher constant value first and then declines to a lower constant value.

关键词： dynamic meshing force reconstruction of tooth profile gear wear Archard's wear equation

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Optomechanical force gradient sensing with levitated nanosphere pair

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Science China(Physics,Mechanics & Astronomy) 2022年第4期65卷 32-40页

作者： Chuang li Yao li huizhu Hu Ying Dong Research Center for Quantum Sensing Zhejiang LaboratoryHangzhou 311100China State Key Laboratory of Modern Optical Instrumentation&College of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China

Guided by recent progress in ground state cooling and ultraweak force sensing in the optomechanical systems with optically levitated particles,we propose a novel quantum sensing protocol that can detect the gradient of a force field directly with extremely high sensitivity.The system consists of a pair of nanospheres levitated in the high vacuum environment with optical tweezers and an optical resonator.By positioning the two spheres suitably relative to the cavity,only the collective breathing mode of the sphere pair couples to the cavity field.This optomechanical coupling will transfer the information of force difference acting on the two sensors to cavity photons,which can then be detected directly at the output of the cavity.Given the optimal control of various technical noise sources,the sensitivity could reach 10^(-15)N m^(-1)/√HZ with a high spatial resolution of micron scale on a state-of-the-art experimental setup.The potential application of this protocol in searching for short range“new force”is analyzed.Compared with conventional searching protocols with a single levitated sphere,the method proposed here can increase the signal-to-noise ratio by more than one magnitude in a large searching parameter space.

关键词： optomechanics optical tweezers force gradient quantum sensing

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线粒体自噬调控哺乳动物胚胎发育的研究进展

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畜牧兽医学报 2024年第3期55卷 905-912页

作者：李钰浚何翃闳杨丽雪杨小耿李键张慧珠青藏高原动物遗传资源保护与利用教育部重点实验室成都610041 西南民族大学畜牧兽医学院成都610041 西南民族大学青藏高原研究院成都610041

线粒体自噬(mitophagy)是一个进化保守的过程,它可以选择性地识别、隔离和降解特定靶标。当细胞处于不利的环境下,线粒体自噬通过降解异常或过量的线粒体来维持细胞稳态,减轻细胞运行的压力。线粒体自噬在哺乳动物生殖调控过程中发挥着... 详细信息

线粒体自噬(mitophagy)是一个进化保守的过程,它可以选择性地识别、隔离和降解特定靶标。当细胞处于不利的环境下,线粒体自噬通过降解异常或过量的线粒体来维持细胞稳态,减轻细胞运行的压力。线粒体自噬在哺乳动物生殖调控过程中发挥着重要的作用,主要涉及卵母细胞的成熟、衰老和早期胚胎的发育等多种生理过程。本文主要综述了线粒体自噬的生物学功能、线粒体自噬的相关因子调控以及线粒体自噬在哺乳动物生殖中的作用机制,为进一步研究线粒体自噬在哺乳动物生殖发育过程中发挥的作用提供参考依据。

关键词：线粒体自噬哺乳动物卵母细胞胚胎

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A review of optically induced rotation

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Frontiers of Information Technology & Electronic Engineering 2022年第2期23卷 171-185页

作者： Qi ZHU Nan li Heming SU Wenqiang li huizhu HU State Key Laboratory of Modern Optical Instrumentation College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China Zhejiang Lab Hangzhou 311121China

The optical rotation technique arose in the 1990 s.Optical tweezer brought an ideal platform for research on the angular momentum of laser beams.For decades,the optical rotation technique has been widely applied in laboratory optical manipulation and the fields of biology and optofluidics.Recently,it has attracted much attention for its potential in the classical and quantum regimes.In this work,we review the progress of experiments and applications of optically induced rotation.First,we introduce the basic exploration of angular momentum.Then,we cover the development and application of optical rotation induced by orbital angular momentum,and the spin angular momentum is presented.Finally,we elaborate on recent applications of the optical rotation technique in high vacuum.As precise optical manipulation in a liquid medium enters its maturity,optical tweezers in high vacuum open a new path for the high-speed micro-rotor.

关键词： Optical tweezer Optically induced rotation Angular momentum Micro-rotor

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云南石漠化地区植被恢复模式及优化建议

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中国岩溶 2024年第1期43卷 137-146页

作者：段华超郑鑫华李世民李燕燕叶澜井卉竹罗润文唐永董琼西南林业大学林学院云南昆明650224 广南县坝美林业站云南广南663300 罗平县林业局云南罗平655800

云南省区域内石漠化面积广布,严重制约着当地社会经济的可持续发展。文章概括了云南石漠化研究现状,主要从石漠化区划,治理模式和石漠化区植被恢复种类三个方面,综述了云南石漠化研究成果。云南石漠化区划分为2个大区和5个小区;经过多... 详细信息

云南省区域内石漠化面积广布,严重制约着当地社会经济的可持续发展。文章概括了云南石漠化研究现状,主要从石漠化区划,治理模式和石漠化区植被恢复种类三个方面,综述了云南石漠化研究成果。云南石漠化区划分为2个大区和5个小区;经过多年的探索形成了4类23种石漠化治理模式,435种可用作石漠化地区生态恢复的植物物种,其中乔灌木376种,草本59种。结合地理位置、气候和海拔对适宜恢复植被进行了初步总结,指出了石漠化研究治理中存在的不足,为后续的石漠化植被恢复治理研究提供重要参考。

关键词：云南石漠化治理模式植被

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参苓白术散联合肠愈灌肠方治疗活动期溃疡性结肠炎疗效观察

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中医药临床杂志 2024年第6期36卷 1158-1162页

作者：陈红王树杰李惠珠李明安徽中医药大学安徽合肥230038 安徽中医药大学第一附属医院肛肠科(安徽省中医院肛肠科) 安徽合肥230038

目的:观察中药参苓白术散内服联合肠愈灌肠方保留灌肠对活动期溃疡性结肠炎的疗效。方法:选取符合标准的安徽省中医院肛肠科收治的70例活动期溃疡性结肠炎患者,随机分为观察组(35例)、对照组(35例)。观察组运用参苓白术散内服配合肠愈... 详细信息

目的:观察中药参苓白术散内服联合肠愈灌肠方保留灌肠对活动期溃疡性结肠炎的疗效。方法:选取符合标准的安徽省中医院肛肠科收治的70例活动期溃疡性结肠炎患者,随机分为观察组(35例)、对照组(35例)。观察组运用参苓白术散内服配合肠愈灌肠方保留灌肠,内服中药每早晚各200mL温服;灌肠中药每晚睡前灌肠1次。对照组则选用美沙拉嗪栓1粒每晚纳肛,分别比较治疗前和治疗30天后2组的临床疗效、中医症候积分(腹泻、腹痛、脓血便、里急后重)、肠镜Baron评分以及炎症因子[C反应蛋白(CRP)、降钙素原(PCT)]水平。结果:观察组临床总有效率94.29%,远高于对照组的80%(P<0.05);2组治疗后肠镜Baron评分均低于治疗前,且观察组低于对照组(P<0.05);2组治疗后中医症候积分均低于治疗前,且观察组低于对照组(P<0.05);2组治疗后CRP、PCT水平均低于治疗前,且观察组低于对照组(P<0.05)。结论:参苓白术散联合肠愈灌肠方治疗活动期溃疡性结肠炎具有确切的效果,可提高临床治疗有效率,其机制可能与抑制炎症反应、快速促进结肠黏膜恢复有关,且具有良好的安全性。

关键词：参苓白术散肠愈灌肠方美沙拉嗪栓溃疡性结肠炎疗效观察

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Nanoscale electric field sensing using a levitated nano-resonator with net charge

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Photonics Research 2023年第2期11卷 279-289页

作者： SHAOCONG ZHU ZHENHAI FU XIAOWEN GAO CUIHONG li ZHIMING CHEN YINGYING WANG XINGFAN CHEN huizhu HU Quantum Sensing Center Zhejiang LabHangzhou 310000China State Key Laboratory of Modern Optical Instruments College of Optical Science and EngineeringZhejiang UniversityHangzhou 310027China

The nanomechanical resonator based on a levitated particle exhibits unique advantages in the development of ultrasensitive electric field detectors. We demonstrate a three-dimensional, high-sensitivity electric field measurement technology using the optically levitated nanoparticle with known net charge. By scanning the relative position between nanoparticle and parallel electrodes, the three-dimensional electric field distribution with microscale resolution is obtained. The measured noise equivalent electric intensity with charges of 100e reaches the order of 1 μV·cm^(-1)·Hz^(-1/2)at 1.4 × 10^(-7) mbar. linearity analysis near resonance frequency shows a measured linear range over 91 d B limited only by the maximum output voltage of the driving equipment. This work may provide an avenue for developing a high-sensitivity electric field sensor based on an optically levitated nano-resonator.

关键词： resonator field charge

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Displacement Calibration of Optical Tweezers With Gravitational Acceleration

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Photonic Sensors 2023年第4期13卷 62-72页

作者： Jianyu YANG Nan li Xunmin ZHU Ming CHEN Mian WU Xingfan CHEN Cheng liU Jian ZHUANG huizhu HU College of Optical Science and Engineering Zhejiang UniversityHangzhou 310027China Quantum Sensing Center Zhejiang LabHangzhou 310000China State Key Laboratory of Modern Optical Instrumentation Zhejiang UniversityHangzhou 310027China HIWING Technology Academy of CASIC Beijing 100074China

In recent years,levitated particles of optical traps in vacuum have shown the enormous potential for precision sensor development and new physics exploration.However,the accuracy of the sensor is still hampered by the uncertainty of the calibration factor relating the detected signal to the absolute displacement of the trapped particle.In this paper,we suggest and experimentally demonstrate a novel calibration method for optical tweezers based on free-falling particles in vacuum,where the gravitational acceleration is introduced as an absolute reference.Our work provides a calibration protocol with a great certainty and traceability,which is significant in improving the accuracy of precision sensing based on levitated optomechanical systems.

关键词： Optical tweezers calibration free-falling particles

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