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Effects of Fe solid solute on grain boundaries of bi-crystal Cu: A molecular dynamics simulation

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Nano Materials Science 2024年第1期6卷 86-95页

作者： Shuohan Yang Hongwei Bao huizhong Bai Yan Li Haodong xu Fei Ma State Key Laboratory for Mechanical Behavior of Materials Xi’an Jiaotong UniversityXi’an710049ShaanxiChina

Grain boundaries(GBs)play a crucial role on the structural stability and mechanical properties of Cu and its *** this work,molecular dynamics(MD)simulations are employed to study the effects of Fe solutes on the formation energy,excess volume,dislocations and melting behaviors of GBs in CuFe *** is illustrated that Fe solute affects the structural stability of Cu GBs substantially,the formation energy of GBs is reduced,but the thickness and melting point of GBs are increased,that is,the structural stability of Cu GBs is significantly improved owing to the Fe solutes.A strong scaling law exists between the formation energy,excess volume,thickness and melting point of ***,Fe solid solute plays an important role in the characteristics of GBs in bi-crystal Cu.

关键词： CuFe alloy Grain boundary Structural stability MD simulations

基于产学研合作的材料学专业学位研究生培养模式创新研究

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科教文汇 2015年第14期 59-60页

作者：杜伟徐惠忠姜付义罗新正王志娟烟台大学环境与材料工程学院山东烟台264005

本文分析了生产单位、高等学校及科研机构在培养专业学位研究生方面相互结合、协调发展的关系,并以烟台大学材料学专业学位研究生培养为例,探索了该类研究生培养模式的内容、存在的问题和解决的办法等,提出了在该模式下培养的研究生是... 详细信息

本文分析了生产单位、高等学校及科研机构在培养专业学位研究生方面相互结合、协调发展的关系,并以烟台大学材料学专业学位研究生培养为例,探索了该类研究生培养模式的内容、存在的问题和解决的办法等,提出了在该模式下培养的研究生是产学研合作的纽带以及参与的主力,这种模式对建设创新型国家所做的贡献越来越受到社会的广泛关注。

关键词：产学研专业学位研究生教育创新

绿色校园视域下高校既有建筑运营管理与维护的对策和措施

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项目管理技术 2020年第5期18卷 70-73页

作者：辛培远李明惠冯晓彤徐惠中宋昕锐金陵科技学院建筑工程学院江苏南京211169

建筑全生命周期的各个阶段都有其存在的重要意义。随着我国新增建筑面积的不断增加,既有建筑的运营管理与维护愈发显现出它的重要性。对比分析国内外高校既有建筑绿色运维发展现状,针对国内高校既有建筑绿色运维过程中存在的问题,提出了... 详细信息

建筑全生命周期的各个阶段都有其存在的重要意义。随着我国新增建筑面积的不断增加,既有建筑的运营管理与维护愈发显现出它的重要性。对比分析国内外高校既有建筑绿色运维发展现状,针对国内高校既有建筑绿色运维过程中存在的问题,提出了"育苗栽花"两手抓、发挥高校师生引领作用、建立合理的绿色运维监管体系、协调绿色运维利益主体间关系的对策和措施。

关键词：绿色运维既有建筑绿色校园

小骨窗开颅治疗慢性硬膜下血肿40例临床疗效观察

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中华神经创伤外科电子杂志 2017年第2期3卷 76-79页

作者：许慧中颜庆华向定朝王存祖季连逸南通大学附属东台医院神经外科东台224200 中国人民解放军第一零一医院神经外科无锡214200 江苏省苏北人民医院神经外科扬州225001 南通大学附属东台医院病案室东台224200

目的探讨小骨窗开颅手术治疗慢性硬膜下血肿的相对适应证和预后。方法回顾性分析了南通大学附属东台医院神经外科2010年12月至2012年12月小骨窗开颅手术治疗的40例慢性硬膜下血肿患者的临床资料,总结小骨窗开颅手术的相对适应证和预后... 详细信息

目的探讨小骨窗开颅手术治疗慢性硬膜下血肿的相对适应证和预后。方法回顾性分析了南通大学附属东台医院神经外科2010年12月至2012年12月小骨窗开颅手术治疗的40例慢性硬膜下血肿患者的临床资料,总结小骨窗开颅手术的相对适应证和预后。结果术后症状立即消失的患者35例(87.5%),术后1个月症状消失的患者2例,随访6个月症状未消失患者2例,植物生存状态1例,无死亡和复发病例。结论由头部外伤导致的慢性硬膜下血肿,在慢性血肿期,以头痛、头昏为首发症状,同时影像学检查有明显占位效应和混杂密度影时,可首先考虑小骨窗开颅血肿清除的手术方法,效果较确切,患者预后好,从而可提高治愈率,减少复发。

关键词：慢性硬膜下血肿小骨窗开颅手术治疗疗效

A chorismate mutase from Radopholus similis plays an essential role in pathogenicity

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Journal of Integrative Agriculture 2024年第3期23卷 923-937页

作者： Sihua Yang Junyi Li Shuai Yang Shiqiao Tang huizhong Wang Chunling xu Hui Xie Laboratory of Plant Nematology andResearch Centerof Nematodes of Plant Quarantine Department of Plant Patholo of Plant ProtectionSouth China Agricultural UniversityGuangzhou 510642China

In the process of infecting plants, plant parasitic nematodes release a series of proteins that play an essential role in the successful infection and pathogenesis of plant cells and tissues through stylets or body walls. In this study,based on transcriptome data, a chorismate mutase gene of Radopholus similis(RsCM) was identified and cloned,which is a single copy gene specifically expressed in the oesophageal gland and highly expressed in juveniles and females. Transient expression of RsCM in tobacco leaves showed that it was localised in the cytoplasm and nucleus of tobacco leaf cells, which inhibited the pattern-triggered immunity(PTI) induced by flg22, including callose deposition and defence gene expression, and cell death induced by immune elicitors BAX, but could not inhibit cell death induced by immune elicitors Gpa2/RBP-1. The RNA interference(RNAi) transgenic tomato of RsCM obviously inhibited the infection, pathogenicity, and reproduction of R. similis. However, the resistance of the overexpression transgenic tomato of RsCM to R. similis infection was significantly reduced, and the expression levels of two salicylic acid(SA) pathway genes(PR1 and PR5) in roots infected by the nematode were significantly down-regulated,which indicated that RsCM might be involved in the inhibition of SA pathway. The results of this study demonstrate that RsCM suppresses the host immune system and might be a new target for the control of R. similis, which also provides new data for the function and mechanism of CM genes of migratory parasitic plant nematodes.

关键词： Radopholus similis chorismate mutase plant defense transgenic tomato

Explicit Topology Optimization Design of Stiffened Plate Structures Based on the Moving Morphable Component(MMC)Method

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Computer Modeling in Engineering & Sciences 2023年第5期135卷 809-838页

作者： xudong Jiang Chang Liu Shaohui Zhang Weisheng Zhang ZongliangDu Xiaoyu Zhang huizhong Zeng xu Guo Department of Engineering Mechanics State Key Laboratory of Structural Analysis for Industrial EquipmentInternational Research Center for Computational MechanicsDalian University of TechnologyDalian116023China Ningbo Institute of Dalian University of Technology Ningbo315016China Beijing Institute of Spacecraft System Engineering Beijing100094China

This paper proposes an explicit method for topology optimization of stiffened plate *** present work is devoted to simultaneously optimizing stiffeners’shape,size and layout by seeking the optimal geometry parameters of a series of moving morphable components(MMC).The stiffeners with straight skeletons and the stiffeners with curved skeletons are considered to enhance the modeling and optimization capability of the current *** the stiffeners are represented under the Lagrangian-description framework in a fully explicit way,and the adaptive ground structure method,as well as dynamically updated plate/shell elements,is used to obtain optimized designs with more accurate analysis *** with existing works,the proposed approach provides an explicit description of the ***,a stiffened plate structure with clear stiffener distribution and smooth geometric boundary can be *** numerical examples provided,including straight and curved stiffeners,hierarchical stiffeners,and a stiffened plate with a cutout,validate the effectiveness and applicability of the proposed approach.

关键词： Topology optimization stiffened plate structures moving morphable component(MMC) straight/curved skeletons

指南临床适用性评价的影响因素分析:一项横断面研究

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中国循证医学杂志 2024年第1期24卷 29-35页

作者：刁莎刘峥石雨晴李思雨曾力楠易秋莎李海龙许慧中王锡雄黄修森杨稀策黄超王强张伶俐四川大学华西第二医院药学部成都610041 四川大学华西第二医院循证药学中心成都610041 国家药品监督管理局药物制剂体内外相关性技术研究重点实验室成都610041 出生缺陷与相关妇儿疾病教育部重点实验室成都610041 四川大学华西临床医学院成都610041 四川大学华西药学院成都610041 东台市人民医院江苏盐城224200 钦州市第一人民医院广西钦州535099 四川大学华西医院成都610041 国家卫生健康委医疗管理服务指导中心北京100044 四川大学华西医院中国循证医学中心成都610041

目的探索指南临床适用性的影响因素,为更好地制订、实施指南提供建议。方法计算机检索CNKI数据库,搜集2015—2020年由中华医学会、中国医师协会发布的临床指南。随机抽取61部,每部指南均由来自东、中、西部的医务人员采用指南临床适用... 详细信息

目的探索指南临床适用性的影响因素,为更好地制订、实施指南提供建议。方法计算机检索CNKI数据库,搜集2015—2020年由中华医学会、中国医师协会发布的临床指南。随机抽取61部,每部指南均由来自东、中、西部的医务人员采用指南临床适用性评价工具(2.0版)共同评价。对统计资料进行描述,组间比较采用t检验或秩和检验或卡方检验;采用逐步Logistic回归筛选指南临床适用性各领域和总体标准化评分的影响因素。结果回收有效问卷6904份,涵盖26省119家医疗机构。调查对象越熟悉指南、指南推荐意见与患者及家属意愿越相符,指南临床适用性的总体标准化评分越高。此外,调查对象越熟悉指南,各领域标准化评分越高;医疗机构越重视指南的依从性,可行性标准化评分越高。结论为改善指南临床适用性,指南制订者应重视推荐意见是否符合患者及家属的意愿,医疗机构应重视医务人员对指南的依从性,同时医务人员应熟悉指南推荐意见。

关键词：指南临床适用性影响因素横断面研究

Genome-wide identification, expression analysis of auxin-responsive GH_3 family genes in maize(Zea mays L.) under abiotic stresses

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Journal of Integrative Plant Biology 2015年第9期57卷 783-795页

作者： Shangguo Feng Runqing Yue Sun Tao Yanjun Yang Lei Zhang Mingfeng xu huizhong Wang Chenjia Shen College of Life and Environmental Sciences Hangzhou Normal University Henan Academy of Agricultural Sciences Department of Plant Pathology Washington State University

Auxin is involved in different aspects of plant growth and development by regulating the expression of auxin-responsive family genes. As one of the three major auxin-responsive families, GH3 (Gretchen Hagen3) genes participate in auxin homeostasis by catalyzing auxin conjugation and bounding free indole-3-acetic acid (IAA) to amino acids. However, how GH3 genes function in responses to abiotic stresses and various hormones in maize is largely unknown. Here, the latest updated maize (Zea mays L.) reference genome sequence was used to characterize and analyze the ZmGH3 family genes from maize. The results showed that 13 ZmGH3 genes were mapped on five maize chromosomes (total 10 chromosomes). Highly diversified gene structures and tissue-specific expression patterns suggested the possibility of function diversification for these genes in response to environmental stresses and hormone stimuli. The expression patterns of ZmGH3 genes are responsive to several abiotic stresses (salt, drought and cadmium) and major stress-related hormones (abscisic acid, salicylic acid and jasmonic acid). Various environmental factors suppress auxin free IAA contents in maize roots suggesting that these abiotic stresses and hormones might alter GH3-mediated auxin levels. The respon-siveness of ZmGH3 genes to a wide range of abiotic stresses and stress-related hormones suggested that ZmGH3s are involved in maize tolerance to environmental stresses.

关键词： Abiotic stress auxin auxin responsive gene GH3 gene family maize

The transcription factor CmLEC1 positively regulates the seed-setting rate in hybridization breeding of chrysanthemum

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Horticulture Research 2021年第1期8卷 2569-2584页

作者： Sujuan xu Ze Wu huizhong Hou Jingya Zhao Fengjiao Zhang Renda Teng Liping Ding Fadi Chen Nianjun Teng College of Horticulture Nanjing Agricultural UniversityKey Laboratory of Landscape DesignMinistry of Agriculture and Rural Affairs210095 NanjingChina

Distant hybridization is widely used to develop crop cultivars,whereas the hybridization process of embryo abortion often severely reduces the sought-after breeding *** LEAFY COTYLEDON1(LEC1)gene has been extensively investigated as a central regulator of seed development,but it is far less studied in crop hybridization *** we investigated the function and regulation mechanism of CmLEC1 from Chrysanthemum morifolium during its seed development in chrysanthemum ***1 encodes a nucleic protein and is specifically expressed in ***1’s overexpression significantly promoted the seed-setting rate of the cross,while the rate was significantly decreased in the amiR-CmLEC1 transgenic *** RNA-Seq analysis of the developing hybrid embryos revealed that regulatory genes involved in seed development,namely,CmLEA(late embryogenesis abundant protein),CmOLE(oleosin),CmSSP(seed storage protein),and CmEM(embryonic protein),were upregulated in the OE(overexpressing)lines but downregulated in the amiR lines ***-type *** analysis demonstrated that CmLEC1 directly activated CmLEA expression and interacted with CmC3H,and this CmLEC1–CmC3H interaction could enhance the transactivation ability of CmLEC1 for the expression of ***,CmLEC1 was able to induce several other key genes related to embryo *** together,our results show that CmLEC1 plays a positive role in the hybrid embryo development of chrysanthemum plants,which might involve activating CmLEA’s expression and interacting with *** may be a new pathway in the LEC1 regulatory network to promote seed development,one perhaps leading to a novel strategy to not only overcome embryo abortion during crop breeding but also increase the seed yield.

关键词： breeding effect. overcome