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genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

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Journal of genetics and genomics 2022年第9期49卷 903-905页

作者： Bao Li Liang Yong Yafen Yu Yanqin Yu Qi Zhen huiyao ge Yiwen Mao Weiwei Chen Yanxia Yu Yirui Wang Zhuo Li Wencheng Fan Chang Zhang Xia Hu Ruixue Zhang Lu Cao Hao Liu Zhuan Bian Miao He Liangdan Sun Department of Dermatology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Institute of Dermatology Anhui Medical UniversityHefeiChina Key Laboratory of Dermatology Ministry of EducationAnhui Medical UniversityHefeiAnhui 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province HefeiAnhui 230022China Anhui Provincial Institute of Translational Medicine HefeiAnhui 230022China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China

Orofacial clefts(OFCs),particularly cleft lip with or without cleft palate(CL/P)and cleft palate only(CPO),are among the most common birth defects in humans(Mossey et al.,2009;Dixon et al.,2011).The birth prevalence r... 详细信息

关键词： al. palate Dixon

Clinical efficacy of low-dose emetine for patients with COVID-19:a real-world study

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Journal of Bio-X Research 2021年第2期4卷 53-59页

作者： Song Fan Qi Zhen Cheng Chen Wenjun Wang Qibing Wu Huihui Ma Chengyuan Zhang Li Zhang Baojing Lu huiyao ge Liang Yong Bao Li Yafen Yu Weiwei Chen Yiwen Mao Guangbo Qu Li Su Aoli Wang Zhen Ding Haiwen Li Jin Zhang Yonglian Wang Yufeng Gao Xihai Xu Zhongming Zhu Jun Chen Long Zhang Hongqiang Liang Song Wu Meng Huang Quan Xia Ping Li Yehuan Sun Chaozhao Liang Wei Wei Qingsong Liu Liangdan Sun Department of Urology the First Affiliated Hospital of Anhui Medical UniversityInstitute of UrologyAnhui Medical University and Anhui Province Key Laboratory of Genitourinary Diseases Department of Dermatology the First Affiliated Hospital of Anhui Medical UniversityKey Laboratory of DermatologyAnhui Medical UniversityMinistry of EducationInflammation and Immune Mediated Diseases Laboratory of Anhui Province High Magnetic Field Laboratory Key Laboratory of High Magnetic Field and Ion Beam Physical BiologyHefei Institutes of Physical ScienceChinese Academy of Sciences Department of Radiation Oncology the First Affiliated Hospital of Anhui Medical UniversityHefei Anhui Lixin County Hospital of Traditional Chinese Medicine Bozhou Department of Respiratory Medicine Anhui Feidong County People’s Hospital Center for Scientific Research of the First Affiliated Hospital of Anhui Medical University Department of Microbiology School of Basic Medical ScienceAnhui Medical University Comprehensive Lab College of BasicAnhui Medical University Department of Epidemiology and Health Statistics School of Public HealthAnhui Medical University Traditional and Western Medicine(TCM)-Integrated Cancer Center of Anhui Medical University the Department of Traditional and Western Integrative Medicine Oncologythe First Affiliated Hospital of Anhui Medical University Department of Respiratory Medicine Binhu Hospital of Hefei The Third Affiliated Hospital of Anhui Medical University the First Affiliated Hospital of Zhengzhou University The Second People’s Hospital of Hefei The Department of Infectious Diseases the First Affiliated Hospital of Anhui Medical University The Department Pulmonary and Critical Care Medicine the First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui Province Anhui Suzhou Hospital SuzhouJiangsu Province Anhui Feidong County People’s Hospital Department of Pharmacy the First Affiliated Hospital of Anhui Medical University Institute of Clinical Pharmacology Anhui Medical UniversityKey Laborat

Objective:Emetine,an isoquinoline alkaloid that is enriched at high concentrations in the lung,has shown potent in vitro activity against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).The aim of this study was to better understand the effectiveness of low-dose emetine for patients with coronavirus disease 2019(COVID-19).Methods:In this real-world study,63 patients with mild or common COVID-19 were recruited from Wuhan Fangcang Shelter Hospital and five COVID-19-designated hospitals in Anhui Province,China from February to March ***-nine patients from Wuhan Fangcang Shelter Hospital were assigned to a pragmatic randomized controlled clinical trial,and 24 patients from the 5 COVID-19-designated hospitals in Anhui Province underwent a real-world *** medication course of emetine was less than 10 *** main symptoms and adverse reactions of all patients were observed and *** primary outcome measure was the time required for a negative SARS-CoV-2 RNA result or the negative result rate on day *** outcomes included axillary temperature,transcutaneous oxygen saturation,and respiratory frequency *** study was approved by the Ethics Committee of The First Affiliated Hospital of Anhui Medical University on February 20,2019(approval ***2020-03-19)and was registered with the Chinese Clinical Trial Registry on February 20,2019(registration number:ChiCTR2000030022).Results:The oxygen saturation values were higher in the treatment group than in the control group on the first day after enrollment for patients treated at Fangcang Shelter *** axillary body temperature,respiratory rate,and oxygen saturation among patients in Fangcang Shelter Hospital were related to the time effect but not to the intervention *** respiratory rate and oxygen saturation of patients in the Anhui designated hospitals were related to the intervention measures but not to the time *** axillary body temperature of patients in A

关键词： arbidol COVID-19 emetine randomized controlled clinical trial real-world study

High-resolution Mo KαX-ray monochromatic backlight imaging using a toroidal crystal

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Chinese Optics Letters 2023年第10期21卷 114-118页

作者：司昊轩单连强杜慧瑶蒋励伊圣振周维民王占山 Institute of Precision Optical Engineering MOE Key Laboratory of Advanced Micro-Structured MaterialsShanghai Frontiers Science Center of Digital OpticsShanghai Professional Technical Service Platform for Full-Spectrum and High-Performance Optical Thin Film Devices and ApplicationsSchool of Physics Science and EngineeringTongji UniversityShanghai 200092China Research Center of Laser Fusion China Academy of Engineering PhysicsMianyang 621900China

Curved crystal imaging is an important means of plasma *** to the short wavelengths of high-energy X rays and the fixed lattice constant of the spherical crystal,it is difficult to apply the spherical crystal in high-energy X-ray *** this study,we have developed a high-energy,high-resolution X-ray imager based on a toroidal crystal that can effectively correct *** prepared a getoroidal crystal for backlighting Mo Kα1 characteristic lines(∼17.48 keV)and verified its high-resolution imaging ability in high-energy X-ray region,achieving a spatial resolution of 5–10μm in a field of view larger than 1.0 mm.

关键词： laser plasma diagnostics toroidal crystal monochromatic X-ray imaging

射频功率对反应溅射淀积的a－ge：H薄膜特性的影响

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无机材料学报 1994年第2期9卷 139-143页

作者：王辉耀王印月张仿清兰州大学物理系

本文通过红外透射谱（ＩＲ）、拉曼散射谱（Ｒａｍａｎ）、电子自族共振谱（ＥＳＲ）、光吸收谱、电导率和淀积速率的测量，比较全面地研究了射频功率对反应溅射法淀积的ａ－Ｇｅ：Ｈ薄膜特性的影响．发现ａ－Ｇｅ：Ｈ膜的淀积速率、氢... 详细信息

本文通过红外透射谱（ＩＲ）、拉曼散射谱（Ｒａｍａｎ）、电子自族共振谱（ＥＳＲ）、光吸收谱、电导率和淀积速率的测量，比较全面地研究了射频功率对反应溅射法淀积的ａ－Ｇｅ：Ｈ薄膜特性的影响．发现ａ－Ｇｅ：Ｈ膜的淀积速率、氢量、膜结构、光电性能随功率发生规律性的变化．对实验结果作了初步讨论．

关键词：锗射频功率薄膜无定形半导体

生物絮团技术在凡纳滨对虾池塘淡化养殖中的应用研究

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渔业研究 2022年第6期44卷 562-572页

作者：李慧耀张哲葛辉潘柏霖杨章武福建省水产研究所福建省海洋生物增养殖与高值化利用重点实验室海洋生物种业技术国家地方联合工程研究中心福建厦门361013

为探索絮团养殖技术在凡纳滨对虾淡化养殖中的可行性,在养殖过程无换水和养殖废水隔茬再利用的基础上,结合生物絮团技术(Biofloc technology,BFT)进行生态养殖试验。试验以蔗糖(红糖)为添加碳源,芽孢杆菌、光合细菌和嗜酸乳杆菌为异养... 详细信息

为探索絮团养殖技术在凡纳滨对虾淡化养殖中的可行性,在养殖过程无换水和养殖废水隔茬再利用的基础上,结合生物絮团技术(Biofloc technology,BFT)进行生态养殖试验。试验以蔗糖(红糖)为添加碳源,芽孢杆菌、光合细菌和嗜酸乳杆菌为异养菌进行生物絮团培养,蔗糖添加量为投饵量的70%,在当日第一次投饵时随饵料一起投入,异养菌每5 d添加一次;以传统养殖模式为对照组。结果显示,与对照池相比,BFT模式在不同养殖阶段均能有效调节养殖水质,总磷、活性磷酸盐、氨氮和无机氮含量降低比例最高分别为45.37%、94.82%、90.14%和20.74%;浮游植物多样性提高17.36%~22.93%,对虾生长速度提高18.39%。将废水再利用养殖模式与BFT技术相结合,有利于水质调节,对促进对虾养殖业节能减排有重要意义。

关键词：凡纳滨对虾生物絮团水质废水再利用

河北省城市、农村地区成人甲状腺疾病流行病学调查分析

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中华地方病学杂志 2023年第4期42卷 292-295页

作者：郝志华王绵郝慧瑶高明葛艳红朱秋霄刘子渤赵雪李杰王星焦丽静袁玲玲张力辉河北医科大学第二医院内分泌科石家庄050051

目的了解河北省城市和农村地区成人甲状腺疾病患病及分布情况。方法采取多阶段分层整群抽样方法,分别选择河北省任丘市和鹿泉市李村镇作为城市、农村调查点,对当地18岁以上常住居民(≥5年)进行问卷调查、体格检查和甲状腺B超检查;并采... 详细信息

目的了解河北省城市和农村地区成人甲状腺疾病患病及分布情况。方法采取多阶段分层整群抽样方法,分别选择河北省任丘市和鹿泉市李村镇作为城市、农村调查点,对当地18岁以上常住居民(≥5年)进行问卷调查、体格检查和甲状腺B超检查;并采集调查对象空腹静脉血进行血清甲状腺功能指标测定。结果共调查成人2650人,其中城市人口1393人、农村人口1257人;男性1357人、女性1293人。检出甲状腺疾病患者435例,检出率为16.42%;共包括7种甲状腺疾病,分别为亚临床甲状腺功能减退(60.92%,265/435),桥本甲状腺炎(34.02%,148/435),甲状腺功能减退(4.83%,21/435),单纯性甲状腺肿(3.22%,14/435),甲状腺功能亢进(2.53%,11/435),亚临床甲状腺功能亢进(2.53%,11/435),甲状腺癌(1.84%,8/435)。城市、农村人群甲状腺疾病检出率分别为21.18%(295/1393)、11.14%(140/1257),男、女性甲状腺疾病检出率分别为11.42%(155/1357)、21.66%(280/1293),18~<30、30~<40、40~<50、50~<60、≥60岁人群甲状腺疾病检出率分别为13.46%(91/676)、14.81%(81/547)、15.42%(89/577)、20.94%(85/406)、20.05%(89/444),不同地区、性别、年龄比较,差异均有统计学意义(χ^(2)=48.54、50.53、14.68,均P<0.05)。结论河北省城市和农村地区成人亚临床甲状腺功能减退检出率较高,其次是桥本甲状腺炎。应对城市女性人群甲状腺功能的筛查、评估和干预予以重视。

关键词：甲状腺城乡流行病学成人

方庄社区智慧家庭医生优化协同服务模式对新型冠状病毒肺炎联防联控的效果研究

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中国全科医学 2020年第19期23卷 2385-2389页

作者：魏学娟聂慧瑶吴浩葛彩英王丽陈颖高文娟首都医科大学方庄社区教研室北京市丰台区方庄社区卫生服务中心北京市100053

为了积极应对新型冠状病毒肺炎,方庄社区卫生服务中心创新应用智慧家庭医生优化协同服务模式(智慧家医模式),与方庄街道办事处和居委会协作,组建16个家庭医生服务团队,将医护人员分为下沉防控组和非下沉防控组,包片负责对新型冠状病毒... 详细信息

为了积极应对新型冠状病毒肺炎,方庄社区卫生服务中心创新应用智慧家庭医生优化协同服务模式(智慧家医模式),与方庄街道办事处和居委会协作,组建16个家庭医生服务团队,将医护人员分为下沉防控组和非下沉防控组,包片负责对新型冠状病毒肺炎实施“网格化”分类分级管理。应用智能语音外呼系统通过语音电话形式对居民全面排查,结合社区居委会和办事处排查登记的数据,以及传染病网络直报系统信息和丰台区疾病预防控制中心信息,将社区居民分为普通人群和重点人群,后者包括异地返京、高危人群、密切接触人群、疑似病例和确诊病例。对于普通人群,借助智慧家医模式下的“互联网+人工智能”信息技术手段,包括智能语音外呼系统、智能化慢性病管理系统和智能移动终端APP,将新型冠状病毒肺炎知识和防护措施划分为12个专题模块,以多种形式对居民进行全面的科普教育,线上线下医护、医患协同联动,实施“网格化”管理。对于重点人群,包片实施传染病三级管理,“一对一”线下跟踪。方庄社区卫生服务中心应用智慧家医模式从多角度、全方位和多种渠道提高居民对新型冠状病毒肺炎的认知水平和防护能力,协助居民科学防控新型冠状病毒肺炎,值得其他城镇社区参考和借鉴。

关键词：新型冠状病毒肺炎社区卫生服务信息技术人工智能联防联控北京

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《唐会要》讹误校订举例

南京农业大学学报（社会科学版） 2007年第2期7卷 89-93,100页

作者：邢永革南京大学中文系江苏南京210093

作为现存最早的会要体史书,《唐会要》是研究唐史,特别是研究玄宗天宝以后历史的重要典籍。由于《唐会要》在编纂及传抄的过程中,文字脱讹严重,大大影响了该书的使用价值。这里将发现的讹误择其要者共三十条按卷排列如次,以裨学者考证。

关键词：《唐会要》讹误校订

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《唐会要》正文错误类型及成因探析

菏泽学院学报 2006年第4期28卷 116-119,132页

作者：邢永革菏泽学院中文系山东菏泽274015

《唐会要》是现存最早的会要体史书,是研究唐史,特别是研究玄宗天宝以后历史的重要典籍。由于《唐会要》的编纂历经唐、五代至宋初几个阶段,成书于不同人之手,记事难免有舛误之处,加之宋以后至清初一直未曾刊刻,仅靠抄本流传,故文字脱... 详细信息

《唐会要》是现存最早的会要体史书,是研究唐史,特别是研究玄宗天宝以后历史的重要典籍。由于《唐会要》的编纂历经唐、五代至宋初几个阶段,成书于不同人之手,记事难免有舛误之处,加之宋以后至清初一直未曾刊刻,仅靠抄本流传,故文字脱讹严重,大大影响了该书的使用价值。本文把今本《唐会要》中的错误类型归纳为十二个方面,并对其成因略作分析。

关键词：《唐会要》错误类型成因探析