Genome-wide analyses of nonsyndromic cleft lip with or without palate identify 20 new risk loci in the Chinese Han population

作     者：Bao Li Liang Yong Yafen Yu Yanqin Yu Qi Zhen Huiyao Ge Yiwen Mao Weiwei Chen Yanxia Yu Yirui Wang Zhuo Li Wencheng Fan Chang Zhang Xia Hu Ruixue Zhang Lu Cao Hao Liu Zhuan Bian Miao He Liangdan Sun Bao Li;Liang Yong;Yafen Yu;Yanqin Yu;Qi Zhen;Huiyao Ge;Yiwen Mao;Weiwei Chen;Yanxia Yu;Yirui Wang;Zhuo Li;Wencheng Fan;Chang Zhang;Xia Hu;Ruixue Zhang;Lu Cao;Hao Liu;Zhuan Bian;Miao He;Liangdan Sun

作者机构：Department of DermatologyThe First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China Institute of DermatologyAnhui Medical UniversityHefeiChina Key Laboratory of DermatologyMinistry of EducationAnhui Medical UniversityHefeiAnhui 230022China Inflammation and Immune Mediated Diseases Laboratory of Anhui ProvinceHefeiAnhui 230022China Anhui Provincial Institute of Translational MedicineHefeiAnhui 230022China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)and Key Laboratory of Oral Biomedicine Ministry of EducationSchool and Hospital of StomatologyWuhan UniversityWuhanHubei 430079China 

出 版 物：《Journal of Genetics and Genomics》 (遗传学报（英文版）)

年 卷 期：2022年第49卷第9期

页      面：903-905页

核心收录：

学科分类：0710[理学-生物学] 1003[医学-口腔医学] 100302[医学-口腔临床医学] 10[医学] 

基　　金：funded by the National Natural Science Foundation of China(81970904 to MH,81970923 to ZB) Anhui Institute of Translational Medicine(ZHYX2020A005 to LS) the University Synergy Innovation Program of Anhui Province(GXXT-2020-064 to LS) Clinical medicine discipline construction project of Anhui Medical University(2021lcxk008 to LS) the National Key Research and Development Program(2016YFC1000505 to ZB) 

主　　题：al. palate Dixon 

摘      要：Orofacial clefts(OFCs),particularly cleft lip with or without cleft palate(CL/P)and cleft palate only(CPO),are among the most common birth defects in humans(Mossey et al.,2009;Dixon et al.,2011).The birth prevalence rate of OFCs in China is reported to be as high as 1.66 per thousand newborns.