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A long-term follow-up study on clinical features and coronary artery outcomes of different age patients with Kawasaki disease

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A long-term follow-up study on clinical features and coronar...

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： Zengyou Jin Hongying Shi huixian qiu Niannian Huang Lianhong Jia Jiacheng Lu Zhimin Geng Lulu Pan Rongzhou Wu Maoping Chu Department of Pediatrics the First Affiliated Hospital of Wenzhou Medical University Department of preventive medicine School of Environmental Science and Public HealthWenzhou Medical University Children's Heart Center the Second Affiliated Hospital & Yuying Children's HospitalInstitute of cardiovascular development and translational medicineWenzhou Medical University

Background:Kawasaki disease(KD) is the leading cause of the acquired heart disease in children,which predominantly affects coronary *** short-term,small sample studies suggest thatyoung infants might be susceptible to developing coronary artery lesion(CAL) than older ones,although the mechanism remains *** study was to identify the clinical features and coronary artery outcomes in a 5-years follow-up period among1135 patients of KD with different ***:The clinical features and echocardiography of coronary artery lesions of KD patients in the follow-up period were *** Cox regression analysis was used to screen out the independent risk factors for the development of coronary artery ***:During the follow-up,the rate of new developed CAL in the 60 months age *** CAL incidence in the 60 months age groups after intravenous immunoglobulin(IVIG) treatment during follow-up *** CAL recover among three age groups,who had CAL before treatment,was ***,incomplete KD,IVIG method,IVIG-nonresponse and hypoalbuminemia were also identified as independent prognostic factors for CAL development in addition to ***:This large sample,long-term follow-up study demonstrates that the KD patient younger than 12 months is a high risk population of CAL,even after *** Results remind us to pay more attention to these high risk KD patients who may need a more active therapy.

关键词： Kawasaki disease coronary artery age clinical features prognostic factor

Interventional treatment of patent ductus arteriosus combined with congenital bronchial artery pulmonary arteriovenous fistula: clinical outcomes and follow-up

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Interventional treatment of patent ductus arteriosus combine...

2019年浙江省医学会儿科学分会学术大会

作者： Ping Li Songyue Zhang Yaoyao Yan Bo Cheng Yue Ren Xing Rong Zhenquan Wang huixian qiu Youyang Shi Rongzhou Wu The Second Affiliated Hospital of Wenzhou Medical University

Background Congenital bronchial artery to pulmonary artery or vein fistula(BA-PAVF) is a rare abnormality which may induce recurrent pulmonary infection, fatal hemoptysis, and respiratory failure and it is even scarcely reported that BA-PAVF coexisted with patent ductus arteriosus(PDA).Therefore, BA-PAVF can be easily neglected or misdiagnosed in clinic without being treated *** and results In our study, 22 children were diagnosed with congenital BA-PAVF and PDA by cardiac catheterization and selective bronchial *** BAPAVF which was greater than the horizontal adjacent bronchial artery, vascular plug, MicroNester embolization coils, and interlock fibered IDC occlusion system were respectively used to close BA-PAVF after the transcatheter closure of PDA. And the size, shape, number, tortuosity degree of the fistula, the location of the lesions, the specific complications and family economic status were seriously considered before the procedure. 2 of the patients respectively existed small atrial septal defect(ASD) and small ventricular septal defect(VSD). Finally, 9 of them accepted transcatheter embolization(TCE) according to the size of the fistula. After intermediate to long-term followup, all patients have no abnormal ***-stage interventional closure of BA-PAVF and PDA can be used safely and effectively in children coexisted with BA-PAV and PDAand selective bronchial arteriography is an optimal examination to precisely localize BA-PAVF, but the establishment of specific therapy criteria needs more clinical data and summary.

关键词：

Prophylactic Transcatheter Bronchial Arterial Embolization in Treatment of Congenital Bronchial Artery to Pulmonary Artery or Vein Fistula

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Prophylactic Transcatheter Bronchial Arterial Embolization i...

2018年浙江省医学会儿科学分会学术年会

作者： Songyue Zhang Ping Li Youyang Shi Bo Cheng Yue Ren Xing Rong Zhenquan Wang huixian qiu Rongzhou Wu Maoping Chu Children’s Heart Center the Second Affiliated Hospital and Yuying Children’s HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical University

Objective:This study sought to demonstrate that prophylactic transcatheter embolization(TCE) can be used safely and effectively for the treatment of congenital bronchial artery to pulmonary artery or vein(BA-PAV) fistula and selective bronchial arteriography is an optimal examination to precisely localize these abnormal ***:BA-PAV fistula is a rare abnormality and may induce recurrent pulmonary infection,fatal hemoptysis and respiratory ***,there is no recommended treatment experience or protocol in the pediatric population.

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Serum miR-92a as new potential biomarkers for diagnosis of Kawasaki disease with coronary artery lesion

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Serum miR-92a as new potential biomarkers for diagnosis of K...

第十三届江浙沪儿科学术会议暨2016年浙江省医学会儿科学学术年会

作者： Lianhong Jia Lulu Pan Jiacheng Lu Zhimin Geng Niannian Huang Zengyou Jin Rongzhou Wu huixian qiu Yuee He Xiangyang Xue Maoping Chu Department of pediatrics the First Affiliated Hospital of Wenzhou Medical University Department of Cardiology the Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Department of microbiology and immunology Wenzhou Medical University

Serum microRNAs(miRNAs) have been used as a novel noninvasive biomarker for the diagnosis of various diseases,but their role had few reported in Kawasaki *** this study,sera from 72 acute KD patients,30 convalescent KD children,30 febrile children and 30 healthy controls were collected.A quantitative reversetranscription polymerase chain reaction(qRT-PCR) assay was utilized to determine and compare serum levels of 9 miRNAs associated with cardiovascular disease or endothelial damage in these *** assessment of these serum miRNAs in KD diagnosis and the relationship between the expression of these miRNAs in sera and clinical indicators of KD patients were further *** indicated that serum levels of miR-92 a were significantly increased in KD patients compared with fever children and healthy control(P<0.05).When the disease recovered,the levels of miR-92 a expression returned to the level of healthy *** and pathological survey indicated that high expression of miR-92 a was significantly associated with coronary artery lesions(CAL).ROC plot yielded an area under the curve(AUC) of 0.807(95%CI 0.694-0.919,P<0.05),0.690(95%CI 0.551-0.829,P<0.05),0.656(95%CI 0.514-0.797,P<0.05),when distinguishing KD acute patients from normal children,febrile children and convalescent KD children,*** of ROC curve indicates the serum miR-92 a had a sensitivity of 100.0%and a specificity of 45.5%for distinguishing KD with CAL from KD without CAL with an area under the curve(AUC) of 0.759(95%CI 0.573-0.945,P<0.05).In conclusion,the different expressionof miR-92 a may be used as a new potential marker for diagnosis of Kawasaki disease with coronary artery lesion.

关键词： Kawasaki Disease coronary artery lesion miRNA biomarker

静脉注射丙种球蛋白无反应型川崎病的研究进展

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临床儿科杂志 2013年第3期31卷 283-286页

作者：李丰张园海仇慧仙任跃陈其温州医学院附属育英儿童医院儿童心血管科浙江温州325027

川崎病（KD）是一种病因不明的以全身中、小血管炎为主要病变的儿童急性发热性疾病。如未经治疗,约20%~25%的KD患儿可发生冠状动脉损害（CAL）。尽管目前标准化疗法已广泛应用,但仍有10%~15%的患儿对静脉注射丙种球蛋白（IVIG）无反应,... 详细信息

川崎病（KD）是一种病因不明的以全身中、小血管炎为主要病变的儿童急性发热性疾病。如未经治疗,约20%~25%的KD患儿可发生冠状动脉损害（CAL）。尽管目前标准化疗法已广泛应用,但仍有10%~15%的患儿对静脉注射丙种球蛋白（IVIG）无反应,且这部分患儿发生CAL的风险升高。因此,早期识别及有效治疗KD十分重要,现就这方面的研究进展进行综述。

关键词：川崎病丙种球蛋白无反应

经皮黄疸测定仪检测新生儿总胆红素水平的可靠性分析

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大理大学学报 2021年第4期6卷 62-66页

作者：黄循斌程国强丘惠娴深圳市龙岗中心医院新生儿科广东深圳518116 复旦大学附属儿科医院新生儿科上海201102

目的:评价经皮黄疸测定仪与全自动生化分析仪检测新生儿总胆红素(TBIL)的相关性和一致性。方法:回顾性分析2017年6月至2019年6月在深圳市龙岗中心医院新生儿科住院治疗的新生儿高胆红素血症患儿383例。按全自动生化分析仪检测的TBIL值... 详细信息

目的:评价经皮黄疸测定仪与全自动生化分析仪检测新生儿总胆红素(TBIL)的相关性和一致性。方法:回顾性分析2017年6月至2019年6月在深圳市龙岗中心医院新生儿科住院治疗的新生儿高胆红素血症患儿383例。按全自动生化分析仪检测的TBIL值分为中度黄疸组198例、重度黄疸组120例和极重度黄疸组65例。同步使用经皮黄疸测定仪和全自动生化分析仪检测TBIL值,采用Spearman相关系数和Bland-Altman散点图分析两种检测方法TBIL值的相关性和一致性。结果:经皮黄疸测定仪和全自动生化分析仪检测TBIL值在不同程度黄疸组比较,差异均有统计学意义(P<0.01)。经皮黄疸测定仪和全自动生化分析仪两种方法检测TBIL值呈显著正相关(r=0.973,P<0.01);两种仪器检测TBIL值的一致性较差。结论:对于中、重度黄疸患儿经皮测定胆红素(TCB)是较好的监测工具,但是对于极重度黄疸患儿不能仅仅根据TCB进行管理,需要动态监测血清总胆红素(STB)。

关键词：胆红素经皮黄疸测定仪全自动生化分析仪新生儿

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喂养方式对婴幼儿智能发育的影响研究

河北医药 2010年第13期32卷 1697-1698页

作者：谢志才丘惠娴周曙明广东省深圳市龙岗中心医院 518116

目的比较母乳喂养、混合喂养与人工喂养对婴儿智能发育的影响。方法选择足月出生的正常体重儿348例,分母乳喂养、混合喂养和人工喂养3组,纳入婴儿分别于1、3、6月龄进行丹佛智能筛查表(DDST)发育测试,同时记录6个月内患呼吸道感染、肺... 详细信息

目的比较母乳喂养、混合喂养与人工喂养对婴儿智能发育的影响。方法选择足月出生的正常体重儿348例,分母乳喂养、混合喂养和人工喂养3组,纳入婴儿分别于1、3、6月龄进行丹佛智能筛查表(DDST)发育测试,同时记录6个月内患呼吸道感染、肺炎、腹泻、佝偻病等疾病的情况。结果婴儿常见病患病率以母乳喂养组最低、混合喂养组次之,人工喂养组最高,且3组中两两比较差异有统计学意义(P混合喂养组>人工喂养组,且差异有统计学意义(P<0.05)。其中3月龄中62.5%的项目,3组差异有统计学意义(P<0.01);6月龄中38.46%的项目,3组差异有统计学意义(P<0.01)。结论母乳是4个月内婴儿的最佳食物,其营养素齐全,能够减少患病率、全面满足婴儿体格生长,同时适时添加高质量的辅食对婴儿智能发育的作用是不可忽视的。

关键词：喂养方式婴幼儿智能发育

经鼻间歇正压通气在新生儿严重高碳酸血症中的应用价值

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临床医学工程 2015年第4期22卷 478-479页

作者：陈兰珍邱惠仙叶丽芹深圳市人民医院儿科广东深圳518020

目的探讨经鼻间歇正压通气(NIPPV)治疗新生儿严重高碳酸血症的疗效。方法将我院168例新生儿严重高碳酸血症患者随机分成间歇组和机械组各84例,间歇组在基础处理的基础上采用NIPPV治疗,机械组采用机械通气治疗,两组均给予全面护理。观察... 详细信息

目的探讨经鼻间歇正压通气(NIPPV)治疗新生儿严重高碳酸血症的疗效。方法将我院168例新生儿严重高碳酸血症患者随机分成间歇组和机械组各84例,间歇组在基础处理的基础上采用NIPPV治疗,机械组采用机械通气治疗,两组均给予全面护理。观察两组患儿治疗前,治疗后2 h及12 h的动脉血气指标(p H、Pa CO2、Pa O2),并分析两组患儿的脑血流指标(Vs、Vd、S/D、RI、PI)的情况。结果两组的通气时间、治疗前后的动脉血气指标、脑血流指标相比差异均无统计学意义(P>0.05),但两组治疗后2 h及12 h的动脉血气指标均明显改善(P<0.05)。间歇组的并发症发生率为1.19%,显著低于机械组的8.33%,差异有统计学意义(P<0.05)。结论 NIPPV治疗新生儿严重高碳酸血症疗效显著,并发症少,具有较高的临床价值。

关键词：高碳酸血症新生儿经鼻间歇正压通气

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白血病患儿PICC应用的对照研究和护理

护理实践与研究 2010年第2期7卷 5-7页

作者：庄艳云谌朝辉邱惠仙暨南大学医学院第二附属医院深圳市人民医院 518020

目的:探讨外周静脉置入中心静脉导管在白血病患儿中的应用价值。方法:将我院收治的40例白血病患儿随机分为PICC组和对照组各20例,比较两组静脉留置时间、静脉穿刺次数及静脉炎的发生情况。结果:PICC组患儿静脉留置时间高于对照组,而静... 详细信息

目的:探讨外周静脉置入中心静脉导管在白血病患儿中的应用价值。方法:将我院收治的40例白血病患儿随机分为PICC组和对照组各20例,比较两组静脉留置时间、静脉穿刺次数及静脉炎的发生情况。结果:PICC组患儿静脉留置时间高于对照组,而静脉穿刺次数、静脉炎的发生率低于对照组,差异有显著意义。结论:PICC能有效提高静脉留置时间,减少患儿静脉穿刺次数和静脉炎的发生率,为白血病患儿提供了安全、可靠的静脉通路,并减轻了护理工作量,值得临床推广使用。

关键词： PICC置管术白血病患儿护理