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β-胡萝卜素对Pickering乳液中脂质氧化的抑制作用研究

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食品工业科技 2024年第17期45卷 131-138页

作者：马昉新齐文慧淑英张旭梁孙硕杨天一王慧婷张志胜河北农业大学食品科技学院河北保定071000 江南大学食品科学与技术国家重点实验室江苏无锡214122 保定市食品药品检验所河北保定071000

为了考察β-胡萝卜素对Pickering乳液中脂质氧化的抑制作用,以纤维素纳米晶体(cellulose nanocrystal,CNC)为乳化剂制备了包埋β-胡萝卜素的Pickering乳液。以DPPH和ABTS+自由基清除率为评价指标分析β-胡萝卜素包埋前后的抗氧化性能。... 详细信息

为了考察β-胡萝卜素对Pickering乳液中脂质氧化的抑制作用,以纤维素纳米晶体(cellulose nanocrystal,CNC)为乳化剂制备了包埋β-胡萝卜素的Pickering乳液。以DPPH和ABTS+自由基清除率为评价指标分析β-胡萝卜素包埋前后的抗氧化性能。通过测定β-胡萝卜素包埋率及保留率、POV值、TBA值和色差,考察包埋β-胡萝卜素乳液的氧化稳定性及着色稳定性。结果表明,经乳液包埋的β-胡萝卜素具有良好的DPPH、ABTS+自由基清除效果。β-胡萝卜素在乳液中的保留率由于其自由基清除作用和自氧化反应而显著下降(P<0.05),并且与乳液中的TBA值呈极显著负相关(P<0.01)。加速氧化期间,由于乳液中的β-胡萝卜素通过清除自由基和自氧化反应抑制脂质氧化,乳液中的POV、TBA值均随β-胡萝卜素浓度增加而显著降低(P<0.05),乳液的氧化稳定性显著提高。包埋β-胡萝卜素乳液的颜色饱和度显著提高(P<0.05),呈现明亮的黄色。因此,通过包埋脂溶性β-胡萝卜素可提高Pickering乳液的氧化稳定性和着色稳定性,从而为Pickering乳液在替代脂肪和包埋递送营养物质等方面提供更广阔的应用前景。

关键词： β-胡萝卜素 Pickering乳液抗氧化活性氧化稳定性着色稳定性

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基于上海市同卵双生子的胰岛素抵抗与全基因组DNA甲基化关联研究

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中华流行病学杂志 2024年第7期45卷 932-940页

作者：冯静源周荣飞刘宏伟胡子涵吴非王惠婷岳俊宏朱珍妮吴凡复旦大学公共卫生学院上海200032 上海市疾病预防控制中心上海200336

目的基于上海市双生子人群,探讨胰岛素抵抗(IR)与全基因组DNA甲基化之间的关联。方法于2012-2013、2017-2018和2022-2023年招募上海市成年同卵双生子(MZ)作为研究对象,通过问卷调查、体格测量和实验室检测收集相关信息,进行甲基化检测,... 详细信息

目的基于上海市双生子人群,探讨胰岛素抵抗(IR)与全基因组DNA甲基化之间的关联。方法于2012-2013、2017-2018和2022-2023年招募上海市成年同卵双生子(MZ)作为研究对象,通过问卷调查、体格测量和实验室检测收集相关信息,进行甲基化检测,采用广义线性混合效应模型分析单个位点DNA甲基化水平与稳态模型2胰岛素抵抗指数(HOMA2-IR)之间的关联,并采用非配对和配对设计分析DNA甲基化水平与IR表型之间的关联,对筛选出的阳性位点进行聚类分析得到位点簇,通过广义线性回归评估甲基化模式。结果本研究纳入100对MZ,发现cg10535199-2q23.1(β=0.74%,P=1.51×10^(-7),OR=1.06,95%CI:1.03~1.09)和ch.17.49619327-SPOP(β=0.23%,P=7.54×10^(-7),OR=1.17,95%CI:1.08~1.28)位点高甲基化超过有建议意义的关联水平,经多重比较校正后,未发现位点达到基因组显著性水平,配对分析结果无统计学意义。识别出2个HOMA2-IR位点簇,位点簇1甲基化下调(β=-0.39%,P<0.001),位点簇2甲基化上调(β=0.47%,P<0.001)。结论IR与DNA甲基化之间存在关联,遗传因素可能在关联中发挥作用。

关键词：双生子胰岛素抵抗糖尿病 DNA甲基化表观遗传流行病学关联研究

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Mo含量对自熔性铁基合金组织性能的影响

安徽工业大学学报（自然科学版） 2024年第1期41卷 37-45页

作者：潘雄飞王月祥梁怡航高鹏博王会廷安徽工业大学冶金工程学院安徽马鞍山243032

为提高镀铝锌板生产机组316L沉没辊的耐高温磨损–腐蚀性能,采用激光熔覆技术在316L基体表面制备Fe60涂层和4种含Mo(质量分数为2.5%,5.0%,7.5%,10.0%)的Fe60复合涂层,对不同涂层的物相、微观组织、力学性能、摩擦性能和腐蚀性能进行表征... 详细信息

为提高镀铝锌板生产机组316L沉没辊的耐高温磨损–腐蚀性能,采用激光熔覆技术在316L基体表面制备Fe60涂层和4种含Mo(质量分数为2.5%,5.0%,7.5%,10.0%)的Fe60复合涂层,对不同涂层的物相、微观组织、力学性能、摩擦性能和腐蚀性能进行表征,探究Mo含量对Fe60涂层组织和性能的影响。结果表明:含Mo涂层析出硬质相Fe_(9.7)Mo_(0.3),Mo对Fe60涂层晶粒度和组织缺陷均有影响,随Mo含量的增加,涂层晶粒度和组织缺陷数均先减后增,w(Mo)=5.0%涂层晶粒度最小、组织无缺陷;与Fe60涂层相比,含Mo涂层硬度降低,而耐磨性均有提升,随Mo含量的增加,涂层耐磨性能先增后减,w(Mo)=5.0%涂层磨损失重最低;与Fe60涂层相比,含Mo涂层耐高温铝锌液腐蚀性能均有提升,随Mo含量的增加,涂层腐蚀速率下降,但Mo质量分数超过5%时,涂层腐蚀面存在局部断裂,实际耐腐蚀性能下降。

关键词：激光熔覆铁基合金 Mo含量摩擦磨损性能铝锌液腐蚀

Water Changes and Sources of Siling Co Using Landsat and GRACE Data since 1972

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Journal of Earth Science 2024年第2期35卷 687-699页

作者： Chuya wang Yuande Yang Fei Li Junhao wang Leiyu Li huiting Yu Chinese Antarctic Center of Surveying and Mapping Wuhan UniversityWuhan430079China

The inland lakes on the Tibetan Plateau(TP)are undergoing significant changes due to their sensitivity to *** largest lake in Tibet,Siling Co,has expanded most dramatically during recent *** Landsat,GRACE and meteorological data,the expansion of Siling Co was detailed in four stages and the process was further *** results show that the lake area increased from 1647.30 km^(2)in 1972 to 2438.99 km^(2)in *** experienced a slow growth at a rate 6.03 km^(2)/yr from 1972 to 1988,while fluctuating at 1.44 km^(2)/yr during 1989–1997,then accelerated at 60.28 km^(2)/yr between 1998 and 2005,and expanded slowly again at 11.40 km^(2)/yr since *** continued expansion led to its merger with nearby Yagain Co in *** water storage(TWS)increase was also observed from GRACE(0.65 cm/yr),with about 0.75 coefficient of determination between the TWS and lake area during 2002–*** long-term expansion of Siling Co is related to the increasing trends of temperature and precipitation,but their contributions vary with time ***,the accelerated stage between 1998 and 2005 can be explained by the increased temperature and precipitation accompanied by a drop in evaporation,while the slow expansion since 2006 was due to the decrease in precipitation and temperature and the rise in *** is no obvious mass loss of glaciers revealed by GRACE during 2002–2020,which may be related to the negative trend of the ***,the precipitation may still make a major contribution in this phase,as its average is about 93.9 mm higher than that in 1988–1997.

关键词： lake area remote sensing climate change Siling Co Tibetan Plateau environmental geology

5A06-O铝镁合金板材差温拉深凸耳行为研究

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内蒙古工业大学学报（自然科学版） 2024年第5期43卷 385-393页

作者：王会廷杨金顺梁怡航高鹏博方进秀安徽工业大学冶金工程学院安徽马鞍山243032

采用单向热拉伸试验测定了5A06-O铝镁合金在温热条件下(150~275℃)的流变应力曲线及厚向异性系数,通过扫描电镜对不同温度下单向拉伸试样颈缩断裂处的断口进行形貌观察分析。通过差温拉深试验研究了5A06-O铝镁合金在温热条件下的凸耳形... 详细信息

采用单向热拉伸试验测定了5A06-O铝镁合金在温热条件下(150~275℃)的流变应力曲线及厚向异性系数,通过扫描电镜对不同温度下单向拉伸试样颈缩断裂处的断口进行形貌观察分析。通过差温拉深试验研究了5A06-O铝镁合金在温热条件下的凸耳形成及演变规律。结果表明,拉深件的凸耳出现在与轧制方向成45°方向处,且平均凸耳率随着成形温度的升高先降低后增大,在250℃差温拉深条件下平均凸耳率最小,这与平面各向异性系数∆r有密切关系;在150、200、275℃,平均凸耳率随拉深比的增大呈现先增大后减小的趋势,而在250℃平均凸耳率随着拉深比的增大而增大;拉深件45°方向的减薄率与增厚率明显低于0°及90°方向,其原因在于该方向有着最大的塑性应变比r;250℃成形的零件三个方向均有着最低的减薄率与增厚率,壁厚分布最为均匀,其原因在于该温度有着最大的平均塑性应变比r。成形速度对5A06-O铝镁合金的成形性能有着显著影响,在室温及温热条件宜采用较快的拉深速度,本试验中5mm/s为最佳,但随着拉深速度的增加,平均凸耳率呈现上升趋势。

关键词： 5A06-O铝镁合金高温拉伸塑性应变比温成形凸耳成形速度

Advances in lung cancer screening and early detection

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Cancer Biology & Medicine 2022年第5期19卷 591-608页

作者： Caichen Li huiting wang Yu Jiang Wenhai Fu Xiwen Liu Ran Zhong Bo Cheng Feng Zhu Yang Xiang Jianxing He Wenhua Liang Department of Thoracic Oncology and Surgery the First Affiliated Hospital of Guangzhou Medical UniversityChina National Center for Respiratory MedicineChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120China Dongguan Affiliated Hospital of Southern Medical University Dongguan People HospitalDongguan 523059China Department of Internal Medicine Detroit Medical Center Sinai-Grace HospitalDetroitMichigan 48235USA Department of Thoracic Surgery Nanfang Hospital of Southern Medical UniversityGuangzhou 510515China Department of Oncology the First People’s Hospital of ZhaoqingZhaoqing 526020China

Lung cancer is associated with a heavy cancer-related burden in terms of patients’physical and mental health *** randomized controlled trials,the US-National Lung Screening Trial(NLST)and Nederlands-Leuvens Longkanker Screenings Onderzoek(NELSON),indicated that low-dose CT(LDCT)screening results in a statistically significant decrease in mortality in patients with lung cancer,LDCT has become the standard approach for lung cancer ***,many issues in lung cancer screening remain unresolved,such as the screening criteria,high false-positive rate,and radiation *** review first summarizes recent studies on lung cancer screening from the US,Europe,and Asia,and discusses risk-based selection for screening and the related ***,an overview of novel techniques for the differential diagnosis of pulmonary nodules,including artificial intelligence and molecular biomarker-based screening,is ***,current explorations of strategies for suspected malignancy are ***,this review aims to help clinicians understand recent progress in lung cancer screening and alleviate the burden of lung cancer.

关键词： Lung cancer screening low-dose CT early detection strategies biomarkers

TREM-2 Drives Development of Multiple Sclerosis by Promoting Pathogenic Th17 Polarization

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Neuroscience Bulletin 2024年第1期40卷 17-34页

作者： Siying Qu Shengfeng Hu huiting Xu Yongjian Wu Siqi Ming Xiaoxia Zhan Cheng wang Xi Huang Center for Infection and Immunity and Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China The State Key Laboratory of Respiratory Disease Guangdong Provincial Key Laboratory of Allergy and Clinical ImmunologyThe Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China Department of Laboratory Medicine The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Division of Nephrology Department of Medicinethe Fifth Affliated Hospital of Sun Yat-sen UniversityZhuhai 519000China

Multiple sclerosis(MS)is a neuroinflammatory demyelinating disease,mediated by pathogenic T helper 17(Th17)***,the therapeutic effect is accompa-nied by the fluctuation of the proportion and function of Th17 cells,which prompted us to find the key regulator of Th17 differentiation in ***,we demonstrated that the triggering receptor expressed on myeloid cells 2(TREM-2),a modulator of pattern recognition receptors on innate immune cells,was highly expressed on pathogenic CD4-positive T lymphocyte(CD4^(+)T)cells in both patients with MS and experimental autoimmune encephalomyelitis(EAE)mouse *** knockout of Trem-2 in CD4^(+)T cells significantly alleviated the disease activity and reduced Th17 cell infiltration,activation,differentiation,and inflammatory cytokine production and secretion in EAE ***,with Trem-2 knockout in vivo experiments and in vitro inhibitor assays,the TREM-2/zeta-chain associated protein kinase 70(ZAP70)/signal transducer and activator of transcription 3(STAT3)signal axis was essential for Th17 activation and differentiation in EAE *** conclusion,TREM-2 is a key regulator of pathogenic Th17 in EAE mice,and this sheds new light on the potential of this therapeutic target for MS.

关键词： Multiple sclerosis Experimental autoimmune encephalomyelitis T helper 17 Triggering receptor expressed on myeloid cells 2

Complete-basis-reprogrammable coding metasurface for generating dynamicallycontrolled holograms under arbitrary polarization states

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Opto-Electronic Advances 2024年第9期7卷 65-80页

作者： Zuntian Chu Xinqi Cai Ruichao Zhu Tonghao Liu huiting Sun Tiefu Li Yuxiang Jia Yajuan Han Shaobo Qu Jiafu wang Shaanxi Key Laboratory of Artificially-Structured Functional Materials and Devices Air Force Engineering UniversityXi’an 710051China Suzhou Laboratory Suzhou 215000China Zhijian Laboratory Rocket Force University of EngineeringXi’an 710025China.

Reprogrammable metasurfaces,which establish a fascinating bridge between physical and information domains,can dynamically control electromagnetic(EM)waves in real time and thus have attracted great attentions from researchers around the *** control EM waves with an arbitrary polarization state,it is desirable that a complete set of basis states be controlled independently since incident EM waves with an arbitrary polarization state can be decomposed as a linear sum of these basis *** this work,we present the concept of complete-basis-reprogrammable coding metasurface(CBR-CM)in reflective manners,which can achieve independently dynamic controls over the reflection phases while maintaining the same amplitude for left-handed circularly polarized(LCP)waves and right-handed circularly polarized(RCP)*** LCP and RCP waves together constitute a complete basis set of planar EM waves,dynamicallycontrolled holograms can be generated under arbitrarily polarized wave *** dynamically reconfigurable metaparticle is implemented to demonstrate the CBR-CM’s robust capability of controlling the longitudinal and transverse positions of holograms under LCP and RCP waves ***’s expected that the proposed CBR-CM opens up ways of realizing more sophisticated and advanced devices with multiple independent information channels,which may provide technical assistance for digital EM environment reproduction.

关键词： basis vector control reprogrammable metasurface dynamically-controlled holograms arbitrary polarization state broadband

Cyclocarysaponins A–J, dammarane-type triterpenoid glycosides from the leaves of Cyclocarya paliurus

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Chinese Journal of Natural Medicines 2024年第10期22卷 955-964页

作者： XI huiting YUAN Mingming XIE Jianhua wang Yuanxing State Key Laboratory of Food Science and Resources Nanchang University Jiangxi Institute for Drug Control NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality

Ten previously undescribed dammarane-type triterpenoid glycosides, cyclocarysaponins A–J(1–10), were isolated from the leaves of Cyclocarya paliurus(Batal.) Iljinskaja. The structures of these compounds were characterized through detailed spectroscopic analysis, including 1D and 2D nuclear magnetic resonance(NMR) and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS). The cytotoxic activities of all isolates were assessed against five human cancer cell lines(Bel-7402, Caski, BGC-823, A2780, and HCT-116). Of the tested compounds, compounds 1, 7, and 9 exhibited selective cytotoxicity against one or more human cancer cell lines.

关键词： Cyclocarya paliurus Cyclocarysaponin Cytotoxic activities Juglandaceae Triterpenoid glycosides