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Rapid estimation of earthquake loss based on instrumental seismic intensity: design and realization

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Earthquake Science 2013年第1期26卷 67-73页

作者： Hongsheng Huang Lin Chen Gengqing Zhu Lin wang Yanzhao Lin huishan wang Earthquake Administration of Fujian Province

As a result of our ability to acquire large volumes of real-time earthquake observation data, coupled with increased computer performance, near real-time seismic instrument intensity can be obtained by using ground motion data observed by instruments and by using the appropriate spatial interpolation methods. By combining vulnerability study results from earthquake disaster research with earthquake disaster assessment models, we can estimate the losses caused by devastating earthquakes, in an attempt to provide more reliable information for earthquake emergency response and decision support. This paper analyzes the latest progress on the methods of rapid earthquake loss estimation at home and abroad. A new method involving seismic instrument intensity rapid reporting to estimate earthquake loss is proposed and the relevant software is developed. Finally, a case study using the ML4.9 earthquake that occurred in Shun-chang county, Fujian Province on March 13, 2007 is given as an example of the proposed method.

关键词： Earthquake loss estimation Seismicinstrument intensity rapid report Buildingvulnerability

Sequential stabilization of RNF220 by RLIM and ZC4H2 during cerebellum development and Shh-group medulloblastoma progression

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Journal of Molecular Cell Biology 2022年第1期14卷 32-46页

作者： Yuwei Li Chencheng Yang huishan wang Ling Zhao Qinghua Kong Yu Cang Shuhua Zhao Longbao Lv Yan Li Bingyu Mao Pengcheng Ma State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650203China Experimental Animal Center Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Kunming Institute of Botany Chinese Academy of SciencesKunming 650223China Department of Urology the Affiliated Hospital of Yunnan UniversityKunming 650021China First Affiliated Hospital of Kunming Medical University Kunming 650032China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China

Sonic hedgehog (Shh) signaling is essential for the proliferation of cerebellar granule neuron progenitors (CGNPs), and its misregulation is linked to various disorders, including cerebellar cancer medulloblastoma (MB). During vertebrate neural development, RNF220, a ubiquitin E3 ligase, is involved in spinal cord patterning by modulating the subcellular location of glioma-associated oncogene homologs (Glis) through ubiquitination. RNF220 is also required for full activation of Shh signaling during cerebellum development in an epigenetic manner through targeting embryonic ectoderm development. ZC4H2 was reported to be involved in spinal cord patterning by acting as an RNF220 stabilizer. Here, we provided evidence to show that ZC4H2 is also required for full activation of Shh signaling in CGNP and MB progression by stabilizing RNF220. In addition, we found that the ubiquitin E3 ligase RING finger LIM domain-binding protein (RLIM) is responsible for ZC4H2 stabilization via direct ubiquitination, through which RNF220 is also thus stabilized. RLIM is a direct target of Shh signaling and is also required for full activation of Shh signaling in CGNP and MB cell proliferation. We further provided clinical evidence to show that the RLIM‒ZC4H2‒RNF220 cascade is involved in Shh-group MB progression. Disease-causative human RLIM and ZC4H2 mutations affect their interaction and regulation. Therefore, our study sheds light on the regulation of Shh signaling during cerebellar development and MB progression and provides insights into neural disorders caused by RLIM or ZC4H2 mutations.

关键词： ZC4H2 RLIM RNF220 Shh signaling cerebellum medulloblastoma(MB)

CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target

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Cancer Communications 2020年第2期40卷 69-80页

作者： Wen Zhang huishan wang Mingyang Sun Xueting Deng Xueru Wu Yilan Ma Mengjing Li Said Maisam Shuoa Qiang You Lin Miao Medical Center for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Department of Surgery The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Department of Biotherapy The Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Key Laboratory for Aging and Disease Nanjing Medical UniversityNanjing 210011JiangsuP.R.China

The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in ***-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer *** TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and *** CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in *** the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor ***5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the *** this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in *** possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed.

关键词： biomarker CXCL5 CXCR2 molecular targeted therapy tumor microenvironment

ZC4H2 stabilizes RNF220 to pattern ventral spinal cord through modulating Shh/Gli signaling

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Journal of Molecular Cell Biology 2020年第5期12卷 337-344页

作者： Pengcheng Ma Ning-Ning Song Xiaoning Cheng Liang Zhu Qiong Zhang Long long Zhang Xiangcai Yang huishan wang Qinghua Kong Deli Shi Yu-Qiang Ding Bingyu Mao State Key Laboratory of Genetic Resources and Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institute of Brain SciencesFudan UniversityShanghai 200032China Affiliated Hospital of Guangdong Medical University Zhanjiang 524001China Kunming College of Life Science University of Chinese Academy of SciencesKunming 650223China Key Laboratory of Arrhythmias Ministry of Education of ChinaEast Hospitaland Department of Anatomy and NeurobiologyCollaborative Innovation Center for Brain ScienceTongji University School of MedicineShanghai 200092China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650203China Department of Laboratory Animal Science Fundan UniversityShanghai 200032China Center for Excellence in Animal Evolution and Genetics Chinese Academy of SciencesKunming 650223China Present address:Department of Clinical Laboratory The Affiliated Hospital of KMUSTMedical FacultyKunming University of Science and TechnologyKunming 650032China

ZC4H2 encodes a C4H2 type zinc-finger nuclear factor,the mutation of which has been associated with disorders with various clinical phenotypes in human,including developmental delay,intellectual disability and ***4H2 has been suggested to regulate spinal cord patterning in zebrafish as a co-factor for RNF220,an ubiquitin E3 ligase involved in Gli *** we showed that ZC4H2 and RNF220 knockout animals phenocopy each other in spinal patterning in both mouse and zebrafish,with mispatterned progenitor and neuronal domains in the ventral spinal *** showed evidence that ZC4H2 is required for the stability of RNF220 and also proper Gli ubiquitination and signaling in *** data provides new insights into the possible etiology of the neurodevelopmental impairments observed in ZC4H2-associated syndromes.

关键词： ZC4H2 RNF220 spinal cord patterning Gli signaling

重视桡动脉桥在冠状动脉旁路移植术中的地位并着力推进其在中国人群中的应用

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中华医学杂志 2019年第42期99卷 3281-3283页

作者：陈绪军王辉山华中科技大学同济医学院附属武汉第一医院心外科武汉430022 解放军北部战区总医院心血管外科沈阳110016

桡动脉桥在冠状动脉旁路移植术中的地位日益突出。本期重点栏目探讨桡动脉桥在中国人群冠状动脉旁路移植术中作为第二血管桥的观点,并集中报道我国几个中心桡动脉应用的初步经验,包括桡动脉在重度狭窄的右主干的应用及桡动脉序贯桥的应... 详细信息

桡动脉桥在冠状动脉旁路移植术中的地位日益突出。本期重点栏目探讨桡动脉桥在中国人群冠状动脉旁路移植术中作为第二血管桥的观点,并集中报道我国几个中心桡动脉应用的初步经验,包括桡动脉在重度狭窄的右主干的应用及桡动脉序贯桥的应用等,期望我国冠状动脉外科医师重视桡动脉的应用,大力推进其应用比例及使用范围,以使更多的中国冠心病患者受益。

关键词：桡动脉冠状动脉分流术

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基于移动终端的地震应急辅助决策系统研究

自然灾害学报 2017年第5期26卷 30-35页

作者：王辉山肖健郑韵福建省地震局福建福州350003

以现有的各类地震应急指挥技术系统为基础,充分利用实时融合技术、三维地理信息技术、Web GIS技术等先进的计算机技术,并将这些系统优化整合到一起,建立起一个融合了灾情评估、三维电子沙盘、灾情实时上报的辅助决策系统。通过该系统,... 详细信息

以现有的各类地震应急指挥技术系统为基础,充分利用实时融合技术、三维地理信息技术、Web GIS技术等先进的计算机技术,并将这些系统优化整合到一起,建立起一个融合了灾情评估、三维电子沙盘、灾情实时上报的辅助决策系统。通过该系统,在地震应急时前方救援人员可以实时查询各类情报资料并实时上报灾情,后方指挥部决策人员可以了解灾情预测结果,查询震区三维地形地貌并分析移动端上报的灾情信息拟定救灾方案,完成指挥决策,部署救援力量。保证了整个地震应急工作的联动性、协同性和透明性。

关键词：地震应急移动终端三维电子沙盘辅助决策

孕产期母亲用药、环境接触及分娩方式与婴幼儿过敏性疾病的关联性研究

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中华流行病学杂志 2017年第7期38卷 893-896页

作者：王硕王惠珊蒋竞雄王燕徐韬中国疾病预防控制中心妇幼保健中心北京100081

目的探讨孕产期母亲用药、环境接触及分娩方式对婴幼儿过敏性疾病的影响。方法基于横断面调查的病例对照研究。按我国的地理和人口分布，在全国范围内选择33个城市，采用整群抽样方法在各城市的城区随机选择一个社区作为样本区，调查对... 详细信息

目的探讨孕产期母亲用药、环境接触及分娩方式对婴幼儿过敏性疾病的影响。方法基于横断面调查的病例对照研究。按我国的地理和人口分布，在全国范围内选择33个城市，采用整群抽样方法在各城市的城区随机选择一个社区作为样本区，调查对象为0～24月龄婴幼儿母亲，进行面对面问卷调查。调查对象分为两组，曾出现过敏性疾病症状且被诊断为过敏性疾病的婴幼儿为过敏组（2113例）和从未发生过敏性疾病症状的婴幼儿为对照组（6303例）。结果父母双方有过敏史和父母单方有过敏史均为婴幼儿发生过敏的危险因素，父母双方均有过敏史（OR=3．950）的危险关联强度高于父母单方有过敏史者（OR=2．277）；孕期使用抗生素（DR=1．396）、孕期接触消毒剂及清洁剂（OR=1．386）、孕期吸烟或接触吸烟环境（OR=1．301）、剖宫产（OR=1．255）是婴幼儿发生过敏性疾病的危险因素，各因素组间差异均有统计学意义（P〈0．05）。结论婴幼儿过敏预防重点在孕产期的一级预防，应避免无临床指征情况下剖宫产、孕期滥用抗生素和消毒剂以及接触烟草。

关键词：过敏性疾病婴幼儿危险因素孕期

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海南潭门港“两院禁示”碑辨证及其意义

南海学刊 2017年第1期3卷 90-95页

作者：王辉山海南省博物馆征集部海南海口570203

2016年5月,琼海市潭门镇发现一块"两院禁示"碑,记载的是明代晚期各地商船到海南岛进行海上贸易的有关规定。根据"两院禁示"碑碑文内容推断,"两院"是指明代广东行省的承宣布政使司和提刑按察使司,刻碑时间为明代"隆庆开海"至明末之际。... 详细信息

2016年5月,琼海市潭门镇发现一块"两院禁示"碑,记载的是明代晚期各地商船到海南岛进行海上贸易的有关规定。根据"两院禁示"碑碑文内容推断,"两院"是指明代广东行省的承宣布政使司和提刑按察使司,刻碑时间为明代"隆庆开海"至明末之际。该碑还反映出明朝不准自海南贩卖粮食到外地的严格规定。"两院禁示"碑见证了潭门港至迟在明代就是海上丝绸之路的重要港口之一,佐证了海南岛自古以来就是南海贸易往来的交通要冲,是海上丝绸之路无法替代的重要组成部分。

关键词： “两院禁示”碑两院机构刻碑时间贩卖粮食潭门港

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功能性三尖瓣关闭不全的治疗策略

中华胸心血管外科杂志 2015年第10期31卷 585-589页

作者：祝岩王辉山金岩中国人民解放军沈阳军区总医院心脏血管外科 110016

目的探讨和比较三尖瓣Kay成形术与MC3三尖瓣成形环治疗功能性三尖瓣反流（FTR）的方法和疗效。方法2010年1月至2014年5月，于我院因合并FTR行左心系统手术同期接受三尖瓣成形手术共759例，男355例，女404例，平均年龄（54．1±8．3）岁... 详细信息

目的探讨和比较三尖瓣Kay成形术与MC3三尖瓣成形环治疗功能性三尖瓣反流（FTR）的方法和疗效。方法2010年1月至2014年5月，于我院因合并FTR行左心系统手术同期接受三尖瓣成形手术共759例，男355例，女404例，平均年龄（54．1±8．3）岁。术前NYHA心功能分级：I级13例，Ⅱ级177例，Ⅲ级400例，Ⅳ级169例。平均左心室射血分数（LVEF）0．53±0．04，平均肺动脉压（62．5±17．6）mmHg（1mmHg=0．133kPa）。病因包括风心病517例，退行性变209例，心内膜炎33例。行二尖瓣成形术132例，二尖瓣置换术295例，二尖瓣成形与主动脉瓣置换术20例，二尖瓣与主动脉瓣置换术388例。行冠状动脉旁路移植术86例，MazeII型手术23例。术前三尖瓣反流程度I级88例，Ⅱ级189例，Ⅲ级352例，Ⅳ级130例。全部患者中2010年1月至2012年5月连续行Kay成形术447例（Kay组），2012年5月至2014年5月连续行EdwardsMC3人工瓣环置人312例（MC3组）。术前经超声心动图明确三尖瓣反流（TR）程度，测量三尖瓣瓣环直径，肺动脉压力及心功能等指标。两种三尖瓣成形术均在心脏复跳后进行。MC3组根据瓣环大小置入成形环28mm79例、30mm155例、32mm66例、34mm12例。结果两组患者均无死亡、不良事件及针对三尖瓣再次手术发生。两组主动脉阻断时间、体外循环时间、术后机械通气辅助时间、ICU滞留时间、平均住院日以及术后并发症发生率差别均无统计学意义（P〉0．05）。随访率90．4％（686／759），平均随访时间（39．9±7．7）个月。两组术后随访期间右心室EF值均有不同程度增加，右心室内径逐渐减小。术后3个月两组均无中度以上的TR，1年内Kay组有1例中-重度TR，MC3组为2例（P〉0．05）；2年内Kay组出现5例中一重度及以上程度的TR，而MC3组为3例中度TR且无更严重的TR发生（P〈0．05）。术后2年以上Kay组出现中一重度及以上程度的TR为12例，MC3组仍为3例。超声心动图测量患者术后3个月、1年、2年的三尖瓣反流量，Kay组与MC3组分别为（3．4±1．4）ml与（6．5±2．1）ml、（7．9±2．5）ml与（2．9±0．9）ml、（3．5±1．3）ml与（3．4±2．1）ml。Kay组术后2年以后为（12．4±4．7）m1，提示二者近期术后效果相似（P〉0．05），远期效果MC3组明显好于Kay组（P〈0．05）。结论Kay成形术近期效果较好，但术后长期反流率偏高，可应用于高龄或预期寿命较短的患者；MC3瓣环可以持久、有效地纠正FTR，特别是小型号的MC3成形环，可以在最大程度上防止术后残余或再次出现TR，适用于年轻患者或对术后预期较高的患者。

关键词：三尖瓣闭锁不全三尖瓣成形术 Kay三尖瓣成形术 MC3三尖瓣成形环