CXCL5/CXCR2 axis in tumor microenvironment as potential diagnostic biomarker and therapeutic target
作者机构：Medical Center for Digestive DiseasesThe Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Department of SurgeryThe Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Department of BiotherapyThe Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011JiangsuP.R.China Key Laboratory for Aging and DiseaseNanjing Medical UniversityNanjing 210011JiangsuP.R.China
出 版 物：《Cancer Communications》 (癌症通讯（英文）)
年 卷 期：2020年第40卷第2期
页 面：69-80页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：the Project of Jiangsu Provincial Key medical talents in Jiangsu Province Grant/Award Number:ZDRCA2016034
主 题：biomarker CXCL5 CXCR2 molecular targeted therapy tumor microenvironment
摘 要：The components of the tumor microenvironment(TME)in solid tumors,especially chemokines,are currently attracting much attention from scientists.C-X-C motif chemokine ligand 5(CXCL5)is one of the important chemokines in ***-expression of CXCL5 is closely related to the survival time,recurrence and metasta-sis of cancer *** TME,CXCL5 binds to its receptors,such as C-X-C motif chemokine receptor 2(CXCR2),to participate in the recruitment of immune cells and promote angiogenesis,tumor growth,and *** CXCL5/CXCR2 axis can act as a bridge between tumor cells and host cells in *** the trans-mission of CXCL5/CXCR2 signals can increase the sensitivity and effectiveness of immunotherapy and slow down tumor ***5 and CXCR2 are also regarded as biomarkers for predicting prognosis and molecular targets for customiz-ing the *** this review,we summarized the current literature regarding the biological functions and clinical significance of CXCL5/CXCR2 axis in *** possibility to use CXCL5 and CXCR2 as potential prognostic biomarkers and thera-peutic targets in cancer is also discussed.
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