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International Journal of Coal Science & Technology 2018年第2期5卷 167-178页

作者： Bo Zhao Guangcai Wen Haitao Sun Dongling Sun huiming yang Jie Cao Linchao Dai Bo Wang College of Resources and Environment Science Chongqing University Shazheng Street Chongqing 400030 China Coal Science and Industry Group Chongqing Research Institute Chongqing 40037 China State Key Laboratory of Gas Disaster Monitoring and Emergency Technology Chongqing 40039 China

Coal and gas outburst is one of the main gas hazards in coal mines. However, due to the risks of the coal and gas outburst, the field test is difficult to complete. Therefore, an effective approach to studying the mechanism and development of outburst is to conduct the similar physical simulation. However, the similarity criteria and similar materials in outburst are the key factors which restrict the development of physical simulation. To solve those problems, this paper has established similarity criteria base on mechanics model, solid-fluid coupling model and energy model, and presented high similar materials. Combining with three groups of similar number, and considering similar mechanical parameters and deformation and failure regularity, the similarity criteria of outburst is determined on the basis of the energy model. According to those criteria, we put forward a similar material consists of pulverized coal, cement, sand, activated carbon, and water. The similar material has high compressive strength and the accordant characteristics with the raw coal, include density, porosity, adsorption, desorption. The new research is promising for preventing and controlling gas hazards in the future.

关键词： Coal and gas outburst Physical simulation Similarity criteria Similar material

Molecular Analysis of Pathogenicity Differences of Avian Paramyxovirus 1 Genotypes VI and VII in Chickens

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Veterinary Science Research 2019年第1期1卷 1-7页

作者： yang Song Jing Zhao huiming yang Yawen Bu Guozhong Zhang Key Laboratory of Animal Epidemiology of the Ministry of Agriculture College of Veterinary MedicineChina Agricultural UniversityBeijing100193China

Background:Genotypes VI and VII of(APMV-1)have different host range and pathogenicity in pigeons and ***,the molecular determinants of these differences are still ***:Here,we aligned the DNA sequences of 56 genotype VI and 33 genotype VII APMV-1 *** alignment results revealed that there are 17 amino acids sites differed between APMV-1 strains of these two *** then constructed a plasmid based on the full-length genome of rSG10 APMV-1 strain,which belongs to genotype VII but was mutated with these 17 VI-genotype-specific amino acids,and rescued as rSG10-17 *** restriction digestion and ligation and overlapping PCR methods were used in the construction of plasmids with amino acids *** virus was evaluated for its virulence and growth *** and conclusion:The results indicated that the virulence and the growth characteristics have no obvious difference between the rSG10-17 virus and its parental strain *** simultaneous mutation of 17 genotype-specific amino acids did not affect the virulence of APMV-1 in *** analysis of these amino acids is required by taking into consideration of the functions of encoded proteins.

关键词： Avian avulavirus-1 Genotype Pathogenicity Chicken Molecular determinant

氮化锗多形体的四方、单斜和正交畸变的理论研究

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高等学校化学学报 2016年第4期37卷 674-681页

作者：仓玉萍陈东杨帆杨慧明信阳师范学院物理电子工程学院信阳464000

采用量子化学从头算方法,对Ge3N4的四方、单斜和正交结构同质异相体的微结构、态密度和声子谱进行了研究.形成焓为负值、弹性常数满足Born稳定性准则和声子谱无虚频等结果证实在0～20 GPa范围内3种相都能保持结构稳定.温度变化影响到晶... 详细信息

采用量子化学从头算方法,对Ge3N4的四方、单斜和正交结构同质异相体的微结构、态密度和声子谱进行了研究.形成焓为负值、弹性常数满足Born稳定性准则和声子谱无虚频等结果证实在0～20 GPa范围内3种相都能保持结构稳定.温度变化影响到晶胞体积,从而使体模量发生改变.3种Ge3N4都属于半导体,Ge原子和N原子之间存在明显的s-p杂化现象.当压强增大时诱发了离域电子,从而使体系的带隙减小.本文还采用准谐近似对Ge3N4的热力学性质进行了研究,结果表明,温度和压强对热膨胀系数、熵、热容、德拜温度和格林爱森参数产生了明显影响.m-Ge3N4和t-Ge3N4的热膨胀系数分别为o-Ge3N4的3倍和2倍.t-Ge3N4和o-Ge3N4的晶格谐振频率基本不受温度的影响.

关键词：从头算氮化锗电子结构稳定性

Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li Xu huiming Xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

应力条件对受载煤体声发射活动特征的影响研究

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煤炭科学技术 2019年第2期47卷 7-13页

作者：杨慧明瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

为研究外部应力条件对受载煤体的声发射活动特征的影响作用,采用岩石力学试验系统和声发射仪,开展了单轴、不同围压三轴、卸围压三类应力条件下的煤样破坏试验,对比分析了煤体在不同应力条件下的破坏特征及声发射活动特征。试验结果表明... 详细信息

为研究外部应力条件对受载煤体的声发射活动特征的影响作用,采用岩石力学试验系统和声发射仪,开展了单轴、不同围压三轴、卸围压三类应力条件下的煤样破坏试验,对比分析了煤体在不同应力条件下的破坏特征及声发射活动特征。试验结果表明:煤体的声发射活动宏观上与煤体的破坏阶段相对应,应力条件对煤的破坏特征及声发射活动特征具有重要影响作用。在增围压作用下,煤体的弹性模量、强度增加,主破裂面与轴向加载方向的角度逐渐增大,主破裂机制由张拉破坏向剪切破坏转变;在卸围压作用下,煤的主破裂机制由剪切破坏向张拉破坏转变。在围压应力增加条件下,在弹性变形阶段,煤体的声发射事件显著减少;在屈服变形阶段,声发射事件的能量逐步降低,并且能量的分布形态从相对"聚集"向相对"分散"的转变;在峰后变形阶段,煤体呈现渐进损伤的延性破坏特征,声发射活动持续逐步降低。在三轴卸载围压应力条件下,在煤体屈服阶段,声发射事件率与能量都随着应力的快速跌落而迅速增加,声发射活动趋于活跃,煤体的破坏方式最为剧烈。

关键词：深部矿井应力条件声发射煤体破坏

PINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis

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Protein & Cell 2022年第1期13卷 26-46页

作者： Weili yang Xiangyu Guo Zhuchi Tu Xiusheng Chen Rui Han Yanting Liu Sen Yan Qi Wang Zhifu Wang Xianxian Zhao Yunpeng Zhang Xin Xiong huiming yang Peng Yin Huida Wan Xingxing Chen Jifeng Guo Xiao-Xin Yan Lujian Liao Shihua Li Xiao-Jiang Li Guangdong Key Laboratory of Non-human Primate Research Guangdong-Hongkong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510632China Key Laboratory of Brain Functional Genomics of Ministry of Education Shanghai Key Laboratory of Brain Functional Genomicsand Shanghai Key Laboratory of Regulatory BiologySchool of Life SciencesEast China Normal UniversityShanghai 100021China Department of Neurology Xiangya HospitalCentral South UniversityChangsha 410008China Department of Anatomy and Neurobiology Xiangya School of MedicineCentral South UniversityChangsha 410008China

In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson's disease(PD).However,difficulty in detecting endogenous PINK1 protein in rodent brains and cell lines has prevented the rigorous investigation of the in vivo role of *** we report that PINK1 kinase form is selectively expressed in the human and monkey ***/Cas9-mediated deficiency of PINK1 causes similar neurodegeneration in the brains of fetal and adult monkeys as well as cultured monkey neurons without affecting mitochondrial protein expression and ***,PINK1 mutations in the primate brain and human cells reduce protein phosphorylation that is important for neuronal function and *** findings suggest that PINK1 kinase activity rather than its mitochondrial function is essential for the neuronal survival in the primate brains and that its kinase dysfunction could be involved in the pathogenesis of PD.

关键词： Parkinson's disease neurogenesis neurodegeneration mitochondria non-human primates

深部低透煤层水力割缝卸压增透技术研究现状及发展趋势

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煤矿安全 2018年第6期49卷 147-151页

作者：杨慧明瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

中国煤矿煤层的渗透率普遍较低,瓦斯抽采难度高、抽采率低、抽采达标工程量大,深部高应力条件下瓦斯抽采难度更大。煤层卸压增透是深部低透气性煤层瓦斯灾害防治与煤层气高效开发的关键,而水射流割缝技术是煤层卸压增透的重要技术之一... 详细信息

中国煤矿煤层的渗透率普遍较低,瓦斯抽采难度高、抽采率低、抽采达标工程量大,深部高应力条件下瓦斯抽采难度更大。煤层卸压增透是深部低透气性煤层瓦斯灾害防治与煤层气高效开发的关键,而水射流割缝技术是煤层卸压增透的重要技术之一。围绕水射流割缝技术研究发展,系统总结了水力割缝的卸压增透机理、强化射流方法、割缝工艺、射流割缝装备等4个方面的研究现状,分析了当前水力割缝技术在卸压增透量化机理、割缝工艺方法、增透效果评价、装备性能等方面存在的问题,并对水力割缝技术的切割增透能力、装备研发方向、推广应用前景等发展趋势进行了展望。

关键词：深部煤层透气性水力割缝瓦斯抽采卸压增透研究现状发展趋势

煤岩动力灾害声发射预警判识方法的研究现状及趋势

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矿业安全与环保 2015年第4期42卷 91-95页

作者：杨慧明瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037 贵州安和矿业科技工程股份有限公司贵州贵阳550023

煤岩动力灾害是矿山煤岩体在地应力和瓦斯作用下发生的一种具有动力效应和灾害后果的快速失稳现象,在灾害演化过程的孕育、激发、发展等阶段煤岩体产生破裂,会释放出声发射。通过对煤岩体破坏过程释放出的声发射信息进行监测分析,可以... 详细信息

煤岩动力灾害是矿山煤岩体在地应力和瓦斯作用下发生的一种具有动力效应和灾害后果的快速失稳现象,在灾害演化过程的孕育、激发、发展等阶段煤岩体产生破裂,会释放出声发射。通过对煤岩体破坏过程释放出的声发射信息进行监测分析,可以实现煤岩动力灾害的提前预警。基于岩石声发射技术在矿山工程应用的研究成果,系统总结了煤岩动力灾害预警的声发射判识方法的研究现状,指出了当前声发射技术在矿山应用中存在的主要问题,并对该技术的发展趋势进行了展望。

关键词：煤岩动力灾害声发射预警现状趋势

塑性煤与脆性煤破坏过程的声发射演化特征试验研究

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矿业安全与环保 2015年第1期42卷 9-12页

作者：杨慧明瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

在单轴压缩条件下,进行了塑性煤与脆性煤试件破坏过程声发射监测试验,研究两类煤破坏过程的声发射演化特征。试验结果表明:煤体破坏失稳过程中的声发射与煤体中的裂纹萌生、扩展、贯通等活动相对应,煤体的声发射演化特征与其破坏特征密... 详细信息

在单轴压缩条件下,进行了塑性煤与脆性煤试件破坏过程声发射监测试验,研究两类煤破坏过程的声发射演化特征。试验结果表明:煤体破坏失稳过程中的声发射与煤体中的裂纹萌生、扩展、贯通等活动相对应,煤体的声发射演化特征与其破坏特征密切相关。塑性煤破坏过程的声发射事件率呈现"上升—峰值—下降"的演化规律;声发射事件率出现急速增大之后的稳步下降是煤体主破裂面即将贯通、煤体破坏失稳的前兆。脆性煤破坏过程的声发射事件率呈现"上升—峰值"的演化规律,声发射"下降"段不明显。研究结果可为煤体稳定性监测的声发射参数演化的解译、灾变判识准则的建立提供理论基础。

关键词：塑性煤脆性煤破坏声发射演化特征