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Clinical observation on 90 cases of primary dysmenorrhea treated by buccal acupuncture therapy:a randomized controlled study

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Journal of Traditional Chinese Medicine 2024年第1期44卷 172-181页

作者： YANG Yi YE Huijun zheng huiling JIN Lihua Department of Obstetrics and Gynecology the Second Affiliated Hospital of Zhejiang Chinese Medical UniversityXinhua Hospital of Zhejiang ProvinceHangzhou 310005China

OBJECTIVE:To explore the short-term and long-term efficacy of buccal acupuncture therapy in the treatment of patients with primary dysmenorrhea(PD).METHODS:A total of 90 patients with PD who were admitted to the Second Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from January 2020 to December 2021 were included in this study and randomly divided into three groups,including the observation group,the control group,and the placebo group,with 30 patients in each *** in the observation group were treated according to the syndrome types of Traditional Chinese Medicine,those in the control group were treated with Saridon,and those in the placebo group received a *** visual analog scale(VAS)scores of these patients were evaluated at different time points(before treatment,5 min after needle retention,30 min after needle retention,1 h after treatment,2 h after treatment,1 d after treatment,and 2 d after treatment).The Cox Menstrual Symptom Scale(CMSS)scores were assessed before the treatment and after three courses of ***,these two scales were also evaluated during ***,the pain score and adverse reactions of these patients were assessed during ***:After treatment,the VAS and CMSS scores in the observation group decreased significantly(P<0.05)5 and 30 min after needle retention and after ***:Buccal acupuncture therapy is verified to have short-term efficacy in the treatment of *** addition,this therapy has an immediate analgesic effect and long-term efficacy in reducing the severity and frequency of PD.

关键词： buccal acupuncture therapy primary dysmenorrhea pain score randomized controlled trial

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Constructing hierarchical ZSM-5 coated with small ZSM-5 crystals via oriented-attachment and in situ assembly for methanol-to-aromatics reaction

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Frontiers of Chemical Science and Engineering 2024年第7期18卷 41-53页

作者： Ning Yang Tingjun Fu Chuntao Cao Xueqing Wu huiling zheng Zhong Li State Key Laboratory of Clean and Efficient Coal Utilization College of Chemical Engineering and TechnologyTaiyuan University of TechnologyTaiyuan 030024China

Developing hierarchical and nanoscale ZSM-5 catalysts for diffusion-limited reactions has received ever-increasing attention. Here, ZSM-5 architecture integrated with hierarchical pores and nanoscale crystals was successfully prepared via in situ self-assembly of nanoparticles-coated silicalite-1. First, the oriented attachment of amorphous nanoparticles on external surface of silicalite-1 was achieved by controlling the alkalinity of Si-Al coating solution. The partial exposure of the external surface of silicalite-1 ensured the uniform removal of silicon in the bulk phase for the creation of hierarchical pores during the subsequent desilication-recrystallization. The uniform removal of silicon species in the bulk phase was mainly due to the synergistic effect of surface protection and alkaline etching, which could be balanced by regulating the relative amount of tetrapropylammonium cation and OH– in desilication-recrystallization solution. Importantly, the removed silicon from silicalite-1 recrystallized and in situ assembled into final ZSM-5 nanocrystals induced by surface Si-Al nanoparticles. The hierarchical pores and nanoscale crystals on this integrated architecture not only promoted the removal of coke precursors from micropores but also provided large external specific surface (91 m2·g^(-1)) for coke deposition. Consequently, a much longer catalytic lifetime was achieved for methanol-to-aromatics reaction compared to conventional hollow structure ZSM-5 (84 h vs 46 h), with relatively high stability.

关键词： hierarchical ZSM-5 nanocrystal integrated architecture diffusion coke

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Cmtm4 deficiency exacerbates colitis by inducing gut dysbiosis and S100a8/9 expression

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Journal of Genetics and Genomics 2024年第8期51卷 811-823页

作者： Qiao Meng Jing Ning Jingjing Lu Jing Zhang Ming Zu Jing Zhang Xiurui Han huiling zheng Yueqing Gong Xinyu Hao Ying Xiong Fang Gu Wenling Han Weiwei Fu Jun Wang Shigang Ding Department of Gastroenterology Peking University Third HospitalBeijing 100191China Beijing Key Laboratory for Helicobacter Pylori Infection and Upper Gastrointestinal Diseases(BZ0371) Beijing 100191China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Immunology School of Basic Medical SciencesPeking University Health Science CenterNHC Key Laboratory of Medical Immunology(Peking University)Beijing 100191China Peking University Center for Human Disease Genomics Beijing 100191China

The dysfunction of innate immunity components is one of the major drivers for ulcerative colitis(UC),and increasing reports indicate that the gut microbiome serves as an intermediate between genetic mutations and UC ***,we find that the IL-17 receptor subunit,CMTM4,is reduced in UC patients and dextran sulfate sodium(DSS)-induced *** deletion of CMTM4(Cmtm4^(-/-))in mice leads to a higher susceptibility to DSS-induced colitis than in wild-type,and the gut microbiome significantly changes in *** causal role of the gut microbiome is confirmed with a cohousing *** further identify that S100a8/9 is significantly up-regulated in Cmtm4^(-/-)colitis,with the block of its receptor RAGE that reverses the phenotype associated with the CMTM4 ***4 deficiency rather suppresses S100a8/9 expression in vitro via the IL17 pathway,further supporting that the elevation of S100a8/9 in vivo is most likely a result of microbial *** together,the results suggest that CMTM4 is involved in the maintenance of intestinal homeostasis,suppression of S100a8/9,and prevention of colitis *** study further shows CMTM4 as a crucial innate immunity component,confirming its important role in UC development and providing insights into potential targets for the development of future therapies.

关键词： Ulcerative colitis CMTM4 Gut microbiota IL-17 receptor C(IL-17RC) S100a8/9

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基于企业级地理信息的产业辐射带动效应研究——以京津冀地区为例

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城市发展研究 2024年第6期031卷 22-30页

作者：时英龙高湘昀李煜赵怡然郑慧玲中国地质大学(北京)经济管理学院

以企业级地理信息为基础，从企业—行业—区域三个维度构建了辐射带动效应模型，研究了产业辐射带动效应网络的结构特征，测度了京津冀核心产业集群的辐射带动范围。并通过构建产业转移适应性模型对北京市新增产业的禁止限制类行业进行... 详细信息

以企业级地理信息为基础，从企业—行业—区域三个维度构建了辐射带动效应模型，研究了产业辐射带动效应网络的结构特征，测度了京津冀核心产业集群的辐射带动范围。并通过构建产业转移适应性模型对北京市新增产业的禁止限制类行业进行产业环境适应性测度。研究发现，京津冀地区形成了六个产业集群，其中两个为跨地区产业集群；北京与河北间辐射带动效应较强，天津与北京、河北间辐射带动效应较弱；辐射带动效应集中于北京金融业与商务服务业，天津金融业与交通运输业，以及河北能源供应行业和制造业；北京产业集群辐射范围最大，覆盖了京津冀中北部。廊坊市是北京新增产业的限制禁止类行业产业环境适应性较高的地区。

关键词：企业级地理信息引力模型复杂网络京津冀辐射范围

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1960—2020年黄河、长江、珠江入海水沙通量演变特征

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水土保持通报 2024年第1期44卷 147-157页

作者：郑慧玲王永红中国海洋大学海洋地球科学学院山东青岛266100 中国海洋大学海洋地球科学学院海底科学与探测技术教育部重点实验室山东青岛266100 青岛海洋科学与技术试点国家实验室山东青岛266237

[目的]基于动态更新数据综合对比中国三大河流入海水沙通量的特征,为流域开发和管理提供依据。[方法]收集黄河(利津站)、长江(大通站)、珠江(高要站、石角站、博罗站)5个水文控制站1960—2020年实测数据,采用滑动平均法、Pettitt检验法... 详细信息

[目的]基于动态更新数据综合对比中国三大河流入海水沙通量的特征,为流域开发和管理提供依据。[方法]收集黄河(利津站)、长江(大通站)、珠江(高要站、石角站、博罗站)5个水文控制站1960—2020年实测数据,采用滑动平均法、Pettitt检验法、双累积曲线法以及小波变换分别对水沙通量的趋势性、变异性、周期性特征进行分析,采用交叉小波变换和小波相干谱探究径流量和泥沙量的共振周期与相干性。[结果]近60a黄河、长江、珠江入海水沙通量均发生了明显变化,黄河径流量和泥沙量在1986年突变减少,泥沙量在1997年二次突变减少;长江和珠江入海径流量未发生变异,泥沙量分别于1992,1999年突变减少。这三大河流入海水沙具有显著的年际和年代际周期特征,年代际共同演化周期分别集中于1980年以前、1990年以前和2000年以前。年际共同演化周期为5a,“丰—枯”转换频繁。交叉小波分析结果显示,黄河、长江和珠江的入海径流量和泥沙量在1965—1975年具有显著的1~3a的共振周期,以正相位演变为主。[结论]中国三大河流入海水沙具有显著的趋势性、变异性和周期性特征,可以据此进行的流域开发和管理更有效。

关键词：水沙通量趋势性突变性周期性交叉小波变换

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山羊P2RY12-P2RY13单倍型渗入鉴定及其功能分析

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家畜生态学报 2024年第1期45卷 9-15页

作者：刘晓懿蔡钰东郑惠玲姜雨西北农林科技大学动物科技学院陕西杨凌712100

基因渗入对动物的驯化以及适应性的提高起到了至关重要的作用。该研究收集了世界范围内共163只现代家山羊、81只古代家山羊以及69只山羊野生近缘种的基因组数据,进行全基因组遗传变异检测、构建Neighbor-joining树、单倍型网络图以及蛋... 详细信息

基因渗入对动物的驯化以及适应性的提高起到了至关重要的作用。该研究收集了世界范围内共163只现代家山羊、81只古代家山羊以及69只山羊野生近缘种的基因组数据,进行全基因组遗传变异检测、构建Neighbor-joining树、单倍型网络图以及蛋白质结构预测。我们发现家山羊基因组chr1:116312 kb~116397 kb区域内存在来自阿尔卑斯北山羊或伊比利亚北山羊的渗入。这段长达85 kb的渗入单倍型包含2个与乳腺炎相关的蛋白编码基因P2RY12和P2RY13,其中P2RY12基因上来自渗入单倍型的变异Pro317Ser导致了蛋白质末端α-螺旋的增长,该渗入单倍型主要存在于欧洲和非洲的现代家山羊群体中,频率分别为52.1%和32.1%。通过对古代样本进行分析,推测该单倍型的渗入最早发生于3000 a前的欧洲地区,可能由于对泌乳性状的选择而导致其频率升高并扩散至非洲地区。该研究为家山羊基因组中P2RY12-P2RY13单倍型的来源与功能提供了新的见解。

关键词：山羊渗入基因组古代DNA

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COVID-19 pharmacological research trends:a bibliometric analysis

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Intelligent Medicine 2023年第1期3卷 1-9页

作者： Yanyan Shi Yahan Song Zhijun Guo Wei Yu huiling zheng Shigang Ding Siyan Zhan Research Center of Clinical Epidemiology Peking University Third HospitalBeijing 100191China Library of Peking University Third Hospital Beijing 100191China Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Gastroenterology Affiliated Hospital of Jining Medical UniversityJiningShandong 272007China

Background:The coronavirus disease 2019(COVID-19)pandemic is ravaging the *** therapies have been explored to treat *** report aimed to assess the global research trends for the development of COVID-19 ***:We searched the relevant articles on COVID-19 therapies published from January 1,2020,to May 25,2022,in the Web of Science Core Collection Database(WOSCC).VOSviewer 1.6.18 software was used to assess data on the countries,institutions,authors,collaborations,keywords,and journals that were most implicated in COVID-19 pharmacological *** latest research and changing trends in COVID-19-relevant pharmacological research were ***:After manually eliminating articles that do not meet the requirements,a total of 5,289 studies authored by 32,932 researchers were eventually included in the analyses,which comprised 95 randomized controlled trials.3,044(57.6%)studies were published in *** USA conducted the greatest number of studies,followed by China and *** primary USA collaborators were China and *** topics covered in the publications included:the general characteristics,the impact on pharmacists’work,the pharmacological research,broad-spectrum antiviral drug therapy and research,and promising targets or preventive measures,such as *** temporal diagram revealed that the current research hotspots focused on the vaccine,molecular docking,Mpro,and drug delivery ***:Comprehensive bibliometric analysis could aid the rapid identification of the principal research topics,potential collaborators,and the direction of future *** research is critical for the development of therapeutic and preventive COVID-19-associated *** study may therefore provide valuable information for eradicating COVID-19.

关键词： Bibliometric analysis COVID-19 Pharmacological interventions Vaccine SARS-CoV-2

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养老机构老年痴呆照顾者虐待倾向与护理能力和社会支持的相关性

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中华老年病研究电子杂志 2024年第1期11卷 45-50页

作者：郑瑶仲祎璐刘彩霞郑慧玲李斐斐胡镕镕浙江医院干部保健科杭州310013 浙江医院护理部杭州310013 浙江中医药大学研究生院杭州310053

目的调查养老机构老年痴呆照顾者虐待倾向现状,分析其与照顾者护理能力、社会支持的相关性。方法采用便利抽样法,选取浙江省11家养老机构中的316名老年痴呆照顾者进行调查,包括一般资料调查表、照顾者虐待倾向评估量表、痴呆患者照顾者... 详细信息

目的调查养老机构老年痴呆照顾者虐待倾向现状,分析其与照顾者护理能力、社会支持的相关性。方法采用便利抽样法,选取浙江省11家养老机构中的316名老年痴呆照顾者进行调查,包括一般资料调查表、照顾者虐待倾向评估量表、痴呆患者照顾者护理能力问卷及社会支持评定量表等。采用Spearman秩相关分析照顾者的虐待倾向评分与其护理能力、社会支持的相关性;采用二元logistic回归分析照顾者虐待倾向的影响因素。结果发放问卷316份,回收有效问卷298份,有效回收率为94.3%。298名照顾者中,有虐待倾向者125名,占比为41.9%。相关分析显示,养老机构失智症照顾者虐待倾向得分与护理能力总分、技能维度、人际关系维度、社会支持总分、客观支持维度呈负相关(r=-0.159、-0.135、-0.155、-0.115、-0.127,P<0.05)。二元logistic回归分析结果显示,同时照顾2位老人,老人生活部分自理、完全不能自理,老人有精神行为症状、照顾者感到重度痛苦是虐待倾向的危险因素(OR=3.213、10.621、15.221、4.523、7.002,P<0.05或0.01),人际关系是虐待倾向的保护因素(OR=0.643,P<0.01)。结论养老机构老年痴呆照顾者虐待倾向发生率仍较高,与照顾者护理能力、社会支持具有相关性,可通过提升老年痴呆照顾者专业护理能力,增强照顾者人际关系、改善社会支持,来降低老年痴呆照顾者虐待倾向的发生风险。

关键词：虐待倾向老年痴呆照顾者护理能力人际关系社会支持

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Food nutrition and toxicology targeting on specific organs in the era of single-cell sequencing

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Food Science and Human Wellness 2024年第1期13卷 75-89页

作者： Xiaofei Wang Xiaowen Cheng huiling Liu Xiaohuan Mu Hao zheng National Engineering Technology Research Center for Fruit and Vegetable Processing Key Open Laboratory of Fruit and Vegetable ProcessingMinistry of Agriculture and Rural AffairsBeijing Key Laboratory of Food Non-Thermal ProcessingCollege of Food Science and Nutritional EngineeringChina Agricultural UniversityBeijing 100083China

Due to the complex natures of dietary food components,it is difficult to elucidate how the compounds affect host *** food often selectively presents its mechanism of action on different cell types,and participates in the modulation of targeted cells and their microenvironments within ***,the limitations of traditional in vitro assays or in vivo animal experiments cannot comprehensively examine cellular heterogeneity and the tissue-biased ***-cell RNA sequencing(sc RNA-seq)has emerged as an indispensable methodology to decompose tissues into different cell types for the demonstration of transcriptional profiles of individual *** RNA-seq applications has been summarized on three typical organs(brain,liver,kidney),and two representative immune-and tumor related health *** everincreasing role of sc RNA-seq in dietary food research with further improvement can provide sub-cellular information and the coupling between other cellular *** this review,we propose utilizing sc RNAseq to more effectively capture the subtle and complex effects of food chemicals,and how they may lead to health problems at single-cell *** novel technique will be valuable to elucidate the underlying mechanism of both the health benefits of food nutrients and the detrimental consequences food toxicants at the cellular level.

关键词： Dietary food Cellular heterogeneity Single-cell RNA sequencing Food nutrients Food toxicants

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经鼻高流量氧疗在支气管哮喘急性发作伴1型呼吸衰竭患者中的临床获益分析

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首都食品与医药 2024年第6期31卷 39-42页

作者：李春燕马婷婷阚士慧郑慧玲山东省枣庄市薛城区人民医院山东枣庄277000

目的研究经鼻高流量氧疗(HFNC)在支气管哮喘(BA)急性发作伴1型呼吸衰竭患者中的临床获益.方法观察对象为2019年10月-2023年10月入院的80例BA急性发作伴1型呼吸衰竭患者,随机分为研究组、对照组,每组各40例,研究组行HFNC治疗,对照组行无... 详细信息

目的研究经鼻高流量氧疗(HFNC)在支气管哮喘(BA)急性发作伴1型呼吸衰竭患者中的临床获益.方法观察对象为2019年10月-2023年10月入院的80例BA急性发作伴1型呼吸衰竭患者,随机分为研究组、对照组,每组各40例,研究组行HFNC治疗,对照组行无创正压通气(NIPPV),比较两组治疗前与治疗1d后呼吸功能指标、氧合指数(OI)、血流动力学指标,及治疗后氧疗时间、住院时间、有创通气插管率.结果两组治疗前血流动力学指标、呼吸功能指标、OI无显著差异(P>0.05);两组治疗1d后动脉血氧分压(PaO2)、OI高于治疗前,平均动脉压(MAP)、呼吸频率(HR)、心率(RR)低于治疗前,差异显著(P<0.05);研究组治疗后PaO2、OI高于对照组,MAP、HR、RR与有创通气插管率低于对照组,氧疗及住院时间短于对照组,差异显著(P<0.05).结论BA急性发作伴1型呼吸衰竭患者治疗中HFNC应用效果显著,能够进一步改善患者血流动力学、呼吸功能及氧和指数,还可降低有创通气插管率,促使其快速康复.

关键词：经鼻高流量氧疗支气管哮喘急性发作无创正压通气 1型呼吸衰竭呼吸功能

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