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检索条件"作者=Huiling Cao"
356 条 记 录,以下是1-10 订阅
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Molecular mechanosensors in osteocytes
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Bone Research 2020年 第2期8卷 115-138页
作者: Lei Qin Wen Liu huiling cao Guozhi Xiao Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen Key Laboratory of Cell Microenvironmentand School of MedicineSouthern University of Science and TechnologyShenzhen 518055China
Osteocytes, the most abundant and long-lived cells in bone, are the master regulators of bone remodeling. In addition to their functions in endocrine regulation and calcium and phosphate metabolism, osteocytes are the... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
The role of E3 ubiquitin ligases in bone homeostasis and related diseases
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Acta Pharmaceutica Sinica B 2023年 第10期13卷 3963-3987页
作者: Yuechao Dong Yangshan Chen Guixing Ma huiling cao Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchKey University Laboratory of Metabolism and Health of GuangdongShenzhen 518055China
The ubiquitin-proteasome system(UPS)dedicates to degrade intracellular proteins to modulate demic homeostasis and functions of *** enzymatic cascades mark and modifies target proteins diversly through covalently bindi... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues
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Bone Research 2021年 第4期9卷 456-472页
作者: Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi huiling cao Guozhi Xiao Department of Orthopedics Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdongChina Department of Biochemistry School of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentSouthern University of Science and TechnologyShenzhenGuangdongChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina
Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal *** mechanotransduction process requires a range of special prot... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
A novel sprayable thermosensitive hydrogel coupled with zinc modified metformin promotes the healing of skin wound
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Bioactive Materials 2023年 第2期20卷 610-626页
作者: Zhengwei Liu Wanze Tang Jiayi Liu Yingying Han Qinnan Yan Yuechao Dong Xiaomei Liu Dazhi Yang Guixing Ma huiling cao Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen518055China Southern University of Science and Technology Shenzhen518055China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen518055China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen518055China
A novel sprayable adhesive is established(ZnMet-PF127)by the combination of a thermosensitive hydrogel(Pluronic F127,PF127)and a coordination complex of zinc and metformin(ZnMet).Here we demonstrate that ZnMet-PF127 p... 详细信息
来源: 维普期刊数据库 维普期刊数据库 评论
LIM domain proteins Pinch1/2 regulate chondrogenesis and bone mass in mice
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Bone Research 2020年 第4期8卷 416-428页
作者: Yiming Lei Xuekun Fu Pengyu Li Sixiong Lin Qinnan Yan Yumei Lai Xin Liu Yishu Wang Xiaochun Bai Chuanju Liu Di Chen Xuenong Zou Xu cao huiling cao Guozhi Xiao Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen Key Laboratory of Cell Microenvironmentand School of MedicineSouthern University of Science and TechnologyShenzhen 518055China Department of Spine Surgery Orthopedic Research InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Orthopedics and TraumatologyGuangzhou 510080China Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Orthopedic Surgery New York University School of MedicineNew YorkNY 10003USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Orthopedic Surgery The Johns Hopkins UniversityBaltimoreMD 21205USA
The LIM domain-containing proteins Pinch1/2 regulate integrin activation and cell–extracellular matrix interaction and ***,we report that deleting Pinch1 in limb mesenchymal stem cells(MSCs)and Pinch2 globally(double... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Kindlin-2 inhibits Nlrp3 inflammasome activation in nucleus pulposus to maintain homeostasis of the intervertebral disc
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Bone Research 2022年 第1期10卷 165-177页
作者: Sheng Chen Xiaohao Wu Yumei Lai Di Chen Xiaochun Bai Sheng Liu Yongchao Wu Mingjue Chen Yuxiao Lai huiling cao Zengwu Shao Guozhi Xiao Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Biochemistry School of MedicineSouthern University of Science and TechnologyGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentShenzhen 518055China Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Centre for Translational Medicine Research and Development Institute of Biomedical and Health EngineeringShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China
Intervertebral disc(IVD) degeneration(IVDD) is the main cause of low back pain with major social and economic burdens;however, its underlying molecular mechanisms remain poorly defined. Here we show that the focal adh... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Targeting Kindlin-2 in adipocytes increases bone mass through inhibiting FAS/PPARγ/FABP4 signaling in mice
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Acta Pharmaceutica Sinica B 2023年 第11期13卷 4535-4552页
作者: Wanze Tang Zhen Ding Huanqing Gao Qinnan Yan Jingping Liu Yingying Han Xiaoting Hou Zhengwei Liu Litong Chen Dazhi Yang Guixing Ma huiling cao Department of Biochemistry School of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchKey University Laboratory of Metabolism and Health of GuangdongSouthern University of Science and TechnologyShenzhen 518055China The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518055China Clinical Laboratory of the Third Affiliated Hospital of Southern Medical University Guangzhou 510630China
Osteoporosis(OP)is a systemic skeletal disease that primarily affects the elderly population,which greatly increases the risk of *** we report that Kindlin-2 expression in adipose tissue increases during aging and hig... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
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Bone Research 2020年 第1期8卷 26-38页
作者: huiling cao Qinnan Yan Dong Wang Yumei Lai Bo Zhou Qi Zhang Wenfei Jin Simin Lin Yiming Lei Liting Ma Yuxi Guo Yishu Wang Yilin Wang Xiaochun Bai Chuanju Liu Jian QFeng Chuanyue Wu Di Chen Xu cao Guozhi Xiao Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research Shenzhen Key Laboratory of Cell Microenvironmentand Department of BiologySouthern University of Science and TechnologyShenzhen 518055China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantong 226001China Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA Department of Cell Biology School of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510515China Department of Orthopedic Surgery New York University School of MedicineNew YorkNY 10003USA Department of Cell Biology New York University School of MedicineNew YorkNY 10016USA Department of Biomedical Sciences Texas A&M University College of DentistryDallasTX 75246USA Department of Orthopedic Surgery The Johns Hopkins UniversityBaltimoreMD 21205USA
Our recent studies demonstrate that the focal adhesion protein Kindlin-2 is critical for chondrogenesis and early skeletal development. Here, we show that deleting Kindlin-2 from osteoblasts using the 2.3-kb mouse Col... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
基于QAR数据的碳当量值适航符合性验证方法
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北京航空航天大学学报 2020年 第3期46卷 474-480页
作者: 曹惠玲 汤鑫豪 中国民航大学航空工程学院 天津300300
为评估飞机碳排放水平并验证适航性,对国际民用航空组织最新的碳排放认证程序进行了研究。以比航程(SAR)和基准几何因子(RGF)组成的综合指标碳当量值作为评估适航性的度量,根据飞机最大起飞重量(MTOM)值选取试飞测量点,并确定对应的飞... 详细信息
来源: 维普期刊数据库 维普期刊数据库 同方期刊数据库 同方期刊数据库 评论
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
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Signal Transduction and Targeted Therapy 2021年 第1期6卷 131-143页
作者: Xuekun Fu Bo Zhou Qinnan Yan Chu Tao Lei Qin Xiaohao Wu Sixiong Lin Sheng Chen Yumei Lai Xuenong Zou Zengwu Shao Meiqing Wang Di Chen Wenfei Jin Youqiang Song huiling cao Ge Zhang Guozhi Xiao School of Medicine Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Researchand Shenzhen Key Laboratory of Cell MicroenvironmentSouthern University of Science and Technology1088 Xue Yuan Road518055 ShenzhenGuangdongChina Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist University999077 Hong KongSARChina Department of Biology Southern University of Science and Technology518055 ShenzhenChina School of Biomedical Sciences University of Hong Kong21 Sassoon RoadHong KongChina Department of Spine Surgery Orthopedic Research InstituteThe First Affiliated Hospital of Sun Yat-sen UniversityGuangdong Provincial Key Laboratory of Orthopedics and Traumatology510080 GuangzhouChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and Technology430022 WuhanChina Department of Orthopedic Surgery Rush University Medical CenterChicagoIL 60612USA State Key Laboratory of Military Stomatology National Clinical Research Center for Oral DiseasesShanxi International Joint Research Center for Oral DiseasesDepartment of Oral Anatomy and Physiology and TMDSchool of Stomatologythe Fourth Military Medical University145 Changle West RoadXi’anChina Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced TechnologyChinese Academy of Sciences518055 ShenzhenChina
In vertebrates,the type 1 parathyroid hormone receptor(PTH1R)is a critical regulator of skeletal development and homeostasis;however,how it is modulated is incompletely *** we report that deleting Kindlin-2 in osteobl... 详细信息
来源: 维普期刊数据库 维普期刊数据库 维普期刊数据库 维普期刊数据库 评论