Roles of mechanosensitive channel Piezo 1/2 proteins in skeleton and other tissues

作     者：Lei Qin Tailin He Sheng Chen Dazhi Yang Weihong Yi Huiling Cao Guozhi Xiao Lei Qin;Tailin He;Sheng Chen;Dazhi Yang;Weihong Yi;Huiling Cao;Guozhi Xiao

作者机构：Department of OrthopedicsHuazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdongChina Department of BiochemistrySchool of MedicineGuangdong Provincial Key Laboratory of Cell Microenvironment and Disease ResearchShenzhen Key Laboratory of Cell MicroenvironmentSouthern University of Science and TechnologyShenzhenGuangdongChina Department of OrthopedicsUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiChina 

出 版 物：《Bone Research》 (骨研究（英文版）)

年 卷 期：2021年第9卷第4期

页      面：456-472页

核心收录：

学科分类：081703[工学-生物化工] 08[工学] 0817[工学-化学工程与技术] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 

基　　金：This work was supported by the National Key Research and Development Program of China Grant(2019YFA0906004) the National Natural Science Foundation of China Grants(81991513,82022047,81630066,81870532,81972100) the Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018) the Science and Technology Innovation Commission of Shenzhen Municipal Government Grants(JCYJ20180302174117738,JCYJ20180302174246105,KQJSCX20180319114434843,JSGG20180503182321166) the China Postdoctoral Science Foundation(2019M651641) 

主　　题：mec sensation organs 

摘      要：Mechanotransduction is a fundamental ability that allows living organisms to receive and respond to physical signals from both the external and internal *** mechanotransduction process requires a range of special proteins termed mechanotransducers to convert mechanical forces into biochemical signals in *** Piezo proteins are mechanically activated nonselective cation channels and the largest plasma membrane ion channels reported thus *** regulation of two family members,Piezol and Piezo2#has been reported to have essential functions in mechanosensation and transduction in different organs and ***,the predominant contributions of the Piezo family were reported to occur in the skeletal system,especially in bone development and mechano-stimulated bone *** we review current studies focused on the tissue-specific functions of Piezol and Piezo2 in various backgrounds with special highlights on their importance in regulating skeletal cell *** this review,we emphasize the diverse functions of Piezol and Piezo2 and related signaling pathways in osteoblast lineage cells and *** also summarize our current understanding of Piezo channel structures and the key findings about PIEZO gene mutations in human diseases.