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Journal of Materials Science & Technology 2016年第8期32卷 729-732页

作者： Changlu Xu Haoran Liu huilin yang Lei yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated Hospital Soochow University International Research Center for Translational Orthopaedics (IRCTO) Soochow University

A green biocompatible foaming method utilizing natural coconut oil and cornstarch was developed to fabricate highly porous functional ceramics with controllable strengths and pore structures. The poros- ity of A1203 ceramics prepared via this method reached 79.6%-86.9% while these ceramics maintained high compressive strengths of 2.2-5.5 MPa. More importantly, porous A1203 ceramic with a pore size gra- dient was also readily fabricated by casting serial layers of foams that were set for different time periods. The potential applications of porous Al2O3 and HA ceramics fabricated by this green foaming method in- cluding scaffolds for oil cleaning and cell culture, respectively, were also demonstrated.

关键词： Porous ceramic Pore structure Bioceramics Hydroxyapatite Alumina

Natural diatomite particles： Size-, dose- and shape- dependent cytotoxicity and reinforcing effect on injectable bone cement

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Journal of Materials Science & Technology 2018年第6期34卷 1044-1053页

作者： Xiang Zhang huilin yang Song Li Gaowu Qin Lei yang College of Chemistry Chemical Engineering and Materials Science Orthopaedic Institute Soochow University Suzhou 215006 China Key LaboratoryforAnisotropy and Texture of Materials (Ministry of Education) School of Materials Science and Engineering Northeastern University Shenyang 110819 China International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou 215006 China

Natural diatomite （DT） is the ancient deposit of diatom skeleton with many regular pores of 50-200 nm and also an abundant source of biogenic silica. Although silica is considered biologically safe and there is an increasing interest of using natural diatomite for biomedical applications, the toxicity information about natural diatomite is still missing. Here, cytotoxicity of natural diatomite on osteoblasts and fibroblasts were compared to hydroxyapatite and the relationships between cytotoxicity and diatomite sizes, dose, geometry or impurity were systematically investigated. Cell adhesion and interaction with diatomite particles were also fluorescently observed, The results clearly suggested a size-, dose- and shape-dependent cytotoxicity of natural diatomite. Disk-shaped diatomite particles with average size of 30μm in diameter revealed the least toxicity, while the diatomite particles with irregular shapes and sizes less than 10 μm were remarkably toxic. Diatomite particles with proper sizes were then selected to investigate the reinforcing effect on injectable calcium phosphate bone cement. Results showed that diatomite significantly improved the compressive strength of bone cement but did not alter the injectability of the cement, This work provided important biocompatibility information of natural diatomite and demonstrated the feasibility of using selected diatomite as bone implant material.

关键词： Biocompatibility Size and shape effect Bone cement Particle Silica Kyphoplasty

Injectable hydrogel wound dressing based on strontium ion cross-linked starch

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Frontiers of Materials Science 2020年第2期14卷 232-241页

作者： Yuxuan MAO Mingming PAN huilin yang Xiao LIN Lei yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou 215006China Department of Orthopaedics The First ffiliated HospitalSoochow UniversitySuzhou 215006China Center for Health Science and Engineering School of Materials Science and EngineeringHebei University of TechnologyTianjin 300131China

Severe skin wounds cause great problems and sufferings to *** this study,an injectable wound dressing based on strontium ion cross-linked starch hydrogel(SSH)was developed and *** good inject-ability of SSH made it easy to be delivered onto the wound *** good tissue adhesiveness of SSH ensured a firm protection of the ***,SSH supported the proliferation of NIH/3T3 fibroblasts and facilitated the migration of human umbilical vein endothelial cells(HUVECs).Importantly,SSH exhibited strong antibacterial effects on Staphylococcus aiireiis(***/rec/s),which could prevent wound *** results demonstrate that SSH is a promising wound dressing material for promoting wound healing.

关键词： wound dressing injectable antibacterial gel-point adhesive hydrogel(GPAH)

Functional recovery and microenvironmental alterations in a rat model of spinal cord injury following human umbilical cord blood-derived mesenchymal stem cells transplantation

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Neural Regeneration Research 2010年第3期5卷 165-170页

作者： Hongtao Zhang huilin yang Huanxiang Zhang Jing Qu Department of Orthopedics First Affiliated Hospital of Soochow University Suzhou 215007 Jiangsu Province China Department of Cell Biology Medical College of Soochow University Suzhou 215123 Jiangsu Province China Key Laboratory of Stem Cell Research of Jiangsu Province Suzhou 215000 Jiangsu Province China

BACKGROUND： Transplantation of human umbilical cord blood-derived mesenchymal stem cells （MSCs） has been shown to benefit spinal cord injury （SCI） repair. However, mechanisms of microenvironmental regulation during differentiation of transplanted MSCs remain poorly understood. OBJECTIVE： To observe changes in nerve growth factor （NGF）, brain-derived neurotrophic factor （BDNF）, and interleukin-8 （IL-8） expression following transplantation of human umbilical cord-derived MSCs, and to explore the association between microenvironment and neural functional recovery following MSCs transplantation. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Department of Orthopedics, First Affiliated Hospital of Soochow University from April 2005 to March 2007. MATERIALS： Human cord blood samples were provided by the Department of Gynecology and Obstetrics, First Affiliated Hospital of Soochow University. Written informed consent was obtained. METHODS： A total of 62 Wister rats were randomly assigned to control （n = 18）, model （n = 22, SCI ＋ PBS）, and transplantation （n = 22, SCI ＋ MSCs） groups. The rat SCI model was established using the weight compression method. MSCs were isolated from human umbilical cord blood and cultured in vitro for several passages. 5-bromodeoxyuridine （BrdU）-Iabeled MSCs （24 hours before injection） were intravascularly transplanted. MAIN OUTCOME MEASURES： The rats were evaluated using the Basso, Beattie and Bresnahan （BBB） locomotor score and inclined plane tests. Transplanted cells were analyzed following immunohistochemistry. Enzyme-linked immunosorbant assay was performed to determine NGF, BDNF, and IL-8 levels prior to and after cell transplantation. RESULTS： A large number of BrdU-positive MSCs were observed in the SCI region of the transplantation group, and MSCs were evenly distributed in injured spinal cord tissue 1 week after transplantation. BBB score and inclined plane test results revealed significant fu

关键词： human umbilical cord blood-derived mesenchymal stem cells nerve growth factor brain-derived neurotrophic factor interleukin-8 spinal cord injury neural stem cells neural regeneration

Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury

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Neural Regeneration Research 2013年第33期8卷 3087-3094页

作者： Yiming Ji Bin Meng Chenxi Yuan huilin yang Jun Zou Department of Orthopedic Surgery the First Affiliated Hospital of Soochow University

It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials. Therefore, we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology. The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia. After reperfusion for 30-180 minutes, the amplitude and latency began to gradually recover; at 360 minutes of reperfusion, the latency showed no significant difference compared with the pre-ischemic value, while the somatosensory evoked potential amplitude in- creased, and severe hindlimb motor dysfunctions were detected. Experimental findings suggest that changes in somatosensory evoked potentia~ ~atency can reflect the degree of spinat cord ischemic injury, while the amplitude variations are indicators of the late spinal cord reperfusion injury, which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury.

关键词： neural regeneration spinal cord injury somatosensory evoked potentials spinal cord ischemia reperfusion iatrogenic spinal cord injury histopathology abdominal aorta occlusion model latency grants-supported paper neuroregeneration

A flexible conductive hybrid elastomer for high-precision stress/strain and humidity detection

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Journal of Materials Science & Technology 2019年第1期35卷 176-180页

作者： Haoran Liu Zhenyi Zhang Jun Ge Xiao Lin Xinye Ni huilin yang Lei yang Orthopaedic Institute Department of Orthopaedics Soochow University Division of Environmental Technology INET Tsinghua University Second People’s Hospital of Changzhou Nanjing Medical University International Research Center for Translational Orthopaedics (IRCTO) Soochow University

Flexible and environment-responsive materials are essential for a large number of applications from artificial skin to wearable devices. The present study develops a flexible, ultra-low cost conductive hybrid elastomer(CHE), which possesses high responsive capabilities to stress/strain and humidity. CHE was composed of polydimethylsiloxane(PDMS) and starch hydrogel(SH), enabling great elasticity(56 kPa),high conductivity(10^(-2)S/m) and high sensitivity to external stimuli(gauge factor of CHE under stress and strain are 0.71 and 2.22, respectively, and sensitivity to humidity is 1.2 × 10^(-6)S/m per RH%). These properties render CHE a promising candidate for artificial skin and wearable electronics applications of continuously monitoring environmental information.

关键词： Conductive composites Electrical properties Mechanical properties Moisture Hybrid Elastomer

Macroporous and Antibacterial Hydrogels Enabled by Incorporation of Mg-Cu Alloy Particles for Accelerating Skin Wound Healing

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Acta Metallurgica Sinica(English Letters) 2022年第5期35卷 853-866页

作者： Jiewei Yin Pengcheng Xu Kang Wu Huan Zhou Xiao Lin Lili Tan huilin yang Ke yang Lei yang College of Chemistry Chemical Engineering and Materials ScienceOrthopedic InstituteSoochow UniversitySuzhou215006China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215006China Center for Health Science and Engineering(CHSE) School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin300130China Institute of Metal Research Chinese Academy of SciencesShenyang110016China

Repair of severe skin tissue injury remains a great challenge and wound infection is still a formidable *** this study,new macroporous and antibacterial gelatin/alginate(SAG)-based hydrogels for wound repair were designed and developed based on in-situ gas foaming method and ion release strategy as a result of Mg-Cu particles degradation in the hydrogel *** addition of Mg-Cu particles decreased the storage modulus of SAG,maintained its mechanical resilience and enhanced its water-absorbing ***,the water vapor transmission rate of SAG added with 2 wt.%Mg-Cu(SAG-2 MC)was 124%of that of medical gauze and 804%of commercial Tegaderm^(TM)film *** bacterial inhibition rates of SAG-2 MC against *** and *** reached 99.9%±0.1%,98.7%±1.2%and 98.0%±0.7%,respectively,significantly greater than those of the SAG hydrogel and Mg particle-modified *** addition,SAG-2 MC hydrogel was biocompatible and promoted cell *** vivo experiment results indicated that SAG-2 MC significantly accelerated the skin wound healing in murine model as demonstrated by higher epidermis thickness,more collagen deposition and enhanced angiogenesis compared with SAG-OMC,SAG-2 M and TegadermTM *** summary,Mg-Cu particles have great potential to modulate the physiochemical and biological properties of SAG ***-Cu particle-modified SAG hydrogels reveal significant promise in the treatment of severe skin wound or other soft tissue lesions.

关键词： Mg-Cu alloy Wound repair Macroporous Hydrogel Bacterial inhibition

An injectable curcumin-releasing organohydrogel with non-drying property and high mechanical stability at low-temperature for expe dite d skin wound care

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Journal of Materials Science & Technology 2023年第2期133卷 123-134页

作者： Kang Wu Qiang yang Lin Zhang Pengcheng Xu Xiexing Wu huilin yang Huan Zhou Xiao Lin Lei yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteDepartment of Orthopaedic SurgeryThe First Affiliated HospitalSoochow UniversitySuzhou 215031China Center for Health Sciences and Engineering(CHSE) School of Health Sciences and Biomedical EngineeringHebei University of TechnologyTianjin 300130China Department of Minimally Invasive Spine Surgery Tianjin HospitalTianjin 300211China

Although hydrogels have demonstrated great potential as new wound dressing materials,their instability in shape and/or mechanical characteristics due to water loss or freezing remains a shortcoming for wound care ***,a novel injectable organohydrogel(IOH)of physically crosslinked polyvinyl alco-hol/glycerol that possesses non-drying capability and high stability at low temperature was developed for wound *** has a skin-like stiffness(G’,∼280 Pa),high injectability,self-healing capability,high water-vapor transmission rate,and bacterial inhibitory *** exhibits high shape and mechanical stabilities after curing at 37°C and 50%relative humidity for 7 days or after curing at-20°C for 1 *** addition,glycerol in IOH enabled an efficient loading and release of water-insoluble curcumin,a well-known anti-bacterial and anti-inflammation *** curcumin-releasing IOH(Cur-IOH)demonstrated significantly enhanced anti-bacterial performance compared to IOH or curcumin-loading polyvinyl alco-hol *** importantly,Cur-IOH could accelerate wound healing in a murine full-thickness skin defect wound model,revealing improved wound contraction,collagen deposition,angiogenesis,and epi-dermis *** study demonstrates the great potential of organohydrogel for the reparation of severe wounds and Cur-IOH as a new type of injectable wound healing material.

关键词： Wound dressing Organohydrogel Non-drying Stability Curcumin

Protective effects of human umbilical cord mesenchymal stem cell vein transplantation against spinal cord ischemia/reperfusion injury in rats

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Neural Regeneration Research 2010年第3期5卷 171-177页

作者： Jun Zou Minfeng Gan Xuesong Zhu Dechun Geng huilin yang Department of Orthopedics First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu Province China

BACKGROUND： The majority of studies addressing spinal cord ischemia/reperfusion injury （SCIRI） have focused on drugs, proteins, cytokines, and various surgical techniques. A recent study reports that human umbilical cord mesenchymal stem cell （hUCMSC） transplantation achieves good therapeutic effects, but the mechanisms underlying nerve protection remain poorly understood. OBJECTIVE： To observe survival of transplanted hUCMSCs in SCIRI rat models and the influence on motor function in the hind limbs, to determine interleukin-8 expression and cellular apoptosis in spinal cord tissues, and to verify the hypothesis that hUCMSC transplantation exhibits protective effects on SCIRI. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Laboratory of the Department of Orthopedics in the First Affiliated Hospital of Soochow University, China between January 2007 and December 2008. MATERIALS： hUCMSCs were harvested from umbilical cord blood of healthy pregnant women after parturition in the Obstetrical Department of the First Affiliated Hospital of Soochow University, China. Rabbit anti-human BrdU monoclonal antibody was provided by DAKO, USA. Terminal deoxynucleotidyl transferase dUTP nick end labeling （TUNEL） Kit and enzyme-linked immunosorbent assay （ELISA） Kit were purchased by Wuhan Boster, China. METHODS： A total of 72 healthy, Wistar, adult rats were randomly assigned to three groups： sham-surgery, model, and transplantation, with 24 rats in each group. SCIRI was induced in the model and transplantation groups via the abdominal aorta block method. The infrarenal abdominal aorta was not blocked in the sham-surgery group. Prior to abdominal aorta occlusion, 0.2 03 mL bromodeoxyuridine （BrdU）-Iabeled hUCMSCs suspension （cell concentration 5 × 10 3/uL） was injected through the great saphenous vein of the hind limb, and an equal volume of physiological saline was administered to the model and sham-surgery groups. MAIN OUTCOME MEASURES：

关键词： human umbilical cord mesenchymal stem cells spinal cord ischemia/reperfusion injury protective effect apoptosis inflammatory mediators neural regeneration

Starch-based adhesive hydrogel with gel-point viscoelastic behavior and its application in wound sealing and hemostasis

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Journal of Materials Science & Technology 2021年第4期63卷 228-235页

作者： Yuxuan Mao Peng Li Jiewei Yin Yanjie Bai Huan Zhou Xiao Lin huilin yang Lei yang College of Chemistry Chemical Engineering and Materials ScienceOrthopaedic InstituteSoochow UniversitySuzhou215000China Department of Orthopaedics The First Affiliated HospitalSoochow UniversitySuzhou215000China School of Public Health Soochow UniversitySuzhou215000China Center for Health Science and Engineering(CHSE) School of Materials Science and EngineeringHebei University of TechnologyTianjin300000China School of Mechanical Engineering Jiangsu University of TechnologyChangzhou213000China

Hydrogels with tissue adhesiveness have demonstrated great promise for wearable electronics,artificial skin,soft robotics,and tissue ***,adhesive hydrogels that are capable of sealing and hemostasis of wound with severe hemorrhage still *** this purpose,a series of ionically crosslinked starch hydrogels were developed *** viscoelastic properties and tissue adhesiveness of the starch hydrogels were *** is shown that the starch and cross linkers had significant influence on the viscoelastic properties of the starch hydrogels,which further resulted in varied tissue *** the starch gels,there was one exhibiting a unique and stable"Gel Point"viscoelastic characteristic and it was named as gel-point adhesive hydrogel(GPAH).GPAH showed electrical conductivity,high tissue adhesiveness,high stretch-ability,self-healing capability,injectability,and *** GPAH also exhibited high cytocompatibility,low hemolysis risk,and strong antibacterial *** wound sealing and hemostatic performance of GPAH was further evaluated by a rat femoral artery injury *** blood loss after the sealing of GPAH(2.4±1.3 g)was significantly decreased compared to the group using gauze for sealing(6.3±1.5 g).Meanwhile,GPAH did not cause pathological changes of the soft tissues surrounding the *** above results indicate that GPAH,with high tissue adhesiveness,suitable viscoelastic property,strong antibacterial capacity,as well as electro-conductivity,bears great potential for the applications in smart wound management.

关键词： sealing viscoelastic hydrogel