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Science China Chemistry 2024年第6期67卷 1922-1928页

作者： Shasha Zhang Wei Yao Anqi Lv Kun Liu Yusheng Zhang Chifeng Zhou huili ma Huifang Shi Zhongfu An Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced materials(IAM) Nanjing Tech UniversityNanjing211816China

High-efficiency long-wavelength phosphorescence emissions of large singlet-triplet energy gap(ΔE_(ST))materials are essential for applications in biology and ***,few long-wavelength phosphorescence emissions of largeΔE_(ST)materials have been reported due to the weak spin-orbit coupling(SOC)and strong non-radiative ***,we develop a strategy to achieve highly efficient long-wavelength room temperature phosphorescence(RTP)emission of largeΔE_(ST)materials,which display bright red RTP emission with above 400μs lifetime and 6.5%phosphorescent quantum *** experiments and theoretical calculations reveal that the fishbone-like packing and the zig-zag interactions provide favorable conditions for suppressing the non-radiative transitions of triplet state excitons,and heavy atoms effectively promote the intersystem crossing(ISC)process for highly efficient long-wavelength phosphorescence *** universality of the method for highly efficient long-wavelength RTP emission of largeΔE_(ST)materials was further investigated in various ***,these materials with largeΔE_(ST)manifest the advantages of large color contrast on the display and utilization potentiality in information *** strategy paves the way for the high contrast display and development of information encryption with RTP emission.

关键词： room temperature phosphorescence singlet-triplet energy gap host-guest doping heavy atom effect red phosphorescence

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Research on Localized English Education for Transnational Left-behind Children in the Context of English Global Localization: A Case Study of Wenzhou Overseas Chinese Hometown

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教育技术与创新 2024年第1期6卷 36-49页

作者： Yujie Su Xueyan Li huili ma Shuchang Dong Ruoruo Lin Lijuan Zou Qiaoqiao Lin School of Foreign Studies Wenzhou UniversityChina Li'ao Overseas Chinese Primary School ZhejiangChina Wenzhou Xianyan No.2 Middle School ZhejiangChina Wenzhou High School ZhejiangChina

With the increasing development of English globalization,the trend of combining English with local cultures has become more *** research focuses on five schools in the Wenzhou overseas Chinese hometown to investigate the current status of English education from the perspectives of teachers,students,and *** aim was to propose bilingual education strategies for the education of transnational left-behind children(TLC).By examining the situation of English education in this specific context,this study sought to address the unique challenges faced by TLC and provide effective educational ***,observations,and document analysis were employed to gather data by means of questionnaire research *** findings of this study settled on the improvement of bilingual education for TLC and insights into enhancing English education in multicultural settings.

关键词： glocalization transnational left-behind children(TLC) bilingual education Wenzhou Overseas Chinese Hometown

Acceptor Engineering Produces Ultrafast Nonradiative Decay in NIR-Ⅱ Aza-BODIPY Nanoparticles for Efficient Osteosarcoma Photothermal Therapy via Concurrent Apoptosis and Pyroptosis

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Research 2024年第1期2024卷 625-635页

作者： Zhenxiong Shi Hua Bai Jiaxing Wu Xiaofei Miao Jia Gao Xianning Xu Yi Liu Jiamin Jiang Jiaqi Yang Jiaxin Zhang Tao Shao Bo Peng huili ma Dan Zhu Guojing Chen Wenbo Hu Lin Li Wei Huang Frontiers Science Center for Flexible Electronics Xi’an Institute of Flexible Electronics(IFE)and Xi’an Institute of Biomedical Materials&EngineeringNorthwestern Polytechnical UniversityXi’an 710072China Key Laboratory for Organic Electronics and Information Displays&Institute of Advanced materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)and IAM Nanjing Tech UniversityNanjing 211800China Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging FacilityHuazhong University of Science and TechnologyWuhan 430074China Department of Orthopedics Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Small-molecule photothermal agents(PTAs)with intense second near-infrared(NIR-Ⅱ,1,000 to 1,700 nm)absorption and high photothermal conversion efficiencies(PCEs)are promising candidates for treating deep-seated tumors such as *** date,the development of small-molecule NIR-Ⅱ PTAs has largely relied on fabricating donor–acceptor–donor(D–A–D/D′)structures and limited success has been ***,through acceptor engineering,a donor–acceptor–acceptor(D–A–A′)-structured NIR-Ⅱ aza-boron-dipyrromethene(aza-BODIPY)PTA(SW8)was readily developed for the 1,064-nm laser-mediated phototheranostic treatment of *** the donor groups to acceptor groups produced remarkable red-shifts of absorption maximums from first near-infrared(NIR-Ⅰ)regions(~808 nm)to NIR-Ⅱ ones(~1,064 nm)for aza-BODIPYs(SW1 to SW8).Furthermore,SW8 self-assembled into nanoparticles(SW8@NPs)with intense NIR-Ⅱ absorption and an ultrahigh PCE(75%,1,064 nm).This ultrahigh PCE primarily originated from an additional nonradiative decay pathway,which showed a 100-fold enhanced decay rate compared to that shown by conventional pathways such as internal conversion and vibrational ***,SW8@NPs performed highly efficient 1,064-nm laser-mediated NIR-Ⅱ photothermal therapy of osteosarcoma via concurrent apoptosis and *** work not only illustrates a remote approach for treating deep-seated tumors with high spatiotemporal control but also provides a new strategy for building high-performance small-molecule NIR-Ⅱ PTAs.

关键词： donor BODIPY intense

阿帕替尼联合埃克替尼治疗EGFR基因21号外显子L858R突变型NSCLC的临床观察

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实用癌症杂志 2024年第4期39卷 594-597页

作者：罗娜马慧丽杨启河南省南阳市中心医院 473000

目的探究对表皮生长因子受体(EGFR)基因21号外显子L858R突变型非小细胞肺癌(NSCLC)采用阿帕替尼联合埃克替尼治疗的临床效果。方法将EGFR基因21号外显子L858R突变型NSCLC患者101例按随机数表法分为观察组(n=51)与对照组(n=50)。观察组... 详细信息

目的探究对表皮生长因子受体(EGFR)基因21号外显子L858R突变型非小细胞肺癌(NSCLC)采用阿帕替尼联合埃克替尼治疗的临床效果。方法将EGFR基因21号外显子L858R突变型NSCLC患者101例按随机数表法分为观察组(n=51)与对照组(n=50)。观察组采用阿帕替尼联合埃克替尼治疗,对照组仅采用埃克替尼治疗,治疗时间为56 d,2个周期。比较2组近期疗效、不良反应,并采用K-M生存分析曲线图分析2组远期疗效。结果观察组与对照组的客观缓解率(ORR)(74.51%vs 74.00%)与疾病控制率(DCR)(92.16%vs 94.00%)差异均无统计学意义(P>0.05);治疗期间2组未出现2级以上不良反应,观察组高血压和蛋白尿发生率分别为52.94%、50.98%,分别高于对照组的16.00%、10.00%,差异有统计学意义(P<0.05)。观察组生存率显著高于对照组(69.3%vs 43.1%),差异有统计学意义(P<0.05)。结论EGFR基因21号外显子L858R突变型NSCLC采用阿帕替尼联合埃克替尼治疗,可延长患者的无进展生存时间,不良反应的发生可接受。

关键词：非小细胞肺癌阿帕替尼埃克替尼表皮生长因子受体 21号外显子L858R突变型

不同光质对香椿种子萌发、幼苗总黄酮合成及相关酶活性的影响

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食品工业科技 2024年第15期45卷 100-106页

作者：马慧新马慧丽齐学慧隋娟娟屈长青蒋侠森杨京霞阜阳师范大学生物与食品工程学院安徽阜阳236037 阜阳师范大学抗衰老中草药安徽省工程技术研究中心安徽阜阳236037

为探索不同光照对香椿幼苗生长、总黄酮合成及相关酶活性的影响,以‘红油椿’为试验材料,采用LED光源,对萌发种子及幼苗进行白光(CK)、蓝光(B)、红蓝复合光2:1(R2B1)、红蓝复合光1:1(R1B1)、红蓝复合光1:2(R1B2)、红光(R)处理,在不同光... 详细信息

为探索不同光照对香椿幼苗生长、总黄酮合成及相关酶活性的影响,以‘红油椿’为试验材料,采用LED光源,对萌发种子及幼苗进行白光(CK)、蓝光(B)、红蓝复合光2:1(R2B1)、红蓝复合光1:1(R1B1)、红蓝复合光1:2(R1B2)、红光(R)处理,在不同光照处理15 d后对种子发芽指标、幼苗总黄酮合成以及相关酶活性进行了测定。结果表明,与对照组CK相比,红光为主的光质处理(R、R1B1、R2B1)促进了香椿种子萌发,其中R2B1处理全株干质量与鲜质量最高,与CK相比分别提高了55.06%、82.86%。与CK和R相比,其他光照处理均显著(P<0.05)提高了香椿幼苗中总黄酮的含量,其中B处理显著高于其他处理组,同时B处理显著(P<0.05)提高了苯丙氨酸解氨酶(PAL)、查尔酮合成酶(CHS)、查尔酮异构酶(CHI)的活性,与香椿叶片中总黄酮含量的变化呈显著正相关。因此,采用R2B1处理香椿种子能促进其萌发,采用B处理香椿幼苗能有效促进PAL、CHS、CHI酶活性以显著提高总黄酮的合成。

关键词：香椿光质萌发总黄酮酶活性

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manipulating intermolecular interactions for ultralong organic phosphorescence

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聚集体(英文)

聚集体(英文) 2023年第3期4卷 36-54页

作者： Suzhi Cai Xiaokang Yao huili ma Huifang Shi Zhongfu An School of Flexible Electronics(Future Technologies)and Institute of Advanced materials(IAM) Nanjing Tech UniversityNanjingChina Strait Institute of Flexible Electronic(SIFE Future Technologies)Fujian Normal UniversityFuzhouChina Strait Laboratory of Flexible Electronics(SLoFE) FuzhouChina

Ultralong organic phosphorescence(UOP)materials have received considerable attention in the field of organic optoelectronics due to their long lifetime,high exciton utilization,large Stokes shift,and so *** advancements have been achieved through manipulating intermolecular interactions for high-performance UOP materials in recent *** review will discuss the influence of various intermolecular interactions,includingπ-πinteractions,n-πinteractions,halogen bonding,hydrogen bonding,coordinative bonding,and ionic bonding on phosphorescent properties at room temperature,*** summarize the rule of manipulating intermolecular interactions for UOP materials with superior phosphorescent *** review will provide a guideline for developing new UOP materials with superior phosphorescent properties for potential applications in organic electronics and bioelectronics.

关键词： aggregation intermolecular interactions molecular stacking room temperature phosphorescence ultralong organic phosphorescence

Engineering trienzyme cascade-triggered fluorescent immunosensor platform by sequentially integrating alkaline phosphatase, tyrosinase and horseradish peroxidase

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Chinese Chemical Letters 2023年第4期34卷 444-448页

作者： Yujie Sun Lei Wen huili ma Wenlin ma Zhenqian Fu Yinhui Li Chengwu Zhang Lin Li Jinhua Liu Institute of Advanced materials(IAM) Key Laboratory of Flexible Electronics(KLOFE)Nanjing Tech UniversityNanjing 211816China Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly ChemistryApplication of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China School of Basic Medical Sciences Shanxi Medical UniversityTaiyuan 310003China

Mulit-enzyme cascades are a major type of chemical transformations and play a crucial role in biological signal transduction and metabolism. Herein, a trienzyme cascade-triggered fluorescent immunosensor platform was constructed by sequentially integrating alkaline phosphatase(ALP), tyrosinase(TYR)and horseradish peroxidase(HRP). The proposed platform was based on HRP-induced a rapid in situ fluorogenic reaction between dopamine(DA) and 1,5-dihydroxynaphthalene(DHA) to produce a strong yellow azamonardine fluorescent compound(AFC). The obtained AFC was clearly characterized by highresolution mass spectrum,1H NMR,^(13)C NMR and theoretical calculations. The integration of the twoenzyme system(TYR and HRP) or three-enzyme system(ALP, TYR and HRP) led to a maximum of 400.0-fold and 250.0-fold fluorescence enhancements, respectively. Using cardiac troponin I(c Tn I) as the model antigen, a trienzyme cascade-triggered fluorescent immunosensor platform was developed for quantitative detecting c Tn I in a wide linear range from 2 ng/m L to 150 ng/m L with a detection limit of 0.67ng/m L. In addition, the proposed platform was successfully applied in detection of c Tn I in serum of clinical patients. Overall, the developed fluorescent immunosensor performs powerful implications for researching enzyme cascade systems in the field of biomedicine.

关键词： Enzyme cascade Alkaline phosphatase Tyrosinase Horseradish peroxidase Cardiac troponin I

Dynamic room-temperature phosphorescence by reversible transformation of photo-induced free radicals

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Science China Chemistry 2022年第8期65卷 1538-1543页

作者： Xiaokang Yao Huifang Shi Xiao Wang He Wang Qiuying Li Yuxin Li Jian Liang Jingjie Li Yixiao He huili ma Wei Huang Zhongfu An Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced materials(IAM) Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Organic Electronics and Information Displays&Institute of Advanced materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China

Room-temperature phosphorescence(RTP)with a dynamic feature endows organic luminescent materials with promising application in optoelectronic ***,it remains a formidable challenge to obtain dynamic RTP ***,we reported a strategy for dynamic RTP via reversible transformation of radicals under external *** gradually disappeared with continuous UV-light irradiation owing to the conversion of NDIA to NDIA^(·-)in NDIA/PVA film,which can be recovered by oxidation with *** the excellent reversibility and repeatability,the potential applications for round-the-clock anticounterfeiting and tag were first *** finding not only outlines a principle to synthesize new RTP materials with dynamic behavior,but also expands the scope of applications of dynamic RTP materials.

关键词： room-temperature phosphorescence radical emission supramolecular self-assembly anti-counterfeiting

Analytical derivative techniques for TDDFT excited-state properties:Theory and application

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Science China Chemistry 2014年第1期57卷 48-57页

作者： CHEN DanPing LIU Jie ma huili ZENG Qiao LIANG WanZhen State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy materials Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry Department of Chemistry College of Chemistry and Chemical Engineering Xiamen University Hefei National Laboratory for Physical Science at Microscale University of Science and Technology of China Department of Chemical Physics University of Science and Technology of China

We review our recent work on the methodology development of the excited-state properties for the molecules in vacuum and liquid *** general algorithms of analytical energy derivatives for the specific properties such as the first and second geometrical derivatives and IR/Raman intensities are demonstrated in the framework of the time-dependent density functional theory(TDDFT).The performance of the analytical approaches on the calculation of excited-state energy Hessian has also been *** is found that the analytical approaches are superior to the finite-difference method on the computational accuracy and *** computational cost for a TDDFT excited-state Hessian calculation is only 2–3 times as that for the DFT ground-state Hessian *** the low computational complexity of the developed analytical approaches,it becomes feasible to realize the large-scale numerical calculations on the excited-state vibrational frequencies,vibrational spectroscopies and the electronic-structure parameters which enter the spectrum calculations of electronic absorption and emission,and resonance Raman spectroscopies for medium-to large-sized systems.

关键词： molecular excited-state properties,molecular Hessian,IR Raman intensities,the time-dependent density functional theory,analytical energy derivatives

Comparison of viscoelasticity between normal human sciatic nerve and amniotic membrane

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Neural Regeneration Research 2013年第14期8卷 1269-1275页

作者： Donghui Xu Conghai Zhao huili ma Jun Wei Dongyuan Li Department of Neurosurgery China-Japan Union HospitalJilin University Department of Road & Bridge College of TransportationJilin University

Sciatic nerve tissue was obtained from the gluteus maximus muscle segment of normal human cadavers and amniotic membrane tissue was obtained from healthy human puerperant placentas. Both tissues were analyzed for their stress relaxation and creep properties to determine suitability for transplantation applications. Human amniotic membrane and sciatic nerve tissues had similar tendencies for stress relaxation and creep properties. The stress value of the amniotic membrane stress relaxation group decreased to a greater extent compared with the sciatic nerve stress relaxation group. Similarly, the stress value of the amniotic membrane creep group increased to a greater extent compared with the sciatic nerve creep group. The stress relaxation curve for human amniotic membrane and sciatic nerve showed a logarithm correlation, while the creep curve showed an exponential correlation. These data indicate that amniotic membrane tissue has better stress relaxation and creep properties compared with sciatic nerve tissue.

关键词： neural regeneration basic research cadaver human sciatic nerve amniotic membrane stressrelaxation creep viscoelasticity stress biomechanics nerve tissue engineering neuroregeneration