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Asymmetric synthesis of ABC tricyclic systems in Daphniphyllum alkaloid

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Chinese Chemical Letters 2020年第3期31卷 685-688页

作者： huijing wang Qiuyan Dong Qinxia Xie Pei Tang Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research School of Pharmaceutical SciencesChongqing UniversityChongqing 401331China Skaggs School of Pharmacy and Pharmaceutical Sciences University of California San DiegoLa Jolla 92093-0934United States

Efficient synthetic routs for the direct and rapid construction of[5-6-6]ABC tricyclic systems of daphmanidin A-type and calyciphylline A-type alkaloids have been successfully *** the daphmanidin A-type,the synthesis of[5-6-6]tricyclic framework utilize a HCl-mediated intramolecular Aldol reaction to construct the bicyclo[2.2.2]octane core and a thermal condensation to afford the ABC ring *** addition,for the calyciphylline A-type,an improved synthesis of ABC[5-6-6]tricyclic system was developed,featuring an introduction of methyl ester group at C2 before the Pd-catalyzed intramolecular oxidative alkylation to construct the desired bowl-shape tricyclic core with stereochemical control.

关键词： Daphniphyllum alkaloid Calyciohylline N 21-Deoxymacropodumine D ABC tricyclic framework Intramolecular Aldol reaction Pd-catalyzed intramolecular oxidative alkylation

Bifunctional copper modified graphitic carbon nitride catalysts for efficient tetracycline removal:Synergy of adsorption and photocatalytic degradation

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Chinese Chemical Letters 2020年第10期31卷 2789-2794页

作者： huijing wang Jun Zhang Pu wang Linlin Yin Yu Tian Junjing Li State Key Laboratory of Urban Water Resources and Environment(SKLUWRE) School of EnvironmentHarbin Institute of TechnologyHarbin 150090China State Key Laboratory of Separation Membranes and Membrane Processes School of Environmental and Chemical EngineeringTianjin Polytechnic UniversityTianjin 300387China

In order to efficiently re move tetracycline in wastewater through the synergistic effect of adsorption and photocatalytic degradatio n,a series of novel composite materials(Cu doped g-C_(3)N_(4))were synthesized by two-pot hydrothermal *** was found that the composite materials with optimized ratio(Cu/CN-1)displayed outstanding adsorption and photocatalytic performance as compared with pure g-C_(3)N_(4) *** removal efficiency of tetracycline(TC,50 mg/L)reached almost 99%within 30 min by Cu/CN-1 through the synergy of adsorption and photocatalysis under visible-light irradiation,which was the highest re moval efficiency ever *** adsorption kinetics and isotherms of TC on the Cu/CN-1 were well fitted with the pseudo-second-order kinetic model and Langmuir model,***,it was confirmed that the main effective reactive groups were O_(2)^·and h^(+) in photocatalytic *** Cu/CN-1 exhibited high stability and excellent reusability after five cycle ***,the mechanism of synergy between Cu and g-C_(3)N_(4) was proposed:on the one hand,the decoration of Cu particles significantly increased the adsorption sites of Cu/CN-1 to tetracycline,on the other hand,the modification of Cu particles effectively inhibits charge recombination and broadens the visible light absorption range of the *** study provided a promising photocatalyst to be used for TC removal in the actual wastewater.

关键词： Carbon nitride Tetracycline Adsorption Photocatalysis Environment remediation

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及物性的多域性及跨域隐喻映射

外语教学与研究 2023年第3期55卷 347-358,478页

作者：王惠静西南大学

及物性是语言学研究中的核心话题,但已有研究主要聚焦物理事件,忽视了心理事件和社会事件中的及物性。本文从认知语言学视角出发,探讨及物性的判断参数,并以此为依据重点分析心理域和社会域的及物性特征,探寻不同认知域及物性之间的关系... 详细信息

及物性是语言学研究中的核心话题,但已有研究主要聚焦物理事件,忽视了心理事件和社会事件中的及物性。本文从认知语言学视角出发,探讨及物性的判断参数,并以此为依据重点分析心理域和社会域的及物性特征,探寻不同认知域及物性之间的关系,揭示及物性的多域性本质、跨域隐喻映射方式以及背后的人类认知。

关键词：及物性多域性隐喻映射认知语言学

基于TLR-2/MyD88/NF-κB通路探讨养阴清肺汤加味对肺炎支原体感染小鼠炎症的影响

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中华中医药学刊 2024年第2期42卷 79-83,I0018页

作者：齐兆东吴振起王慧婧张心放梁翔宇辽宁中医药大学附属第二医院辽宁沈阳110034 辽宁中医药大学辽宁沈阳110847

目的探讨养阴清肺汤加味(Yangyin Qingfei decoction plus,YQDP)对肺炎支原体(Mycoplasma pneumoniae,MP)感染小鼠炎症反应及Toll样受体2(Toll-like receptor 2,TLR-2)/髓样分化因子88(Myeloid differentiation factor 88,MyD88)/核转录因子-κB(Nuclear factor-κB,NF-κB)信号通路的影响。方法选取BALB/c小鼠60只,随机分为正常组、模型组、阿奇霉素组、YQDP低、中、高剂量组,每组10只,除正常组外均建立MP感染小鼠模型,模型建立成功后开始给药治疗并于第7天取材。采用HE染色法观察小鼠的肺部病理改变情况,ELISA法检测血清中白介素-6(Interleukin-6,IL-6)、IL-8(Interleukin-8)、IL-17(Interleukin-17)水平,RT-PCR法、Western blot法检测TLR-2、MyD88、NF-κB mRNA及蛋白表达水平。结果与正常组比较,模型组小鼠大部分肺泡结构破坏严重,完整肺泡较少,肺泡间隔明显增厚并可见大量炎性细胞,血清中IL-6、IL-8、IL-17含量明显升高(P<0.05),肺组织中TLR-2、MyD88、NF-κB mRNA及蛋白表达量升高(P<0.05)。与模型组比较,给予阿奇霉素、YQDP治疗后,小鼠肺组织病理显示肺泡结构有明显恢复,肺泡周围存在的炎性细胞浸润均有不同程度减少,血清中IL-6、IL-8、IL-17含量明显降低(P<0.05),肺组织中TLR-2、MyD88、NF-κB mRNA及蛋白表达量降低(P<0.05),并且YQDP治疗组的降低趋势与其低、中、高剂量呈现依赖性。结论YQDP可能通过调控TLR-2/MyD88/NF-κB信号通路,起到减轻MP感染小鼠肺部炎症作用。

关键词：养阴清肺汤加味肺炎支原体炎症信号通路小鼠

Noninvasive Prenatal Testing Test Versus Chorionic Villus Sampling,Where Are We Now?

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Maternal-Fetal Medicine 2024年第2期6卷 128-130页

作者： huijing Zhang Branko Denona Fetal Medicine Unit Royal Prince Alfred HospitalSydney 2050Australia.

Introduction The discovery of cell-free fetal DNA(cff-DNA),also known as noninvasive prenatal testing(NIPT),by Lo et *** 1997,1 has significantly changed the screening for common chromosomal *** widespread acceptance globally underscores its *** analyzes fetal DNA originating from the apoptosis of the outer cytotrophoblast,the fetal hematopoietic system,and lysis of other fetal *** DNA fraction increases from 10%to 15%between 10 and 20 gestational *** cff-DNA clearance occurs in maternal circulation,spanning from 4 minutes to 2 weeks postpartum.

关键词： fetal globally outer

Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis

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Green Synthesis and Catalysis 2020年第1期1卷 26-41页

作者： Pei Tang huijing wang Wen Zhang Fen-Er Chen Sichuan Research Center for Drug Precision Industrial Technology West China School of PharmacySichuan UniversityChengdu 610041China Engineering Center of Catalysis and Synthesis for Chiral Molecules Department of ChemistryFudan UniversityShanghai 200433China Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs Shanghai 200433China

Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral amine structures in organic *** review focuses on recent applications of asymmetric hydrogenations of imine and enamine substrates in the total syntheses of natural *** applications include diverse processes involving asymmetric transfer hydrogenation(ATH)and asymmetric hydrogenation(AH)to form key chiral amine motifs in natural products with good efficiency and high-level enantiocontrol.

关键词： Asymmetric catalytic hydrogenation Imine substrates Enamine substrates Natural product synthesis Enantioselectivity

The existence theorem of absolute equilibrium about games on connected graph with state payoff vector

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Science China Mathematics 2010年第6期53卷 1483-1490页

作者： GAO HongWei,YANG huijing,wang GuiXi & YU Kun College of Mathematics,Qingdao University,Qingdao 266071,China College of Mathematics Qingdao University

By introducing state payoff vector to every state node on the connected graph in this paper,dynamic game is researched on finite *** concept of simple strategy about games on graph defined by Berge is introduced to prove the existence theorem of absolute equilibrium about games on the connected graph with state payoff *** complete algorithm and an example in the three-dimensional connected mesh-like graph are given in this paper.

关键词： connected graph state payoff vector simple strategy absolute equilibrium three-dimensional mesh-like graph

相邻复杂矿体开采过程对地表稳定性的时空影响研究

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金属矿山 2022年第12期 233-237页

作者：王辉镜许威江西江铜银珠山矿业有限公司江西贵溪335400 江西理工大学资源与环境工程学院江西赣州341000

为探究相邻复杂矿体开采过程与地表稳定性的时空规律,提出了考虑开采过程的Flac3D三维数值模拟计算方法。以冷水坑银铅锌矿田内3座相邻且中段下降速度不同的矿山为例,建立了银珠山矿业、银海矿业、鲍家矿业的矿体与围岩模型。通过井下... 详细信息

为探究相邻复杂矿体开采过程与地表稳定性的时空规律,提出了考虑开采过程的Flac3D三维数值模拟计算方法。以冷水坑银铅锌矿田内3座相邻且中段下降速度不同的矿山为例,建立了银珠山矿业、银海矿业、鲍家矿业的矿体与围岩模型。通过井下调查、钻探取样、室内试验,获得了矿岩/充填体的物理力学参数,根据井田内各矿山的排采计划,设计了符合实际情况的计算工况并进行了数值模拟计算。研究结果表明:(1)冷水坑银铅锌矿田各矿山采用嗣后充填采矿法且保证充填质量的前提下,矿体开采对地表无显著不利影响;(2)开采过程与地表变形参数在时空上呈双参数指数函数递增规律,且在2025—2035年和2037—2041年两个重点生产时段可能出现地表变形显著增大的情况。研究成果对于冷水坑银铅锌矿田内的矿山开采方案设计、安全生产管理具有一定的参考意义。

关键词：地下开采相邻复杂矿体地表稳定性开采过程

Phase II study of novel orally PI3Kα/δinhibitor TQ-B3525 in relapsed and/or refractory follicular lymphoma

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2193-2201页

作者： Huaqing wang Jifeng Feng Yanyan Liu Zhengzi Qian Da Gao Xuehong Ran Hui Zhou Lihong Liu Binghua wang Meiyun Fang Hebing Zhou Zhenqian Huang Shi Tao Zhuowen Chen Liping Su Hang Su Yu Yang Xiaobao Xie huijing Wu Ping Sun Guoyu Hu Aibin Liang Zhiming Li Department of Oncology Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China The Institute of Translational Medicine Tianjin Union Medical Center of Nankai UniversityTianjin 300121PR China Department of Medical Oncology Jiangsu Cancer HospitalThe Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009PR China Department of Medical Oncology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003PR China Department of Medical Oncology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Hematology The Affiliated Hospital of Inner Mongolia Medical College010050 HohhotPR China Department of Hematology Weifang People’s HospitalThe First Affiliated Hospital of Weifang Medical University261000 WeifangPR China Department of Lymphoma&Hematology Hunan Cancer HospitalThe Affiliated Cancer Hospital of Xiangya School of MedicineCentral South University410013 ChangshaPR China Department of Hematology The Fourth Hospital of Hebei Medical University and Hebei Tumor Hospital050011 ShijiazhuangPR China Department of Lymphoma Weihai Central Hospital264400 WeihaiPR China Department of Hematology and Rheumatology The Affiliated Zhongshan Hospital of Dalian University116001 DalianPR China Department of Hematology Beijing Luhe Hospital101199 BeijingPR China Department of Hematology The First Affiliated Hospital of Guangzhou Medical University510120 GuangzhouPR China Department of Hematology The First Affiliated Hospital of Hainan Medical College570102 HaikouPR China Department of Hematology The First People’s Hospital of Foshan528000 FoshanPR China Department of Hematology Shanxi Cancer Hospital030013 TaiyuanPR China Department of Lymphoma Senior Department of HematologyThe Fifth Medical Center of Chinese PLA General Hospital100039 BeijingPR China Department of Lymphoma and Head and Neck Cancer Fujian Cancer Hospital350014 FuzhouPR China Department of Hematology The First People’s Hospit

This registration study assessed clinical outcomes of TQ-B3525,the dual phosphatidylinositol-3-kinase(PI3K)α/δinhibitor,in relapsed and/or refractory follicular lymphoma(R/R FL).This phase II study(*** *** March 27,2020)comprised run-in stage and stage 2.R/R FL patients after≥2 lines therapies received oral 20 mg TQ-B3525 once daily in a 28-day cycle until intolerable toxicity or disease *** endpoint was independent review committee(IRC)-assessed objective response rate(ORR).Based on results(ORR,88.0%;duration of response[DOR],11.8 months;progression-free survival[PFS],12.0 months)in 25 patients at run-in stage,second stage study was initiated and included 82 patients for efficacy/safety *** received prior-line(median,3)therapies,with 56.1%refractory to previous last therapies;73.2%experienced POD24 at *** stage 2,ORR was 86.6%(71/82;95%CI,77.3-93.1%),with 28(34.2%)complete *** control rate was 95.1%due to 7(8.5%)stable *** time to response was 1.8 *** 71 responders,median DOR was not reached;18-month DOR rate was 51.6%.with median follow-up of 13.3 months,median PFS was 18.5(95%CI,10.2-not estimable)*** overall survival(OS)was not reached by cutoff date;24-month OS rate was estimated as 86.1%.Response rates and survival data were consistent across all *** 3 or higher treatment-related adverse events were observed in 63(76.8%)cases,with neutropenia(22.0%),hyperglycemia(19.5%),and diarrhea(13.4%)being ***-B3525 showed favorable efficacy and safety for R/R FL patients after≥2 lines prior therapies.

关键词： lymphoma assessed initiated