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The role of circadian rhythm in breast cancer

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Chinese Journal of Cancer Research 2013年第4期25卷 442-450页

作者： Shujing Li Xiang Ao huijian wu The School of Life Science and Biotechnology Dalian University of Technology

The circadian rhythm is an endogenous time keeping system shared by most organisms. The circadian clock is comprised of both peripheral oscillators in most organ tissues of the body and a central pacemaker located in the suprachiasmatic nucleus （SCN） of the central nervous system. The circadian rhythm is crucial in maintaining the normal physiology of the organism including, but not limited to, cell proliferation, cell cycle progression, and cellular metabolism; whereas disruption of the circadian rhythm is closely related to multi-tumorigenesis. In the past several years, studies from different fields have revealed that the genetic or functional disruption of the molecular circadian rhythm has been found in various cancers, such as breast, prostate, and ovarian. In this review, we will investigate and present an overview of the current research on the influence of circadian rhythm regulating proteins on breast cancer.

关键词： Circadian rhythm breast cancer circadian proteins chronotherapy

MZF1(Myeloid Zinc Finger 1)activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF(P300/CBP associated factor)

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Genes & Diseases 2023年第5期10卷 1775-1778页

作者： Bowen Li Shujing Li Xiaoxia Shi Yini Zhang Zhiqiang Xin Yuxi Yang Binggong Zhao Ping Ren huijian wu School of Bioengineering&Key Laboratory of Protein Modification and Disease Liaoning ProvinceDalian University of TechnologyDalianLiaoning 116024China The Second Hospital of Dalian Medical University DalianLiaoning 116024China

p53 is an important tumor suppressor *** p53 pathway is activated in response to cellular stress ***,in more than 50%of breast cancers,p53 is mutated or inactivated,which permits cancer growth.1 Although a large number of co-regulators of p53 have been identified,the integrated molecular network of p53 and the key co-factors that could transactivate p53 remain unclear.2 Myeloid Zinc Finger 1(MZF1),a member of the SCAN-ZFP(SCAN-Zinc finger protein)family,has been involved in the occurrence and development of various types of malignant tumors,including breast cancer.3 However,the exact mechanism of action remains *** study aims to investigate the cross-regulatory loop between MZF1 and p53 in breast cancer cells.

关键词： SCAN Zinc p53

重译林语堂——从My Country and My People的翻译谈起

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学术界 2008年第6期 194-199页

作者：吴慧坚广东教育学院外语系广东广州510303

"对外讲中",是林语堂毕生努力最多成就最大的一个领域,集中体现在林语堂的一系列英文著述上。迄今为止,已有的相关译本在语言风格、意义表达上与原作大多存在明显差距,直接影响了林语堂研究的深入开展。只有把重译的工作做好,才能期待... 详细信息

"对外讲中",是林语堂毕生努力最多成就最大的一个领域,集中体现在林语堂的一系列英文著述上。迄今为止,已有的相关译本在语言风格、意义表达上与原作大多存在明显差距,直接影响了林语堂研究的深入开展。只有把重译的工作做好,才能期待出现高质量的研究成果,在林语堂研究日渐升温,林语堂的文化价值日益得到肯定的今天,学术界和出版界应该把重译林语堂提上议事日程。

关键词：林语堂重译《吾国与吾民》林语堂研究

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日本网络游戏典型案例评析

电子知识产权 2005年第6期 45-47页

作者：吴慧建日本立命馆大学

日本主要是依据日本著作权法及民法等现行法律和判例来解决有关游戏软件包括与网络游戏虚拟物相关的法律纠纷,保护权利人的合法权益.下面通过两个典型判例,介绍日本法院是如何适用这些规定的.

关键词：网络游戏日本案例评析法律纠纷著作权法合法权益软件包权利人判例民法适用法院

DEC1 Up-regulates the Stability of Cyclin E by inhibiting its ubiquitination

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DEC1 Up-regulates the Stability of Cyclin E by inhibiting it...

Steroid Receptor Co-activator-3 promotes breast cancer cell invasion and metastasis through SNAI1 expression

遗传学进步促进粮食安全与人口健康高峰论坛

作者： Dao Wang,huijian wu Department of Bioscience and Biotechnology,Dalian University of Technology,Dalian 116023

Overexpression of cyclin E associates with multi-tumorigenesis,including breast,colon, bladder,skin,lung cancer and so *** is noteworthy that cyclin E can be a prognostic marker in breast *** embryo-chondrocyte expressed gene 1(DEC1,also called BHLHE40, BHLHB2,Stra13,or Sharp2) and its related protein DEC2,are members of the basic helix-loop-helix(bHLH) family proteins which are involved in multi-cell progressions,such as cellular differentiation,proliferation,or apoptosis in various tumor *** our research,we found that DEC1 up-regulated the protein level of cyclin E in a dose-dependent manner and markedly extended the half-life of cyclin E in breast cancer cell,***,the level of cyclin E has no significant change in DEC1 overexpressed cells with treatment of MG132(ubiquitin-proteasome inhibitor),suggesting that DEC1 may regulate cyclin E protein stability through ubiquitin-proteasome ***,co-immunoprecipitation experiment showed that DEC1 significantly repressed the ubiquitination of cyclin E and the interaction between cyclin E and its ubiquitin E3 ligase ***,DEC1 stabilized cyclin E by blocking cyclin E proteasome *** the same time,overexpression of Cyclin E resulted in the decrease in the percentage of G1 phase ***,the study on the stability of Cyclin E will contribute to elucidating the molecular mechanism of the generation and development of breast cancer.

关键词： Cyclin E DEC1 Ubiquitination

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Steroid Receptor Co-activator-3 promotes breast cancer cell ...

向世界说“道”——论《老子的智慧》中“道”的互文阐释及其传播功用

遗传学进步促进粮食安全与人口健康高峰论坛

作者： Miao Wang,huijian wu School of Life Science and Biotechnology,Dalian University of Technology,Liaoning,China

Tumor metastasis is the major cause of treatment failure in mammary *** receptor co-activator-3(SRC-3) plays important roles in tumorigenesis and participated in the stage of breast cancer and contributes to invasion and metastasis of ***,the molecular mechanisms that mediate the role of SRC-3 in invasion and metastasis remains largely *** our study,SRC-3 wild type cells exhibited strong metastasis and invasion capabilities,reduced E-cadherin epithelial marker,and gained N-cadherin mesenchymal *** contrast,cells with SRC-3 knockout showed a weak ability to metastasis and invasion,along with retaining the expression of E-cadherin and less level of ***,SRC-3 wild type cells showed a significantly higher expression level of zinc finger protein SNAI1[a major factor governing epithelial-mesenchymal transition(EMT)]versus knockout ***,SNAI1 knockdown in SRC-3 wild type cells increased the expression of E-cadherin and reduced cell metastasis and *** demonstrated that SRC-3 directly binds to the SNAI1 promoter and acts as a transcriptional factor of SNAI1 Furthermore,we observed that SRC-3 cooperates with the SNAI1 to regulate the expression of E-cadherin,and then promotes breast cancer cell invasion and metastasis. The mechanism behind this cooperation involves physical interaction between these factors,leading to an increased binding of SNAI1 to the E-cadherin ***,SRC-3 raises SNAI1 expression to promote the invasiveness and metastasis of breast cancer *** data revealed that SRC-3 plays roles in transcriptional regulation network in a gene specific manner which is necessary for the EMT *** of SRC-3 function may provide new strategies to inhibit breast cancer metastasis.

关键词： SNAIL SRC-3 EMT

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广东第二师范学院学报 2019年第2期39卷 77-82页

作者：吴慧坚广东第二师范学院外语系广东广州510303

向世界阐释中华传统学说中的核心术语,是对外文化传播中的难点。从《老子的智慧》可以看到,林语堂在对外传播中华典籍时,善于运用互文阐释的翻译策略,创造性地突破单纯照本翻译的局限,利用多篇文本之间的互动,构筑起文本的网络系统,帮... 详细信息

向世界阐释中华传统学说中的核心术语,是对外文化传播中的难点。从《老子的智慧》可以看到,林语堂在对外传播中华典籍时,善于运用互文阐释的翻译策略,创造性地突破单纯照本翻译的局限,利用多篇文本之间的互动,构筑起文本的网络系统,帮助读者在互文性参照下加深对中华传统学说中"道"等核心概念的理解。林语堂"对外讲中"的成功经验,仍可为今天的中华文化对外传播实践提供富有启发意义的独特视角与路径选择。

关键词：林语堂互文阐释老子道

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碳含量对自保护明弧高铬堆焊涂层性能的影响

热加工工艺 2014年第16期43卷 137-140,144页

作者：龚建勋吴慧剑田兵湘潭大学机械工程学院湖南湘潭411105

采用药芯焊丝明弧自保护焊方法制备了含有2.0%～4.5%C、21%～23%Cr、1.5%～1.7%Si、0.2%～0.3%B（质量分数）的耐磨涂层,对其显微组织及耐磨性进行了表征,并考察了碳含量的影响。结果表明,其显微组织由酌-Fe＋α-Fe＋M7C3＋M3（C,B）＋S... 详细信息

采用药芯焊丝明弧自保护焊方法制备了含有2.0%～4.5%C、21%～23%Cr、1.5%～1.7%Si、0.2%～0.3%B（质量分数）的耐磨涂层,对其显微组织及耐磨性进行了表征,并考察了碳含量的影响。结果表明,其显微组织由酌-Fe＋α-Fe＋M7C3＋M3（C,B）＋Si5C3＋Fe4N等组成。随碳含量提高,胞状富铬酌-Fe基体数量逐渐减小,直至消失,而位于晶界区域的硬质相体积分数增加。当碳含量为3.5%时,出现15～40μm六边形初生M7C3相颗粒,Fe4N相因石墨氧化形成保护气体量增加而下降。此外,湿砂耐磨性试验结果显示,堆焊涂层磨损为磨粒微切削机制为主,但无明显的塑性变形痕迹,其耐磨性不仅取决于其初生M7C3相数量,还与其共晶组织中二次M7C3数量和形态相关。

关键词：明弧自保护堆焊耐磨性显微组织

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ERα辅调节因子在乳腺癌中的双重调控作用

中国细胞生物学学报 2014年第10期36卷 1437-1442页

作者：许兆伟赵锋伍会健大连理工大学生命科学与技术学院大连116024

在发达国家,乳腺癌一直是威胁女性健康的恶性肿瘤之一。雌激素受体α(estrogen receptor alpha,ERα)是一种配体依赖性的转录因子,其介导的基因转录调控在乳腺癌的增殖、分化、侵袭和转移等过程中发挥重要作用。ERα主要依赖于辅调节因... 详细信息

在发达国家,乳腺癌一直是威胁女性健康的恶性肿瘤之一。雌激素受体α(estrogen receptor alpha,ERα)是一种配体依赖性的转录因子,其介导的基因转录调控在乳腺癌的增殖、分化、侵袭和转移等过程中发挥重要作用。ERα主要依赖于辅调节因子共同调控下游靶基因的表达。近年来,有研究证实,一些关键转录辅调节因子在调节ER转录活性的同时,也可以作为泛素E3连接酶,促进ERα的降解。该文详细介绍几种辅调节因子对ERα的双重调节作用,有助于从分子水平阐明不同类型乳腺癌中造成ERα表达量差异的机制,为乳腺癌的靶向治疗和预防提供理论依据。

关键词： ERα 辅调节因子乳腺癌转录调控泛素E3连接酶