MZF1(Myeloid Zinc Finger 1)activates transcriptional activity of p53 and suppresses breast cancer cell proliferation via acetyltransferase PCAF(P300/CBP associated factor)

作     者：Bowen Li Shujing Li Xiaoxia Shi Yini Zhang Zhiqiang Xin Yuxi Yang Binggong Zhao Ping Ren Huijian Wu Bowen Li;Shujing Li;Xiaoxia Shi;Yini Zhang;Zhiqiang Xin;Yuxi Yang;Binggong Zhao;Ping Ren;Huijian Wu

作者机构：School of Bioengineering&Key Laboratory of Protein Modification and DiseaseLiaoning ProvinceDalian University of TechnologyDalianLiaoning 116024China The Second Hospital of Dalian Medical UniversityDalianLiaoning 116024China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第5期

页      面：1775-1778页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by grants(No.81872263 to H.W.)from the National Natural Science Foundation of China 

主　　题：SCAN Zinc p53 

摘      要：p53 is an important tumor suppressor *** p53 pathway is activated in response to cellular stress ***,in more than 50%of breast cancers,p53 is mutated or inactivated,which permits cancer growth.1 Although a large number of co-regulators of p53 have been identified,the integrated molecular network of p53 and the key co-factors that could transactivate p53 remain unclear.2 Myeloid Zinc Finger 1(MZF1),a member of the SCAN-ZFP(SCAN-Zinc finger protein)family,has been involved in the occurrence and development of various types of malignant tumors,including breast cancer.3 However,the exact mechanism of action remains *** study aims to investigate the cross-regulatory loop between MZF1 and p53 in breast cancer cells.