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Four centrosome-related genes to predict the prognosis and drug sensitivity of patients with colon cancer

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1908-1924页

作者： hui-yan wang yan Diao Pei-Zhu Tan Huan Liang Department of Clinical Laboratory Harbin Medical University Cancer HospitalHarbin 150086Heilongjiang ProvinceChina Department of Clinical Laboratory Heilongjiang Province HospitalHarbin 150000Heilongjiang ProvinceChina Translational Medicine Center of Northern China Harbin Medical UniversityHarbin 150081Heilongjiang ProvinceChina

BACKGROUND As the primary microtubule organizing center in animal cells,centrosome abnormalities are involved in human colon *** To explore the role of centrosome-related genes(CRGs)in colon *** CRGs were collected from public *** clustering analysis was performed to separate the Cancer Genome Atlas *** Cox and least absolute shrinkage selection operator regression analyses were performed to identify candidate prognostic CRGs and construct a centrosome-related signature(CRS)to score colon cancer patients.A nomogram was developed to evaluate the CRS risk in colon cancer *** integrated bioinformatics analysis was conducted to explore the correlation between the CRS and tumor immune microenvironment and response to immunotherapy,chemotherapy,and targeted ***-cell transcriptome analysis was conducted to examine the immune cell landscape of core prognostic *** A total of 726 CRGs were collected from public databases.A CRS was constructed,which consisted of the following four genes:TSC1,AXIN2,COPS7A,and *** cancer patients with a high-risk signature had poor *** with a high-risk signature exhibited decreased levels of plasma cells and activated memory CD4+T *** treatment response,patients with a high-risk signature were resistant to immunotherapy,chemotherapy,and targeted ***7A expression was relatively high in endothelial cells and ***1 expression was high in endothelial cells,fibroblasts,and malignant *** We constructed a centrosome-related prognostic signature that can accurately predict the prognosis of colon cancer patients,contributing to the development of individualized treatment for colon cancer.

关键词： Colon cancer Centrosome Signature Prognostic Immune microenvironment Therapy

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Notably Accelerated Nano-Bainite Transformation via Increasing Undissolved Carbides Content on GCr15Si1Mo Bearing Steel

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Acta Metallurgica Sinica(English Letters) 2024年第4期37卷 703-712页

作者： yan-hui wang Hua-Qiang Sun Wen-Jing Feng Lei-Jie Zhao Xiang Chen Qing-An Chen Hai-Tao Sun Jian-Jun wang Zhi-Nan yang Key Laboratory of Intelligent Industrial Equipment Technology of Hebei Province School of Mechanical and Equipment EngineeringHebei University of EngineeringHandan056038China Collaborative Innovation Center for Modern Equipment Manufacturing of Jinan New Area Hebei University of EngineeringHandan056038China School of Materials Science and Engineering Tsinghua UniversityBeijing100084China Avic Shang da Superalloys Company Limited Xingtai054800China National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004China

In this study, a high-carbon nano-bainitic GCr15Si1Mo bearing steel was investigated. Specifically, the effects of content and size of undissolved carbides on the microstructure and transformation kinetics of nano-bainite were analyzed. The results demonstrated that after prolonged austempering at low temperatures, the mixed microstructure composed of nano-bainite (NB), undissolved carbides (UC), and retained austenite (RA) was obtained in GCr15SiMo steel. When the experimental steel was austenitized at 900 ℃, the undissolved carbides gradually dissolved until reaching a stable state with increasing holding time. Furthermore, at the same austempering temperature, despite different volume fractions of undissolved carbides in the substrate, the volume fractions of nano-bainite in the final microstructures remained essentially the same. Moreover, the higher the content of undissolved carbides in steel, the faster the transformation rate of nano-bainite and the shorter the total transformation time.

关键词： Nano-bainite Undissolved carbides Bainitic transformation kinetics Carbon concentration

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Two different autorefractors for vision screening in children and adolescents

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 331-338页

作者： Xiao-Jun Chen Lin-Jie Liu Bing Sun Dan-Dan Jiang Shu-Shu Zuo yan-hui wang Chun-Hua Zhang yan-yan Chen School of Optometry and Ophthalmology Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina

AIM:To compare the consistency of two autorefractors(Tianle RM-9000 and Topcon KR-800)for school-age myopia children,and to provide a basis for largescale data analysis and ***:The refractive error in 909 subjects(age 4–18y)were measured using both autorefractors without *** data were analyzed using Fourier decomposition and the correlation coefficients,intraclass correlation coefficients(ICC),and Bland-Altman limits of agreement(LoA)for each parameter were ***:There was a strong correlation between the spherical equivalent(SE),sphere diopter(DS),and cylinder diopter(DC)readings of the Tianle RM-9000 and those of the Topcon KR-800,with correlation coefficient values of 0.98,0.98 and 0.83 and ICC values of 0.99,0.99 and 0.93,***,the correlation coefficients and ICC values of J0 and J45 were unreliable(R=-0.004,-0.034;both ICC<0.10).Bland-Altman analysis revealed that SE,DS,and DC measured by the Tianle RM-9000 were significantly biased toward myopia compared with the Topcon KR-800,and the mean differences were-0.072,-0.026,-0.091 D,respectively(all P<0.01).The minimum absolute value of the difference within the 95%LoA for SE,DS,and DC was 0.63 D,0.50 D,0.62 D,respectively;all these values were in the clinically acceptable *** J0 and J45,the mean differences were close to zero(P=0.43,0.84);however,the 95%LoA were relatively wide(J0 SD:0.53;95%CI:-1.00,1.10;J45 SD:0.52;95%CI:-1.00,1.00).CONCLUSION:The two autorefractors are consistent with each other,as the differences in SE,DS,and DC were within the clinically acceptable *** can compare the data measured by either device in different studies and use the two devices in the same study to generate a dataset that can be analyzed ***,the J0 and J45 vectors are unreliable and should not be used to assess astigmatism.

关键词： refractive error autorefractors school-age myopia children

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A model for automatic identification of human pulse signals

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2008年第10期9卷 1382-1389页

作者： hui-yan wang Pei-yong ZHANG College of Computer Science and Information Engineering Zhejiang Gongshang University Hangzhou 310018 China Institute of VLSI Design Zhejiang University Hangzhou 310027 China

This paper presents a quantitative method for automatic identification of human pulse signals. The idea is to start with the extraction of characteristic parameters and then to construct the recognition model based on Bayesian networks. To identify depth, frequency and rhythm, several parameters are proposed. To distinguish the strength and shape, which cannot be represented by one or several parameters and are hard to recognize, the main time-domain feature parameters are computed based on the feature points of the pulse signal. Then the extracted parameters are taken as the input and five models for automatic pulse signal identification are constructed based on Bayesian networks. Experimental results demonstrate that the method is feasible and effective in recognizing depth, frequency, rhythm, strength and shape of pulse signals, which can be expected to facilitate the modernization of pulse diagnosis.

关键词： Pulse signal identification Feature extraction Bayesian network Quantitative diagnosis Wavelet transform

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Capillary electrophoresis with direct chemiluminescence detection for the analysis of catecholamines in human urine

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Chinese Chemical Letters 2007年第4期18卷 452-454页

作者： Cheng Quan wang hui wang yan Ming Liu College of Chemistry and Chemical Engineering Xinyang Normal University Xinyang 464000 China

A rapid and sensitive method for the analysis of three catecholamines by capillary electrophoresis （CE） with direct chemiluminescence （CL） detection is described. The detection limits （S/N= 3） were 1.3 × 10^-8 g/mL for isoprenaline, 1.0 × 10^-8g/mL for epinephrine and 2.8 × 10^-8 g/mL for dopamine. The proposed method was successfully applied to the analysis of catecholamines in urine samples of cigarette smokers and nonsmokers. The results showed that there is a close relation between the release of dopamine in human body fluids and cigarette smoking/nonsmoking.

关键词： Capillary electrophoresis Catecholamines Chemiluminescence detection Urine

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Lipase immobilized on HOOC-MCF:A highly enantioselective catalyst for transesterification resolution of (R,S)-1-phenylethanol

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Chinese Chemical Letters 2007年第8期18卷 929-932页

作者： Ping Xue Xiang hui yan Zheng wang Key Laboratory of Energy Resources and Chemical Engineering Ningxia University Yinchuan 750021 China

Pseudomonas cepacia lipase （PSL） immobilized on the carboxyl-functionalized meso-cellular foams （HOOC-MCF） was used for the transesterification resolution of （R,S）-l-phenylethanol in organic solvent. The results showed that the ee value of （S）-1- phenylethanol and （R）-1-phenylethyl acetate reached 99% with 50% conversion of 1-phenylethanol using toluene as solvent. Furthermore, it was found that PSL/HOOC-MCF exhibited high enantioselectivity in organic solvent with log P ≤ 2 such as toluene and hexane.

关键词： Immobilized lipase Enantioselectivity Chiral resolution 1-Phenylethanol

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Coordinate Control,Motion Optimization and Sea Experiment of a Fleet of Petrel-Ⅱ Gliders

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Chinese Journal of Mechanical Engineering 2018年第1期31卷 127-141页

作者： Dong-yang Xue Zhi-Liang Wu yan-hui wang Shu-Xin wang Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin University School of Mechanical Engineering Tianjin University The Joint Laboratory of Ocean Observing and Detecting Qingdao National Laboratory for Marine Science and Technology

The formation of hybrid underwater gliders has advantages in sustained ocean observation with high resolution and more adaptation for complicated ocean tasks. However, the current work mostly focused on the traditional gliders and *** research on control strategy and energy consumption minimization for the hybrid gliders is necessary both in methodology and experiment. A multi-layer coordinate control strategy is developed for the fleet of hybrid underwater gliders to control the gliders’ motion and formation geometry with optimized energy consumption. The inner layer integrated in the onboard controller and the outer layer integrated in the ground control center or the deck controller are designed. A coordinate control model is proposed based on multibody theory through adoption of artificial potential fields. Considering the existence of ocean flow, a hybrid motion energy consumption model is constructed and an optimization method is designed to obtain the heading angle, net buoyancy, gliding angle and the rotate speed of screw propeller to minimize the motion energy with consideration of the ocean flow. The feasibility of the coordinate control system and motion optimization method has been verified both by simulation and sea trials. Simulation results show the regularity of energy consumption with the control variables. The fleet of three Petrel-Ⅱ gliders developed by Tianjin University is deployed in the South China Sea. The trajectory error of each glider is less than 2.5 km, the formation shape error between each glider is less than 2 km, and the difference between actual energy consumption and the simulated energy consumption is less than 24% actual energy. The results of simulation and the sea trial prove the feasibility of the proposed coordinate control strategy and energy optimization method. In conclusion, a coordinate control system and a motion optimization method is studied, which can be used for reference in theoretical research and practical f

关键词： Underwater glider Petrel-Ⅱ Coordinate control Path planning Artificial potential fields(APFs) Energy consumption

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Discharge estimation based on machine learning

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Water Science and Engineering 2013年第2期6卷 145-152页

作者： Zhu JIANG hui-yan wang Wen-wu SONG School of Energy and Environment Xihua University

To overcome the limitations of the traditional stage-discharge models in describing the dynamic characteristics of a river, a machine learning method of non-parametric regression, the locally weighted regression method was used to estimate discharge. With the purpose of improving the precision and efficiency of river discharge estimation, a novel machine learning method is proposed： the clustering-tree weighted regression method. First, the training instances are clustered. Second, the k-nearest neighbor method is used to cluster new stage samples into the best-fit cluster. Finally, the daily discharge is estimated. In the estimation process, the interference of irrelevant information can be avoided, so that the precision and efficiency of daily discharge estimation are improved. Observed data from the Luding Hydrological Station were used for testing. The simulation results demonstrate that the precision of this method is high. This provides a new effective method for discharge estimation.

关键词： stage-discharge relationship discharge estimation locally weighted regression clustering-tree weighted regression k-nearest neighbor method

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Analysis of Rolling Pressure in Asymmetrical Rolling Process by Slab Method

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Journal of Iron and Steel Research International 2009年第4期16卷 22-26,38页

作者： TIAN Yong GUO yan-hui wang Zhao-dong wang Guo-dong State Key Laboratory of Rolling and Automation Laboratory Northeastern University Shenyang 110004 Liaoning China

The plane strain asymmetrical rolling was analyzed using slab method. The contact arc was replaced by parabola, and the constant surface friction status was adopted during the analysis. The deformation area was divided into three zones according to the direction of the friction. Then, the three zones were studied, respectively. A rolling force model and a rolling torque model were developed based on the analysis, and they were used to analyze the influ- ence of asymmetrical rolling factors on deformation area and unit pressure if they had good precision which was determined by comparing the calculated results with the measured ones.

关键词： asymmetrical rolling slab method asymmetrical factor specific pressure distribution

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System Identification Method for Evaluating the Effect of Thickness Error on Backcalculated Pavement Layer Moduli

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上海交通大学学报 2004年第Z2期38卷 182-187页

作者： ZHONG yan-hui wang Fu-ming ZHANG Bei CAI Ying-chun Dalian University of Technology Dalian116024 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Zhengzhou University Zhengzhou450002 P. R. China Chonging University Chongqing400044 P. R. China Dalian University of Technology Dalian116024 P. R. China Zhengzhou University Zhengzhou450002 P. R. China

Based on system identification theory and FWD testing data, the effect of thickness error on backcalculating pavement layer moduli is studied and the method of singular value decomposition (SVD) is presented to solve the morbidity problem of sensitivity matrix in this *** results show that the thickness error has great effects on the backcalculated pavement layer moduli. The error of backcalculated moduli can be controlled within the range of ±15% by limiting the thickness error within the range of ±5%.

关键词： system identification singular value decomposition (SVD) backcalculation pavement falling weight deflectometer (FWD) moduli thickness

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