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Relationship between different surgical methods,hemorrhage position,hemorrhage volume,surgical timing,and treatment outcome of hypertensive intracerebral hemorrhage

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World Journal of Emergency Medicine 2014年第3期5卷 203-208页

作者： Feng-ling Chi Tie-cheng Lang Shu-jie Sun Xue-jie Tang Shu-yuan Xu Hong-bo Zheng hui-song zhao Department of Neurosurgery Shanghai 7th Hospital Yueyang Hospital Aff iliated to Shanghai University of Traditional Chinese Medicine Emergency Medicine Department Dongfang Hospital of Shanghai Second Hospltal of Dalian Medical University Shanghai Pudong New Area Gongli Hospital First People's Hospital of Qiqihaer City Third Aff iliated Hospital Qiqihar Medical College

BACKGROUND:The present study aimed to explore the relationship between surgical methods,hemorrhage position,hemorrhage volume,surgical timing and treatment outcome of hypertensive intracerebral hemorrhage(HICH).METHODS:A total of 1 310 patients,who had been admitted to six hospitals from January 2004 to January 2008,were divided into six groups according to different surgical methods:craniotomy through bone fl ap(group A),craniotomy through a small bone window(group B),stereotactic drilling drainage(group C1 and group C2),neuron-endoscopy operation(group D) and external ventricular drainage(group E) in consideration of hemorrhage position,hemorrhage volume and clinical practice. A retrospective analysis was made of surgical timing and curative effect of the surgical ***:The effectiveness rate of the methods was 74.12% for 1 310 patients after onemonth follow-up. In this series,the disability rate was 44.82% 3–6 months after the operation. Among the 1 310 patients,241(18.40%) patients died after the operation. If hematoma volume was >80 mL and the operation was performed within 3 hours,the mortality rate of group A was signifi cantly lower than that of groups B,C,D,and E(P<0.05). If hematoma volume was 50–80 mL and the operation was performed within 6–12 hours,the mortality rate of groups B and D was lower than that of groups A,C and E(P<0.05). If hematoma volume was 20–50 mL and the operation was performed within 6–24 hours,the mortality rate of group C was lower than that of groups A,B and D(P<0.05).CONCLUSIONS:Craniotomy through a bone f lap is suitable for patients with a large hematoma and hernia of the brain. Stereotactic drilling drainage is suggested for patients with hematoma volume less than 80 mL. The curative effect of HICH individualized treatment would be improved via the suitable selection of operation time and surgical method according to the position and volume of hemorrhage.

关键词： Hypertensive intracerebral hemorrhage Hemorrhage position Hemorrhage volume Surgical timing Stereotactic drilling drainage Treatment effect Individualized Polycentric

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TRIPLET combined with microwave ablation:A novel treatment for advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 10-12页

作者： Fei-Yu zhao Guo-Wei Si Nian-song Qian Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100853China Department of Gastroenterology Fourth Medical CentreGeneral Hospital of the People's Liberation ArmyBeijing 100142China Senior Department of Thoracic Oncology Respiratory and Critical Care MedicineThe Eighth Medical Center of People’s Liberation Army General HospitalBeijing 100091China

This editorial comments on a study by Zuo et *** focus is on the efficacy of he-patic arterial infusion chemotherapy combined with camrelizumab and apatinib(the TRIPLET regimen),alongside microwave ablation therapy,in treating advanced hepatocellular carcinoma(HCC).The potential application of this combination therapy for patients with advanced HCC is evaluated.

关键词： Microwave ablation Hepatic arterial infusion chemotherapy Apatinib Camrelizumab Hepatocellular carcinoma

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基于工业机器人的汽车轮毂表面缺陷的视觉检测系统设计

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计算机测量与控制 2018年第9期26卷 13-16,22页

作者：宋辉李钊沈阳工业大学信息科学与工程学院沈阳110870

由于汽车轮毂结构复杂,为解决当前轮毂检测效率低,检测速度慢,工作量大等问题,文章给出了一种基于工业机器人的视觉检测方法;通过把视觉系统安装在机器人的末端执行器上,利用机器人的精确运动来改变视觉系统的姿态,以实现对汽车轮毂各... 详细信息

由于汽车轮毂结构复杂,为解决当前轮毂检测效率低,检测速度慢,工作量大等问题,文章给出了一种基于工业机器人的视觉检测方法;通过把视觉系统安装在机器人的末端执行器上,利用机器人的精确运动来改变视觉系统的姿态,以实现对汽车轮毂各表面的检测,进而可实现对多规格轮毂进行动态检测,并针对多次重复测量时定位累计误差导致成像质量退化的问题,通过对轮毂图像的预处理找到了轮毂的气阀作为检测的初始位置,对机器人调节相应的位姿进行校正;该文以HONDA 1.6X17摩托车轮毂作为研究对象,实验表明,该系统在准确检测的同时,提高了检测效率。

关键词：工业机器人视觉系统定位图像处理

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电厂化学废水处理中重金属离子的去除技术研究

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纯碱工业 2024年第4期 26-29页

作者：惠兆松中石化(天津)石油化工有限公司天津300000

概述了传统重金属离子去除技术,包括化学沉淀法、离子交换法和电解法等,并指出其优缺点。随后,重点介绍了新型重金属离子去除技术,如纳米材料吸附技术、微生物燃料电池技术和植物修复技术等,这些技术以其高效、环保的特点备受关注。文... 详细信息

概述了传统重金属离子去除技术,包括化学沉淀法、离子交换法和电解法等,并指出其优缺点。随后,重点介绍了新型重金属离子去除技术,如纳米材料吸附技术、微生物燃料电池技术和植物修复技术等,这些技术以其高效、环保的特点备受关注。文章详细探讨了电厂化学废水处理中重金属离子去除技术的优化策略,包括精确调控化学沉淀条件、利用新型吸附材料以及引入电化学技术等。旨在为电厂化学废水处理提供新的高效解决方案。

关键词：化学废水处理重金属离子去除技术电化学技术纳米材料

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响应曲面优化余甘子多酚的亚临界水萃取工艺及其抗氧化性研究

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中国食品添加剂 2017年第9期28卷 75-81页

作者：唐仕荣宋慧高兆建黄莹徐州工程学院食品(生物)工程学院徐州221018 徐州工程学院江苏省食品资源开发与质量安全重点建设实验室徐州221018

以余甘子干果粉为原料,研究亚临界水萃取余甘子多酚的工艺条件及其抗氧化活性。通过单因素试验探讨了亚临界水萃取余甘子多酚工艺中萃取温度、萃取时间、萃取压力和液料比等因素对多酚提取率的影响,利用响应曲面分析法优化提取工艺。最... 详细信息

以余甘子干果粉为原料,研究亚临界水萃取余甘子多酚的工艺条件及其抗氧化活性。通过单因素试验探讨了亚临界水萃取余甘子多酚工艺中萃取温度、萃取时间、萃取压力和液料比等因素对多酚提取率的影响,利用响应曲面分析法优化提取工艺。最佳优化工艺参数:余甘子干果粉碎过40目筛,纯水80m L,液料比47∶1,亚临界萃取温度212℃,提取11min,余甘子多酚平均提取率17.08%,实测值与预测值符合良好。高效液相分析表明,亚临界水萃取样品中没食子酸提取率达3.284%,远高于溶剂回流提取。体外抗氧化活性研究表明,亚临界水萃取余甘子多酚具有一定清除DPPH自由基和羟基自由基的能力,其IC50值分别为7.05μg/m L和54.35μg/m L,小于TBHQ和溶剂回流提取样品。体现了亚临界水萃取具有较好的选择性、快速、高效、环境友好等优点。

关键词：亚临界水萃取余甘子多酚响应曲面抗氧化性

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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige song Chao Xu Kai zhao Guoqiang Liu Youming Lu Xinyan Li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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车号识别系统的收发天线研究

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铁道学报 2002年第4期24卷 73-77页

作者：邱景辉宋朝晖李红梅哈尔滨工业大学铁路高新技术研究所黑龙江哈尔滨150001

收发天线采用微带矩形贴片天线阵 ,本文用传输线模型法分析和设计。为简化分析 ,辐射单元被看成是由一段低阻抗传输线连接的两个缝隙。本文给出了开路半波谐振器及微带线阵的设计方法与步骤。该天线在设计时选用最小单元间距方法 ,减小... 详细信息

收发天线采用微带矩形贴片天线阵 ,本文用传输线模型法分析和设计。为简化分析 ,辐射单元被看成是由一段低阻抗传输线连接的两个缝隙。本文给出了开路半波谐振器及微带线阵的设计方法与步骤。该天线在设计时选用最小单元间距方法 ,减小天线体积 ,同时易于匹配 ,提高增益带宽。在 90 2 MHz～ 92 8MHz工作时 ,实测天线驻波小于 1.4 ,增益大于 9d B,半功率波瓣宽度大于 6

关键词：车号识别系统收发天线微带天线天线阵射频识别

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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng zhao Bin Dai Lei Ye Tao song Shuai Huang Jia Wang Tao You Department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina Department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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中国黄淮海地区玉米杂种优势候选位点的鉴定

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玉米科学 2017年第1期25卷 15-23页

作者：周玲梁帅强吕远大张体付戴惠学赵松涛赵涵江苏省农业科学院农业生物技术研究所/江苏省农业生物学重点实验室南京210014 南京市蔬菜科学研究所南京210042 江苏农科种业研究院有限公司南京210014

通过对全基因组重测序数据分析发现120 122个高质量In Del和SNP变异位点,通过这些位点可以将具有不同遗传背景的285份玉米自交系划分为9大类群,包括黄淮海地区两大杂种优势群PA和SPT群。检测PA和SPT群间自交系基因型频率的分布和差异发... 详细信息

通过对全基因组重测序数据分析发现120 122个高质量In Del和SNP变异位点,通过这些位点可以将具有不同遗传背景的285份玉米自交系划分为9大类群,包括黄淮海地区两大杂种优势群PA和SPT群。检测PA和SPT群间自交系基因型频率的分布和差异发现,1 251个杂种优势候选位点不均匀分布在玉米10条染色体上,其中,675个位点与42个已报道的杂种优势相关QTLs一致。基于候选位点,对部分黄淮海地区的主栽杂交品种进行杂合性分析,In Del和SNP结果均表明,这些位点的杂合性显著高于其他区域,研究结果验证了本研究获得的候选区域的可靠性,表明这些候选位点的杂合性已被广泛的运用于育种过程中。

关键词：玉米杂种优势群群体结构遗传变异位点遗传杂合率

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Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige Jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan song Yahong Cheng Tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

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