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The intragraft vascularized bone marrow component plays a critical role in tolerance induction after reconstructive transplantation

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Cellular & Molecular Immunology 2021年第2期18卷 363-373页

作者： cheng-Hung Lin Madonna R.Anggelia hui-yun cheng Aline Yen Ling Wang Wen-Yu Chuang Chih-Hung Lin W.P.Andrew Lee Fu-Chan Wei Gerald Brandacher Center for Vascularized Composite Allotransplantation Department of Plastic and Reconstructive SurgeryChang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Graduate Institute of Biomedical Sciences College of MedicineChang Gung UniversityTaoyuanTaiwanChina Department of Pathology Chang Gung Memorial HospitalChang Gung Medical College and Chang Gung UniversityTaoyuanTaiwanChina Department of Plastic and Reconstructive Surgery Chiayi Chang Gung Memorial HospitalChiayi CountyTaiwanChina Department of Plastic and Reconstructive Surgery Vascularized Composite Allotransplantation(VCA)LaboratoryJohns Hopkins University School of MedicineBaltimoreMDUnited States

The role of the vascularized bone marrow component as a continuous source of donor-derived hematopoietic stem cells that facilitate tolerance induction of vascularized composite allografts is not completely *** this study,vascularized composite tissue allograft transplantation outcomes between recipients receiving either conventional bone marrow transplantation(CBMT)or vascularized bone marrow(VBM)transplantation from Balb/c(H2d)to C57BL/6(H2b)mice were *** high-or low-dose CBMT(1.5×10^(8)or 3×10^(7)bone marrow cells,respectively)was *** addition,recipients were treated with costimulation blockade(1 mg anti-CD154 and 0.5 mg CTLA4Ig on postoperative days 0 and 2,respectively)and short-term rapamycin(3 mg/kg/day for the first posttransplant week and then every other day for another 3 weeks).Similar to high-dose conventional bone marrow transplantation,5/6 animals in the vascularized bone marrow group demonstrated long-term allograft survival(>120 days).In contrast,significantly shorter median survival was noted in the low-dose CBMT group(~64 days).Consistently high chimerism levels were observed in the VBM transplantation ***,low levels of circulating CD4^(+)and CD8^(+)T cells and a higher ratio of Treg to Teff cells were maintained in VBM transplantation and high-dose CBMT recipients(>30 days)but not in low-dose VBM transplant ***-specific hyporesponsiveness was shown in tolerant recipients in *** of the vascularized bone marrow component after secondary donor-specific skin transplantation did not affect either primary allograft or secondary skin graft survival.

关键词： Vascularized composite allotransplantation Costimulation blockade Donor-specific tolerance Vascularized bone marrow transplantation Chimerism

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Clinical analysis of multiple primary malignancies in the digestive system: A hospital-based study

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World Journal of Gastroenterology 2005年第27期11卷 4215-4219页

作者： hui-yun cheng cheng-Hsin Chu Wen-Hsiung Chang Tzu-Chi Hsu Shee-Chan Lin Chuan-Chuan Liu An-Ming Yang Shou-Chuan Shih Shih Health Evaluation Center Mackay Memorial hospital TaipeiTaiwan China Department of Internal Medicine Mackay Memorial Hospital Taipei Taiwan China Department of Surgery Mackay Memorial HospitalTaipei Taiwan China Mackay Medicine Nursing and Management College Taipei Taiwan China

AIM： To analyze the characteristics of multiple primary malignancies （MPMs） of digestive system; including incidence, types of tumor combinations, time intervals between development of multiple tumors, clinical course,and prognostic factors affecting survival and ***： Data from a total of 129 patients treated from January 1991 to December 2000 for pathologically proved MPMs, including at least one originating from the digestive system, were reviewed ***： Among 129 patients, 120 （93.02%） had two primary cancers and 9 （6.98%） had three primary cancers. The major sites of MPMs of the digestive system were large intestine, stomach, and liver. Associated nondigestive cancers included 40 cases of gynecological cancers, of which 31 were carcinoma of cervix and 10 cases of genitourinary cancers, of which 5 were bladder cancers. Other cancers originated from the lung, breast,nasopharynx, larynx, thyroid, brain, muscle, and *** tract cancers, especially cervical, ovarian,bladder, and prostate cancers were the most commonlyassociated non-G! cancers, followed by cancer of the lung and breasts. Forty-three cases were synchronous, while the rest （86 cases） were metachronous cancers. Staging of MPMs and treatment regimes correlated with the prognosis between survival and non-survival ***： As advances in cancer therapy bring about a progressively larger percentage of long-term survivors, the proportion of patients with subsequent primary lesions will increase. Early diagnosis of these lesions, based on an awareness of the possibility of second and third cancers, and multidiscipiinary treatment strategies will substantially increase the survival of these patients.

关键词： Multiple primary malignancies Digestive system

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan cheng hui Gao Shujia Huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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SM22α参与血清饥饿诱导的血管平滑肌细胞微丝重塑

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细胞生物学杂志 2006年第1期28卷 95-98页

作者：程云会韩梅温进坤河北医科大学基础医学研究所河北省医学生物技术重点实验室石家庄050017

血清饥饿可诱导体外培养的血管平滑肌细胞(vascularsmoothmusclecells,VSMC)由合成型转变为收缩型,微丝重塑是该过程的一个重要事件。平滑肌22α(smoothmuscle22alpha,SM22α)是VSMC的标志蛋白,为了证实SM22α是否参与调节VSMC的微丝重... 详细信息

血清饥饿可诱导体外培养的血管平滑肌细胞(vascularsmoothmusclecells,VSMC)由合成型转变为收缩型,微丝重塑是该过程的一个重要事件。平滑肌22α(smoothmuscle22alpha,SM22α)是VSMC的标志蛋白,为了证实SM22α是否参与调节VSMC的微丝重塑过程,采用反义技术,封闭SM22α表达,利用间接免疫荧光染色、透射电镜观察SM22α表达对VSMC微丝重塑的影响,利用细胞平面迁移实验观察SM22α表达对VSMC运动功能的影响。实验结果显示,在血清饥饿培养的VSMC中,伴随着SM22α和SMα肌动蛋白表达上调,微丝数量明显增多,呈极性束状分布。用反义SM22α抑制SM22α表达后,血清饥饿诱导的VSMC微丝重塑受阻,微丝纤细,排列紊乱,且细胞迁移活性下降。结果提示,在VSMC微丝组装过程中,SM22α可能起一种捆绑蛋白作用。

关键词：血管平滑肌细胞平滑肌22 α 丝重塑迁移

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Ideal Bi-Based Hybrid Anode Material for Ultrafast Charging of Sodium-Ion Batteries at Extremely Low Temperatures

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NANO-MICRO LETTERS 2025年第1期17卷 1-16页

作者： Bai, Jie Jia, Jian hui Wang, Yu Yang, Chun cheng Jiang, Qing Jilin Univ Key Lab Automobile Mat Sch Mat Sci & Engn Minist Educ Changchun 130022 Peoples R China

Metallic nanoparticles with excellent size controllability and high loading rate are obtained via ultrafast high temperature shock *** Bi/CNRs-15 electrode exhibits an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, while the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C.A novel strategy of high-rate activation is proposed to obtain high capacity and superior stability at low temperature by creating new active sites for interfacial reaction. Sodium-ion batteries have emerged as competitive substitutes for low-temperature applications due to severe capacity loss and safety concerns of lithium-ion batteries at - 20 degrees C or lower. However, the key capability of ultrafast charging at ultralow temperature for SIBs is rarely reported. Herein, a hybrid of Bi nanoparticles embedded in carbon nanorods is demonstrated as an ideal material to address this issue, which is synthesized via a high temperature shock method. Such a hybrid shows an unprecedented rate performance (237.9 mAh g-1 at 2 A g-1) at - 60 degrees C, outperforming all reported SIB anode materials. Coupled with a Na3V2(PO4)3 cathode, the energy density of the full cell can reach to 181.9 Wh kg-1 at - 40 degrees C. Based on this work, a novel strategy of high-rate activation is proposed to enhance performances of Bi-based materials in cryogenic conditions by creating new active sites for interfacial reaction under large current.

关键词： Bi nanoparticles High temperature shock High-rate activation Ultrafast charging Low-temperature sodium-ion batteries

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改进MUSIC算法对信号DOA的估计

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系统仿真学报 2005年第1期17卷 223-224,230页

作者：高星辉张承云常鸿森广州大学信息与控制工程系广东广州510091 华南师范大学物理系广东广州510631

MUSIC算法能有效地估计出独立信号源的DOA,并且在模型准确的前提下,对DOA的估计可以达到任意精度;但对相干信号源和相隔比较近的小信噪比信号源,MUSIC算法就不能估计出它们的DOA了。这里通过理论推导提出了一种改进MUSIC算法,计算机仿... 详细信息

MUSIC算法能有效地估计出独立信号源的DOA,并且在模型准确的前提下,对DOA的估计可以达到任意精度;但对相干信号源和相隔比较近的小信噪比信号源,MUSIC算法就不能估计出它们的DOA了。这里通过理论推导提出了一种改进MUSIC算法,计算机仿真的结果表明了该改进MUSIC算法既能够有效地估计出独立信号源的DOA,也能有效地估计出相关信号源和相隔比较近的小信噪比信号源的DOA,从而证明了这种改进MUSIC算法的合理性。

关键词： DOA MUSIC 相关仿真

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第三代流式细胞分选仪及96孔板分选单个细胞的方法及参数优化

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中国临床医学 2016年第6期23卷 846-850页

作者：闵智慧程韵枫复旦大学附属中山医院临床研究院实验研究中心上海200032 复旦大学附属中山医院青浦分院实验研究中心上海201700 上海市器官移植重点实验室上海200032 复旦大学附属中山医院血液科上海200032 复旦大学附属中山医院青浦分院血液科上海201700

目的：用第三代流式细胞分选仪比较不同直径喷嘴分选的单细胞的得率及细胞活性,进一步完善单细胞微孔板分选的参数设置及条件优化。方法：用FACSAriaⅢ流式细胞分选仪及96孔板对Raji细胞、A549、DT 40、RAW 264.7细胞系进行单细胞分选,... 详细信息

目的：用第三代流式细胞分选仪比较不同直径喷嘴分选的单细胞的得率及细胞活性,进一步完善单细胞微孔板分选的参数设置及条件优化。方法：用FACSAriaⅢ流式细胞分选仪及96孔板对Raji细胞、A549、DT 40、RAW 264.7细胞系进行单细胞分选,分别采用70μm、100μm和130μm喷嘴分选,比较分选后单细胞得率及克隆形成率。结果：在单细胞分选模式下,用3种不同直径喷嘴及96孔板分选后的单细胞得率为86.55%-93.44%,即96孔板有单细胞的孔数为84-92孔;分选后的单个细胞培养7d后,经70μm、100μm和130μm喷嘴分选的单细胞克隆孔数分别为31-52孔、49-70孔、58-78孔。结论：进行单细胞微孔板分选时,在精确调节及优化实验参数的前提下,为了保证单细胞的活性,应优先选择100μm或130μm喷嘴。

关键词：单细胞分选流式细胞分选仪 96孔板喷嘴液滴延迟

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： Zhao-Jun Zhang Wen-Wei Wang Jing-Shui Zhen Bo-cheng Li De-cheng Cai Yang-Yang Du hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China Department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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教学的文化实践属性及三个基本认识向度

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 137-143页

作者：程良宏王芸新疆师范大学教育科学学院新疆高等教育发展研究中心新疆乌鲁木齐830017

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深... 详细信息

教学不仅是知识传递行为,而且是具有文化交往和文化生产属性的实践活动。文本认为,从教学目的、教学主体和教学内容入手探析教学在知识传递传承背后的文化实践特质,是理解教学具有文化交往和文化生产属性的三个基本认识向度。因此,要深入体认教学作为一种特殊的文化交往和生产实践形态,明晰以文化人、以文育人的导引和践行为目的指引,以教师与学生为文化交往和文化生产的实践主体,以教学过程中对教材与师生文化的理解再造为文化实践的基本内容。

关键词：教学实践教学的文化属性文化生产

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Analysis of Resistant Spectrum to Rice Blast in Transgenic Rice Lines Introduced Lysozyme Gene from T4 Phage

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Agricultural Sciences in China 2003年第3期2卷 273-279页

作者： XU Ming-hui, LI cheng-yun , LI Jin-bin, TAN Xue-lin, TIAN Wen-zhong and TANG Zuo-shunInstitute of Biotechnology , yunnan Academy of Agricultural Sciences , Kunming 650223 , P. R. China Institute of Plant Protection , yunnan Academy of Agricultural Sciences , Kunming 650205 , P. R. China Rice Research Institute, yunnan Agricultural University, Kunming 650201 , P. R. China Institute ofGenetics and Development Biology , Chinese Academy of Sciences , Beijing 100101 , P. R. China) Institute of Biotechnology Yunnan Academy of Agricultural Sciences Kunming 650223 P. R. China Institute of Plant Protection Yunnan Academy of Agricultural Sciences Kunming 650205 P. R. China Rice Research Institute Yunnan Agricultural University Kunming 650201 P. R. China Institute of Genetics and Development Biology Chinese Academy of Sciences Beijing 100101 P. R. China

The receptor cultivar Nan29 and thirty-six T5 rice lines derived from ten T0 generation transgen-ic plants harboring lysozyme gene were challenged in the greenhouse by inoculating 63 isolates belonging to 48 races of Magnaporthe grisea from yunnan Province. The transgenic rice lines exhibited resistance to more than 72% of isolates inoculated in this experiment, and 38.1% (24 isolates) of them could infect the receptor cultivar Nan29. The results indicated that the transgenic rice lines possessed wide-spectrum resistance against various rice blast races and the resistant spectrum of rice lines were different although some lines derived from same T0 plant. The transgenic rice lines exhibited also high resistance to leaf and neck blast in the disease field evaluation, but not all of resistant lines against leaf blast were resistant to neck blast.

关键词： Rice Lysozyme gene Rice blast Resistant spectrum

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