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高血压病患者血清瘦素含量与IR水平的相关性研究

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同济大学学报（医学版） 2004年第6期25卷 480-483页

作者：肖玲吴国亭韩玉麒复旦大学附属金山医院内分泌科上海200540 同济大学附属第十人民医院内分泌科上海200072

目的　探讨高血压病患者血清瘦素水平与胰岛素抵抗的关系。方法　正常对照组 4 9例 ,高血压组 4 7例 ,用放射免疫分析法检测血清瘦素水平 ,稳态模式评估法计算胰岛素抵抗指数 (insulinresance ,IR)。进行统计学处理 ,分析瘦素与其他各... 详细信息

目的　探讨高血压病患者血清瘦素水平与胰岛素抵抗的关系。方法　正常对照组 4 9例 ,高血压组 4 7例 ,用放射免疫分析法检测血清瘦素水平 ,稳态模式评估法计算胰岛素抵抗指数 (insulinresance ,IR)。进行统计学处理 ,分析瘦素与其他各项参数的相关性。结果　leptin血清浓度有明显的性别差异 ,无论正常对照组还是高血压组男∶女均约为 1∶4。原发性高血压病患者空腹胰岛素、IR值比正常对照组明显升高 (P s(r=0 .0 34,P >0 .0 5 ) ,IR值 (r =0 .0 5 6 ,P >0 .0 5 )无相关。与其余参数均无相关。结论　原发性高血压亻并发症与胰岛素抵抗及高胰岛素血症有关 ,但leptin与胰岛素抵抗及原发性高血压病的发病关系尚不明确。

关键词：胰岛素抵抗瘦素高血压原发性

sUR1基因多态性与胰岛β细胞功能相关性家系研究

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同济大学学报（医学版） 2004年第6期25卷 465-468页

作者：汪纯吴国亭于永春滕小宏王吉影李文君同济大学附属第十人民医院内分泌科上海200072 同济大学附属第十人民医院中心实验室上海200072

目的　通过对上海地区 2.糖尿病家系sUR1基因多态性的研究 ,探讨sUR1基因对胰岛β细胞功能影响。方法　上海地区 2.糖尿病家系 5 5个 ,共 2.5 3人。选定sUR1基因 2.多态性位点 ,运用PCR -RFLP方法对每位入选者均进行基因型分析并经... 详细信息

目的　通过对上海地区 2.糖尿病家系sUR1基因多态性的研究 ,探讨sUR1基因对胰岛β细胞功能影响。方法　上海地区 2.糖尿病家系 5 5个 ,共 2.5 3人。选定sUR1基因 2.多态性位点 ,运用PCR -RFLP方法对每位入选者均进行基因型分析并经测序证实。测定空腹C肽及胰岛素判断胰岛 β细胞功能 ,并测定体重指数、血压等生理指标及总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯等临床指标。结果　 (1 )空腹C肽 :1 6号外显子c/t基因型、t/t基因型高于c/c基因型 ,差异存在显著性 ;31号外显子G/A +A/A基因型低于G/G基因型 ,差异存在显著性 ;G/A +A/A +c/c组低于G/G +c/c组 ,差异存在显著性。 (2.)空腹胰岛素 :1 6号外显子 - 3c→t多态性tt纯合子明显高于cc纯合子 ,而 31号外显子AGG→AGA多态性则差异无显著性。结论　sUR1基因的多态性和突变对胰岛β细胞功能有一定影响。 1 6号外显子t等位基因携带者空腹C肽较cc纯合子升高。 31号外显子A等位基因携带者空腹C肽较非携带者低。 1 6号外显子tt纯合子空腹胰岛素明显高于cc纯合子。

关键词： sUR1 基因多态性聚合酶链反应限制性片段长度多态性胰岛β细胞

Cine MRI对女性盆底功能障碍性疾病的诊断价值

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同济大学学报（医学版） 2009年第5期30卷 62-65,69页

作者：姚晓岚汤光宇姚冀平刘勇成佳景童晓文同济大学附属第十人民医院妇产科上海200072 同济大学附属第十人民医院医学影像科上海200072

目的探讨cine MRI在女性盆底功能障碍性疾病(pelvic floor disfunction,PFD)的诊断价值,为临床术前制定手术方案提供信息。方法2.07年1至12.,以同济大学附属第十人民医院盆底功能障碍性疾病需手术治疗的住院患者2.例为研究组,同期临床... 详细信息

目的探讨cine MRI在女性盆底功能障碍性疾病(pelvic floor disfunction,PFD)的诊断价值,为临床术前制定手术方案提供信息。方法2.07年1至12.,以同济大学附属第十人民医院盆底功能障碍性疾病需手术治疗的住院患者2.例为研究组,同期临床无盆底功能障碍性疾病症状和体征的患者15例为对照组。两组患者在平静状态和Valsalva动作时分别进行正中矢状位动态磁共振扫描,观察盆腔器官的位置和盆底形态。结果对照组膀胱颈、子宫颈、肛直肠连接位置静息时均位于耻尾线以上,盆腔用力时均有不同程度的下降,但平均下降幅度不大;研究组术前膀胱颈、子宫颈、肛直肠连接位置在盆腔用力时下降幅度明显。结论Cine MRI优于普通MRI扫描可用于全面评价盆腔器官脱垂和盆底形态;发现一些平时难以发现的轻微改变,对复杂盆底功能性疾病进行早期而全面的影像诊断,有助于临床手术方案的制定。

关键词：盆腔器官脱垂 cine MRI 诊断

Changes of the peripapillary vascular parameters inpremature infants without retinopathy of prematurityusing U-net segmentation

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International Journal of Ophthalmology(English edition) 2024年第8期17卷 1453-1461页

作者： shuai Liu Lei Liu Cui-Xia Ma Liu-hui Huang Bin Li school of Information science and Technology University of Science and Technology of ChinaHefei 230022Anhui ProvinceChina Zhejiang Lab Hangzhou 311121Zhejiang ProvinceChina Eye Institute Affiliated Hospital of Nantong UniversityMedical School of Nantong UniversityNantong 226006Jiangsu ProvinceChina Anhui Province Maternity and Child Health Hospital Maternity and Child Health Hospital Affiliated to Anhui Medical UniversityHefei 230001Anhui ProvinceChina department of Ophthalmology Tenth People’s Hospital Affiliated with Shanghai Tongji University School of MedicineShanghai 200072China

AIM:To quantitatively assess the changes in mean vascular tortuosity(mVT)and mean vascular width(mVW)around the optic disc and their correlation with gestational age(GA)and birth weight(BW)in premature infants without retinopathy of prematurity(ROP).METHODs:A single-center retrospective study included a total of 133(133 eyes)premature infants[mean corrected gestational age(CGA)43.6wk]without ROP as the premature group and 130(130 eyes)CGA-matched fullterm infants as the control *** peripapillary mVT and mVW were quantitatively measured using computerassisted ***:Premature infants had significantly higher mVT(P=0.0032.and lower mVW(P=0.0086)by 2.68(10^(4) cm^(-3))and 1.85μm,*** analysis with GA showed significant differences(P=0.02.4)in mVT between the early preterm and middle to late preterm groups,but the differences between mVW were not significant(P=0.6652..The results of the multiple linear regression model showed a significant negative correlation between GA and BW with mVT after adjusting sex and CGA(P=0.02.1 and P=0.0006,respectively).For each day increase in GA at birth,mVT decreased by 0.12.1(10^(4) cm^(-3))and for each 1 g increase in BW,mVT decreased by 0.006(10^(4) cm^(-3)).However,GA(P=0.9402.and BW(P=0.72.5)were not significantly correlated with ***:Preterm birth significantly affects the peripapillary vascular parameters that indicate higher mVT and narrower mVW in premature infants without *** in these parameters may provide new insights into the pathogenesis of ocular vascular disease.

关键词： premature infants retinopathy of prematurity retinal vessels parameter computer-assisted techniques

Multidisciplinary integration of frontier technologies facilitating the development of anesthesiology and perioperative medicine in aging society

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Fundamental Research 2024年第4期4卷 795-796页

作者： Lize xiong Junli Cao Hailong Dong Weihong song Dong Ming Translational Research Institute of Brain and Brain-Like Intelligence and department of Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital Affiliated to Tongji University School of MedicineShanghai 200434China Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical UniversityXuzhou 221004China department of Anesthesiology and Perioperative Medicine Xijing Hospitalthe Fourth Military Medical UniversityXi'an 710032China The second Affliated Hospital and Yuying Children's Hospital Institute of AgingKey Laboratory of Alzheimer's Disease of Zhejiang ProvinceWenzhou Medical UniversityWenzhou325035China state Key Laboratory of Advanced medical Materials and Devices Medical SchoolTianjin UniversityTianjin 300072China Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration Tianjin 300380China

The population aged 60 and over in china reached approximately 2.7 million in 2.2. according to the National Bureau of statistics,accounting for 2..1%of the national *** population aged 65 and over was about 2.7 million,accounting for 15.4%[1].It is estimated that by 2.35,china will have an elderly population of over 400 million,accounting for more than 30%of the total population,thereby entering a stage of severe *** brings many challenges to the society,especially in terms of {2. care for elderly *** continuous advancement of science and technology,especially the breakthrough in basic research as well as new technologies and interdisciplinary integration,has brought new opportunities for the development of various professional *** better address the challenges of anesthesia and perioperative medicine in the aging era and to accelerate the rehabilitation of patients while maintaining life and health services,it is crucial to promote interdisciplinary integration.

关键词： breakthrough frontier thereby

Beneficial Effects of Traditional Chinese Medicine Fuzheng Huayu on the Occurrence of Hepatocellular Carcinoma in Patients with Compensated Chronic Hepatitis B Cirrhosis Receiving Entecavir:A Multicenter Retrospective Cohort study

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Journal of Clinical and Translational Hepatology 2024年第5期12卷 505-515页

作者： Haina Fan shujuan Lei Zhimin Zhao Yan Huang hui Wang xudong Liu Xiaodong Li Min xu Wei Zhang Kewei sun huichun Xing Yang Mei Jiaquan Huang Chuanwu Zhu Kejun Zhang Yali Zong Xizhong shen Qing Xie Chenghai Liu Institute of Liver Diseases Shanghai Key Laboratory of Traditional Chinese Clinical MedicineKey Laboratory of Liver and Kidney Diseases(Ministry of Education)Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Infectious Diseases Ruikang Hospital Affiliated to Guangxi University of Chinese MedicineNanningGuangxiChina Institute of Liver Diseases Hubei Provincial Hospital of Traditional Chinese MedicineWuhanHubeiChina department of Infectious Diseases Huaian Fourth People’s HospitalHuai’anJiangsuChina Institute of Liver Diseases Shijiazhuang Fifth HospitalShijiazhuangHebeiChina department of Liver Diseases The First Hospital of Hunan University of Chinese MedicineChangshaHunanChina Center of Hepatology Capital Medical University Affiliated Beijing Ditan HospitalBeijingChina department of Hepatology The Fifth People’s Hospital of AnyangAnyangHenanChina department and Institute of Infectious Disease Tongji Hospital of Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubeiChina department of Hepatology The Fifth People’s Hospital of SuzhouSuzhouJiangsuChina department of Gastroenterology The First People’s Hospital of JingmenJingmenHubeiChina department of Integrated Traditional and Western Medicine The Ninth Hospital of NanchangNanchangJiangxiChina department of Gastroenterology Zhongshan HospitalFudan UniversityShanghaiChina

Background and Aims:The application of antifibrotic drugs to treat patients with chronic liver diseases who are receiving antiviral therapies for hepatocellular carcinoma(HCC)has not been ***,we aimed to assess the impact of the Traditional Chinese Medicine Fuzheng Huayu(FZHY)on the occurrence of HCC in patients with hepatitis B virus-related compensated cirrhosis receiving the antiviral drug entecavir(ETV).Methods:A multicenter retrospective cohort study was *** liver cirrhosis patients were divided into the ETV+FZHY group or the ETV group according to *** cumulative incidence of HCC was analyzed using Kaplan-Meier and log-rank *** score matching was used for confounding *** analysis and Cox regression were used to determine the effects of FZHY on the occurrence of HCC and liver function ***:Out of 910 chronic hepatitis B patients,458 were in the ETV+FZHY group and 452.were in the ETV *** propensity score matching,the 5-year cumulative incidence of HCC was 9.8%in the ETV+FZHY group and 2..8%in the ETV group(psted hazard ratio for HCC was 0.2.6(0.108,0.432.when FZHY treatment was>36 ***,diabetes,alanine aminotransferase,􀇄-glutamyl transpeptidase,albumin,hepatitis B e-antigen,and fibrosis 4 score were associated with the occurrence of *** decreased the risk of HCC in patients aged>45 years with a hepatitis B virus DNA level of􀂕2.000 IU/***:Adjunctive FZHY treatment reduced HCC occurrence in patients with hepatitis B virus cirrhosis who were treated with ETV,possibly due to the antifibrotic properties of FZHY.

关键词： Entecavir Fuzheng Huayu Hepatitis B virus Cirrhosis Hepatocellular carcinoma Traditional Chinese Medicine

Best practice for infection prevention in pediatric respiratory clinics during the COVID‑19 epidemic

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World Journal of Pediatrics 2020年第4期16卷 326-332页

作者： Jing Zhang Lei Zhang Yong Yin Quan Lu Jian‑Guo Hong Xiao‑Bo Zhang Xiao‑Jian Zhou Li‑Bo Wang Jian‑Hua Zhang Min Lu Xiao‑Yan Dong Jie shao Yan‑Ming Lu Jun Yu Li Gu Respiratory Disease Group,Pediatric Committee of shanghai medical Association,shanghai,china department of Respiratory Medicine Shanghai Children’s Medical CenterShanghai Jiao Tong University School of MedicineNo.1678 Dongfang RoadShanghaiChina department of Respiratory Medicine Children’s Hospital of Shanghai Jiao Tong UniversityShanghaiChina department of Pediatrics Shanghai General HospitalShanghai Jiao Tong UniversityShanghaiChina department of Respiratory Medicine Children’s Hospital of Fudan UniversityShanghaiChina department of Respiratory Medicine XinHua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Pediatrics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Pediatrics Renji HospitalShanghai Jiao Tong University School of MedicineShanghaiChina department of Pediatrics Shanghai FengXian District Central HospitalShanghaiChina department of Pediatrics Shanghai Tenth People’s HospitalTong Ji UniversityShanghaiChina 不详

During the COVID-19 epidemic,it is important for ensuring infection prevention and control in the pediatric respiratory ***,we introduced the practice of infection prevention and control in pediatric respiratory clinics in *** measures for patients who visit respiratory clinics,quality control for pediatric respiratory clinics and other preventive measures for related examinations and treatment have been introduced in this review article.

关键词： prevention pediatric respiratory

A modified CZ-1 preservation solution for multi-organ transplantation:comparative study with UW preservation solution

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A modified CZ-1 preservation solution for multi-organ transp...

Innovation of Urban Planning Administration system of china

第十五届全国泌尿外科学术会议

作者： ZHENG Jun-hua1, MIN Zhi-lian2. LI Yu-li3, ZHU You-hua2. YE Ting-jun3, LI Jian-qiu4, PAN Tie-wen4, DING Guo-shan5, WANG Meng-long5 department of Urology, shanghai 10th {2.’s Hospital, tongji university, shanghai 2.0072

Objective: To validate a china-made multi-organ preservation solution CZ-1 experimentally and clinically, and compare it with UW solution. Methods: A new organ preservation solution called NO.1 Changzheng Multi-Organ ...

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china City Planning Review 2008年第2期17卷 24-32页

作者： GAO Zhonggang,PhD,College of Architecture and Urban Planning,tongji university senior Planner,{2.,P.R.china.LI Caige

1. Problems existing in current urban planning administration system of china since china’s reform and especially the promulgation of City Planning Law of the {2.’s Republic of china,

关键词： administration execution municipal provincial supe