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Novel noninvasive quantification of penile corpus caver no sum lesions in hyperlipidemia-induced erectile dysfunction in rabbits by two-dimensional shear-wave elastography

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Asian Journal of Andrology 2019年第2期21卷 143-149页

作者： Jian-Lin Hu hui-Xing chen hui-rong chen Yu Wu Xiao-Wen Sun Zheng Li Jin-Fang Xing Department of Reproductive Medicine Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Andrology Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China Department of Urology Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 201620China Department of Medical Ultrasound Shanghai General HospitalShanghai Jiao Tong UniversitySchool of MedicineShanghai 200080China

Structural alterations in fibroelastic compone nts of the penile corpus caver no usum(CC)may impair its compliance,resulting in venous leakage and erectile dysfunction(ED).Our study evaluated the effectiveness of noninvasive two-dimensional shear-wave elastography(2-D SWE)in quantifying penile CC lesions in rabbits with hyperlipidemia-induced ED.A total of 12 New Zealand white rabbits were randomly divided into two *** were fed a high-cholesterol diet containing 2%cholesterol and 8.5%lard for 10 weeks and the other six were fed normal diet as *** measured the shear-wave elastic quantitative(SWQ)value of penile CC by 2-D *** function was inv estigated by intracavernous injecti on of pa pa ver i ne,and immunohistochemical(IHC)stain inga nd the wester n blot analysis to determine the penile CC *** 10 weeks,the SWQ values obtained from penile CC were remarkably higher in the high-cholesterol-fed compared with the control group,and the AICP(ICP plateau minus ICP baseline)/MAP(ICP:intracavernous pressure,MAP:mean arterial pressure)was markedly *** IHC staining and western blot revealed extracellular matrix(ECM)accumulation in penile cavernous tissues,and the smooth muscle cell(SMC)phenotypic transition was affected,as indicated by reduced alpha-smooth muscle actin and calponinexpression and increased phospho-myosin light chain?。(p-MLC20)/MLC20 and osteopontin *** resulted in ECM accumulation accompanied with SMC phenotypic transition in penile CC and impaired the erectile function *** might,in turn,lead to variations in the SWQ *** suggests that 2-D SWE may be a novel,noninvasive and effective approach that distinguishes penile CC lesions secondary to hyperlipidemia from normal.

关键词： corpus cavernosum erectile dysfunction extracellular matrix accumulation phenotypic transition shear-wave elastography smooth muscle cells

Modeling of Magneto-Rheological Damper with Neural Network

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Journal of China University of Mining and Technology 2006年第1期16卷 50-52,56页

作者： Zhang Hong-hui Liao Chang-rong chen Wei-min The Key Laboratory for Opto-Electronic Technology ＆ Systems Education Ministry of China Chongqing University Chongqing 400044 China

With the revival of magnetorheological technology research in the 1980’s, its application in vehicles is in- creasingly focused on vibration suppression. Based on the importance of magnetorheological damper modeling, non- parametric modeling with neural network, which is a promising development in semi-active online control of vehicles with MR suspension, has been carried out in this study. A two layer neural network with 7 neurons in a hidden layer and 3 inputs and 1 output was established to simulate the behavior of MR damper at different excitation currents. In the neural network modeling, the damping force is a function of displacement, velocity and the applied current. A MR damper for vehicles is fabricated and tested by MTS; the data acquired are utilized for neural network training and vali- dation. The application and validation show that the predicted forces of the neural network match well with the forces tested with a small variance, which demonstrates the effectiveness and precision of neural network modeling.

关键词： magneto-theological damper modeling neural network

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Clinical features and microsurgical reconstruction of congenital unilateral absence of the vas deferens with obstructive azoospermia:a tertiary care center experience

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Asian Journal of Andrology 2023年第1期25卷 73-77页

作者： Yi-Hong Zhou Jian-Jun Dong Er-Lei Zhi chen-cheng Yao Yu-Hua Huang Ru-hui Tian hui-Xing chen Ying-Bo Dai Yu-Xin Tang Na-Chuan Liu hui-rong chen Fu-Jun Zhao Zheng Li Peng Li Department of Andrology The Center for Men's HealthUrologic Medical CenterShanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Department of Urology The Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Department of Andrology Jiaozuo Maternity and Infant Health HospitalJiaozuo 454000China

Patients with congenital unilateral absence of the vas deferens(CUAVD)manifest diverse symptoms from normospermia to *** for CUAVD patients with obstructive azoospermia(OA)is complicated,and there is a lack of relevant *** this study,we describe the clinical features and evaluate the treatments and outcomes of CUAVD patients with *** December 2015 to December 2020,33 patients were diagnosed as CUAVD with OA in Shanghai General Hospital(Shanghai,China).Patient information,ultrasound findings,semen analysis,hormone profiles,and treatment information were collected,and the clinical outcomes were *** 33 patients,29 patients were retrospectively ***(VE)or cross VE was performed in 12 patients,the patency rate was 41.7%(5/12),and natural pregnancy was achieved in one of the *** other 17 patients underwent testicular sperm extraction as the distal vas deferens(contralateral side)was *** findings showed that VE or cross VE remains an alternative treatment for CUAVD patients with OA,even with a relatively low rate of patency and natural pregnancy.

关键词： congenital unilateral absence of the vas deferens natural pregnancy obstructive azoospermia patency vasoepididymostomy

The role of urethral pressure profile on treating premature ejaculation by tamsulosin

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Asian Journal of Andrology 2014年第5期16卷 792-793页

作者： hui-rong chen Fu-Jun Zhao Xiao-Hai Wang Qi Jiang Qi Zhang Ban-Ming Han Jun Lu Shu-Jie Xia Department of Urology Shanghai First People's Hospital Shanghai Jiao Tong University Shanghai China

Dear Editor, I am Dr. hui-rong chen, from the Department of Urology in Shanghai First People＇s Hospital at Shanghai Jiao Tong UnNersity, Shanghai, China. Premature ejaculation （PE） is a common sexual dysfunction, affecting approximately 20%-30% of sexually active men. According to intravaginal ejaculatory latency time （IELT） of l min, the incidence is approximately 1%-3%.1 PE is significantly associated with many personal and negative consequences, such as distress, frustration, and avoidance of sexual intimacy due to the inability of successful delayed ejaculation, α1-adrenergic blockers were effective in delaying ejaculation in approximately 50%-67% of the cases.2,3 Recently, abnormal ejaculation, an adverse infrequent side effect associated with the use of α1A-adrenergic blockers such as silodosin or tamsulosin, has drawn significant attention. Clinical studies suggested that this represents a relative anejaculation rather than a retrograde ejaculation. We present here the study to investigate the role of urethral pressure profile （UPP） on treating PE by tamsulosin.

关键词： The role urethral pressure

Laparoscopy-assisted D2 radical distal gastrectomy for advanced gastric cancer： initial experience

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Chinese Medical Journal 2009年第12期122卷 1404-1407页

作者： DU Xiao-hui LI rong chen Lin SHEN Di LI Song-yan GUO Qiang Department of General Surgery General Hospital of PLA Beijing 100853 China

Background Laparoscopy-assisted radical gastrectomy is gaining acceptance for treating early gastric cancer. However, few reports concerning the effectiveness of laparoscopy-assisted D2 radical distal gastrectomy （LADG） for advanced gastric cancer or data comparing the results obtained after open distal gastrectomy （ODG） are yet available. The aim of this study was to evaluate the method, feasibility and clinical result of LADG for advanced gastric cancer. Methods A retrospective study was performed comparing LADG and ODG for advanced gastric cancer. Seventy-eight patients who underwent LADG were compared with 90 patients who underwent ODG in terms of pathologic findings, operative outcome, and complications. Results There was no conversion to open surgery in the LADG group and no postoperative mortality of any patients. There were no significant differences between LADG and ODG in operative time （（245±35） vs （220±620） minutes）, complication rate （7.7% vs 10.0%）, and number of lymph nodes （23.5±6.0 vs 21.0±7.5）, while the blood loss was less after LADG （（110±25） vs （196±30） ml, P 〈0.05）. The time to postoperative flatus and postoperative hospital stay were shorter after LADG （（73.0±8.5） vs （102.0±10.5） hours, and （8.6±1.2） vs （12.1 ±2.5） days, P 〈0.05, respectively）. Conclusion LADG for advanced gastric cancer is feasible, safe, and minimally invasive.

关键词： gastric cancer laparoscopic distal gastrectomy minimally invasive surgery lymph node dissection

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A mutation in signal peptide of rat resistin gene inhibits differentiation of 3T3-L1 preadipocytes

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Acta Pharmacologica Sinica 2004年第12期25卷 139-145页

作者： Xi-rong GUO2,3, Hai-xia GONG2, Yan-qin GAO4, Li FEI, Yu-hui NI, rong-hua chen Department of Pediatrics, Center of Human Functional Genomics, Nanjing Medical University, Nanjing 210029, China 4Department of Pediatrics, the Third Affiliated Hospital of Nanjing Medical University, Yizheng 211900, China Department of Pediatrics Center of Human Functional Genomics Nanjing Medical University Nanjing 210029 Department of Pediatrics the Third Affiliated Hospital of Nanjing Medical University Yizheng 211900

AIM: To detect the resistin expression of white adipose tissue in diet-induced obese (DIO) versus diet-resistant (DR)rats, andto investigatethe relationshipof mutatedresistin and 3T3-L1 preadipocytes differentiation. METHODS: RT-PCR and Western Blot were used to detect gene /protein expression. 3T3-L1 cells were cultured, transfected, and induced to differentiation using 0.5 mmol/L 3-isobutyl-1-methyxanthine (MIX), 1 mg/L insulin, and 1 μmol/L dexamethasone. Oil red O staining was applied to detect the degree of preadipocytes differentiation. RESULTS: Expression of resistin mRNA was upregulated in DIO rats and downregulated in DR rats. However, the expression levels varied greatly within the groups. Sequencing of the resistin genes from DIO and DR rats revealed a Leu9Val (C25G) missense mutation within the signal peptide in one DR rat. The mutant resistin inhibited preadipocyte differentiation. Local experiments and Western blotting with tagged resistin fusion proteins identified both mutant and wild type proteins in the cytoplasm and secreted into the culture medium. Computer predictions using the Proscan and Subloc programs revealed four putative phosphorylation sites and a possible leucine zipper motif within the rat resistin protein. CONCLUSION: Resistin-increased differentiation may be inhibited by the mutation- containing precursor protein, or by the mutant non-secretory resistin isoform.

关键词： resistin mutation adipocyte differentiation obesity

Correlation between grain size,mechanical properties and deformed microstructure of Fe-20Mn-6Al-0.6C-0.15Si low-density steel

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Journal of Iron and Steel Research International 2025年第1期32卷 282-292页

作者： Qi Zhang Guang-hui chen Zheng-liang Xue Zheng-kun chen Guang Xu State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan430081HubeiChina Red Eagle Novel Refractory Materials Research Institute Zhejiang Red Eagle Group Co.Ltd.Huzhou313000ZhejiangChina

The effects of austenite grain size on the deformed microstructure and mechanical properties of an Fe-20Mn-6Al-0.6C-0.15Si(wt.%)low-density steel were *** microstructure of the experimental steel after solution treatment was single austenitic *** austenite grain size increased with solution temperature and time.A model was established to show the relationship between temperature,time and austenite grain size for the experimental *** addition,as the solution temperature increased,the strength decreased,while the elongation first increased and then *** decrease in elongation after solution treatment at 1100℃ for 90 min is contributed to the over-coarse austenite ***,after solution treatment at 900℃ for 90 min,the strength-elongation product reached the highest value of 44.4 GPa%.As the austenite grain size increased,the intensity of//tensile direction fiber *** was accompanied by a decrease in dislocation density,resulting in a lower fraction of low-angle grain boundaries and a lower work hardening ***,the austenite grain size has a critical influence on the mechanical properties of the low-density *** grains lead to a lower yield strength due to the Hall-Petch effect and a lower tensile strength because of lower dislocation strengthening.

关键词： Austenitic low-density steel Solution treatment Grain size Mechanical property Deformed microstructure

Federated local causal structure learning

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Science China(Information Sciences) 2025年第03期68卷 110-124页

作者： Kui YU chen rong Hao WANG Fuyuan CAO Jiye LIANG School of Computer and Information Hefei University of Technology School of Computer and Information Technology Shanxi University

Local causal structure learning(LCS) efficiently identifies a set of direct neighbors of a specified variable from observational data. Additionally, it distinguishes direct causes and direct effects of this variable without learning the entire causal structure. While many LCS algorithms have been proposed, they do not consider the data privacy-preserving problem,which has attracted extensive attention from academia and industry. To address this issue, we propose a federated local causal structure learning(FedLCS) algorithm to learn local causal structures in privacy-preserving data in a federated ***, FedLCS introduces a layer-wise federated local skeleton learning algorithm to construct the local skeleton. Based on this skeleton, it introduces a federated local skeleton orientation algorithm and an extension-and-backtracking orientation algorithm to orient the edges. Finally, FedLCS uses a federated local extension-and-backtracking orientation algorithm to orient the remaining edges. Extensive experiments on benchmark, synthetic, and real datasets demonstrate that FedLCS can learn the local causal structure of a given variable in a federated setting.

关键词： local causal structure learning federated learning directed acyclic graph privacy-preserving data federated layer-wise strategy

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Post-tunable salt gel electrolytes toward flexible supercapacitor switches

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Journal of Energy Chemistry 2025年第1期100卷 114-124页

作者： hui Wang Shuang chen Xuming Liu Qin Zhang Xin Liu Polymeric and Soft Materials Laboratory School of Chemistry and Life Science and Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012JilinChina Polymeric and Soft Materials Laboratory School of Chemical Engineering and Advanced Institute of Materials ScienceChangchun University of TechnologyChangchun 130012JilinChina

Convertible hydrogel supercapacitors have emerged as promising energy storage devices in switches,diodes,and ***,inherent weaknesses in ionic conductivity,mechanical properties,and water retention of hydrogel electrolytes seriously hinder their *** by the hardness conversion of sea cucumber skin,a conductivity and mechanics dual-tunable salt gel electrolyte is successfully *** salt gel presents a reversible switching of conductors-insulators and a mechanical regulation between softness and hardness via the dissolution-crystallization transition of sodium acetate trihydrate(SAT).Meanwhile,the salt gels spontaneously grow a layer of“armor”through saturated phase-change salt crystals effectively reducing water evaporation of hydrogel ***,this phase-change soft-rigid conversion strategy will expand the capabilities of gel-based flexible supercapacitors(area capacitance:258.6 mF cm^(-2)),and the capacitance retention rate could still reach 86.9%after 3000 cycles at high ***,the salt gel supercapacitor is potentially used in over-heat alarm *** is anticipated that the strategy of conductivity and mechanics of dual-tunable salt gel would provide a new perspective on the development of energy storage devices,wearable electronics,and flexible robots.

关键词： Supercapacitors Salt gels Reversible phase transition Post-tuning Conductivity switching

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