Estradiol is an independent risk factor for organic erectile dysfunction in eugonadal young men
作者机构：Department of AndrologyThe Center for Men's HealthUrologic Medical CenterShanghai Key Laboratory of Reproductive MedicineShanghai General HospitalShanghai Jiao Tong UniversityShanghai 200080China
出 版 物：《Asian Journal of Andrology》 (亚洲男性学杂志（英文版）)
年 卷 期：2020年第22卷第6期
页 面：636-641页
核心收录：
学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学]
基 金：This work was supported by grants from the National Key Research and Development Program(No.2017YFC1002003) the National Science Foundation for Young Scientists of China(No.81701428)
主 题：erectile dysfunction estradiol organic etiology testosterone young
摘 要：Erectile dysfunctio n attributable to testosterone deficiency is less comm on in young males,and the effect of estradiol on erectile function in eug on adal young males is un *** an a lyzed data from 195 male participa nts,including 143 eug on adal patients with erectile dysfunction and 52 healthy *** distinguish psychogenic and organic erectile dysfunction,penile rigidity was measured using the nocturnal penile tumescenee rigidity *** levels of sexual hormones were quantified by electrochemiluminescence,and penile vascular status was assessed by penile color Doppler *** serum estradiol levels and the ratio of estradiol to testosterone were higher in patients with organic erectile dysfunction than in patients with psychogenic erectile dysfunction or healthy *** erectile dysfunction was negatively associated with estradiol levels and the ratio of estradiol to testosterone,and estradiol was the only sign ifica nt risk factor for orga nic erectile dysf un ction(odds ratio:1.094;95%con fide nee interval:1.042-1.149,P=0.000).Moreover,serum estradiol levels were negatively correlated with penile *** estradiol levels were higher and penile rigidity was lower in patients with venous erectile dysfunction than in patients with nonvascular erectile dysf *** con elude that elevated serum estradiol levels may impair erectile function and may be involved in the pathoge nesis of organic erectile dysfunction in eugonadal young men.
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