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Application of antibody-conjugated small intestine submucosa to capture urine-derived stem cells for bladder repair in a rabbit model

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Bioactive Materials 2022年第8期7卷 443-455页

作者： Yu-Ting Song Yan-qing Li Mao-Xuan Tian Jun-Gen Hu Xiu-Ru Zhang Peng-Cheng Liu Xiu-Zhen Zhang qing-Yi Zhang Li Zhou Long-Mei Zhao Jesse Li-Ling hui-Qi Xie Laboratory of Stem Cell and Tissue Engineering Orthopedic Research InstituteMed-X Center for MaterialsState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengduSichuan610041China Department of Aesthetic Surgery The People’s Hospital of PengzhouChengduSichuan611930China Surgery of Spine and Spinal Cord Henan Provincial People’s HospitalZhengzhouHenan450000China Department of Burn and Plastic Surgery West China HospitalSichuan UniversityChengduSichuan610041China Research Core Facility of West China Hospital Sichuan UniversityChengduSichuan610041China Department of Medical Genetics and Prenatal Diagnosis West China Second HospitalSichuan UniversityChengduSichuan610041China

The need for bladder reconstruction and side effects of cystoplasty have spawned the demand for the development of alternative material *** such as submucosa of small intestine(SIS)have been widely used as patches for bladder repair,but the outcomes are not fully *** capture stem cells in situ has been considered as a promising strategy to speed up the process of re-cellularization and *** this study,we have developed an anti-CD29 antibody-conjugated SIS scaffold(AC-SIS)which is capable of specifically capturing urine-derived stem cells(USCs)in situ for tissue repair and *** scaffold has exhibited effective capture capacity and sound *** vivo experiment proved that the AC-SIS scaffold could promote rapid endothelium healing and smooth muscle *** endogenous stem cell capturing scaffolds has thereby provided a new revenue for developing effective and safer bladder patches.

关键词： Regenerative medicine Bladder tissue engineering Scaffold Antibody-conjugated

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Neuropsychiatric disorders and cognitive dysfunction in patients with Cushing＇s disease

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Chinese Medical Journal 2013年第16期126卷 3156-3160页

作者： CHEN Yu-fan LI Yun-feng CHEN Xiao SUN qing-fang Department of Neurosurgery Ruijin Hospital Affiliated Hospital ofShanghai Jiaotong University Shanghai 200025 China

Objective To review the main neuropsychiatric disorders and cognitive deficits in patients with Cushing＇s disease （CD） and the associated pathophysiological mechanisms underlying *** mechanistic details may provide recommendations for preventing or treating the cognitive impairments and mood disorders in patients with *** sources Data were obtained from papers on psychiatric and cognitive complications in CD published in English within the last 20 *** perform the PubMed literature search,the following keywords were input：cushing＇s disease,cognitive,hippocampal,or *** selection Studies were selected if they contained data relevant to the topic addressed in the particular *** of the limited length of this article,we have frequently referenced recent reviews that contain a comprehensive amalgamation of literature rather than the actual source *** Patients with active CD not only suffer from many characteristic clinical features,but also show some neuropsychiatric disorders and cognitive *** the psychiatric manifestations,the common ones are emotional instability,depressive disorder,anxious symptoms,impulsivity,and cognitive *** effects of previous glucocorticoid （GC） excess on the central nervous system,such as hippocampal and the basal ganglia,is the most reasonable *** secretion of cortisol brings much structural and functional changes in hippocampal,such as changes in neurogenesis and morphology,signaling pathway,gene expression,and glutamate *** volume loss can be found in most patients with CD,and decreased glucose utilization caused by GCs may lead to brain atrophy,neurogenesis impairment,inhibition of long-term potentiation,and decreased neurotrophic factors; these may also explain the mechanisms of GC-induced brain atrophy and hippocampal *** Brain atrophy and hippocampal changes caused by excess secretion of cortisol are thoug

关键词： cushing's disease psychology cognitive symptoms hippocampal glucocorticoids

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Proteome Analysis of Neisseria meningitidis Serogroup Strains C Associated with Outbreaks in China

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Biomedical and Environmental Sciences 2010年第4期23卷 251-258页

作者： YUAN HU ZHU-JUN SHAO XIAO-MEI YAN BO-qing LI FEI ZHAO DI XIAO JUN REN MING-HUAN ZHENG CHUN-XIANG fan LI-HUA HE LI XU YI-XIN GU HAI JIANG FENG-HUA GUO ZHEN-WEI DAI HONG-YU REN MEI-JUAN LU XIA CHEN qing-HUA ZOU fan-LIANG MENG JIAN-ZHONG ZHANG National Institute for Communicable Disease Control and Prevention China CDC P O Box 5 Changping Beijing 102206 China Anhui Provincial Center for Disease Control and Prevention Hefei 230061 Anhui China

Objective During 2003-2005, an outbreak of meningitis due to Neisseria meningitidis serogroup C occurred in China. With the aim to find strain clues result in the final epidemics, the ancestral strain 053442, a clinical isolate, and a carrier strain 053426 with different gene type were analyzed. Methods Clinical strain 053442 and carrier strain 053426 were cultured on GC agar plates under the same condition. Two-dimensional electrophoresis was performed using the pH 3–10 nonlinear IPG strips of 24 cm length, and all the protein spots were identified by matrix-assisted laser desorption/ionization time of flight spectrometry. Results 502 and 380 protein spots were identified in 053426 and 053442 respectively, relating to 266 and 202 different genes covering a wide range of cellular functions. The express volume and number of proteins involved in energy metabolism, protein synthesis and amino acid biosynthesis in 053426 were higher than in 053442. Virulence factor Opa, Opc and a series of proteins involved in pilus assembly and retraction were identified in 053442, which appear to be of primary importance in colonization and invasion of human cells. Compared to 053442, virulence protein species were less in 053426, with lower express volumes too. No Opa and Opc were detected in 053426. Conclusion The different protein expression profiles of the clinical strain 053442 and carrier strain 053426 in the present study provide some clues of the different pathogenicity of the two strains, which may account for result in the final epidemics.

关键词： Neisseria meningitidis Reference map Two-dimensional gel electrophoresis MALDI-TOF/TOF-MS

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Peripheral monocyte count： an independent diagnostic and prognostic biomarker for prostate cancer - a large Chinese cohort study

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Asian Journal of Andrology 2017年第5期19卷 579-585页

作者： Yan-qing Wang Yin-Jie Zhu Jia-Hua Pan fan Xu Xiao-Guang Shao Jian-Jun Sha Qiang Liu Yi-Ran Huang Bai-Jun Dong Wei Xue Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Pathology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Increasing evidence indicates that inflammation may play important roles in tumorigenesis and progression, and an elevated peripheral monocyte count predicts a poor prognosis in various types of malignancies. Here, we evaluate the roles of peripheral monocyte count in the diagnosis and prognosis for prostate cancer in Chinese patients. A total of 1107 consecutive patients who had undergone prostate biopsy and 290 prostate cancer patients receiving androgen deprivation therapy as first-line therapy were retrospectively analyzed. The parameters were measured at the time of diagnosis. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of a positive biopsy. Patients were categorized in two groups using a cutoff point of 0.425 x 109 1-1 as calculated by the receiver-operating curve analysis for prognosis. Univariate and multivariate Cox regression analyses were performed to determine the associations of monocyte count with progression-free survival, cancer-specific survival, and overall survival. Multivariate logistic regression analyses showed that monocyte count, age, prostate-specific antigen （PSA）, free/total PSA, and prostate volume were independent predictors for prostate cancer. Multivariate Cox regression analyses identified an elevated monocyte count as an independent prognostic factor for worse cancer-specific survival （hazard ratio = 2.244, P 〈 0.05） and overall survival （hazard ratio = 1.995, P 〈 0.05）, but not progression-free survival （P = 0.117）. Our results indicated that an elevated monocyte count was an independent diagnostic biomarker for prostate cancer, and pretreatment peripheral monocyte count might play a significant role in the prognosis of prostate cancer patients treated with androgen deprivation therapy.

关键词： diagnosis monocyte prognosis prostate cancer

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铌酸锶钡陶瓷的固相烧结行为与结构演化研究

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航空材料学报 2006年第3期26卷 333-334页

作者：王炜张洁焦岗成樊慧庆西北工业大学凝固技术国家重点实验室西安710072

采用不同前驱体:Sr(NO3)2,Ba(NO3)2,Nb2O5(NSBN70)和SrCO3,BaCO3,Nb2O5(CSBN70)用传统烧结方法制备Sr0.7Ba0.3Nb2O6陶瓷。通过XRD、SEM实验手段,研究了硝酸盐前驱体制备过程中烧结温度和烧结时间对结构演化的影响。对比了不同前驱体制备... 详细信息

采用不同前驱体:Sr(NO3)2,Ba(NO3)2,Nb2O5(NSBN70)和SrCO3,BaCO3,Nb2O5(CSBN70)用传统烧结方法制备Sr0.7Ba0.3Nb2O6陶瓷。通过XRD、SEM实验手段,研究了硝酸盐前驱体制备过程中烧结温度和烧结时间对结构演化的影响。对比了不同前驱体制备SBN70陶瓷的显微结构。实验结果显示:采用硝酸盐前驱体,1400℃下烧结4h可得到纯SBN70相;1375℃烧结6h得到纯SBN70相。与碳酸盐前驱体相比,NSBN70呈现出双结构,比CSBN70易于出现异常晶粒长大。

关键词：铌酸锶钡陶瓷前驱体烧结行为显微结构.

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预防老年患者跌倒住院环境管理的最佳证据总结

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护理学报 2024年第13期31卷 56-61页

作者：刘璇王小惠张凌杨楠魏婷焦昊然黄峰蓝玉清赣州市人民医院全科医学科江西赣州341000 赣州市人民医院胃肠疝外科江西赣州341000 赣州市人民医院护理部江西赣州341000 赣南医科大学护理学院江西赣州341000

目的老年患者跌倒是常见的临床问题,一旦发生会严重威胁患者的身心健康。本研究旨在总结有效预防老年住院患者跌倒发生环境管理的最佳证据,以提高临床护理安全质量。方法计算机系统检索中英文相关数据库及学科专业网站中有关老年住院患... 详细信息

目的老年患者跌倒是常见的临床问题,一旦发生会严重威胁患者的身心健康。本研究旨在总结有效预防老年住院患者跌倒发生环境管理的最佳证据,以提高临床护理安全质量。方法计算机系统检索中英文相关数据库及学科专业网站中有关老年住院患者跌倒预防的系统评价、证据总结、专家共识、指南、临床决策支持系统,检索时间为建库至2023年11月16日。结果最终共纳入14篇文献,其中7篇指南、4篇专家共识、1篇系统评价、1篇证据总结、1篇临床决策。最终从适老化安全环境、辅助器具/设备、无障碍环境与标识3个方面汇总了29条最佳证据。结论本研究全面系统地检索总结了预防老年患者跌倒住院环境管理的最佳证据,在使用证据时应根据临床情境进行选择、合理转化,从而制定出更具临床专业化和针对性的预防老年住院患者跌倒的环境管理措施,更好地保障老年患者住院安全性。

关键词：环境管理老年患者跌倒最佳证据证据总结循证护理

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精准土地调查技术系统数据通讯设计及实现

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中国惯性技术学报 2010年第4期18卷 425-428页

作者：王慧青王庆东南大学仪器科学与工程学院南京210096

构建定量求精、定性求准的精准土地调查技术系统是实现精准土地管理的技术保障。精准土地调查技术系统由导航定位系统、实地调查系统、网络中继服务系统、室内监控及数据处理系统组成,能够现场完成数据采集、存储、传输。为提高网络通... 详细信息

构建定量求精、定性求准的精准土地调查技术系统是实现精准土地管理的技术保障。精准土地调查技术系统由导航定位系统、实地调查系统、网络中继服务系统、室内监控及数据处理系统组成,能够现场完成数据采集、存储、传输。为提高网络通讯的效率及易移植性,着重研究了基于XML的工程文件实现异构多元数据集成,基于ACE的移动GIS网络传输框架实现了高效网络传输,网络中继传输模式实现了移动GIS与监控中心的双向通讯。该系统的示范应用表明系统能实现精准的数据采集及实时传输,满足土地调查的准确性、现势性的要求。

关键词：精准土地调查网络传输 XML ACE 网络中继服务

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辽河口湿地表层土壤有机碳空间分布及影响因素分析

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湿地科学与管理 2024年第2期20卷 29-33页

作者：田文敬郑冬梅孙帆管强张仲胜黄兆辉沈阳大学环境学院辽宁沈阳110044 东北地质科技创新中心辽宁沈阳110034 辽宁省黑土地演化与生态效应重点实验室辽宁沈阳110034 中国科学院东北地理与农业生态研究所吉林长春130102

为探究辽河口湿地土壤有机碳(SOC)的空间分布及影响因素,利用ArcGIS技术分析了土壤有机碳含量的空间分布,并通过冗余分析确定各因素对有机碳的贡献率。结果表明:辽河口湿地表层土壤有机碳含量为4.35~24.58g/kg,平均值为13.3g/kg。辽河... 详细信息

为探究辽河口湿地土壤有机碳(SOC)的空间分布及影响因素,利用ArcGIS技术分析了土壤有机碳含量的空间分布,并通过冗余分析确定各因素对有机碳的贡献率。结果表明:辽河口湿地表层土壤有机碳含量为4.35~24.58g/kg,平均值为13.3g/kg。辽河口湿地土壤有机碳含量呈斑块状分布,空间变异由结构性因素和随机因素共同主导,从沿海到内陆,从南向北逐渐增加。土壤有机碳含量整体表现为芦苇土>水稻土>碱蓬土。pH值和砂粒占比(<2μm)共同解释了土壤有机碳含量变异的34%,对辽河口湿地土壤有机碳的贡献率达85.4%,是影响辽河口湿地有机碳含量的主要理化性质。辽河口湿地土壤有机碳较高,空间分布集中,植被类型和pH值是影响土壤有机碳的重要因素。

关键词：湿地土壤有机碳空间分布影响因素

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Risk Factors for Recurrence of Ovarian Endometriosis in Chinese Patients Aged 45 and Over

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Chinese Medical Journal 2018年第11期131卷 1308-1313页

作者： Zheng-Xing He Ting-Ting Sun Shu Wang Hong-hui Shi qing-Bo fan Lan Zhu Jin-Hua Leng Da-Wei Sun Jian Sun Jing-He Lang Department of Gynecology and Obstetrics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China Department of Pathology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background： When considering the issue of recurrence, perimenopausal women may have more dilemma during management comparing with young women, for example, whether to retain the uterus and ovary during surgery, whether it is necessary to add adjuvant medicine treatment after operation, and there is no evidence for reference about using ofgonadotropin-releasing hormone agonist. This study aimed to study the risk factors for the recurrence of ovarian endometriosis （EM） in patients aged 45 and over. Methods： This is a retrospective nested case-control study. We reviewed the medical records of patients aged over 45 years who underwent surgical treatments for ovarian EM from 1994 to 2014, in Peking Union Medical College Hospital of Chinese Academy of Medical Sciences. By following up to January 2016, 45 patients were found to have relapses and regarded as the recurrence group. The patients with no recurrence during the same follow-up period were randomly selected by the ratio of 1：4 as the nonrecurrence group （ 180 patients in total）. Stratified Cox regression was used to analyze the risk factors of the recurrence. Results： Univariate analysis showed that there was a significant difference in the postoperative treatment （the percentage of patients who received postoperative treatment in non-recurrence group and recurrence group, 23.9% vs. 40.0%, x2=4.729, P = 0.030） and ovarian preservation （the percentage of patients who received surgery of ovarian preservation in non-recurrence group and recurrence group. 25.0 % vs. 44.4%, x2 = 19.462, P 〈 0.001 ） between the nonrecurrence group and the recurrence group. There was no correlation between recurrence and the following factors including patient＇s age, menarche age, gravidity, parity, CA125 level, ovarian lesions, menopausal status, combined benign gynecological conditions （such as myoma and adenomyoma） and endometrial abnormalities, and surgical approach or surgical staging （all P 〉 0.05）. Multivariate analysis indicated t

关键词： Ovarian Endometriosis Recurrence Risk Factor

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Research progress of ginger in the treatment of gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2023年第11期15卷 1835-1851页

作者： Guo-qing Chen Yi Nan Shi-Cong Huang Na Ning Yu-Hua Du Dou-Dou Lu Ya-Ting Yang fan-Di Meng Ling Yuan College of Pharmacy Ningxia Medical CollegeYinchuan 750004Ningxia Hui Autonomous RegionChina Key Laboratory of Ningxia Ethnomedicine Modernization Ministry of EducationNingxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina

Cancer seriously endangers human *** cancer is the most common and major malignant tumor,and its morbidity and mortality are gradually *** there are effective treatments such as radio-therapy and chemotherapy for gastrointestinal tumors,they are often accom-panied by serious side *** to the traditional Chinese medicine and food homology theory,many materials are both food and ***,food is just as capable of preventing and treating diseases as *** and food homologous herbs not only have excellent pharmacological effects and activities but also have few side *** a typical medicinal herb with both medicinal and edible uses,some components of ginger have been shown to have good efficacy and safety against cancer.A mass of evidence has also shown that ginger has anti-tumor effects on digestive tract cancers(such as gastric cancer,colorectal cancer,liver cancer,laryngeal cancer,and pancreatic cancer)through a variety of *** aim of this study is to investigate the mechanisms of action of the main components of ginger and their potential clinical applications in treating gastrointestinal tumors.

关键词： Ginger Medicine and food homology Gastrointestinal cancer Molecular mechanism Tumor

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