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Variation of hydro-environment during past four decades with underground sponge city planning to control flash floods in wuhan,China:An overview

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Underground Space 2020年第2期5卷 184-198页

作者： hui-long wu Wen-Chieh Cheng Shui-long Shen Meng-Ying Lin Arul Arulrajah Department of Civil Engineering School of Naval ArchitectureOceanand Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Shaanxi Key Laboratory of Geotechnical and Underground Space Engineering School of Civil EngineeringXi’an University of Architecture and TechnologyXi’an 710055China Department of Civil and Environmental Engineering College of EngineeringShantou UniversityShantouGuangdong 515063China Department of Civil Engineering School of Naval ArchitectureOcean&Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Civil and Construction Engineering Swinburne University of TechnologyVictoria 3122Australia

This paper presents a review of the variation in the hydro-environment over the past four decades in wuhan,China,and discusses its close relationship with flash flood *** flash flood events have inundated underground infrastructures and resulted in significant economic losses and casualties,which are also discussed in relation to various external and internal *** external factors are predominantly owing to heavy rainstorms resulting from extreme climate *** internal factors predominantly include a decrease in wetland areas,changes in topography,and disrepair of drainage systems in urban *** the 1970s,lakes in wuhan have been significantly reduced in size(by approximately 40%).This reduction in wetland area decreases the water storage capacity in urban areas,and the frequency of large flooding events thus increased from 0.1 event/year to approximately 0.2 event/***,the disrepair of drainage systems in urban areas has reduced their ability to resist flood *** in topography have also intensified the flood volume per unit time,further burdening the drainage *** 2016,wuhan suffered from several large flooding events that led to some of the most severe economic losses in recorded *** drainage system at the urban center of wuhan and proposed flood prevention methods are discussed in detail in this *** sponge city(SPC)concept has been attempted in Qingshan District,wuhan,and its success proved the reliability of the theory.A SPC is believed to reduce the impacts of future flash floods in China and other developed and developing countries.

关键词： Flash flooding Wetland area Drainage system wuhan Sponge city

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Expression and signifi cance of TLR4 and HIF-1α in pancreatic ductal adenocarcinoma

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World Journal of Gastroenterology 2010年第23期16卷 2881-2888页

作者： Jian-Jun Zhang,He-Shui wu,Lin Wang,Yuan Tian,Jing-hui Zhang,Hai-long wu Department of Pancreatic Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,wuhan 430022,Hubei Province,China Department of Pediatrics,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,wuhan 430022,Hubei Province,China Laboratory of General Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,wuhan 430022,Hubei Province,China Department of Pancreatic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 Hubei Province China. heshuiwu@***

AIM:To investigate the expression of toll-like receptor(TLR) 4,nuclear factor-κB(NF-κB) p65 and hypoxiainducible transcription factor 1α(HIF-1α) in pancreatic ductal adenocarcinoma and their clinical ***:The mRNA of TLR4 and HIF-1α were investigated by real-time polymerase chain reaction in 30 cases of pancreatic ductal adenocarcinoma and its adjacent tissues,and expression of TLR4,NF-κB p65 and HIF-1α protein were detected by immunohistochemistry in 65 cases of pancreatic ductal adenocarcinoma tissues and 38 cases of corresponding adjacent *** relationship between TLR4 or HIF-1α and pathologic features,as well as the association between TLR4 and HIF-1α,were also ***-Meier method was used to assess the impact of expression of TLR4 and HIF-1α on survival of patients with pancreatic ***:The relative quantif ication of TLR4 and HIF-1α mRNA in tumor tissues was 0.81±0.10 and 0.87±0.11,respectively,signif icantly higher than that in adjacent tissues(0.81±0.10 vs 0.70±0.16,P=0.002;0.87±0.11 vs 0.68±0.13,P=0.000).The protein expression of TLR4,NF-κB p65 and HIF-1α in tumor tissues was 69.20%,66.15% and 70.80%,respectively,being signif icantly higher than that in adjacent normal tissues(69.20% vs 39.50%,P=0.003;66.15% vs 31.58%,P=0.001;70.80% vs 36.80%,P=0.001).There was no signif icant correlation between TLR4 or HIF-1α expression and the age,gender,tumor location,the degree of tumor differentiation in the patients(P>0.05).However,there was signif icant correlation between the expression of TLR4 or HIF-1α and tumor size,lymph node metastasis,venous invasion and clinical staging(P<0.05).The expression of TLR4 and HIF-1α had a signif icant impact on survival of patients with pancreatic ***:TLR4,NF-κB p65 and HIF-1α are overexpressed in pancreatic adenocarcinoma,TLR4 may be partly involved in up-regulating HIF-1α,and both synergestically promote development of pancreatic adenocarcinoma.

关键词： Pancreatic ductal adenocarcinoma Toll-like receptor 4 Nuclear factor-κB p65 Hypoxia-inducible factor 1

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Plasmonic tandem heterojunctions enable high-efficiency charge transfer for broad spectrum photocatalytic hydrogen production

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Journal of Energy Chemistry 2025年第1期100卷 710-720页

作者： Wenxuan Chen Xiu-Qing Qiao Guo hui Bojing Sun Dongfang Hou Meidi Wang Xueqian wu Tao wu Dong-Sheng Li College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Hubei Three Gorges Laboratory College of Chemistry and Materials Science and Guangdong Provincial Key Laboratory of Supramolecular Coordination Chemistry Jinan University

Rational engineering of semiconductor photocatalysts for efficient hydrogen production is of great significance but still challenging,primarily due to the limitations in charge transfer ***,a fascinating plasmonic tandem heterojunction with the hc-CdS/Mo2C@C heterostructure is aimfully prepared for effectively promoting the charge separation kinetics of the CdS photocatalyst via the synergistic strategy of phase junction,Schottky junction,and photothermal *** difference in atomic configuration between cubic-CdS （c-CdS） and hexagonal-CdS （h-CdS） leads to effective charge separation through a typical Ⅱ charge transfer mechanism,and plasmonic Schottky junction further extracts the electrons in the hc-CdS phase junction to realize gradient charge ***,the photothermal effect of Mo2C@C helps to expand the light absorption,accelerate charge transfer kinetics,and reduce the hydrogen evolution energy *** carbon layer provides a fast channel for charge transfer and protects the photocatalyst from *** a result,the optimized hc-CMC photocatalyst exhibits a significantly high photocatalytic H2production activity of 28.63 mmol/g/h and apparent quantum efficiency of 61.8%,surpassing most of the reported *** study provides a feasible strategy to enhance the charge transfer kinetics and photocatalytic activity of CdS by constructing plasmonic tandem heterogeneous junctions.

关键词： Heterojunctions LSPR Photocatalyst Phase junction Schottky junction Photothermal effect

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： huidong Li Faqin Li Zhaoyi Chen Erwen wu Xiaoxi Dai Danni Li Haojie An Shiyi Zeng Chunyan Wang Li Yang Cheng long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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Crystallization Modulation and Holistic Passivation Enables Efficient Two‑Terminal Perovskite/CuIn(Ga)Se_(2)Tandem Solar Cells

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Nano-Micro Letters 2025年第1期17卷 205-215页

作者： Cong Geng Kuanxiang Zhang Changhua Wang Chung Hsien wu Jiwen Jiang Fei long Liyuan Han Qifeng Han Yi‑Bing Cheng Yong Peng State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070People’s Republic of China Triumph Photovoltaic Materials Co. Ltd.No.1001 Yannan AvenueHigh‑Tech Development DistrictBengbuAnhui 233000People’s Republic of China College of Materials Science and Engineering Guilin University of TechnologyGuilin 541004People’s Republic of China State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

Two-terminal(2-T)perovskite(PVK)/CuIn(Ga)Se_(2)(CIGS)tandem solar cells(TSCs)have been considered as an ideal tandem cell because of their best bandgap matching regarding to Shockley–Queisser(S–Q)***,the nature of the irregular rough morphology of commercial CIGS prevents people from improving tandem device *** this paper,D-homoserine lactone hydrochloride is proven to improve coverage of PVK materials on irregular rough CIGS surfaces and also passivate bulk defects by modulating the growth of PVK *** addition,the minority carriers near the PVK/C60 interface and the incompletely passivated trap states caused interface recombination.A surface reconstruction with 2-thiopheneethylammonium iodide and N,N-dimethylformamide assisted passivates the defect sites located at the surface and grain ***,LiF is used to create this field effect,repelling hole carriers away from the PVK and C60 interface and thus reducing *** a result,a 2-T PVK/CIGS tandem yielded a power conversion efficiency of 24.6%(0.16 cm^(2)),one of the highest results for 2-T PVK/CIGS TSCs to our *** validation underscores the potential of our methodology in achieving superior performance in PVK/CIGS tandem solar cells.

关键词： PVK/CIGS TSCs Irregular rough surfaces Modulating the growth PVK/C60 interface recombination

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The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu hui Hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing long Pengcheng Yi Jiali Song Luojia wu Wei Wan Xiuqin Rao Yue Lin Gen Wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

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认知空间映射及其神经机制

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心理科学进展 2025年第1期33卷 62-76页

作者：吴际李会杰南宁师范大学教育科学学院南宁530001 中国科学院行为科学重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生... 详细信息

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生成、将信息与背景结构捆绑,以及海马体与其它脑区的协同。未来研究应关注预测性的认知空间地图、海马体对不同精度和层级信息的表征、认知空间映射微观和介观层面的研究空缺以及物理空间和认知空间映射的共同机制和特异性机制等问题。

关键词：认知地图网格细胞位置细胞海马体

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An Efficient Boron Source Activation Strategy for the Low‑Temperature Synthesis of Boron Nitride Nanotubes

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Nano-Micro Letters 2025年第1期17卷 548-558页

作者： Ying Wang Kai Zhang Liping Ding Liyun wu Songfeng E Qian He Nanyang Wang hui Zuo Zhengyang Zhou Feng Ding Yue Hu Jin Zhang Yagang Yao National Laboratory of Solid State Microstructures College of Engineering and Applied SciencesJiangsu Key Laboratory of Artificial Functional Materialsand Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093People’s Republic of China School of Electronic Information and Artificial Intelligence Shaanxi University of Science&TechnologyXian 710000People’s Republic of China College of Bioresources Chemical and Materials Engineering Shaanxi University of Science&TechnologyXian 710000People’s Republic of China Key Laboratory of Carbon Materials of Zhejiang Province College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325000People’s Republic of China Shenzhen Institutes of Advanced Technology Chinese Academy of SciencesShenzhen 518000People’s Republic of China College of Chemical and Molecular Engineering Peking UniversityBeijing 100871People’s Republic of China

Lowering the synthesis temperature of boron nitride nanotubes(BNNTs)is crucial for their *** primary reason for adopting a high temperature is to enable the effective activation of highmelting-point solid *** this study,we developed a novel approach for efficiently activating boron by introducing alkali metal compounds into the conventional MgO–B *** approach can be adopted to form various low-melting-point AM–Mg–B–O growth *** growth systems have improved catalytic capability and reactivity even under low-temperature conditions,facilitating the synthesis of BNNTs at temperatures as low as 850℃.In addition,molecular dynamics simulations based on density functional theory theoretically demonstrate that the systems maintain a liquid state at low temperatures and interact with N atoms to form BN *** findings offer novel insights into the design of boron activation and are expected to facilitate research on the low-temperature synthesis of BNNTs.

关键词： Boron nitride nanotubes Low-temperature Boron activation Density functional theory

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先天性心脏病合并其他系统畸形联合同期矫治手术的效果分析

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心肺血管病杂志 2017年第8期36卷 678-681页

作者：魏丹张辉李龙吴涛秦广宁罗毅首都儿科研究所附属儿童医院心脏外科 100020

目的:总结我科行先天性心脏病合并其他畸形联合同期手术治疗的临床效果,探讨同期联合手术的可行性、安全性及优势,以期在临床推广联合手术方法。方法:回顾总结2015年6月至2015年12月间,在我科行先天性心脏病合并其他畸形联合同期手术的... 详细信息

目的:总结我科行先天性心脏病合并其他畸形联合同期手术治疗的临床效果,探讨同期联合手术的可行性、安全性及优势,以期在临床推广联合手术方法。方法:回顾总结2015年6月至2015年12月间,在我科行先天性心脏病合并其他畸形联合同期手术的患者情况。总结联合手术时间、手术方法、术后监护室滞留时间、气管插管时间、合并手术的部位出血情况及围术期死亡率。结果:在此期间共有8例患儿行先天性心脏病合并其他畸形联合同期手术,其中男性4例,女性4性,中位年龄21(10,98)个月,平均体质量10.5(6.6,11.9)kg。先天性心脏病分别为房间隔缺损(ASD)5例,右心室双出口1例,右心室双出口合并ASD1例,动脉导管未闭合并ASD1例。合并畸形为双侧腹股沟斜疝2例,左侧腹股沟斜疝合并右侧鞘膜积液1例,右手赘生指1例,颈部肿物1例,隐睾1例,双眼霰粒肿1例,巨结肠合并气管狭窄1例。手术方式:1例ASD合并巨结肠的患儿在全身麻醉气管插管下先行ASD修补术后再行巨结肠根治加活检术,其他7例患儿均在全身麻醉气管插管下先行其他合并畸形根治术,之后在体外循环下行先天性心脏病矫治术,术后返回心脏外科术后监护室。联合手术时间170(163,233)min,先天性心脏病手术时间133(113,163)min,合并其他畸形矫治手术时间为45(31,75)min。8例患儿术后监护室滞留时间为(5.8±9.4)d。1例右心室双出口合并左斜疝、右鞘膜积液的患儿监护室滞留时间28d,原因为心功能减低及感染使其延长,与合并畸形无关。1例ASD合并巨结肠及气管狭窄患儿监护室滞留时间10d,原因为感染使其延长,与心脏手术无关。其余6例患儿术后监护室滞留时间为2(1,2)d。8例患儿术后气管插管时间为13(5,150)h。其中1例ASD合并双眼霰粒肿的患儿,因考虑到眼科手术后24h才能去除敷料,为避免患儿清醒后无法视物造成的恐惧感,我们将气管插管时间延长到术后22h去除眼科敷料。1例右心室双出口合并左斜疝、右鞘膜积液的患儿气管插管时间192h,原因为心功能减低及感染使其延长,与合并畸形无关。1例ASD合并巨结肠及气管狭窄患儿的患儿气管插管时间209h,原因为感染使其延长,与心脏手术无关。其余5例患儿术后气管插管时间为7(4,13)h。所有合并畸形的手术部位未出现因体外循环肝素化而发生的渗血情况。结论:对于合并其他畸形的先天性心脏病患儿可以在行先天性心脏病手术矫治同时行其他畸形矫治手术。其术后监护室滞留时间、气管插管时间大部分可根据患儿心脏手术后情况调整,无需考虑合并畸形对监护室滞留时间、气管插管的影响。患儿只需要经历一次麻醉、气管插管就可以同时解决不同系统解剖畸形,较以往需要分开手术而言,未出现任何手术并发症且具有减少创伤、降低费用、减少入院次数的优点,值得在临床推广。

关键词：先天性心脏病联合手术腹股沟斜疝鞘膜积液

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