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Fairy shrimp Branchinella kugenumaensis displays sensitivity to microplastic exposure

Journal of Oceanology and Limnology 2024年第4期42卷 1186-1199页

作者： Yingying ZHANG Xinrui XU Wenbo SUN Yuting WANG hui yang College of Animal Science and Technology Yangzhou UniversityYangzhou 225009China

The increasing global concern regarding plastic pollution has prompted the research into the consequences of microplastics(MPs)on aquatic *** shrimp Branchinella kugenumaensis are freshwater planktonic organisms that have existed for 250 million *** study aimed to uncover the harmful effects of MPs,with a particular focus on their size variations(0.1,1,and 5μm),on the fairy *** focused on how MPs could significantly affect the survival and growth of fairy ***,larger MPs,especially those measuring 5μm,caused higher mortality rates and hindered the growth compared to smaller *** impact of MPs continued even subsequent to depuration in clean *** accumulation of MPs within the intestines of fairy shrimp resulted in intestinal blockages,disrupted excretory functions,and harmed intestinal epithelial *** at the histological,cellular,and molecular levels showed that exposure to MPs triggered necroptosis in intestinal cells,accompanied by alterations in pathways related to transcription,translation,digestion,energy metabolism,and neurological ***,the effects of MPs on gene expression and pathways varied based on particle size,with larger MPs having a more significant effect and causing a strong response in xenobiotic biodegradation and metabolism *** suggest that the increasing severity of MPs pollution could pose a significant threat to the survival of fairy *** study provided vital insights into the complex relationship between microplastics and aquatic organisms,and highlighted the urgent need to address the potential devastating impact of plastic pollution on freshwater ***,due to their rapid growth,strong reproductive capacity,sensitivity,and ease of cultivation,fairy shrimp hold the potential candidate to serve as a model organism for studying the effects of MPs and other pollutants on freshwater ecosystems.

关键词： microplastic freshwater ecosystem toxic effects fairy shrimp model organism

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Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2038-2059页

作者： Xiang-hui Wan Guo-Bing Jin Qun yang Ji-Long Hu Zhi-Liang Liu Jun Rao Can Wen Peng-ling Li Xi-Mei yang Bo Huang Xiao-Zhong Wang Jiangxi Medical College Nanchang UniversityNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Jiangxi Key Laboratory of Translational Research for Cancer Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Abdominal Surgery Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Pathology Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Science and Education Section Jiangxi Cancer HospitalNanchang 330029Jiangxi ProvinceChina Department of Clinical Laboratory Jiangxi Children’s HospitalNanchang 330006Jiangxi ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Jiangxi Province Key Laboratory of Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Heterogeneous ribonucleoprotein A1(hnRNPA1)has been reported to enhance the Warburg effect and promote colon cancer(CC)cell proliferation,but the role and mechanism of the miR-490-3p/hnRNPA1-b/PKM2 axis in CC have not yet been *** To investigate the role and mechanism of a novel miR-490-3p/hnRNPA1-b/PKM2 axis in enhancing the Warburg effect and promoting CC cell proliferation through the PI3K/AKT *** Paraffin-embedded pathological sections from 220 CC patients were collected and subjected to immunohistochemical analysis to determine the expression of *** relationship between the expression values and the clinicopathological features of the patients was *** in mRNA expression were analyzed using quantitative real-time polymerase chain reaction,while differences in protein expression were analyzed using western *** proliferation was evaluated using the cell counting kit-8 and 5-ethynyl-2’-deoxyuridine assays,and cell cycle and apoptosis were detected using flow cytometric *** targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter *** Warburg effect was evaluated by glucose uptake and lactic acid production *** The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls(P<0.05).Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen in different stages of CC,including stage I,II-III,and ***,the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T ***1-b was found to enhance the Warburg effect through the PI3K/AKT pathway,thereby promoting proliferation of HCT116 and SW620 ***,the proliferation of HCT116 and SW620 cells was inhibited when miR-490-3p targeted and bound to hnRNPA1-b,effectively blocking the Warburg ***

关键词： Heterogeneous ribonucleoprotein A1-b MiR-490-3p Colon cancer Alternative splicing Warburg effect

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Significant annealing-induced hardening effect in nanolaminate d-nanotwinne d(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)me dium-entropy alloy by severe cold rolling

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Journal of Materials Science & Technology 2024年第3期170卷 156-166页

作者： Shuqing Yuan hui Fu Lei Qian Chi Fai Cheung Xu-Sheng yang State Key Laboratory of Ultra-precision Machining Technology Department of Industrial and Systems EngineeringThe Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518060China

Due to the easy coarsening caused by poor thermal stability,the verified annealing-induced hardening in nanograined metals can only maintain at a relatively low-temperature *** this study,a nanolam-inated(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8)medium-entropy alloy with an average lamellae thickness of∼20 nm embedded by thinner nanotwins was fabricated by severe cold rolling to achieve superior thermal *** with the conventional nanotwinned CrCoNi with nanotwins inside ultra-fined grains,the hier-archical nanolaminated-nanotwinned(CrCoNi)_(97.4)Al_(0.8)Ti_(1.8) exhibits a significant annealing-induced hard-ening effect,i.e.,hardness increasing from∼250 HV in the original specimen to∼500 HV in the cold-rolled status and finally∼630 HV after annealing at 600℃for 1 *** microstructure characterizations reveal that the reduced dislocation density and formation of L1_(2)ordered domain are mainly responsible for such hardening effect,which is facilitated by the effectively suppressed coarsening with annealing temperature,i.e.,slow detwinning process and well-retained low-angle nanolamellar *** coarsening mechanisms from the cold-rolled nanolamellae to the fully recrystallized micro-equiaxed structures under the annealing temperatures ranging from 400 to 800℃ were also elucidated by atomic observations.

关键词： Annealing-induced hardening Thermal stability Nanolaminated-nanotwinned structure CrCoNi Detwinning Grain boundary migration

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Membrane-less MoO_(3-x)@TiO_(2)-bromine battery with excellent rate capability and cyclic stability

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Journal of Energy Chemistry 2024年第6期93卷 316-321,I0008页

作者： Wenjie Huang hui Wang Bin Yuan Liuzhang Ouyang Lichun yang Min Zhu School of Materials Science and Engineering Guangdong Provincial Key Laboratory of Advanced Energy Storage MaterialsSouth China University of TechnologyGuangzhou 510640GuangdongChina

Bromine has attracted significant attention as a cathode material for aqueous batteries due to its high reduction potential of 1.05 V(Br_(3)^(-)+2e~-■3Br~-),impressive theoretical specific capacity of 223 mA h g^(-1),and rapid reaction kinetics in the ***,searching for compatible anode materials to match with bromine has posed a challenge due to its highly corrosive *** this study,we developed oxygen-deficient MoO_(3) with TiO_(2) coating(referred to as MoO_(3-x)@TiO_(2))as an anode material to pair with a bromine cathode in static full *** oxygen deficiency contributes to enhanced electronic and protonic diffusion within the MoO_(3-x)lattice,while the TiO_(2) coating mitigates structural dissolution and proton trapping during *** MoO_(3-x)@TiO_(2) demonstrates fast charge storage kinetics and excellent resistance to bromine *** impressive compatibility between MoO_(3-x)@TiO_(2) and bromine enables the construction of membrane-less full batteries with exceptional rate capability and cyclic *** MoO_(3-x)@TiO_(2)-bromine battery achieves an energy density of70.8 W h kg^(-1)at a power density of 328.1 W kg^(-1),showcasing an impressive long-term cyclic life of 20,000 *** study provides valuable insights for the development of high-performance aqueous secondary batteries.

关键词： Molybdenum trioxide Oxygen deficiency TiO_(2)coating Compatibility Bromine-based battery

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A porous Eu-PTA/Tb-SSA/ZrO_(2)/ZnZrO_(3) light color adjustable phosphor:Luminescent property and application of warm white LED

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Journal of Rare Earths 2024年第8期42卷 1421-1428,I0001页

作者： Yunxiao Ma Chao linghu Ming yang hui Yu Xiangting Dong Long Xia School of Chemistry and Environmental Engineering Changchun University of Science and TechnologyChangchun130022China School of Materials Science and Engineering Harbin Institute of Technology(Weihai)Weihai264209China

Light emitting diode(LED) is the fourth generation lighting source,but it has some shortcomings such as complex chip packaging process and the unbalanced light color of phosphor in long-time *** this study,a kind of Eu-terephthalic acid/Tb-sulfosalicylate/ZrO_(2)/ZnZrO_(3)(Eu-PTA/Tb-SSA/ZrO_(2)/ZnZrO_(3))phosphor with warm white light emission properties was prepared,and the warm white light LED(wWLEDs) was successfully prepared by encapsulating Eu-PTA/Tb-SSA/ZrO_(2)/ZnZrO_(3) phosphors together with 270 nm *** ZrO_(2)/ZnZrO_(3),Tb-SSA/ZrO_(2)/ZnZrO_(3) and Eu-PTA/ZrO_(2)/ZnZrO_(3) samples show blue emission,green emission and red emission under deep ultraviolet(UV,270 nm) excitation,*** Tb-SSA and Eu-PTA are co-doped into ZrO_(2)/ZnZrO_(3) matrix with blue emission to achieve the warm white light emission,and the light color can be adjusted by controlling the doping amount of Eu^(3+)-and Tb^(3+).Through the excitation method of single-component phosphor by the single chip,the complex chip packaging process of w-LED can be *** doping rare earth organic complexes into porous ZrO_(2)/ZnZrO_(3) matrix,the problems of the light color unbalanced of phosphor and the low luminescence intensity of rare earth doped metal oxides composites can be solved.

关键词： Eu-PTA/Tb-SSA/ZrO_(2)/ZnZrO_(3) Luminescence material Light color adjustable phosphor Warm white emission W-WLEDs Rare earths

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Progress in the research on organic piezoelectric catalysts for dye decomposition

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International Journal of Minerals,Metallurgy and Materials 2024年第2期31卷 245-260页

作者： Zhaoning yang Xiaoxin Shu Di Guo Jing Wang hui Bian Yanmin Jia School of Science Xi’an University of Posts and TelecommunicationsXi’an 710121China School of Physics and Information Technology Shaanxi Normal UniversityXi’an 710119China

Organic contaminants have posed a direct and substantial risk to human wellness and the *** recent years,piezo-electric catalysis has evolved as a novel and effective method for decomposing these *** piezoelectric materials offer a wide range of options,most related studies thus far have focused on inorganic materials and have paid little attention to organic *** materials have advantages,such as being lightweight,inexpensive,and easy to process,over inorganic ***,this paper provides a comprehensive review of the progress made in the research on piezoelectric catalysis using organic materials,high-lighting their catalytic efficiency in addressing various *** addition,the applications of organic materials in piezoelectric cata-lysis for water decomposition to produce hydrogen,disinfect bacteria,treat tumors,and reduce carbon dioxide are ***,fu-ture developmental trends regarding the piezoelectric catalytic potential of organic materials are explored.

关键词： piezoelectric catalysis piezoelectric material dye decomposition organic materials

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Regio-and Stereoselective Polymerization of Bio-based Ocimene by Rare-Earth Metal Catalysts

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Chinese Journal of Polymer Science 2024年第2期42卷 223-229,I0008页

作者： Qi-Yuan Wang Li-Peng Sang Zhen Zhang yang Jiang hui Tian Xia Zhao Xiang Guo Shi-hui Li State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun130022China School of Applied Chemistry and Engineering University of Science and Technology of ChinaHefei230026China Science and Technology on Aerospace Chemical Power Laboratory Hubei Institute of Aerospace ChemotechonologyXiangyang441003China Shanxi Coal Chemical Industry Technology Research Institute Xi’an710000China Hubei Institute of Aerospace Chemotechonology Xiangyang441003China

Coordination polymerization of renewable β-ocimene has been investigated using asymmetric diiminophosphinate lutetium complex1, β-diketiminate yttrium complex 2, bis(phosphino)carbazolide yttrium complex 3, half-sandwich benzyl fluorenyl scandium complex 4 and pyridyl-methylene-fluorenyl rare-metal complexes 5a–5c. Complexes 1, 4 and 5a–5c show trans-1,2-regioselectivities and high activities, of which 5c exhibits excellent isoselectivity(mmmm>99%). Conversely, complexes 2 and 3 promote β-ocimene polymerization to produce isotactic cis-1,4-polyocimenes(cis-1,4>99%, mm>95%). Diblock copolymers cis-1,4-PIP-block-cis-1,4-POc and cis-1,4-PBD-block-cis-1,4-POc are obtained in one-pot reactions of β-ocimene with isoprene and butadiene using complex 3. Epoxidation and hydroxylation of polyocimene afford functionalized polyolefins with enhanced T_(g)(from-20 ℃ to 79 ℃ and 74 ℃) and hydrophilicity.

关键词： Biobased monomer Terpenes Ocimene Rare-earths Polymerization Regio/stereoselectivity Elastomer

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie Fang Bing-Yi Jing Shen ling Qiyue Wang Qing yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

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Transient diabetes mellitus with ABCC8 variant successfully treated with sulfonylurea:Two case reports and review of literature

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World Journal of Diabetes 2024年第8期15卷 1811-1819页

作者： ling-Hua Shen Yan Cui Dong-Xia Fu Wei yang Sheng-Nan Wu hui-Zhen Wang Hai-Hua yang Yong-Xing Chen Hai-Yan Wei Department of Endocrinology and Metabolism Henan Key Laboratory of Children's Genetics and Metabolic DiseasesChildren's Hospital Affiliated to Zhengzhou UniversityHenan Children's Hospital Zhengzhou Children's HospitalZhengzhou 450018Henan ProvinceChina

BACKGROUND Transient neonatal diabetes mellitus(TNDM)is a rare form of diabetes mellitus that usually presents within the first 6 mo of *** often enter remission within several months,although relapse can occur later in *** in the ABCC8 gene,which encodes the sulfonylurea receptor 1 of the ATP-sensitive potassium channel in pancreatic beta cells,are associated with TNDM and permanent neonatal *** study describes a novel de novo c.3880C>T heterozygous ABCC8 variant that causes TNDM and can be treated with sulfonylurea *** SUMMARY We retrospectively analyzed 2 Chinese patients with TNDM who were diagnosed,treated,or referred for follow-up between September 2017 and September *** patients were tested for mutations using targeted next-generation *** with neonatal diabetes mellitus caused by a c.3880C>T heterozygous missense variant in the ABCC8 gene have not been reported *** children had an onset of post-infectious diabetic ketoacidosis,which is worth *** a follow-up visit after discontinuing insulin injection,oral glyburide was found to be effective with no adverse *** Early genetic testing of neonatal diabetes mellitus aids in accurate diagnosis and treatment and helps avoid daily insulin injections that may cause pain.

关键词： Neonatal diabetes mellitus ABCC8 Sulfonylurea receptors 1 KATP channels Sulfonylurea Glyburide Insulinulin Case report

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Post-transcriptional regulation of grain weight and shape by the RBP-A-J-K complex in rice

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Journal of Integrative Plant Biology 2024年第1期66卷 66-85页

作者： Ding Ren hui Liu Xuejun Sun Fan Zhang ling Jiang Ying Wang Ning Jiang Peiwen Yan Jinhao Cui Jinshui yang Zhikang Li Pingli Lu Xiaojin Luo State Key Laboratory of Genetic Engineering and MOE Engineering Research Center of Gene Technology School of Life SciencesFudan UniversityShanghai 200438China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China MOE Key Laboratory of Crop Physiology Ecology and Genetic Breeding College of AgronomyJiangxi Agricultural UniversityNanchang 330045China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China College of Agronomy Anhui Agricultural UniversityHefei 230036China

RNA-binding proteins(RBPs)are components of the post-transcriptional regulatory system,but their regulatory effects on complex traits remain *** an integrated strategy involving map-based cloning,functional characterizations,and transcriptomic and population genomic analyses,we revealed that RBP-K(LOC_Os08g23120),RBP-A(LOC_Os11g41890),and RBP-J(LOC_Os10g33230)encode proteins that form an RBP-A-J-K complex that negatively regulates rice yield-related *** of the RBP-A-J-K complex indicated RBP-K functions as a relatively non-specific RBP chaperone that enables RBP-A and RBP-J to function ***,RBP-J most likely affects GA pathways,resulting in considerable increases in grain and panicle lengths,but decreases in grain width and *** contrast,RBP-A negatively regulates the expression of genes most likely involved in auxin-regulated pathways controlling cell wall elongation and carbohydrate transport,with substantial effects on the rice grain filling process as well as grain length and ***,RBP-K is relatively ancient and highly conserved,whereas RBP-J and RBP-A are more ***,the RBP-A-J-K complex may represent a typical functional model for many RBPs and protein complexes that function at transcriptional and post-transcriptional levels in plants and animals for increased functional consistency,efficiency,and versatility,as well as increased evolutionary *** results clearly demonstrate the importance of RBP-mediated post-transcriptional regulation for the diversity of complex ***,rice grain yield and quality may be enhanced by introducing various complete or partial loss-of-function mutations to specific RBP genes using clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9 technology and by exploiting desirable natural tri-genic allelic combinations at the loci encoding the components of the RBP-A-J-K complex through marker-assisted select

关键词： GL11 grain weight and shape post-transcriptional regulation RNA-binding proteins

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