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Dose-effect correlation of chloride de-icing salt on Euonymus japonicus

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Forestry Studies in China 2013年第3期15卷 238-245页

作者： zhou-Yuan LI jun-hui zhou Ying-Mei LIANG College of Environmental Science and Engineering Beijing Forestry University School of Environment Tsinghua University College of Biological Sciences and Biotechnology Beijing Forestry University Museum of Beijing Forestry University Beijing Forestry University

In order to prevent severe pollution by de-icing salt on greenery along urban roads, a half lethal dose （LD_50）for a plant population was confirmed through stress simulation of chloride de-icing salt on Euonymus japonicus, with an ianalysis of physiological changes, statistics on mortality rate on plant populations and mathematic modeling during a 30- day subacute toxicity test. The results indicate that a significant positive correlation in the early stages and a significant negative correlation in the later stages were observed between the amount of chlorophyll a and b in plants and a cumulative dose of de-icing salt. The amounts of free proline in plants and the dose of de-icing salt were positively correlated Over the entire period. No significant correlation in the initial stage, but a significant negative correlation in later stages was observed between the soluble protein and the dose of de-icing salt. LDs0 of this chloride agent on E. japonicus is 5 kg.（L·m2）-1 over 30 days.

关键词： de-icing salt Euonymus japonicus dose-effect correlation half lethal dose

Acrosin structure-based design,synthesis and biological activities of 7-azaindol derivatives as new acrosin inhibitors

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Chinese Chemical Letters 2011年第3期22卷 272-275页

作者： jun Hang Jiang Xue Fei Liu Can hui Zhen You jun zhou Ju Zhu Jia Guo Lv Chun Quan Sheng Department of Medicinal Chemistry School of Pharmacy Second Military Medical University Shanghai 200433 China

A series of 7-azaindol derivatives were designed based on the homologous 3D model of human *** compounds were synthesized and evaluated for their human acrosin inhibitory activities in *** 7a,7i,7j,7k and 7n showed highly inhibitory activity against human *** three-dimensional structure-activity relationship was investigated through a CoMFA model,which provided valuable information to further study of potential human acrosin inhibitors.

关键词： Rational design Azaindole Synthesis Acrosin CoMFA

Photodegradation of α-naphthaleneacetic acid in aqueous solution

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Journal of Environmental Sciences 2001年第3期13卷 361-364页

作者： LIU hui jun, zhou Zhu fei, LIU Wei ping (Environmental Science Institute, Zhejiang University, Hangzhou 310027, China. Environmental Science Institute Zhejiang University Hangzhou 310027 China.

Kinetic processes of a-naphthaleneacetic acid (NAA) photolysis were studied under different conditions. The results showed that the ultraviolet light was more effective than fluorescent light in promoting degradation, and the degradation of NAA under ultraviolet light followed the first order kinetics with the photolysis rate constant of 1.15 x 10-2 min-1 and half-life time (t1/2) of 60 min. Further, it was proved that the photolysis rate was higher in the presence of oxygen, titanium dioxide (TiO2), and low pH (acidic solution). At last, two photolysis intermediates were identified by GC-MS and possible photolysis pathways were proposed.

关键词： Acids Degradation Fluorescence Photolysis Solutions

Rapidly counting atomic planes of ultra-thin MoSe2 nanosheets(1≤n≤4)on SiO2/Si substrate

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Rare Metals 2016年第8期35卷 632-636页

作者： Yi-Ping Wang hui-jun zhou Gui-Hua Zhao Tian-Long Xia Lei Wang Le Wang Li-Yuan Zhang Department of Physics Renmin University of ChinaBeijing 100872China Beijing Key Laboratory of Opto-electronic Functional Materialsand Micro-nano Devices Renmin University of China Department of Power and Electrical Engineering Northwest A&F UniversityYangling 712100ShaanxiChina

The optical, thermal and electrical properties of ultra-thin two-dimensional （2D） crystal materials are highly related to their thickness. Therefore, identifying the atomic planes of few-layer crystal materials rapidly is crucial to fundamental study. Here, a simple technique was demonstrated based on optical contrast for counting atomic planes （n） of few-layer MoSe2 on SiO2/Si substrates. It is found that the optical contrast of single-layer MoSe2 depends on light wavelength and thickness of SiO2 on Si substrate. The data calculated based on a Fresnel law-based model as well as atomic force microscopy （AFM） mea- surements fit well with the values measured by spectro- scopic ellipsometer. Furthermore, the calculated and measured contrasts were integral and plotted, which can be used to determine the MoSe2 atomic planes （1 ≤ n ≤ 4） accurately and rapidly.

关键词： Thickness identification Optical contrast MoSe2 Optical microscopy

Bioinformatics and Expression Analysis of NAC Transcription Factor Genes in Scutellaria baicalensis

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World Journal of Traditional Chinese Medicine 2018年第2期4卷 37-42页

作者： Juan Liu Ti-Ying Chen Yuan Yuan jun-hui zhou Yu-Yang Zhao Lu-Qi Huang Department in Chinese Academy of Chinese Medical Sciences State Key Laboratory Breeding Base of Dao-di HerbsChinese Academy of Chinese Medical Sciences

Background:NAC,as a unique transcription factor to plants,plays important roles in multiple biological functions,such as regulation of plant growth and development,hormone levels,and responses to various kinds of ***,there is a lack of research of NAC genes in Chinese ***:The study aimed to evaluate the potential functions of NAC genes in Scutellaria baicalensis by bioinformatics and expression analysis,and provide evidence of the molecular regulation mechanism involved in flavonoid biosynthesis in ***:The genes of NAC transcription factors in *** were obtained from cDNA library and their functions were explored using bioinformatic *** NAC genes were screened from the cDNA library of *** using BLAST comparison ***,the open reading frame(ORF) finder online tool was used to predict the full-length ORFs of NAC genes and their protein characteristics were explored by bioinformatic *** expression of NAC genes was then detected by quantitative polymerase chain reaction in different parts of *** and different leaves treated by gibberellin GA3 ***:Six genes of NAC transcription factors were cloned,two of which had complete *** genes cloned in this study were mainly expressed in the flowers of *** expression levels of NAC2,NAC3,NAC4,NAC5,NAC6 were increased firstly and then decreased gradually after 100 μM GA3 ***,some NACs and PAL2 in *** showed strong ***:This study suggested that NACs cloned in this study were mainly regulated the flavonoid biosynthesis in the flowers of ***;NAC6 in *** might be involved in the regulation of PAL2 transcription and affected the accumulation of flavonoids in the root of *** results provided a basis for further understanding the molecular regulation mechanism of flavonoid biosynthesis in ***.

关键词： Bioinformatics expression analysis NAC transcription factors Scutellaria baicalensis

SCC-UEFAS, an urban-ecological-feature based assessment system for sponge city construction

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Environmental Science and Ecotechnology 2022年第4期12卷 8-17页

作者： Zi-Tong Zhao Hou-Ming Cheng Sheng Wang Hai-Yan Liu Zi-Ming Song jun-hui zhou Ji-Wei Pang Shun-Wen Bai Shan-Shan Yang Jie Ding Nan-Qi Ren State Key Laboratory of Urban Water Resource and Environment Harbin Institute of TechnologyHarbin150000China Central&Southern China Municipal Engineering Design and Research Institute Co. LtdWuhan430010China China Energy Conservation and Environmental Protection Group Beijing100089China

An effective sponge city construction evaluation system plays a crucial role in evaluating sponge city construction *** construction of a sponge city evaluation system still faces challenges related to incomplete index selection and unscientific weight *** studies have focused on the comprehensive assessment of sponge city construction in the early *** study constructed a scientific assessment indicator system and a quantitative indicator weight at all levels by literature review and statistical analysis methods from an objective *** demonstrate how to utilize our evaluation methods,three construction schemes randomly generated by MATLAB were evaluated under evaluation states of constant weight and variable weight,*** 3 had the highest score of 0.638 under the constant weight assessment,but it cannot practically be the final construction scheme due to the imbalance between *** to the constant weight assessment,a variable weight assessment can effectively balance the states of the evaluation index with changes in the decision *** the three schemes,Scheme 2 is the best choice with a value of 0.0355 under variable weight evaluation due to punishment and incentives in the variable weight *** concept of“punishing”a disadvantageous indicator and“motivating”an advantageous indicator increases the relative advantages of the indices,ultimately affecting the assessment results of schemes and leading to a more balanced *** study provides reasonable analysis and decision-making mechanisms to support decision-making and guide the scientific selection of a construction scheme.

关键词： Sponge city evaluation system Principal component analysis Factor analysis Variable weight theory

Prognosis of R1-resection at the bronchial stump in patients with non-small cell lung cancer

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Chinese Medical Journal 2014年第16期127卷 2918-2923页

作者： Lyu Jima Hao Xuezhi hui zhouguang Liang jun zhou Zongmei Feng Qinfu Xiao Zefen Chen Dongfu Zhang Hongxing Wang Lyuhua Cancer Institute and Hospital Chinese Academy of Medical SciencesBeijing 100021 China

Background The prognosis of R1-resection at the bronchial stump in patients with non-small cell lung cancer （NSCLC） remains *** study intends to identify the prognostic factors and to optimize treatments for these patients under update *** The data of 124 NSCLC patients who underwent R1-resection at the bronchial stump was *** were 41 patients in the surgery group （S）,21 in the postoperative radiotherapy （PORT） group （S＋R）,30 in the postoperative chemotherapy （POCT） group （S＋C）,and 32 in the PORT plus POCT group （S＋R＋C）.The constitute proportion in different groups was tested using the X2 method,univariate analysis was performed using the Kaplan-Meier and log-rank method,and multivariate analysis was done using the Cox hazard regression with entry factors including age,sex,pathological type and stage,classification of the residual disease,and treatment *** process was performed stepwise backward with a maximum iteration of 20 and an entry possibility of 0.05 as well as an excluded possibility of 0.10 at each *** In univariate analysis,survival was more favorable for patients with squamous cell carcinoma,early pathological T or N stage,and chemotherapy or *** was no significant difference in the survival for patients with different types of the residual disease,except for the difference between patients with carcinoma in situ and lymphangiosis carcinomatosa （P=0.030）.The survival for patients receiving chemoradiotherapy was superior to that for those undergoing surgery alone （P=0.016）.In multivariate analysis,the pathological type （HR 2.51,95% CI 1.59 to 3.96,P=0.000）,pathological T （HR 1.29,95% CI 1.04 to 1.60,P=-0.021） or N stage （HR 2.04,95% CI 1.40 to 2.98,P=0.000）,and chemotherapy （HR 0.24,95% CI 0.13 to 0.43,P=0.000） were independent prognostic *** Patients with squamous cell carcinoma,early pathological T or N stage,or receiving chemotherapy had a more favorable prognosis.

关键词： non-small cell lung cancer thoracic surgery prognosis drug therapy radiotherapy

A functional study of low molecular weight IgM from patients with autoimmune disease

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Journal of Microbiology and Immunology 2006年第3期4卷 207-213页

作者： hui jun zhou XIAO PING YANG WAN SHENG CHEN PETER ROBERTS THOMSON HU JI XU Department of Laboratory Science the Ninth People＇s Hospital School of Medicine Shanghai fiaotongUniversity Shanghai P. R. China Department of Rheumatology and Immunology Department of Pharmacology Changzheng Hospitalthe Second Military Medical University Shanghai P. R. China Department of Immunology Allergy and Arthritis Flinders Medical Centre Australia

High levels of low molecular weight (LMW) IgM in certain diseases are associated with clinical and laboratory indices which reflect the severity of the disease. These associations suggest that LMW IgM may play an important role in the immunopathogenesis of these diseases. To further approach the question concerning the functional activity of LMW IgM in disease, a panel of LMW IgM and high molecular weight (HMW) IgM preparations with or without rheumatoid factor (RF) activity were used to investigate their antibody binding activity and their effector function. It was found that LMW IgM-RF and HMW IgM-RF had a similar binding capacity to Fc fragment as there was no significant difference in the affinity index between them. It further showed that the rate of activation and total amount of utilization of complement by LMW IgM and HMW IgM was similar, although the mean fluorescence of C3 deposition by IgM-RF and HMW IgM-RF was slightly higher than that of LMW IgM-RF and other control RF antibodies. However, the current study demonstrated that LMW IgM had strong neutrophil activating properties when compared with HMW IgM. These findings suggest that one mechanism of LMW IgM contributing to the immunopathogenesis of RA may be due to the formation of circulating immune complex ( CIC) by LMW IgM with subsequent activation of neutrophils. Whether LMW IgM has other functional activity in disease is unclear and needs further investigation.

关键词： Low molecular weight IgM Antoimmune diseases Neutrophil Rheumatoid factor

Application of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lesions

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Chinese Medical Journal 2011年第23期124卷 3988-3992页

作者： ZHAO hui WANG jun zhou Zu-li LI Yun BU Liang YANG Fan SUI Xi-zhao CHEN Ke-zhong LI Xiao LIU jun LI Jian-feng JIANG Guan-chao Department of Thoracic Surgery Peking University People＇s Hospital Beijing 100044 China

Background Mediastinal lesions are often difficult to diagnose in clinical practice because of the unique anatomical position of the mediastinum, which makes performance of biopsy difficult. The value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of lung cancer and mediastinal lymph node staging has been widely accepted. However, few studies have been conducted on the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of mediastinal lesions. The current study was conducted to investigate the value of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis and differential diagnosis of isolated mediastinal lesions without lung abnormalities. Methods We retrospectively analyzed the data of patients with isolated mediastinal lesions without lung abnormalities for whom endobronchial ultrasound-guided transbronchial needle aspiration examination was performed at the Department of Thoracic Surgery of Peking University People＇s Hospital, between September 2009 and December 2010. For patients who could not be diagnosed with endobronchial ultrasound-guided transbronchial needle aspiration, surgical biopsy or more than 6 months of clinical and imaging follow-up was carried out. Results Endobronchial ultrasound-guided transbronchial needle aspiration was performed for 60 patients with isolated mediastinal lesions. Correct diagnosis was made in 48 cases. Nineteen cases were malignant, and 29 were benign. The rate of correct diagnosis was 80%. The sensitivity, specificity, and accuracy of endobronchial ultrasound-guided transbronchial needle aspiration in distinguishing benign from malignant mediastinal lesions were 95%, 100%, and 98%, respectively. The examination was tolerable for all patients. No associated complications were observed. Conclusion Endobronchial ultrasound-guided transbronchial needle aspiration is a safe and effective method of di

关键词： endobronchial ultrasound transbronchial needle aspiration mediastinal lesion diagnosis