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New phenylbutenoids and terpene glycosides from Ginkgo biloba leaves

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Chinese Journal of Natural Medicines 2024年第2期22卷 161-170页

作者： sun Zeshi LIN Shan WU Zhi-Li DONG Hong-Yuan XU Xi-Ke LI hui-Liang WANG Jinxin School of Pharmacy Second Military Medical UniversityShanghai 200433China State Key Laboratory of New Drug and Pharmaceutical Process Shanghai Institute of Pharmaceutical IndustryChina State Institute of Pharmaceutical IndustryShanghai 201203China

Our continued works on the chemical constituents of Ginkgo biloba(***)leaves has led to the isolation of two novel phenylbutenoids(1,2),along with five previously unidentified terpene glycosides(3−7).Among them,compounds 1 and 2 represent unique(Z)-phenylbutenoids,3−6 are megastigmane glycosides,and 7 is identified as a rare bilobanone glycoside(Fig.1).This study marks the first reported isolation of phenylbutenoid and bilobanone glycoside from *** chemical structures of these compounds were elucidated through extensive spectroscopic analysis,including HR-ESI-MS and various 1D and 2D NMR ***,the absolute configurations of these molecules were determined using Mosher’s method,ECD experiments,and Cu-KαX-ray crystallographic analyses.

关键词： Ginkgo biloba Phenylbutenoid Megastigmane glycoside Bilobanone glycoside

An improved algorithm for retrieving thin sea ice thickness in the Arctic Ocean from SMOS and SMAP L-band radiometer data

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Acta Oceanologica Sinica 2024年第3期43卷 127-138页

作者： Lian He Senwen Huang Fengming hui Xiao Cheng School of Geospatial Engineering and Science Sun Yat-Sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 519082China Key Laboratory of Comprehensive Observation of Polar Environment(sun Yat-Sen University) Ministry of EducationZhuhai 519082China

The aim of this study was to develop an improved thin sea ice thickness(SIT)retrieval algorithm in the Arctic Ocean from the Soil Moisture Ocean Salinity and Soil Moisture Active Passive L-band radiometer *** SIT retrieval algorithm was trained using the simulated SIT from the cumulative freezing degree days model during the freeze-up period over five carefully selected regions in the Beaufort,Chukchi,East Siberian,Laptev and Kara seas and utilized the microwave polarization ratio(PR)at incidence angle of 40°.The improvements of the proposed retrieval algorithm include the correction for the sea ice concentration impact,reliable reference SIT data over different representative regions of the Arctic Ocean and the utilization of microwave polarization ratio that is independent of ice *** relationship between the SIT and PR was found to be almost stable across the five selected *** SIT retrievals were then compared to other two existing algorithms(i.e.,UH_SIT from the University of Hamburg and UB_SIT from the University of Bremen)and validated against independent SIT data obtained from moored upward looking sonars(ULS)and airborne electromagnetic(EM)induction *** results suggest that the proposed algorithm could achieve comparable accuracies to UH_SIT and UB_SIT with root mean square error(RMSE)being about 0.20 m when validating using ULS SIT data and outperformed the UH_SIT and UB_SIT with RMSE being about 0.21 m when validatng using EM SIT *** proposed algorithm can be used for thin sea ice thickness(<1.0 m)estimation in the Arctic Ocean and requires less auxiliary data in the SIT retrieval procedure which makes its implementation more practical.

关键词： Arctic sea ice sea ice thickness remote sensing Soil Moisture Active Passive(SMAP) Soil Moisture Ocean Salinity and Soil(SMOS)

Dynamic imaging through scattering medium under white-light illumination [Invited]

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Chinese Optics Letters 2024年第6期22卷 46-51页

作者： Junyao Lei hui Chen Yuan Yuan Yunong sun Jianbin Liu Huaibin Zheng Yuchen He Electronic Material Research Laboratory Key Laboratory of the Ministry of Education and International Centre for Dielectric ResearchXi’an Jiaotong UniversityXi’an 710049China

Imaging objects hidden behind turbid media is of great scientific importance and practical value, which has been drawing a lot of attention recently. However, most of the scattering imaging methods rely on a narrow linewidth of light, limiting their application. A mixture of the scattering light from various spectra blurs the detected speckle pattern, bringing difficulty in phase retrieval. Image reconstruction becomes much worse for dynamic objects due to short exposure times. We here investigate non-invasively recovering images of dynamic objects under white-light irradiation with the multi-frame OTF retrieval engine (MORE). By exploiting redundant information from multiple measurements, MORE recovers the phases of the optical-transfer-function (OTF) instead of recovering a single image of an object. Furthermore, we introduce the number of non-zero pixels (NNP) into MORE, which brings improvement on recovered images. An experimental proof is performed for dynamic objects at a frame rate of 20 Hz under white-light irradiation of more than 300 nm bandwidth.

关键词： scattering imaging white light illumination phase retrieval algorithm

An amorphous FeMoO_(4) nanorod array enabled high-efficiency oxygen evolution electrocatalysis in alkaline seawater

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Nano Research 2024年第4期17卷 2270-2275页

作者： Jie Tang Shengjun sun Xun He hui Zhang Chaoxin Yang Min Zhang Meng Yue Hefeng Wang Yuntong sun Yonglan Luo Sulaiman Alfaifi Asmaa Farouk Mohamed S.Hamdy Xuping sun huiqing Wang Binwu Ying Department of Laboratory Medicine West China HospitalSichuan UniversityChengdu 610041China College of Chemistry Chemical Engineering and Materials ScienceShandong Normal UniversityJinan 250014China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Chemistry Department Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Chemistry College of ScienceKing Khalid UniversityAbha 61413Saudi Arabia Medical Simulation Centre West China Second University HospitalSichuan UniversityChengdu 610041China

The development of highly efficient and durable oxygen evolution reaction(OER)catalysts for seawater electrolysis is of great importance for ***,an amorphous FeMoO_(4) nanorod array on Ni foam is reported as a highly active OER electrocatalyst in alkaline seawater,requiring only overpotentials of 303 and 332 mV to achieve 100 and 300 mA·cm^(-2),***,it shows strong long-term electrochemical durability for at least 50 h.

关键词： amorphous material FeMoO_(4) nanorod array electrocatalyst seawater electrolysis oxygen evolution reaction

Therapeutic Effect of Rhodopseudomonas palustris-Bioconverted Extract of Lycium barbarum on Rats with Lead Exposure

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Biomedical and Environmental Sciences 2024年第4期37卷 440-444页

作者： YANG Hong sun Yi CHAI Shu Tong LIANG Yan hui LIU Ya Ni YANG Guan E School of Pharmacy Shanxi Medical UniversityTaiyuan 030001ShanxiChina

Lead is a ubiquitous pollutant and Pb pollution is a global public health *** has been reported to induce multiple adverse effects,including reproductive toxicity,neurotoxicity,carcinogenicity,nephrotoxicity,immunotoxicity,and hypertension[1].The traditional medical treatment available for Pb poisoning is chelation,which can save lives in individuals with very high blood Pb *** commonly used chelating agents include CaNa2EDTA and meso-2,3-dimercaptosuccinic ***,chelation therapy has strong short-term effects on the overall long-term management of Pb exposure.

关键词： converted chelation chelating

Rosemary leaf powder improves egg quality, antioxidant status, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens

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Animal Nutrition 2024年第2期17卷 325-334页

作者： Lianhua Zhang Junwei Ge Fei Gao Min Yang hui Li Fei Xia Hongtong Bai Xiangshu Piao Zhiying sun Lei Shi Key Laboratory of Plant Resources Institute of Botany Chinese Academy of Sciences China National Botanical Garden State Key Laboratory of Animal Nutrition Institute of Animal Science Chinese Academy of Agricultural Sciences College of Pharmacy Shandong University of Traditional Chinese Medicine University of Chinese Academy of Sciences Beijing Jingwa Agricultural Science&Technology Innovation Center State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University

his study sought to determine the effects of rosemary leaf powder(RP) on laying performance, egg quality, serum indices, gut barrier function, and cecal microbiota and metabolites of late-phase laying hens. A total of 84 “Jing Tint 6” laying hens at 65-week old were randomly divided into 2 groups and fed either a basal diet(CON) or a basal diet supplemented with 0.3% RP. Our study revealed that RP improved the Haugh unit and decreased yolk n-6/n-3 polyunsaturated fatty acid(PUFA) ratio of laying hens,increased serum superoxide dismutase(SOD), jejunal activities of SOD and catalase(CAT), and jejunal zonula occludens-1(ZO-1) expression, as well as decreased serum tumor necrosis factor-a(TNF-a) level and jejunal TNF-a m RNA expression. Rosemary leaf powder markedly enhanced(P < 0.05) cecal abundances of Rikenellaceae, Rikenellaceae＿RC9＿gut＿group, and Turicibacter, tended to promote(P = 0.076)butyrate concentration, and reduced(P < 0.05) cecal abundances of Erysipelatoclostridiaceae, Sutterellaceae, Fusobacteriaceae, Campylobacteraceae, Sutterella, Campylobacter, and Fusobacterium, which were closely linked with Haugh unit, yolk n-6/n-3 PUFA ratio, serum SOD and TNF-a. In addition, RP altered the metabolic functions of cecal microbiota and enhanced the abundances of butyratesynthesizing enzymes, including lysine 2,3-aminomutase, β-lysine 5,6-aminomutase, and 3-oxoacid Co A-transferase. Together, 0.3% RP has the potential to enhance egg quality by partially modulating serum antioxidant status, jejunal barrier function, and cecal microbiota structure and metabolites,indicating that RP could be considered a promising feed additive to promote the production performance of late-phase laying hens.

关键词： Rosemary leaf powder Production Antioxidant status Gut health Microbial community Laying hen

Enhancement of polymyxin B1 production by an artificial microbial consortium of Paenibacillus polymyxa and recombinant Corynebacterium glutamicum producing precursor amino acids

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Synthetic and Systems Biotechnology 2024年第1期9卷 176-185页

作者： hui-Zhong sun Si-Yu Wei Qiu-Man Xu Wei Shang Qing Li Jing-Sheng Cheng Ying-Jin Yuan Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering(Ministry of Education) School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China Tianjin Key Laboratory of Animal and Plant Resistance College of Life ScienceTianjin Normal UniversityBinshuixi Road 393Xiqing DistrictTianjin300387PR China Department of Pharmaceutical School of Chemical Engineering and TechnologyTianjin UniversityYaguan Road 135Jinnan DistrictTianjin300350PR China

Polymyxin B,produced by Paenibacillus polymyxa,is used as the last line of defense *** this study,exogenous mixture of precursor amino acids increased the level and proportion of polymyxin B1 in the total of polymyxin B analogs of *** CJX518-AC(PPAC)from 0.15 g/L and 61.8%to 0.33 g/L and 79.9%,*** co-culture of strain PPAC and recombinant Corynebacterium glutamicum-leu01,which produces high levels of threonine,leucine,and isoleucine,increased polymyxin B1 production to 0.64 g/*** strains PPAC and ***-leu01 simultaneously inoculated into an optimized medium with 20 g/L peptone,polymyxin B1 production was increased to 0.97 g/***,the polymyxin B1 production in the co-culture of strains PPAC and ***-leu01 increased to 2.21 g/L after optimized inoculation ratios and fermentation medium with 60 g/L *** study provides a new strategy to improve polymyxin B1 production.

关键词： Polymyxin Co-culture Paenibacillus polymyxa Corynebacterium glutamicum Medium optimization Metabolic precursors

X-Ray Source Classification Using Machine Learning:A Study with EP-WXT Pathfinder LEIA

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Research in Astronomy and Astrophysics 2024年第8期24卷 175-195页

作者： Xiaoxiong Zuo Yihan Tao Yuan Liu Yunfei Xu Wenda Zhang Haiwu Pan hui sun Zhen Zhang Chenzhou Cui Weimin Yuan National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China National Astronomical Data Center Beijing 100101China

X-ray observations play a crucial role in time-domain *** Einstein Probe(EP),a recently launched X-ray astronomical satellite,emerges as a forefront player in the field of time-domain astronomy and high-energy *** a focus on systematic surveys in the soft X-ray band,EP aims to discover high-energy transients and monitor variable sources in the *** achieve these objectives,a quick and reliable classification of observed sources is *** this study,we developed a machine learning classifier for autonomous source classification using data from the EP-WXT Pathfinder—Lobster Eye Imager for Astronomy(LEIA)and EP-WXT *** proposed Random Forest classifier,built on selected features derived from light curves,energy spectra,and location information,achieves an accuracy of approximately 95%on EP simulation data and 98%on LEIA observational *** classifier is integrated into the LEIA data processing pipeline,serving as a tool for manual validation and rapid classification during *** paper presents an efficient method for the classification of X-ray sources based on single observations,along with implications of most effective features for the *** work facilitates rapid source classification for the EP mission and also provides valuable insights into feature selection and classification techniques for enhancing the efficiency and accuracy of X-ray source classification that can be adapted to other X-ray telescope data.

关键词： methods data analysis-X-rays binaries-stars variables general-X-rays bursts

Oleanonic acid inhibits glioma growth by inactivating STAT3 via upregulating SIRT6 in nude mice

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Food Science and Human Wellness 2024年

作者： Jiancun Wang Yuanyuan Wang hui Gao Qin sun Wen Li Neurosurgery Department of the First Affiliated Hospital of Soochow University Department of Neurosurgery， the Third Affiliated Hospital of Naval Medical University Department of anesthesiology， General Hospital Of Eastern Theater Command Department of Pharmacology， School of Medicine， Shaoxing University

Patients with glioma have a very high mortality rate， thus improving the poor prognosis of glioma has been the goal in the therapeutic field. Searching for more effective drugs for gliomas from natural compounds is a promising strategy. In this study， both oleanonic acid and oleanolic acid inhibited proliferation of glioma cells and reduced expression of cyclin D1 and E1， but the former has a lower IC50 than the latter. Oleanonic acid reduced the expression of p-STAT3 but not p-STAT1 and 5， and also reducing the expression of STAT3 in the nucleus and its transcriptional activity in glioma cells. Furthermore， knockdown of STAT3 expression inhibited proliferation and migration of glioma cells. Next， the expressions of the upstream regulators such as SIRT6 and p-JAK2 but not SIRT1， p-ERK1/2， p300 were increased by oleanonic acid. The overexpression of SIRT6 not only reduced the expression of p-STAT3 and its transcriptional activity but also inhibited the proliferation and migration of glioma cells. In addition， the effects that oleanonic acid reduced the expression of p-STAT3 and its transcriptional activity and inhibited the proliferation and migration were attenuated by the knockdown of SIRT6. Furthermore， oleanonic acid effectively suppressed glioma growth and extended survival in nude mice bearing intracerebral U87 xenografts， but not in nude mice bearing intracerebral SIRT6-knockdown U87 xenografts. In conclusion， oleanonic acid upregulates the expression of SIRT6 to inactivates STAT3 and then inhibits glioma growth.

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