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Association between body mass index and the risk of bleeding in elderly patients with non-valvular atrial fibrillation taking dabigatran:a cohort study

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Journal of Geriatric Cardiology 2020年第4期17卷 193-201页

作者： Ming-hui LI Li-Hua HU Yu-Rong XIONG Yu YU Wei ZHOU Tao WANG Ling-Juan ZHU Xi LIU hui-hui bao Xiao-Shu CHENG Department of Cardiovascular Medicine the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityJiangxiChina Center of Cardiovascular Inner Mongolia People’s HospitalHohhotInner MongoliaChina

Background Uncertainty remains regarding the association between body mass index(BMI)and the risk of bleeding in patients with non-valvular atrial fibrillation(NVAF).We aimed to investigate the association between BMI and the risk of bleeding in elderly NVAF patients taking *** A total of 509 elderly NVAF patients,who were being treated at twelve centers in China from February 2015 to December 2017 and taking dabigatran,were *** exposure and outcome variables were BMI at baseline and bleeding events within the subsequent six months,*** proportional hazards regression analysis was used to evaluate the association between BMI and the risk of ***,the Cox proportional hazards regression with cubic spline functions and smooth curve fitting was *** During the six-month follow-up,50 participants experienced *** 1 kg/m^2 increase in BMI was associated with a 12%increased risk of bleeding(P=0.021).Compared to those with BMI values in Tertile 1(25.3 kg/m^2)were 2.71(95%CI:1.02–7.17)and 3.5(95%CI:1.21–8.70),*** Ptrend-value was significant in all *** adjusted smooth curve showed a linear association between BMI and *** of the stratified variables showed significant effect modification on the association between BMI and bleeding(Pinteraction>0.05).Conclusions BMI was significantly and positively associated with the risk of bleeding in elderly NVAF patients treated with dabigatran.

关键词： Atrial fibrillation Bleeding Body mass index Dabigatran

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Effects of ketamine on proinflammatory cytokines and nuclear factor kappaB in polymicrobial sepsis rats

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World Journal of Gastroenterology 2006年第45期12卷 7350-7354页

作者： Xue-Min Song Jian-Guo Li Yan-Lin Wang Qing Zhou Zhao-hui Du bao-hui Jia Jian-Juan Ke Department of Anesthesiology Zhongnan Hospital of Wuhan University Wuhan 430071 Hubei Province China

AIM： To explore the effects of ketamine on hemodynamics, plasma proinflammatory cytokine （TNF-α and IL-6） levels and nuclear factor kappa B （NF-κB） activation during polymicrobial sepsis. METHODS： Male Sprague-Dawlay rats were subjected to cecal ligation and puncture （CLP） or sham operation. The rats were randomly assigned into four equal groups： sham CLP group, CLP group, ketamine （KT）Ⅰ group and KTⅡgroup. Thirty minutes before CLP, ketamine （5 mg/kg per hour and 10 mglkg per hour, respectively） was infused continuously through the left femoral vein cannula in KT Ⅰ group or KTⅡgroup. Sham CLP group and CLP group received 0.9% saline only （5 mL/kg per hour）. The right femoral artery was cannulated to monitor mean arterial pressure （MAP） and heart rates （HR）,and draw blood samples. The proinflammatory cytokine （TNF-α and IL-6） levels of plasma were measured using enzyme-linked immunosorbent assays （ELISA）. The hepatic NF-κB activation was determined by Western blot and HPIAS 2000 image analysis system. Twenty hours after CLP, the rats were killed by right femoral artery phlebotomization. RESULTS： CLP produced progressive hypotension, and a first increase followed by a decrease in HR. The hypotension was prevented, and the HR was slightly steady in ketamine treated rats. TNF-α levels of plasma reached a peak value at 2 h after CLP. Ketamine （KT Ⅰ group or KTⅡgroup） caused a significant decrease compared with CLP group at 2, 5 and 9 h time points after CLP （14.3 ± 1.9 vs 4.3 ± 0.9, 9.7 ± 1.4 vs 4.3 ± 0.9; 9.3 ± 1.5 vs 4.3 ± 0.9, 8.7 ± 1.4 vs 4.3 ±0.9; 6.0 ± 1.5 vs 5.0 ± 1.7, 5.3 ± 0.8 vs 5.0 ± 1.7; P 〈 0.01, respectively）. The IL-6 levels of plasma firstly ascended and then descended in CLP group, and reached a peak value at 9 h after CLP. Ketamine （KT I group or KTH group） caused a significant decrease compared with CLP group at 5, 9 or 20 h after CLP （135.0 ± 52.6 vs 60.0 ± 16.3, 112.5 ± 52.6 vs 60.0 ± 16.3; 410.0 ± 68.7 vs 62.5 ± 12.5, 250.0 ± 28.0 vs 62.5 ± 12.

关键词： Ketamine Sepsis Hemodynamics Tumor necrosis factor α Interleukin 6 Nuclear factor kappa B

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Individual and joint effects of borderline ankle-brachial index and high plasma total homocysteine on all-cause death in hypertensive adults

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Journal of Geriatric Cardiology 2022年第7期19卷 522-530页

作者： Jun-Pei LI Tian-Yu CAO Xiao-Yuan ZHA Yun YU Zi-Heng TAN Zai-Hua CHENG Hua-Bo YING Wei ZHOU Lin-Juan ZHU Tao WANG Li-Shun LIU hui-hui bao Xiao HUANG Xiao-Shu CHENG Department of Cardiology the Second Affiliated Hospital of Nanchang UniversityNanchangChina University of California Santa BarbaraCAUSA Rancheng Community Health Service Center WuyuanChina Center for Prevention and Treatment of Cardiovascular Diseases the Second Affiliated Hospital of Nanchang UniversityNan-changChina Graduate School at Shenzhen Tsinghua UniversityShenzhenChina

BACKGROUND The cardiovascular hazards of total homocysteine(tHcy)are long *** addition,despite the acknow-ledgment on the importance of low ankle-brachial index(ABI)(<0.9),borderline ABI(0.91-0.99)was once commonly *** study aims to explore the independent and joint effect of tHcy level and borderline ABI on all-cause death in hypertensive *** This study included 10,538 participants from China H-type Hypertension Registry *** was described into two groups:normal ABI(1.00-1.40)and borderline *** level was also divided into two groups:<15.02 and≥15.02μmo/*** groups were analyzed,using COX proportional hazard regression model,separately and pairwise to observe the independ-ent and joint effect on all-cause *** A total of 126(1.2%)deaths were observed in the 1.7 years follow-up *** ABI has a higher predicted risk of death than normal ABI(HR=1.87,95%CI:1.17-3.00)after adjusting for potential *** with tHcy level<15.02μmo/L(low tHcy),those with tHcy≥15.02μmo/L(high tHcy)had higher risk to event outcome(HR=1.99,95%CI:1.30-3.05).According to the cumulative hazard curve,group with borderline ABI and high tHcy level has significantly higher altitude and larger increasing rate over follow-up period compare to other *** those with borderline ABI,participants with high tHcy had higher death risk than those with low tHcy,nevertheless,no significant different between borderline and normal ABI among those with low tHcy *** Borderline ABI and tHcy level both have independent predictive value on all-cause *** combined group of borderline ABI and high tHcy has highest risk factor of outcomes,which suggested the mutual additive value of border-line ABI and *** attention should be given to the importance of borderline ABI in hypertensive population,especially with elevated tHcy level.

关键词： hypertensive death ankle

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CaH2-promoted activity of Ni-carbonate interface for CO2 methanation

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Journal of Energy Chemistry 2025年第1期100卷 522-532页

作者： Jin-Peng Wang Guo-Cui Mao hui-Lin Jiang bao-Xia Dong Yun-Lei Teng School of Chemistry and Chemical Engineering Yangzhou University

Transition metal-carbonate interfaces often act as active sites in heterogeneous catalytic *** interface between transition metal and metal carbonate exhibits a dynamic equilibrium during the CO2hydrogenation reaction,involving surface carbonate hydrogenation and ***,there have been few reports on engineering the activity of the interface between transition metal and alkaline earth metal carbonate for catalytic *** work demonstrated that the incorporation of CaH2in Ni/CaCO3enhances the CO2methanation activity of the *** CO2conversion for Ni/CaH2-CaCO3reached 68.5%at 400°C,which was much higher than that of the Ni/CaCO3（31.6%） and Ni/CaH2-CaO （42.4%） ***,the Ni/CaH2-CaCO3catalysts remained stable during the stability test for 24 h at 400°C and 8 *** research revealed that CaH2played a crucial role in promoting the activity of the Ni-carbonate interface for ***2could modify the electronic structure of Ni and tune the structural properties of CaCO3to generate medium basic sites （OH groups）,which are favorable for the activation of H2and ***-situ Fourier transform infrared spectroscopy （FTIR） analysis combined with density functional theory calculations demonstrated that CO2activation occurs at the hydroxyl group （OH） on the CaH2-modified Ni-carbonate surface,leading to the formation of CO3H****,our study has confirmed that CO2methanation over the Ni/CaH2-CaCO3catalysts proceeds via the formate pathway.

关键词： Metal hydride Ni catalysts Carbonate Metal-carbonate interface

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Independent and joint association of physical activity and sedentary behavior on all-cause mortality

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Chinese Medical Journal 2021年第23期134卷 2857-2864页

作者： Wei Zhou Wei Yan Tao Wang Ling-Juan Zhu Yan Xu Jun Zhao Ling-Ling Yu hui-hui bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China Jiangxi Provincial Cardiovascular Disease Clinical Medical Research Center NanchangJiangxi 330006China Chronic Disease Prevention and Control Institute Jiangxi Province Center for Disease Control and PreventionNanchangJiangxi 330006China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China.

Backgrounds:Physical activity(PA)and sedentary behavior(SB)have been associated with mortality,while the joint association with mortality is rarely reported among Chinese *** aimed to examine the independent and joint association of PA and SB with all-cause mortality in southern ***:A cohort of 12,608 China Hypertension Survey participants aged≥35 years were enrolled in 2013 to 2014,with a follow-up period of 5.4 *** self-reported PA and SB were collected via the ***–Meier curves(log-rank test)and Cox proportional hazards regression were performed to evaluate the associations of PA and SB on all-cause ***:A total of 11,744 eligible participants were included in the *** an average of 5.4 years of follow-up,796 deaths *** risk of all-cause mortality was lower among participants with high PA than those with low to moderate level(5.2%vs.8.9%;hazards ratio[HR]:0.75,95%confidence interval[CI]:0.61–0.87).Participants with SB≥6 h had a higher risk of all-cause mortality than those with SB<6 h(7.8%vs.6.0%;HR:1.37,95%CI:1.17–1.61).Participants with prolonged SB(≥6 h)and inadequate PA(low to moderate)had a higher risk of all-cause mortality compared to those with SB<6 h and high PA(11.2%vs.4.9%;HR:1.67,95%CI:1.35–2.06).Even in the participants with high PA,prolonged SB(≥6 h)was still associated with the higher risk of all-cause mortality compared with SB<6 h(7.0%vs.4.9%;HR:1.33,95%CI:1.12–1.56).Conclusions:Among Chinese population,PA and SB have a joint association with the risk of all-cause *** with inadequate PA and prolonged SB had the highest risk of all-cause mortality compared with others.

关键词： Physical activity Sedentary behavior All-cause mortality Joint association

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Peripheral leukocyte count and risk of bleeding in patients with non-valvular atrial fibrillation taking dabigatran: a real-world study

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Chinese Medical Journal 2019年第18期132卷 2150-2156页

作者： Wei Zhou Tao Wang Ling-Juan Zhu Ming-Hua Wen Li-Hua Hu Xiao Huang Chun-Jiao You Ju-Xiang Li Yan-Qing Wu Qing-Hua Wu hui-hui bao Xiao-Shu Cheng Center for Prevention and Treatment of Cardiovascular Diseases The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China Department of Cardiovascular Medicine The Second Affiliated Hospital of Nanchang University Nanchang Jiangxi 330006 China

Background: The association between peripheral leukocyte count and bleeding events in nonvalvular atrial fibrillation (NVAF) patients treated with dabigatran remains unclear. This study aimed to explore the association between leukocyte count and bleeding events after excluding other confounders in NVAF patients taking dabigatran. Methods: A total of 851 NVAF patients treated with dabigatran (110 mg bid) were recruited from 12 centers in China from February 2015 to December 2017. Follow-up was completed by May 2018. The exposure and outcome variables were leukocyte count measured at baseline and the number of bleeding events within the subsequent 6 months. Multivariate Cox proportional hazards models were constructed to analyze independent associations, and a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (penalized spline method) was used to address nonlinearity between leukocyte count and bleeding. The inflection point was calculated using a recursive algorithm, and then a two-piecewise Cox proportional hazards model for both sides of the inflection point was constructed. Results: During 6-month follow-up, 87 participants occurred bleeding events. For every 1×10^9/L increase in leukocyte count, the risk of bleeding increased by 11%(hazard ratio [HR]: 1.11, 95% confidence interval [CI]: 0.99–1.25). The smooth curve showed nonlinear relationship between leukocyte count and bleeding events. The inflection point of the leukocyte count was 6.75×10^9/L. For leukocyte counts < 6.75×10^9/L, the HR (95% CI) was 0.88 (0.69–1.13), and for leukocyte counts ≥ 6.75×10^9/L, the HR (95% CI) was 1.28 (1.09–1.51). Conclusion: This study found a J-shaped association between baseline leukocyte count and risk of bleeding in NVAF patients treated with dabigatran.

关键词： Peripheral leukocyte count Bleeding Nonvalvular atrial fibrillation Threshold effect

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应用德尔菲法建立寄生虫病健康教育作品评价体系

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中国血吸虫病防治杂志 2018年第3期30卷 307-311,328页

作者：朱慧慧钱门宝周长海诸廷俊陈颖丹中国疾病预防控制中心寄生虫病预防控制所国家卫生和计划生育委员会寄生虫病原与媒介生物学重点实验室科技部国家级热带病国际联合研究中心世界卫生组织热带病合作中心上海200025

目的应用德尔菲研究方法建立寄生虫病健康教育作品评价体系,为健康教育作品评价提供参考。方法成立专家组,通过头脑风暴和面对面讨论确定寄生虫病健康教育作品评价指标。而后基于评价指标设计问卷,通过两轮专家咨询,最终确定各评价指标... 详细信息

目的应用德尔菲研究方法建立寄生虫病健康教育作品评价体系,为健康教育作品评价提供参考。方法成立专家组,通过头脑风暴和面对面讨论确定寄生虫病健康教育作品评价指标。而后基于评价指标设计问卷,通过两轮专家咨询,最终确定各评价指标的权重,形成完整的寄生虫病健康教育作品评价体系。结果专家组分别确定了平面作品、实物作品和影音作品的评价指标,3类作品分别包含4个一级指标和12个二级指标。通过两轮专家咨询,23位专家达成了一致意见,认为在一级指标中最重要的是作品的"科学性"和"可接受性";而在二级指标中,"信息准确性"和"行为指导性"最为重要。结论建立了科学、合理的评价体系,该体系可应用于寄生虫病健康教育作品的综合评价。

关键词：寄生虫病健康教育作品评价指标德尔菲法

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19例假肢穿戴者接受腔消毒效果的评价

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中国康复理论与实践 2017年第5期23卷 616-620页

作者：徐静王佳奇孙惠惠熊宝林方新沈瑾北京社会管理职业学院假肢矫形康复系北京市101601 中国疾病预防控制中心环境与健康相关产品安全所北京市100021

目的探索假肢接受腔常规消毒的可行性。方法 2016年6月至8月,采用复合季铵盐消毒剂对19名下肢假肢穿戴者穿戴的假肢接受腔进行擦拭消毒,对套袜喷雾消毒,每天晚上1次,持续3周。每周现场调查和采样,行菌落计数,分离鉴定金黄色葡萄球菌、... 详细信息

目的探索假肢接受腔常规消毒的可行性。方法 2016年6月至8月,采用复合季铵盐消毒剂对19名下肢假肢穿戴者穿戴的假肢接受腔进行擦拭消毒,对套袜喷雾消毒,每天晚上1次,持续3周。每周现场调查和采样,行菌落计数,分离鉴定金黄色葡萄球菌、铜绿假单胞菌、大肠杆菌、白色念珠菌。结果消毒后,假肢接受腔细菌菌落数降低1.8~3.0个对数值,真菌总数降低1.6~1.9个对数值;消毒前样本分离到金黄色葡萄球菌1株,大肠杆菌1株,消毒后样本中分离出铜绿假单胞菌1株;持续消毒后,假肢接受腔异味除去效果明显,湿疹及瘙痒症状减轻或消失。结论假肢接受腔经复合季铵盐消毒后,可有效减少微生物污染,去除异味,减少湿疹等皮肤病的发生。

关键词：假肢接受腔消毒复合季铵盐

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Zwitterionic hyaluronic acid derivatives for co-delivery of both chemotherapeutic and nucleic acid drugs in breast cancer treatment

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Nano Research 2025年第1期18卷 607-617页

作者： Ruo-Lin Jiang hui-Na Liu Yu-Fan Yang Zhi-Cheng Zhang Qi Dai Xiao-Yan bao Lin-Jie Wu Ya-Xin Qin Xin Tan Xiao-Yan Sun Xu-Fang Ying Zhi-Qing Ben Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Radiation Oncology Key Laboratory of Cancer Prevention and InterventionThe Second Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China Jinhua Institute of Zhejiang University Jinhua 321299China National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang UniversityHangzhou 310058China Polytechnic institute Zhejiang UniversityHangzhou 310015China

Traditionally,hyaluronic acid has been widely used for drug delivery,but the current application bottleneck is that hyaluronic acid is hydrophilic and electronegative,which makes it difficult to carry hydrophobic drugs and small interfering RNA(siRNA)with the same *** on previous studies,we designed and synthesized hyaluronic acid nanocarriers HA-spermine/N,N,N-trimethylcystamine/DOX-TPP(HSTD)for loading siRNA to overcome the problem of siRNA release caused by strong electrostatic ***,N,N,Ntrimethylcystamine in the carrier can be degraded by intracellular glutathione to completely and rapidly release siRNA,thus promoting ***,when codelivered with the chemotherapy drug doxorubicin(DOX),this novel nanocarrier showed promising synergy in inhibiting tumor growth.

关键词： zwitterionic hyaluronic acid N N N-trimethylcystamine small interfering RNA(siRNA) doxorubicin

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ON NODAL LINE OF THE SECOND EIGENFUNCTION OF THE LAPLACIAN OVER CONCAVE DOMAINS IN R^2

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Journal of Systems Science & Complexity 2013年第3期26卷 483-488页

作者： YANG Dong-hui Guo bao-Zhu Department of Mathematics Central South University Academy of Mathematics and Systems Science Academia Sinica

In this note,the Payne's conjecture from convex domains to concave domains is *** is shown that the nodal line N of the second eigenfunction of the Laplacian over some simply connected concave domain Ω in R^2 must in... 详细信息

关键词： Eigenfunction eigenvalue Laplacian.

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