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Software-defined process-near-memory architecture using 3D hybrid bonding integration

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Science China(Information Sciences) 2025年第1期68卷 366-378页

作者： Anlin XU Chenchen DENG Jianfeng ZHU Yao WANG Shaojun wei Leibo LIU School of Integrated Circuits Tsinghua University Beijing Institution of Tracking and Communication Technology Beijing National Research Center for Information Science and Technology Tsinghua University

With the unprecedented explosive growing amount of global data, the development of computing chips, which encounter bottlenecks such as power wall and memory wall, cannot satisfy the demanding requirement. This work proposes a software-defined process-near-memory(SDPNM) computing architecture implemented using 3D hybrid bonding *** software-defined chip architecture, featuring spatial computations and dynamic reconfiguration, innovates in a top-down manner to achieve high energy efficiency while maintaining flexibility after fabrication. The process-near-memory integration further advances the SDNPM chip in a bottom-up way to reduce the energy consumption of data movement while improving the bandwidth. Utilizing a relatively mature fabrication and bonding process can result in feasible solutions for both data-intensive and compute-intensive applications including digital signal processing and artificial intelligence. The logic die is fabricated in the SMIC 40 nm process and the DRAM die is fabricated in the PSMC 25 nm process. The hybrid bonding is implemented by XMC. The experimental results show that the energy efficiency of the proposed SDPNM chip is 33.1× better than the state-of-the-art FPGA ranging from 8.2× to 104.1×.

关键词： software-defined chips process near memory energy efficiency dynamic reconfiguration domain specific

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Design and Application of Turbine Cascade Partitioned Endwall Profiling

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Journal of Thermal Science 2025年第1期34卷 110-128页

作者： ZENG Fei JIANG Ruiqi XUE Xingxu DU wei LUO Lei ZHOU Xun AECC Hunan Aviation Powerplant Research Institute School of Energy Science and Technology Harbin Institute of Technology Science and Technology on Diesel Engine Turbocharging Laboratory China North Engine Research Institute

The influence of partitioned profiling design based on a large-pitch highly loaded cascade is studied by numerical *** partitioned profile is mainly composed of a pressure-side convex structure near the leading edge and a suction-side convex structure at the midstream and downstream sides of the *** influence of the change in the vertex axial position and peak value of the B-line on the secondary flow control is *** this paper,air(ideal gas) is selected as the flow *** average static pressure at the outlet and the average total temperature at the inlet are kept *** γ-θ is used as the turbulence *** results show that the pressure-side convex structure suppresses the spanwise and pitchwise migration of the inlet flow by adjusting the static pressure distribution of the flow field,so the development of the pressure-side leg of the horseshoe vortex is effectively *** suction-side convex structure adjusts the static pressure distribution of the flow field and increases the included angle between the cross-flow and suction surface,so the accumulation of low-momentum fluid,the development of a corner vortex and the flow separation at the trailing edge of the suction-side surface are all suppressed near the endwall-suction ***,the energy loss coefficient of the large-pitch highly loaded cascade is decreased from 0.0564 to 0.0485,representing a 25% reduction in secondary flow losses.

关键词： Vortex flow

Microstructures and magnetic properties of Sm(Co_(bal)Fe_(0.245)Cu_(0.07)Zr_(0.02))_(7.8)sintered magnet solution-treated at high temperature

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Rare Metals 2022年第12期41卷 4230-4234页

作者： wei Sun Ming-gang Zhu Yi-Kun Fang Zhao-hui Guo wei Li Functional Materials Research Institute Central Iron and Steel Research InstituteBejing 100081China Beijing Engineering Laboratory of Advanced Metallic Magnetic Materials and Preparation Techniques Beijing 100081China

Sm(CoFeCuZr)zsintered permanent magnet has been attracting a great deal of attention by virtue of its high-temperature magnetic properties,low temperature coefficient and good corrosion and oxidation *** microstructures and magnetic properties of Sm(Co_(ba1)Fe_(0.245)Cu_(0.07)Zr_(0.02))_(7.8)sintered permanent magnet prepared by a traditional powder metallurgy method were *** magnetic properties,especially the maximum magnetic energy product,(BH)max,were obtained through adjusting solution-treated *** solution-treated temperature increasing from 1155 to 1195℃,remanence(Br)almost keeps constant and knee point coercivity(Hk),magnetic induction coercivity(H_(cb))and(B_(H))maxfirst increase and then *** intrinsic coercivity(H_(cj))of magnet solution-treated at 1195℃is 738 kA·m^(-1),which is less than 2/5 that of magnet solution-treated at 1183℃(>1927 kA·m^(-1)).The reason that magnet solution-treated at 1195℃shows lower Hcjthan magnet solution-treated at 1183℃is considered to be mainly related to the fact that there are a lot of cells with abnormally small *** addition,the lattice constant of Sm(Co_(bal)Fe_(0.245)Cu_(0.07)Zr_(0.02))_(7.8)sintered permanent magnet solution-treated at 1195℃,given by indexing highresolution transition electron microscope(HRTEM)results,is considered to be related to the formation of cells with abnormally small size which decreases H_(cj).

关键词： Microstructures Magnetic properties Sm(CoFeCuZr)_(z)sintered magnet High solution-treated temperature

Corrosion behavior and mechanism of the automotive hot-dip galvanized steel with alkaline mud adhesion

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International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 414-421页

作者： Hong Zhang Xiao-gang Li Cui-wei Du hui-bin Qi School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China Institute of Welding and Surface Technology Baoshan Iron ＆ Steel Co. Ltd. Shanghai 201900 China

The corrosion behavior and mechanism of hot-dip galvanized steel and interstitial-free （IF） substrate with alkaline mud adhesion were investigated by scanning electron microscopy （SEM）, X-ray diffraction （XRD）, electrochemical impedance spectroscopy （EIS）, and linear polarization. The results show that non-uniform corrosion occurs on the galvanized steel and IF substrate during 250 h with the mud adhesion. The corrosion products on the galvanized steel are very loose and porous, which are mainly ZnO, Zn5（OH）8C12·H2O and Zn（OH）2, and Fe-Zn alloy layer with a lower corrosion rate is exposed on the galvanized steel surface; however, the corrosion products on IF substrate are considerably harder and denser, whose compositions of rust are mainly FeOOH and Fe3O4, and several pits appear on their surface. The results of continuous EIS and linear polarization measurements exhibit a corrosion mechanism, that is, under activation control, the charge transfer resistances present different tendencies between the galvanized steel and IF substrate; in addition, the evolution of linear polarization resistances is similar to that of charge transfer resistances. The higher contents of dissolved oxygen and Cl^- ions in the mud play an important role in accelerating the corrosion.

关键词： corrosion mechanism galvanized steel interstitial-free (IF) steel mud adhesion

High-performance poly(aromatic pyridine) copolymers with crown ether moieties for high temperature polymer electrolyte membrane fuel cells

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Science China Chemistry 2025年

作者： Qian Wang Songhao Zhao Yunpeng Guo wei wei Lele Wang Jingshuai Yang Department of Chemistry College of Sciences Northeastern University Institute of Metal Research Chinese Academy of Sciences

This study concentrates on the development of high temperature polymer electrolyte membranes（HT-PEMs）, which are essential components for HT-PEM fuel cells（HT-PEMFCs）. Although the phosphoric acid（PA）-doped polybenzimidazole（PBI） has been regarded as the successful HT-PEM, this system still suffers from several challenges, including the use of carcinogenic monomers, complex synthesis procedures, and poor solubility in organic solvents. To develop more cost-effective, readily synthesized and high-performance alternatives, this study employs a simply superacid-catalyzed Friedel-Crafts reaction to synthesize a series of poly（triphenyl-co-dibenzo-18-crown-6 pyridine） copolymers, denoted as P(TPx%-co-CEy%), using ptriphenyl, dibenzo-18-crown-6 and 4-acetylpyridine as monomers. The copolymerized hydrophilic and bulky crown ether unites introduce large free volumes and multiple interaction sites with PA molecules, as elucidated by theoretical *** microphase separation structures are formed as confirmed by atomic force microscope（AFM）, transmission electron microscopy（TEM） and small-angle X-ray scattering（SAXS）. Thus P(TPx%-co-CEy%) membranes exhibit excellent PA absorption and proton conduction abilities. For example, after immersing in 85 wt% PA at 30 °C, the P(TP91%-co-CE9%) membrane achieves a PA doping content of 205% and a high conductivity of 0.138 S cm-1at 180 °C, while maintaining a tensile strength of 7.5 MPa at room temperature. Without humidification and backpressure, the peak power density of an H2-O2cell equipped with P(TP91%-co-CE9%)/205%PA reaches nearly 1200 mW cm-2, representing one of the highest performances reported for PA-doped HT-PEMs to date. This work demonstrates the enormous potential of poly（triphenyl-co-crown ether pyridine） membranes in the HT-PEMFC applications.

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Application of Dorzagliatin in peritoneal dialysis patients with type 2 diabetes mellitus:A case report

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World Journal of Diabetes 2025年第1期16卷 204-210页

作者： Fang Chen Bo An Wen-Cheng An gang Fu wei Huang hui-Xian Yan Department of Endocrinology Beijing Haidian HospitalBeijing 100080China Department of Nephrology Beijing Haidian HospitalBeijing Haidian Section of Peking University Third HospitalBeijing 100080China

BACKGROUND Treating diabetes in dialysis patients remains a challenge,with many hypoglycemic drugs requiring dose adjustments or avoidance in these *** SUMMARY This report describes an 83-year-old female patient with a 30-year history of type 2 diabetes(T2DM)who had struggled to control her blood sugar for more than a *** had a history of high blood pressure for 30 years,had undergone continuous ambulatory peritoneal dialysis for more than two years,was 163 cm tall,weighed 77 kg,and had a body mass index of 28.98 kg/*** intensive insulin therapy at a daily dose of 150 units,adding Dorzagliatin at a dosage of 75 mg orally twice daily led to immediate blood sugar improvement and a gradual reduction in insulin *** one month of follow-up,the fasting plasma glucose was 6-8 mmol/L,and the 2-hour postprandial glucose was 8-12 mmol/*** To our knowledge,this report is the first to use Dorzagliatin to treat type 2 diabetes peritoneal dialysis patients with challenging glucose ***,a novel glucokinase activator primarily metabolized by the liver,exhibits no pharmacokinetic differences among patients with varying degrees of chronic kidney *** has a high plasma protein binding rate and may not be cleared by peritoneal dialysis,potentially offering a new glycemic control option for Type 2 diabetic patients on peritoneal dialysis.

关键词： Dorzagliatin Type 2 diabetes mellitus Peritoneal dialysis Glucokinase activator Glucose control Case report

Infiltration by monocytes of the central nervous system and its role in multiple sclerosis: reflections on therapeutic strategies

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Neural Regeneration Research 2025年第3期20卷 779-793页

作者： Guangyong Zhang Qing Yao Chubing Long Pengcheng Yi Jiali Song Luojia Wu wei Wan Xiuqin Rao Yue Lin Gen wei Jun Ying Fuzhou Hua Department of Anesthesiology the Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina Key Laboratory of Anesthesiology of Jiangxi Province NanchangJiangxi ProvinceChina

Mononuclear macrophage infiltration in the central nervous system is a prominent feature of neuroinflammation. Recent studies on the pathogenesis and progression of multiple sclerosis have highlighted the multiple roles of mononuclear macrophages in the neuroinflammatory process. Monocytes play a significant role in neuroinflammation, and managing neuroinflammation by manipulating peripheral monocytes stands out as an effective strategy for the treatment of multiple sclerosis, leading to improved patient outcomes. This review outlines the steps involved in the entry of myeloid monocytes into the central nervous system that are targets for effective intervention: the activation of bone marrow hematopoiesis, migration of monocytes in the blood, and penetration of the blood–brain barrier by monocytes. Finally, we summarize the different monocyte subpopulations and their effects on the central nervous system based on phenotypic differences. As activated microglia resemble monocyte-derived macrophages, it is important to accurately identify the role of monocyte-derived macrophages in disease. Depending on the roles played by monocyte-derived macrophages at different stages of the disease, several of these processes can be interrupted to limit neuroinflammation and improve patient prognosis. Here, we discuss possible strategies to target monocytes in neurological diseases, focusing on three key aspects of monocyte infiltration into the central nervous system, to provide new ideas for the treatment of neurodegenerative diseases.

关键词： blood–brain barrier macrophages monocytes multiple sclerosis neuroinflammation review therapy

Tailoring the Texture and Mechanical Properties of Textured-AZ31 Mg Alloy Sheets by Twinning and Recrystallization

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Acta Metallurgica Sinica(English Letters) 2022年第12期35卷 1983-1995页

作者： hui-Hu Lu You Li Li Lu Wang-gang Zhang wei Liang School of Mechanical Engineering North University of ChinaTaiyuan 030051China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China

In this study,a method of corrugated width limit alignment processes(CWLA)was applied to pre-twin in hot-rolled Mg alloy *** microstructure evolution and mechanical properties of the CWLA sheets were *** results demonstrated that the grain orientation was transformed from strong basal texture to RD-rotated texture after CWLA treatment and up to 22.2%of{10-12}tensile twin boundaries were produced in the *** 60±5°twin variant pairs were dominant in the twinned *** kinds of dynamic recrystallization(DRX)mechanism,i.e.,continuous DRX(CDRX)at low-temperature CWLA and the discontinuous DRX(DDRX)at high-temperature condition were *** post-annealing,the twin-induced static recrystallization(SRX)and abnormal grain growth were observed in the CWLA samples,and most twin boundaries were *** CAWL for 60 min at 300℃ and post annealing,an improvement on plasticity and strength were achieved with 55%increment for uniform elongation(UE)and 10%increment for ultimate tensile strength(UTS).

关键词： Magnesium alloy Corrugated width limit alignment processes Tension twinning Dynamic recrystallization Mechanical properties

Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients

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Science China Life Sciences 2025年第1期68卷 297-299页

作者： Junbin Zhou Rongli wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang wei Xiao Xu Department of Hepatobiliary and Pancreatic Surgery People's Hospital of LishuiAffiliated Lishui Hospital of Wenzhou Medical UniversityThe First Affiliated Hospital of Lishui University NHFPC Key Laboratory of Combined Multi-Organ Transplantation Key Laboratory of Integrated Oncology and Intelligent Medicine of Zhejiang Province Department of Hepatobiliary and Pancreatic SurgeryHangzhou First People's Hospital Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of Medicine Department of Urology The Second Affiliated HospitalZhejiang University School of Medicine Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan (Hangzhou) Hospital Hangzhou Medical College Zhejiang University School of Medicine

Dear Editor, Liver transplantation(LT) is the only curative therapy for patients with endstage liver disease(He et al., 2023; Ling et al., 2022). Post-transplant hypertriglyceridemia(PTHT), which has an incidence of up to 32.8% in 6 months after LT, is one of the major post-transplant complications(Toshima et al., 2020).

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