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Importance of SALL4 in the development and prognosis of hepatocellular carcinoma

World Journal of Gastroenterology 2016年第9期22卷 2837-2843页

作者： Fei Yin Xin Han Shu-Kun Yao Xiao-Ling Wang hui-chai yang Department of Gastroenterology the Fourth Hospital of Hebei Medical University Department of Gastroenterology China-Japan Friendship Hospital Department of Pathology the Fourth Hospital of Hebei Medical University

AIM: To detect the expression of sal-like protein 4 (SALL4) and to explore its relationship with clinicopathological characteristics and prognosis of hepatocellular carcinoma (HCC).METHODS: One hundred and twenty-six samples of HCC tissue, 44 of adjacent noncancerous cirrhotic tissue and 10 of liver hemangioma tissue, were obtained from patients who underwent hepatectomy for HCC at the Fourth Hospital of Hebei Medical University. None of the patients had received any form of treatment before the operation. After resection, all the tissues were fixed in 10% neutral formaldehyde and embedded in paraffin. Expression of SALL4 was detected by immunohistochemistry. Patients were followed up for postoperative survival until February 2014. The relationships between SALL4 expression level and clinicopathological data and prognosis of HCC were ***: SALL4 expression was negative in the 10 samples of tissue from liver hemangioma, was weakly positive in the two samples from adjacent noncancerous cirrhotic tissue, and positive in 58 samples of HCC tissues. The differences were statistically significant (P < 0.05). Expression of SALL4 was higher in patients with higher α-fetoprotein (AFP) levels, portal vein tumor thrombus, and later clinical stage based on the Barcelona Clinic Liver Cancer classification (P < 0.05). Among patients with negative expression, weakly positive expression, positive expression, and strongly positive expression of SALL4, the median survival time was 39, 25, 23, and 9 mo, respectively (P < 0.001). When both AFP and SALL4 were detected, patients who were negative for both AFP and SALL4, SALL4-positive only, AFP-positive only, and positive for both AFP and SALL4, had a median survival time of 41, 38, 31, and 12 mo, respectively (P < 0.001).CONCLUSION: Expression of SALL4 is relevant to the prognosis of HCC patients. Patients with higher expression levels of SALL4 and AFP have worse prognosis.

关键词： Sal-like protein 4 Hepatocellular carcinoma Survival analysis α -Fetoprotein Prognosis

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The effect of childbirth on carcinogenesis of DMBA-induced breast cancer in female SD rats

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Chinese Journal of Cancer 2011年第11期30卷 779-785页

作者： Ji-An Zhao Jin-Jun Chen Ying-Chao Ju Jian-Hua Wu Cui-Zhi Geng hui-chai yang Department of Hepatobiliary Surgery The First Affil- iated Hospital Hebei Medical University Shijiazhuang Hebei 050013 P. R. China Experimental Animal Center The Fourth Affiliated Hospital Hebei Medical University Shijiazhuang Hebei 050011 P. R. China. Department of Breast Clinics Center The Fourth Affiliated Hospital Hebei Medical University Shijiazhuang Hebei 050011 P. R. China. Department of Pathology The Fourth Affiliated Hospital Hebei Medical University Shijiazhuang Hebei 050011 P. R. China.

Many epidemiologic and clinical studies have indicated that the frequency of breast cancer was lower in parous women than in nulliparous women. Moreover, the incidence of breast cancer has been reported to be lower in women with early childbirth than in women with late childbirth. To verify the effect of childbirth and the age at first childbirth on carcinogenesis and progression of breast cancer, we induced breast cancer by 7,12-dimethylbenanthracene (DMBA) in 120 female Sprague-Dawley (SD) rats, and divided them into control or experimental (DMBA-treated) nulliparous, early childbirth, and late childbirth groups to observe the incidence, latency, and size of breast cancer. Argyrophilic nucleolar organizer regions (AgNOR) count and the expression of C-erbB-2, proliferating cell nuclear antigen (PCNA), Ki-67, and minichromosome maintenance protein 2 (MCM2) in breast cancer tissues were detected by immunohistochemistry. The breast cancer incidences were 95.0%, 16.7%, and 58.8% in the experimental nulliparous, early childbirth, and late childbirth groups, respectively (all P < 0.05). Between any two of these groups, the latency was significantly different, but tumor size was similar. AgNOR count and the expression of C-erbB-2, PCNA, Ki-67, and MCM2 were significantly higher in the experimental nulliparous group than in the experimental early or late childbirth groups (P < 0.05), but no significant differences were observed between the latter two groups. Taken together, the results suggest that childbirth, especially early childbirth, can reduce the incidence and postpone the onset of DMBA-induced breast cancer.

关键词： SD大鼠乳腺癌分娩雌性诱发增殖细胞核抗原 AgNOR 免疫组化检测

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Doping engineering of iron oxide nanoparticles towards high performance and biocompatible T_(1)-weighted MRI contrast agents

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Rare Metals 2024年第1期43卷 298-308页

作者： Xue Xu Ping-Li Dong Yu-Yun chai Run yang Zhen-hui Ma Chi-Chong Lu Department of Chemistry College of Chemistry and Materials EngineeringBeijing Technology and Business UniversityBeijing 100048China Department of Physics Beijing Technology and Business UniversityBeijing 100048China

Extremely small-sized iron oxide nanoparticles(IONPs) are of great interest in magnetic resonance imaging(MRI) due to their biosafety as an alternative to clinical gadolinium(Ⅲ) complexes-based contrast *** when the particle size is less than 10 nm,it has strong diffusion ability and deep penetration distance in tumor *** doping can significantly enhance the T_(1)contrast effect of nanoparticles by regulating the surface exposed ***,the nucleation and growth processes of multi-component synthesis systems are complex and difficult to be accurately controlled,leading to great challenges in the synthesis of ultra-small-sized nanoparticles with different components and ***,extremely smallsized superparamagnetic gadolinium-doped iron oxide nanoparticles(GdIONPs,Gd_(x)Fe_(3-x)O_(4) NPs) with adjustable doping amount and controllable size in the range of 3.5-7.5 nm were synthesized by thermal ***,as-synthesized GdIONPs were surface modified with a highly water-soluble and biocompatible carboxyl-polyethylene glycol-phosphoric acid ligand with high binding ***_(0.65)Fe_(2.35)O_(4) NPs exhibited very high r_(1) relaxivity of 10.6 mmol^(-1)·L·s^(-1) in terms of all metal concentrations and 49.0 mmol^(-1)·L·s^(-1) in terms of gadolinium alone,respectively,3 and 14 times higher than clinical T_(1) contrast agents(Gd-DTPA).GdIONPs can continuously obtain high resolution images of blood vessels,and can be used as an efficient and multifunctional contrast agent for MR T_(1)*** stable and efficient doping strategy provides an easy and effective method to individually optimize the magnetic properties of complex oxides and their relaxation effects for a variety of biomedical applications.

关键词： Iron oxide nanoparticles Small size Magnetic resonance imaging Substitutional doping Gd dopant

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The determination of sedimentary environment and associated energy in deep-buried marine carbonates:insights from natural gamma ray spectrometry log

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Frontiers of Earth Science 2024年第1期18卷 204-218页

作者： Jingyan LIU Qian CHANG Junlong ZHANG hui chai Feng HE Yizan yang Shiqiang XIA School of Energy Resources China University of Geosciences(Beijing)Beijing 100083China Exploration and Development Research Institute Daqing Oilfield CompanyPetroChinaDaqing 163712China China National Oil and Gas Exploration and Development Co. Ltd(CNODC)Beijing 100032China Beijing Research Institute of Uranium Geology Beijing 100029China College of Mining Engineering North China University of Science and TechnologyTangshan 063210China

It has always been challenging to determine the ancient sedimentary environment and associated energy in deep-buried marine *** energy represents the hydrodynamic conditions that existed when the carbonates were *** energy includes light and chemical energies in compounds and kinetic energy in currents and mass ***-buried marine carbonates deposited during the Ordovician depositional period in the eastern Tarim Basin result from a complex interplay of tectonics,sedimentation,and *** a result,determining the ancient sedimentary environment and associated energy is *** natural gamma-ray spectrometry(GRS)log(from 12 wells)is used in this paper to conduct studies on the sedimentary environment and associated energy in deep-buried marine *** findings show that the values of thorium(Th),uranium(U),potassium(K),and gamma-ray without uranium(KTh)in a natural GRS log can reveal lithological associations,mineral composition,diagenetic environment,stratigraphic water activity,and ancient climatic *** the Ordovician,quantitative analysis and determination of sedimentary environment energy are carried out using a comprehensive calculation of natural GRS log parameters in typical wells(penetrating through the Ordovician with cores and thin sections)of well GC4,well GC6,well GC7,and well *** results show that GRS log can determine different lithology associations in typical wells than a sieve residue ***,cores and thin sections can be used to validate the determination of lithology *** on the determination of lithology associations,the lithology associations that reflect the sedimentary environment and associated energy can be analyzed in a new ***,the sedimentary environment energy curve derived from a natural GRS log can reveal hydrodynamic fluctuations during depositional periods,which will aid in the discovery of carbonate reservoirs,establishing sequence stratigra

关键词： ancient sedimentary environment energy of sedimentary environment marine deep-buried carbonates natural GRS the Ordovician eastern Tarim Basin

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Therapeutic Effect of Rhodopseudomonas palustris-Bioconverted Extract of Lycium barbarum on Rats with Lead Exposure

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Biomedical and Environmental Sciences 2024年第4期37卷 440-444页

作者： yang Hong SUN Yi chai Shu Tong LIANG Yan hui LIU Ya Ni yang Guan E School of Pharmacy Shanxi Medical UniversityTaiyuan 030001ShanxiChina

Lead is a ubiquitous pollutant and Pb pollution is a global public health *** has been reported to induce multiple adverse effects,including reproductive toxicity,neurotoxicity,carcinogenicity,nephrotoxicity,immunotoxicity,and hypertension[1].The traditional medical treatment available for Pb poisoning is chelation,which can save lives in individuals with very high blood Pb *** commonly used chelating agents include CaNa2EDTA and meso-2,3-dimercaptosuccinic ***,chelation therapy has strong short-term effects on the overall long-term management of Pb exposure.

关键词： converted chelation chelating

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High-Quality and Wafer-Scale Cubic Silicon Carbide Single Crystals

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Energy & Environmental Materials 2024年第4期7卷 442-449页

作者： Guobin Wang Da Sheng Yunfan yang hui Li Congcong chai Zhenkai Xie Wenjun Wang Jiangang Guo Xiaolong Chen Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

Cubic silicon carbide (3C-SiC) has superior mobility and thermal conduction over that of widely applied hexagonal ***,much lower concentration of interfacial traps between insulating oxide gate and3C-SiC helps fabrica... 详细信息

关键词： cubic SiC high-temperature solution growth high-temperature surface tension solid–liquid interfacial energy wide band gap semiconductor

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Provenance of the Lower Jurassic pyroclastic sediments in the Zigui Basin:Implication for crustal thickening in the eastern Qinling orogenic belt

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Science China Earth Sciences 2024年第1期67卷 196-207页

作者： Rong chai Jianghai yang Yuansheng DU Chengshan WANG School of Earth Sciences and Resources China University of Geosciences(Beijing)Beijing 100023China School of Earth Sciences China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Geological Sciences Beijing 100037China

The Late Triassic witnessed significant collisional orogenic events in the Qinling orogenic belt,accompanied by magma underplating and tectonic *** processes potentially resulted in substantial crustal thickening and uplift of the Qinling ***,due to the absence of igneous rock records from this period in the eastern section of the Qinling orogen,the changes in crustal thickness during this orogenic process have not been thoroughly investigated.A series of foreland basins emerged during the Early Mesozoic to the south of the East Qinling orogenic *** basins have preserved clastic sedimentary rocks derived from the uplift and erosion of the orogenic *** sedimentary records serve as crucial records to reconstruct the evolutionary history of the Qinling *** further clarify the collisional orogenic process of the Qinling orogenic belt,this study conducted in situ volcanic lithic fragment geochemistry,detrital zircon U-Pb chronology and trace element composition analysis on the sandstones of the Lower Jurassic Tongzhuyuan Formation in the Zigui *** results suggest that the sandstones,which exhibit a significant abundance of volcanic lithic fragments,has a characteristic detrital zircon age group of 250–200 Ma,indicating a major provenance from the Triassic volcanic *** with regional correlation and paleocurrent analysis,the detrital zircon U-Pb age data show that the source area of volcanic rocks should be in the Qinling orogenic belt to the north of the *** interpretation is further supported by the Triassic granitic rocks exposed in the western part of the orogenic belt,representing the magmatism during the Triassic collisional orogenesis in the Qinling *** on the co-varying relationships between present-day crust thickness with the chemical compositions of granite rocks and zircons,the La/Yb ratio of volcanic lithic fragments in the Tongzhuyuan Formation and the Eu/Eu*ratio of detrital zircon

关键词： Qinling orogenic belt Zigui Basin Late Triassic Detrital zircons Crustal thickening

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Stabilization/solidification mechanisms of tin tailings and fuming slag-based geopolymers for different heavy metals

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Frontiers of Environmental Science & Engineering 2024年第5期18卷 43-55页

作者： Xian Zhou Zhengfu Zhang hui yang School of Materials Science and Engineering Kunming University of Science and TechnologyKunming650093China Kunming Metallurgical Research Institute Co. Ltd.Kunming650031China

Tin mine tailings(TMT)and fuming slag(FS)contain many heavy metals(As,Cr,Cu,Zn and Mn)that cause severe pollution to the ***,geopolymers were prepared using TMT,FS and flue gas desulfurization gypsum(FGDG)to immobilize heavy metals,and their compressive strength and heavy metal leaching toxicity were *** was first determined that T4F5(TMT:FS=4:5)sample exhibited the highest compressive strength(7.83 MPa).T4F5 achieved 95%immobilization efficiency for As and Cr,and nearly 100%for Cu,Zn and Mn,showing good immobilization performance.A series of characterization analyses showed that heavy metal cations can balance the charge in the geopolymer and replace Al in the geopolymer structure to form covalent *** addition,about 2%–20%of heavy metal Fe was immobilized in hydration products,heavy metal hydroxides and non-bridging Si–O and Al–O coordination with silica-aluminate ***_(3)^(3−) was oxidized into AsO_(4)^(3−),which may form Ca–As or Fe–As ***_(2)O_(7)^(2−)was converted to CrO_(4)^(2−)under alkaline environment and then combined with OH−to form Cr(OH)3 ***^(2+)may react directly with dissolved silicate to form Mn_(2)SiO_(4) and also form Mn(OH)_(2) *** unstable Mn(OH)_(2) can be further oxidized to MnO_(2).The heavy metal cations were immobilized in the silicoaluminate lattice,while the anions tended to form insoluble *** results may benefit the industry and government for better handling of TMT,FS and solid wastes containing the abovementioned five heavy metals.

关键词： Heavy metals Cementitious materials Tin tailings Stabilization/solidification Redox

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Ionically Imprinting-Based Copper(Ⅱ)Label-Free Detection for Preventing Hearing Loss

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Engineering 2024年第2期33卷 276-282页

作者： Huan Wang hui Zhang Xiaoli Zhang Hong Chen Ling Lu Renjie chai The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033China State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck SurgeryZhongda Hospital&Advanced Institute for Life and HealthSoutheast UniversityNanjing 210096China Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging Department of Biomedical EngineeringShenzhen UniversityShenzhen 518060China Department of Otolaryngology Head and Neck Surgery Jiangsu Provincial Key Medical DisciplineNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijing 100101China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical UniversityBeijing 100069China

Copper is a microelement with important physiological functions in the ***,the excess copper ion(Cu^(2+))may cause severe health problems,such as hair cell apoptosis and the resultant hearing ***,the assay of Cu^(2+)is *** integrate ionic imprinting technology(IIT)and structurally colored hydrogel beads to prepare chitosan-based ionically imprinted hydrogel beads(IIHBs)as a low-cost and high-specificity platform for Cu^(2+)*** IIHBs have a macroporous microstructure,uniform size,vivid structural color,and magnetic *** incubated in solution,IIHBs recognize Cu^(2+)and exhibit a reflective peak change,thereby achieving label-free *** addition,benefiting from the IIT,the IIHBs display good specificity and selectivity and have an imprinting factor of 19.14 at 100μmol·L^(-1).These features indicated that the developed IIHBs are promising candidates for Cu^(2+)detection,particularly for the prevention of hearing loss.

关键词： Structural color Microfluidics Ionic imprinting Label-free detection Hearing loss

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Cooperative UAV search strategy based on DMPC-AACO algorithm in restricted communication scenarios

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Defence Technology（防务技术） 2024年第1期31卷 295-311页

作者： Shiyuan chai Zhen yang Jichuan Huang Xiaoyang Li Yiyang Zhao Deyun Zhou School of Electronics and Information Northwestern Polytechnical UniversityXi'an 710072China School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China The 93147th Unit of Chinese PLA Air Force Chengdu610091China

Improvement of integrated battlefield situational awareness in complex environments involving dynamic factors such as restricted communications and electromagnetic interference(EMI)has become a contentious research *** certain mission environments,due to the impact of many interference sources on real-time communication or mission requirements such as the need to implement communication regulations,the mission stages are represented as a dynamic combination of several communication-available and communication-unavailable ***,the data interaction between unmanned aerial vehicles(UAVs)can only be performed in specific communication-available *** cooperative search algorithms cannot handle such situations *** solve this problem,this study constructed a distributed model predictive control(DMPC)architecture for a collaborative control of UAVs and used the Voronoi diagram generation method to re-plan the search areas of all UAVs in real time to avoid repetition of search areas and UAV collisions while improving the search efficiency and safety *** attention mechanism ant-colony optimization(AACO)algorithm is proposed for UAV search-control decision *** search strategy is adaptively updated by introducing an attention mechanism for regular instruction information,a priori information,and emergent information of the mission to satisfy different search expectations to the maximum *** results show that the proposed algorithm achieves better search performance than traditional algorithms in restricted communication constraint scenarios.

关键词： Unmanned aerial vehicles(UAV) Cooperative search Restricted communication Mission planning DMPC-AACO

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