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DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson’s disease

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Neural Regeneration Research 2023年第1期18卷 194-199页

作者： Chun-Bo Hu hui jiang Yin Yang Guo-Hua Wang Qiu-Hong ji Zhong-Zheng jia Li-Hua Shen Qian-Qian Luo Department of Neurology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology and Hypoxic Biomedicine Institute of Special Environmental Medicine and Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Medical Imaging Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

DL-3-n-butylphthalide(NBP)-a compound isolated from Apium graveolens seeds-is protective against brain ischemia via various mechanisms in humans and has been approved for treatment of acute ischemic *** has shown recent potential as a treatment for Parkinson’s ***,the underlying mechanism of action of NBP remains poorly *** this study,we established a rat model of Parkinson’s disease by intraperitoneal injection of rotenone for 28 successive days,followed by intragastric injection of NBP for 14-28 *** found that NBP greatly alleviated rotenone-induced motor disturbance in the rat model of Parkinson’s disease,inhibited loss of dopaminergic neurons and aggregation ofα-synuclein,and reduced iron deposition in the substantia nigra and iron content in *** changes were achieved by alterations in the expression of the iron metabolism-related proteins transferrin receptor,ferritin light chain,and transferrin *** also inhibited oxidative stress in the substantia nigra and protected mitochondria in the rat model of Parkinson’s *** findings suggest that NBP alleviates motor disturbance by inhibition of iron deposition,oxidative stress,and ferroptosis in the substantia nigra.

关键词： cystine/glutamate antiporter solute carrier family 7 member 11 DL-3-n-butylphthalide ferritin light chain ferroportin 1 ferroptosis glutathione peroxidase 4 oxidative stress iron rotenone transferrin receptor

Mapping the emergence of visual consciousness in the human brain via brain-wide intracranial electrophysiology

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The Innovation 2022年第3期3卷 88-96页

作者： Liang Shan hui Huang Zhiting Zhang Yuyin Wang Fei Gu Mingwei Lu Wen Zhou Yi jiang ji Dai Guangdong Provincial Key Laboratory of Brain Connectome and Behavior CAS Key Laboratory of Brain Connectome and ManipulationThe Brain Cognition and Brain Disease Institute(BCBDI)Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions Shenzhen 518055China Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of PsychologyChinese Academy of SciencesBeijing 100101China

Consciousness lies at the heart of our existence and *** probe how perceptual consciousness emerges in the brain,we recorded brainwide intracranial electroencephalography signals from human patients while their perceptual consciousness was effectively manipulated using the continuous flash suppression *** observed substantial differences in brain activities when visual information gradually enters consciousness.

关键词： visual flash Mapping

Cas12a-based on-site, rapid detection of genetically modified crops

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Journal of Integrative Plant Biology 2022年第10期64卷 1856-1859页

作者： Zhiqiang Duan Xiaoliang Yang Xingkun ji Ying Chen Xiaomu Niu Anping Guo jian‐Kang Zhu Feng Li Zhaobo Lang hui Zhao Hainan Key Laboratory for Biosafety Monitoring and Molecular Breeding in Off‐Season Reproduction Regions Institute of Tropical Bioscience and Biotechnology&San Ya Research InstituteChinese Academy of Tropical Agricultural SciencesHaikou 571101China Bellagen Biotechnology Co.Ltd. Jinan 250000China College of Life Sciences Shandong Normal UniversityJinan 250014China Institute of Advanced Biotechnology and School of Life Sciences Southern University of Science and TechnologyShenzhen 518055China Center for Advanced Bioindustry Technologies Chinese Academy of Agricultural SciencesBeijing 100081China Hainan Yazhou Bay Seed Lab SanyaHainan 572024China Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China

Genetically modified(GM)crops that impart herbicide resistance,improved tolerance to biotic and abiotic stresses,and enhanced yield or nutritional quality have been developed and grown worldwide(ISAAA Brief 55-2019:International Servicefor theAcquisition ofAgri-biotech Applications(ISAAA),2019).In response topublic concern on genetically modified organisms(GMOs),DNA-based and protein-based methods have been developed to detect GMOs infood/feed samples(Fraitureetal.,2015).These methods,however,require expensive equipment and technical expertise and are unsuitable for field diagnosis(DNA-based methods)or cannot detect non-coding sequences such as promoters or terminators(protein-based methods).

关键词： crops modified diagnosis

Electronic Non-Resonant Tunneling through Diaminoacenes:A First-Principles Investigation

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Chinese Physics Letters 2011年第2期28卷 187-190页

作者： ZHENG ji-Ming HUANG Yao-Qing REN Zhao-Yu YANG hui-jing CAO Mao-Sheng Institute of Photonics and Photo-technology National Key Laboratory of Photoelectric Technology and Functional Materials(Culture Base)and National Photoelectric Technology and Functional Materials and Application of Science and Technology International Cooperation BaseNorthwest UniversityXi’an 710069 School of Science Shanghai Institute of TechnologyShanghai 200235 School of Material Science and Engineering Beijing Institute of TechnologyBeijing 100081

The electron transport through diaminoacenes sandwiched between two Au electrodes is simulated by using a first-principles *** nonlinear current-voltage characteristic is *** of the ring number and positions of amine groups on equilibrium transport properties are *** 1,4 series,the greater the number of the rings,the stronger the transmission spectrum near the Fermi *** 2,6 series,the larger the number of the rings,the weaker the transmission spectrum near the Fermi *** is helpful for understanding the recently reported results on conductance measurements using amines.

关键词： energy Fermi rings

基于网络药理学研究地锦草对糖尿病的作用机制

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临床合理用药杂志 2024年第28期17卷 1-5,11页

作者：于武华桂明明何平平苏慧纪德佳邓小燕江西中医药高等专科学校江西省抚州市344000

目的使用网络药理学方法分析地锦草对糖尿病产生作用的物质成分及治疗机制。方法借助TCMSP数据库检索地锦草中所含的主要活性成分及其作用靶点并进行筛选,得到地锦草治疗糖尿病的活性成分和作用靶点。筛选数据库GeneCards和OMIM以得到... 详细信息

目的使用网络药理学方法分析地锦草对糖尿病产生作用的物质成分及治疗机制。方法借助TCMSP数据库检索地锦草中所含的主要活性成分及其作用靶点并进行筛选,得到地锦草治疗糖尿病的活性成分和作用靶点。筛选数据库GeneCards和OMIM以得到治疗糖尿病的相关基因,与药物活性成分作交集。依据STRING数据库并采用Cytoscape软件分析蛋白质相互作用(PPI)网络,获得核心靶点后通过在线分析网站Metascape进行GO分析和KEGG通路分析。结果共获得地锦草6个主要活性成分与糖尿病有关的作用靶点131个,GO分析结果显示主要与血管生成、抗缺氧、血小板激活、炎性反应等生物过程相关,KEGG富集分析表明关键通路主要集中于癌症通路与炎症相关通路等。结论PPI研究发现TNF-α、IL-6、AKT1均居于地锦草治疗糖尿病相关靶点的前5位,验证了网络药理学预测靶点的准确性。了解了地锦草治疗糖尿病的物质基础和分子机制,研究结果对地锦草的后续开发利用有一定的积极作用。

关键词：糖尿病地锦草网络药理学

清热活血方联合阿奇霉素治疗儿童肺炎支原体肺炎临床研究

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陕西中医 2021年第5期42卷 616-619页

作者：赵珍珍史艳平邱锐汪琼李春阳李隽田纪凤吉慧李霞陕西中医药大学陕西咸阳712000 西安市儿童医院陕西西安710003

目的:探讨清热活血方联合阿奇霉素治疗儿童肺炎支原体肺炎(MPP)的临床疗效。方法:将134例患儿按随机数字表法分为对照组及治疗组,对照组67例给予阿奇霉素及对症支持治疗,治疗组67例在对照组基础上给予清热活血方治疗。对比分析两组患儿... 详细信息

目的:探讨清热活血方联合阿奇霉素治疗儿童肺炎支原体肺炎(MPP)的临床疗效。方法:将134例患儿按随机数字表法分为对照组及治疗组,对照组67例给予阿奇霉素及对症支持治疗,治疗组67例在对照组基础上给予清热活血方治疗。对比分析两组患儿临床疗效及治疗前后血清炎性因子白介素-6(IL-6)、白介素-4(IL-4)、白介素-8(IL-8)及肿瘤坏死因子-α(TNF-α)水平、临床症状及肺部体征消失时间、C反应蛋白(CRP)、血沉(ESR)、白细胞计数、肺炎支原体(MP)血清学试验改善情况。结果:治疗组总有效率为89.55%,优于对照组的74.63%,差异具有统计学意义(P0.05)。结论:清热活血方联合阿奇霉素治疗儿童MPP疗效显著,其机制可能与降低炎性因子水平,改善炎性指标有关。

关键词：肺炎支原体肺炎儿童清热活血方炎性因子白介素-6

探讨多元化教学在系统解剖学教学中的应用效果

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中国继续医学教育 2022年第7期14卷 35-38页

作者：金海峰姚立杰郭林娜马勇姜杨李永涛张晓东纪慧齐齐哈尔医学院基础医学院解剖学教研室黑龙江齐齐哈尔161000 齐齐哈尔医学院基础医学院教务科黑龙江齐齐哈尔161000

目的探讨多元化教学在系统解剖学教学中的应用效果。方法选取齐齐哈尔医学院2018级临床医学本科1班50名学生随机分成对照组和试验组,对照组进行传统讲授式教学,试验组进行多元化教学,包括学生录制微视频、在系统解剖学第一次理论课播放... 详细信息

目的探讨多元化教学在系统解剖学教学中的应用效果。方法选取齐齐哈尔医学院2018级临床医学本科1班50名学生随机分成对照组和试验组,对照组进行传统讲授式教学,试验组进行多元化教学,包括学生录制微视频、在系统解剖学第一次理论课播放医学纪录片、“案例式”教学、“数字人”教学、学生进行解剖绘图。通过调查问卷统计和期末考试成绩比较两组学生的教学效果。结果调查问卷收回统计显示学生对多元化教学满意度较高;两组期末实验和理论成绩对比,试验组平均成绩明显高于对照组(P<0.05)。结论多元化教学丰富系统解剖学教学手段,提高教学质量,激发学生学习兴趣。

关键词：多元化教学系统解剖学基础教学教学改革教学效果医学生教育

Fast Photoacoustic Imaging of Blood Vessels Based on an Annular Transducer Array

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Chinese Physics Letters 2012年第10期29卷 85-88页

作者： YANG Di-Wu ZENG Lv-Ming ji Xuan-Rong HUANG Zhong CHEN Xing-hui TAN Zhi Department of Physics and Engineering Hunan University of TechnologyZhuzhou 412000 Key Lab of Optic-Electronic and Communication Jiangxi Sciences and Technology Normal CollegeNanchang 330038 Doppler Electronic Technologies Company Ltd. Guangzhou 510663

We present a photoacoustic imaging system for rapid high-resolution photoacoustic imaging of blood vessels based on an annular transducer *** annular transducer array consists of 256 elements arranged along a 300°arc with a 50-mm radius of curvature,using piezocomposite technology for high sensitivity and high signal-to-noise *** eight-channel data acquisition system is applied to capture the photoacoustic signals using multiplexing and a limited-view filtered back projection algorithm is used to reconstruct the photoacoustic *** experiments with phantom and blood vessels of a chicken are performed and clear photoacoustic images are *** results demonstrate that the photoacoustic imaging system using the annular transducer array holds the potential application in monitoring neovascularization in tumor angiogenesis.

关键词： Transducer annular Blood

Endoscopic retrograde cholangiopancreatography in elderly patients: Difficult cannulation and adverse events

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World Journal of Clinical Cases 2020年第14期8卷 2988-2999页

作者： Fatema Tabak hui-Shan Wang Quan-Peng Li Xian-Xiu Ge Fei Wang Guo-Zhong ji Lin Miao Institute of Digestive Endoscopy and Medical Centre for Digestive Disease Second Affiliated Hospital of Nanjing Medical UniversityNanjing 210011Jiangsu ProvinceChina

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is a valuable therapeutic technique for pancreatobiliary diseases,and its application in the elderly is no longer ***,a higher incidence of procedure difficulty and periprocedural adverse events might be expected in elderly patients due to the presence of other medical disorders and the poor general condition of this *** To evaluate the incidence,causes,and management of difficult biliary cannulation during ERCP in elderly patients and the role of difficult cannulation as a risk factor for adverse *** A total of 614 patients who underwent ERCP during the study period were prospectively studied and divided into two groups based on their *** hundred and forty-six patients were aged 80 years or older and 468 patients were aged less than 80 *** primary outcome measurements were cannulation difficulty,cannulation success rate,ERCP procedure time,and related adverse *** There was no difference in the incidence of difficult cannulation among the two groups(32.9%vs 34.4%,P=0.765),as well as in the cannulation success rate(96.6%vs 96.8%,P=0.54).The cannulation techniques were shown to be safe and efficient in achieving successful *** regression analysis showed that patients aged 80 years or older were not associated with increased adverse events;however,difficult cannulation cases[adjusted odds ratio(AOR)=3.478;95%confidence interval(CI):1.877-6.442;P<0.001]and patients with Charlson Comorbidity Index≥2(AOR=1.824;95%CI:0.993-3.349;P=0.045)were more likely to develop adverse *** contrast,other factors including age≤65(AOR=3.460;95%CI:1.511-7.922;P=0.003),female gender(AOR=2.362;95%CI=1.089-5.124;P=0.030),difficult cannulation(AOR=4.527;95%CI:2.078-9.860;P<0.001),and patients with cholangitis(AOR=3.261;95%CI:1.204-8.832;P=0.020)were strongly associated with a higher rate of post-ERCP *** Advanced age has not been prove

关键词： Endoscopic retrograde cholangiopancreatography Difficult cannulation Cannulation techniques Elderly Adverse events Post-endoscopic retrograde cholangiopancreatography pancreatitis