检索结果-南通市图书馆

Journal of Magnesium and Alloys 2024年第1期12卷 120-138页

作者： zhao-Qi Zhang Bing-Zhi Li Pei-Duo Tong Shao-Kang Guan Li Wang Zheng-hui Qiu Cun-Guo lin Rong-Chang Zeng School of Material Science and Engineering&Henan Key Laboratory of Advanced Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou University100 Science RoadZhengzhou 450001China State Key Laboratory for Marine Corrosion and Protection Luoyang Ship Material Research InstituteQingdao 266101China Corrosion Laboratory for Light Metals College of Material Science and EngineeringShandong University of Science and TechnologyQingdao 266590China

Constructing a functional hybrid coating appears to be a promising strategy for addressing the poor corrosion resistance and insufficient endothelialization of Mg-based ***,the steps for preparing composite coatings are usually complicated and ***,a novel composite coating,composed of bioactive magnesium thioctic acid(MTA)layer formed by deposition and corrosion-resistant magnesium hydroxide(Mg(OH)_(2))layer grown in situ,is simply fabricated on ZE21B alloys via one-step *** electron microscopy(SEM)shows that the electrodeposited coating has a compact and uniform *** the high adhesion of the MTA/Mg(OH)_(2)hybrid coating is also confirmed by the micro-scratch *** test,scanning kelvin probe(SKP),and hydrogen evolution measurement indicate that the hybrid coating effectively reduces the degradation rate of Mg *** experiment and cell culture trial detect that the composite coating is of fine ***,the preparation mechanism of MTA/Mg(OH)_(2)hybrid coatings is discussed and *** coating shows a great potential application for cardiovascular stents.

关键词： Magnesium alloy Corrosion resistance Hybrid coating Endothelialization Biocompatibility

taBOX: A water-soluble tetraanionic rectangular molecular container for conjugated molecules and taste masking for berberine and palmatine

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 175-178页

作者： Qihan lin Jiabin Xing Yue-Yang liu Gang Wu Shi-Jia liu hui Wang Wei Zhou Zhan-Ting Li Dan-Wei Zhang Department of Chemistry Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsFudan UniversityShanghai 200438China

A water-soluble macrocycle that bears four carboxylate anions has been designed and prepared,which forms a rectangular cavity that can efficiently encapsulate discrete electron-deficient aromatic compounds,including berberine and *** macrocycle is revealed to be highly biocompatible and able to inhibit the bitter taste of the two drugs.

关键词： Macrocycle Multianion Molecular container Molecular recognition Bitter taste masking

Phase modulation of nickel-tin alloys in regulating electrocatalytic nitrogen reduction properties

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第6期43卷 2851-2858页

作者： lin Wang Hang-Ning liu Xin Meng Chang-hui Sun Hai-Dong liu Liang-Yu Gong Zhen-Hua Yan Jie Wang College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdao 266109China Department of Chemistry-Angstrom Laboratory Uppsala University75121UppsalaSweden Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) College of ChemistryNankai UniversityTianjin 300071China

Electrocatalytic nitrogen reduction reaction(NRR)is one of the attractive methods for ammonia(NH_(3))production at ambient conditions,but the catalytic performance largely depends on the physical properties of the ***,Ni-Sn alloy nanoparticles with well-controlled physical properties have been synthesized via a simple two-step method,which are applied as efficient electrocatalysts for the NRR.

关键词： alloys alloy nickel

Edge dislocation-induced strains break the limit of PtNi alloys in boosting Pt mass activity for efficient alkaline hydrogen evolution

在线全文

学校读者我要写书评

暂无评论

Nano Research 2024年第6期17卷 4711-4719页

作者： Miao Zhou Yao zhao Zhanwei liu Xueru zhao Enzuo liu Liyang Xiao Pengfei Yin Cunku Dong hui liu Xiwen Du Jing Yang New Energy Materials Institute School of Materials Science and EngineeringTianjin UniversityTianjin 300072China School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Chemistry Division Brookhaven National LaboratoryUptonNew York 11973USA Advanced Metallic Materials Institute School of Materials Science and EngineeringTianjin UniversityTianjin 300072China

Creating lattice defects and alloying to produce strain effect in Pt-based bimetallic alloys are both effective methods to optimize the crystal and electronic structure and improve the electrocatalytic ***,the principles that govern the alkaline hydrogen evolution reaction(HER)performance remain unclear,which is detrimental to the rational design of efficient Pt-based ***,PtNi alloys with different Pt/Ni ratios and edge dislocations were synthesized,and the effects of Pt/Ni composition and edge dislocations on the alkaline HER electrocatalytic activity of PtNi alloys were systematically *** experimental and theoretical investigations reveal that tuning Pt/Ni ratio results in only 1.1 times enhancements in Pt mass activity,whereas edge dislocations-induced extra tensile strain on Ni site and compressive strain on Pt site further boost the alkaline HER intrinsic activity at all Pt/Ni ***,the introduction of edge dislocations in PtNi alloys could break the limit of alloying in boosting Pt mass activity and result in up to 13.7-fold enhancement,in the case that Pt and Ni contents are nearly identical and thus edge dislocation density reaches the *** mechanism studies demonstrate that the edge dislocation strategy could make a breakthrough in facilitating water dissociation kinetics of PtNi alloys.

关键词： edge dislocations PtNi composition strain effects water dissociation hydrogen evolution reaction

Scorpiones,Scolopendra and Gekko Inhibit Lung Cancer Growth and Metastasis by Ameliorating Hypoxic Tumor Microenvironment via PI3K/AKT/mTOR/HIF-1αSignaling Pathway

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第9期30卷 799-808页

作者： MAO Qi-yuan WANG Xue-qian lin Fei YU Ming-wei FAN hui-ting ZHENG Qi liu Lan-chun ZHANG Chu-chu LI Dao-rui lin Hong-sheng Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Department of Oncology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100010China Department of Cardiology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing100053China Institute of Traditional Chinese Medicine Information China Academy of Chinese Medical SciencesBeijing100700China

Objective:To investigate whether Buthus martensii karsch(Scorpiones),Scolopendra subspinipes mutilans ***(Scolopendra)and Gekko gecko linnaeus(Gekko)could ameliorate the hypoxic tumor microenvironment and inhibit lung cancer growth and metastasis by regulating phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α(PI3K/AKT/mTOR/HIF-1α)signaling ***:Male C57BL/6J mice were inoculated with luciferase labeled LL/2-luc-M38 cell suspension to develop lung cancer models,with rapamycin and cyclophosphamide as positive *** methyl cellulose solutions of Scorpiones,Scolopendra and Gekko were administered intragastrically as 0.33,0.33,and 0.83 g/kg,respectively once daily for 21 *** expression were detected every 7 days after inoculation,and tumor growth curves were *** was performed to determine CD31 and HIF-1αexpressions in tumor tissue and microvessel density(MVD)was *** blot was performed to detect the expression of PI3K/AKT/mTOR/HIF-1αsignaling pathway-related ***-linked immunosorbent assay was performed to detect serum basic fibroblast growth factor(bFGF),transforming growth factor-β1(TGF-β1)and vascular endothelial growth factor(VEGF)in ***:Scorpiones,Scolopendra and Gekko prolonged the survival time and inhibited lung cancer metastasis and expression of HIF-1α(all Pling pathway.

关键词： Scorpiones Scolopendra Gekko dredging collaterals and activating blood Chinese medicine of worms lung cancer hypoxic tumor microenvironment phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin/hypoxia-inducible factor-1α signaling pathway

Sparse antenna array design methodologies:A review

在线全文

学校读者我要写书评

暂无评论

Journal of Electronic Science and Technology 2024年第3期22卷 1-15页

作者： Pan Wu Yan-hui liu Zhi-Qin zhao Qing-Huo liu School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Eastern Institute of Technology Ningbo315200China

Designing a sparse array with reduced transmit/receive modules(TRMs)is vital for some applications where the antenna system’s size,weight,allowed operating space,and cost are *** arrays exhibit distinct architectures,roughly classified into three categories:Thinned arrays,nonuniformly spaced arrays,and clustered *** numerous advanced synthesis methods have been presented for the three types of sparse arrays in recent years,a comprehensive review of the latest development in sparse array synthesis is *** work aims to fill this gap by thoroughly summarizing these *** study includes synthesis examples to facilitate a comparative analysis of different techniques in terms of both accuracy and ***,this review is intended to assist researchers and engineers in related fields,offering a clear understanding of the development and distinctions among sparse array synthesis techniques.

关键词： Clustered array Nonuniformly spaced array Sparse antenna array Synthesis method Thinned array

Structural engineering of hard carbon through spark plasma sintering for enhanced sodium-ion storage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第9期43卷 4274-4285页

作者： Hao-Ming Xiao Heng Zheng Ping Yuan Jun-hui Luo lin-lin Shen Jie-Feng Tan Xian-You Luo De Li Yong Chen Guangdong Key Laboratory for Hydrogen Energy Technologies School of Materials Science and Hydrogen EnergyFoshan UniversityFoshan 528000China State Key Laboratory of Marine Resource Utilization in South China Sea Hainan Provincial Key Laboratory of Research on Utilization of Si-Zr-Ti ResourcesHainan UniversityHaikou 570228China

Hard carbon(HC)has emerged as one of the superior anode materials for sodium-ion batteries(SIBs),with its electrochemical performance significantly influenced by the presence of oxygen functional groups and its closed pore ***,current research on the structural adjustment of these oxygen functional groups and the closed pore architecture within HC remains ***,energy-efficient and contamination-free spark plasma sintering technology was employed to tune the structure of coconut-shell HC,resulting in significant adjustments to the content of carboxyl(decreasing from 5.71 at%to 2.12 at%)and hydroxyl groups(decreasing from 7.73 at%to 6.26 at%).Crucially,these modifications reduced the irreversible reaction of oxygen functional groups with Na^(+).Simultaneously,a substantial number of closed pores with an average diameter of 1.22 nm were generated within the HC,offering an ideal environment for efficient Na^(+)*** structural changes resulted in a remarkable improvement in the electrochemical performance of the modified *** reversible specific capacity of the modified HC surged from 73.89 mAh·g^(-1)to an impressive 251.97 m Ah·g^(-1)at a current density of 50 mA·g^(-1).Even at 400 mA·g^(-1),the reversible specific capacity increased significantly from 14.55 to 85.44 mAh·g^(-1).Hence,this study provides a novel perspective for designing tailored HC materials with the potential to develop high-performance SIBs.

关键词： Hard carbon Spark plasma sintering Sodiumion batteries Closed pores Oxygen functional groups

Harnessing innate immune pathways for therapeutic advancement in cancer

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1506-1564页

作者： Ankang Hu Li Sun Hao lin Yuheng Liao hui Yang Ying Mao Department of Neurosurgery Huashan HospitalFudan UniversityShanghaiP.R.China Institute for Translational Brain Research Shanghai Medical CollegeFudan University ShanghaiPR.China National Center for Neurological Disorders Huashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration Shanghai Clinical Medical Center of NeurosurgeryNeurosurgical Institute of Fudan UniversityHuashan HospitalShanghai Medical CollegeFudan UniversityShanghaiP.R.China State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science and MOE Frontiers Center for Brain Science Institutes of Brain ScienceShanghai Medical CollegeFudan UniversityShanghaiP.R.China Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology)and Key Laboratory of Metabolism and Molecular Medicine(Ministry of Education)and Molecular and Cell Biology LabInstitutes of Biomedical SciencesShanghai Medical College of Fudan UniversityShanghaiP.R.China

The innate immune pathway is receiving increasing attention in cancer *** pathway is ubiquitous across various cell types,not only in innate immune cells but also in adaptive immune cells,tumor cells,and stromal *** targeting the innate immune pathway have shown profound changes in the tumor microenvironment(TME)and improved tumor prognosis in preclinical ***,to date,the clinical success of drugs targeting the innate immune pathway remains ***,recent studies have shown that activation of the innate immune pathway can paradoxically promote tumor *** uncertainty surrounding the therapeutic effectiveness of targeted drugs for the innate immune pathway is a critical issue that needs immediate *** this review,we observe that the role of the innate immune pathway demonstrates heterogeneity,linked to the tumor development stage,pathway status,and specific cell *** propose that within the TME,the innate immune pathway exhibits multidimensional *** diversity is fundamentally rooted in cellular heterogeneity and is manifested as a variety of signaling *** pro-tumor effect of innate immune pathway activation essentially reflects the suppression of classical pathways and the activation of potential pro-tumor alternative *** our understanding of the tumor's innate immune pathway network and employing appropriate targeting strategies can enhance our ability to harness the anti-tumor potential of the innate immune pathway and ultimately bridge the gap from preclinical to clinicalapplication.

关键词： drugs therapeutic innate

Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU Shi-hao SHI Wei-qi LI Yu-hang liu Ru-hui HU Da-yi ZHENG Li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, Plinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, Pline(all P<0.01) as assessed by SAQ: physical limitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

Phase evolution,hydrogen storage thermodynamics,and kinetics of ternary Mg_(98)Ho_(1.5)Fe_(0.5) alloy

在线全文

学校读者我要写书评

暂无评论

Journal of Rare Earths 2024年第9期42卷 1800-1808,I0006页

作者： Jinming liu hui Yong Yang zhao Shuai Wang Yiwan Chen Baosheng liu Jifan Hu Yanghuan Zhang College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China China Institute of Ocean Engineering(Tsing Tao) Qingdao266000China Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and TechnologyBaotou014010China

Rare earth elements and transition metals have been found to improve the hydrogen storage characteristics of magnesium-based *** study investigated the Mg-Ho-Fe(MHF) ternary alloy prepared using the vacuum induction melting technique.X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),pressure-composition-temperature(PCT),and differential scanning calorimetry(DSC) were used to analyze the alloy's phase transitions,microstructure,thermodynamics,and kinetic *** results reveal that the Mg_(98)Ho_(1.5)Fe_(0.5) alloy forms a solid solution with Ho and Fe in the magnesium *** hydrogen absorption,the activated alloy transforms into a mixture of Mg/MgH_(2) phases and nanoscale HoH_(2) ***,only the MgH_(2) phase decomposes during hydrogen desorption,while the HoH_(2) phase remains unchanged,exhibiting a positive catalytic *** alloy demonstrates excellent hydrogen absorption kinetics,achieving a capacity of 5.56 wt% H_(2) within 10 min at 360℃,owing to the combined catalytic effects of Ho and *** activation energy for hydrogen desorption is found to be 135.87 kJ/mol,which is lower than that of the activation energies of pure MgH_(2) and MgFe alloys,indicating an enhancement in desorption ***,the enthalpy and entropy changes for hydrogen absorption and desorption are determined to be-70.51 kJ/mol H_(2),-125.62 J/(K·mol) H_(2),72.83 kJ/mol H_(2),and 128.95 J/(K·mol) H_(2),***,it is worth noting that the thermodynamic properties of the alloy are improved due to the catalytic effect of Ho and Fe.

关键词： Rare earths Magnesium-based hydrogen storage Hydrogen storage thermodynamics Hydrogen storage kinetics