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Solitary acral persistent papular mucinosis nodule:A case report and summary of eight Korean cases

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World Journal of Clinical Cases 2023年第13期11卷 3086-3091页

BACKGROUND Acral persistent papular mucinosis(APPM)is a rare idiopathic subtype of localized lichen *** date,there have been 40 APPM cases reported worldwide;however,only 7 cases have been reported in the Korean *** SUMMARY A 70-year-old man was referred to our hospital with a solitary pinkish nodule on the dorsum of his right *** the absence of symptoms,the patient wanted to know the exact diagnosis;thus,a biopsy was *** examination of a biopsy specimen obtained from the nodule on the dorsum of his hand revealed orthokeratotic hyperkeratosis with patchy parakeratosis,prominent hypergranulosis,and diffuse dissecting mucinous deposition between collagen bundles,along with some bland-looking spindle cells throughout the *** nodule was histologically diagnosed as an APPM,and an intralesional triamcinolone injection(2.5 mg/mL)was started every 2 *** three sessions of treatment,the patient showed marked *** To the best of our knowledge,this is the first case of a Korean APPM presenting as a solitary nodule that showed a marked response to triamcinolone intralesional *** it is a rare disease,we report this case to contribute to future research on the pathogenesis and treatment of APPM.

关键词： Acral persistent papular mucinosis Localized lichen myxedematosus Cutaneous mucinosis Mucin Case report

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin shin Sun-young Kwon Sojin shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Late Paleozoic to early Mesozoic volcanic-sedimentary history of the southeastern margin of the Central Asian Orogenic Belt: Timing of uplift of the Inner Mongolia paleo-uplift

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Science China Earth Sciences 2025年第1期68卷 297-309页

作者： Wenxing HAO Jin-hui YANG Guang ZHU State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences School of Resource and Environmental Engineering Hefei University of Technology

The Kulun region is located in the eastern Bainaimiao arc belt on the southeastern margin of the Central Asian Orogenic Belt(CAOB), adjacent to the North China Craton(NCC) to the south. This region records the closure of the PaleoAsian Ocean during the Paleozoic to early Mesozoic and is key to study the tectonic evolution of the northern margin of the *** conducted zircon U-Pb geochronology and Hf isotope analysis of volcanic-sedimentary and intrusive rocks in the Kulun region. The volcanic-sedimentary rocks were previously assigned an early Carboniferous age, but include volcanic rocks with ages of 267–266 Ma and sedimentary rocks with youngest detrital zircon age peaks of 265–244 Ma, which were intruded by a granite with an age of 242 Ma. This indicates that these rocks are actually middle Permian to Middle Triassic in age(267–242Ma) and correspond to the Qingfengshan and Liujiagou formations. Moreover, two volcanic rock samples have high εHf(t) values(+1.6 to +16.1) and relatively young two-stage Hf model ages(1095–327 Ma), indicating their sources associated with the CAOB. The age spectra and Hf isotopic characteristics of detrital zircons from the sedimentary rocks suggest that, during the middle Permian to Middle Triassic, the sedimentary provenance in the Kulun region was mainly the CAOB. However, by the Early Jurassic, the provenance changed to the NCC(i.e., the Inner Mongolia Paleo-uplift, IMPU). This result, combined with the development of a series of conglomerates on the northern margin of the NCC in the Late Triassic(i.e., Xingshikou, Xiaoyingzi,and Xiaohekou formations), indicates the Kulun region experienced an abrupt change in paleogeography during the Late Triassic, with the IMPU undergoing significant uplift and thus becoming the main sediment source in the Kulun region. Based on the Late Triassic alkaline igneous belt(235–215 Ma) in the IMPU, we speculate that this uplift was caused by detachment of the southward-subducting Paleo-Asian oceanic

关键词： Central Asian Orogenic Belt the North China Craton Zircon geochronology Hf isotopes Inner Mongolia Paleo-uplift

Design of multifunctional interfaces on ceramic solid electrolytes for high-performance lithium-air batteries

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Green Energy & Environment 2025年第1期10卷 183-192页

作者： Yunxin Shi Ziyang Guo Changhong Wang Mingze Gao Xiaoting Lin hui Duan Yonggang Wang Xueliang Sun College of Energy Material and Chemistry College of Chemistry and Chemical EngineeringInner Mongolia UniversityHohhot010021China Department of Mechanical and Materials Engineering Western UniversityLondonONN6A 5B9Canada Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Fudan UniversityShanghai200433China Eastern Institute for Advanced Study Eastern Institute of TechnologyNingboZhejiang315100China

High-energy-density lithium(Li)–air cells have been considered a promising energy-storage system,but the liquid electrolyte-related safety and side-reaction problems seriously hinder their *** address these above issues,solid-state Li–air batteries have been widely ***,many commonly-used solid electrolytes generally face huge interface impedance inLi–air cells and also showpoor stability towards ambient air/Li ***,we fabricate a differentiating surface-regulated ceramic-based composite electrolyte(DSCCE)by constructing disparately LiI-containing polymethyl methacrylate(PMMA)coating and Poly(vinylidene fluoride-co-hexafluoropropylene)(PVDF-HFP)layer on both sides of Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3)(LAGP).The cathode-friendly LiI/PMMA layer displays excellent stability towards superoxide intermediates and also greatly reduces the decomposition voltage of discharge products in Li–air ***,the anode-friendly PVDF-HFP coating shows low-resistance properties towards ***,Li dendrite/passivation derived from liquid electrolyte-induced side reactions and air/I-attacking can be obviously suppressed by the uniformand compact composite *** a result,the DSCCE-based Li–air batteries possess high capacity/low voltage polarization(11,836mAh g^(-1)/1.45Vunder 500mAg^(-1)),good rate performance(capacity ratio under 1000mAg^(-1)/250mAg^(-1) is 68.2%)and longterm stable cell operation(~300 cycles at 750 mA g^(-1) with 750 mAh g^(-1))in ambient air.

关键词： Li-air batteries Li_(1.5)Al_(0.5)Ge_(1.5)(PO_(4))_(3) Polymers Composite electrolyte Ambient air

Nusinersen for spinal muscular atrophy types Ⅱ and Ⅲ:a retrospective single-center study in South Korea

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World Journal of Pediatrics 2023年第5期19卷 450-459页

作者： hui Jin shin Ji-Hoon Na Hyunjoo Lee young-Mock Lee Department of Pediatrics Gangnam Severance HospitalYonsei University College of Medicine211 Eonju-RoGangnam-GuSeoul135-720Korea

Background This study investigated the efficacy and safety of nusinersen,an antisense oligonucleotide,in patients with spinal muscular atrophy(SMA)types II(OMIM:253,550)or III(OMIM:253,400),including those with severe scoliosis or requiring respiratory support via mechanical *** Data from 40 patients with genetically confirmed SMA who were treated with nusinersen at our institute from March 2019 to April 2022 were retrospectively *** these,30 patients with an age of onset<3 years and not on permanent ventilation were *** and genetic characteristics were investigated,and motor function was evaluated based on the Hammersmith Functional Motor Scale-Expanded(HFMSE)*** The mean age of symptom onset was 1.2 *** patients were diagnosed with SMA type II(27/30,90%).Nusinersen was administered via computed tomography-guided or direct intrathecal injection in 87%(26/30)and 13%(4/30)of the patients,*** the 6-,14-,22-,and 26-month follow-ups,72%,71%,88%,and 86%of patients showed motor improvement,respectively,with mean changes in HFMSE scores of 2.10,2.88,4.21,and 5.29,*** analysis showed that the use of noninvasive ventilation was associated with poorer outcomes of motor *** Patients with SMA type II or III who received nusinersen treatment showed significant improvement in motor function.A longer treatment duration led to a higher number of patients with improved motor *** significant side effects of nusinersen were *** with SMA,even those with severe scoliosis or on respiratory support,can be safely treated using nusinersen.

关键词： Hammersmith Functional Motor Scale Expanded Motor function Nusinersen South Korea Spinal muscular atrophy

Facial Expression Recognition of Various Internal States via Manifold Learning

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Journal of Computer Science & Technology 2009年第4期24卷 745-752页

作者： young-Suk shin IEEE Department of Information and Communication Engineering Chosun University

Emotions are becoming increasingly important in human-centered interaction architectures. Recognition of facial expressions, which are central to human-computer interactions, seems natural and desirable. However, facial expressions include mixed emotions, continuous rather than discrete, which vary from moment to moment. This paper represents a novel method of recognizing facial expressions of various internal states via manifold learning, to achieve the aim of humancentered interaction studies. A critical review of widely used emotion models is described, then, facial expression features of various internal states via the locally linear embedding （LLE） are extracted. The recognition of facial expressions is created with the pleasure-displeasure and arousal-sleep dimensions in a two-dimensional model of emotion. The recognition result of various internal state expressions that mapped to the embedding space via the LLE algorithm can effectively represent the structural nature of the two-dimensional model of emotion. Therefore our research has established that the relationship between facial expressions of various internal states can be elaborated in the two-dimensional model of emotion, via the locally linear embedding algorithm.

关键词： manifold learning locally linear embedding dimension model pleasure-displeasure dimension arousal-sleep dimension

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CD4＋VEGFR1HIGH T cell as a novel Treg subset regulates inflammatory bowel disease in lymphopenic mice

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Cellular & Molecular Immunology 2015年第5期12卷 592-603页

作者： Jin-young shin Department of Microbiology and Immunology Seoul National University College of Medicine Seoul South Korea Department of Biomedical Sciences Seoul National University College of Medicine Seoul South Korea Xenotransplantation Research Center Seoul National University College of Medicine Seoul South Korea Cancer Research Institute Seoul National University College of Medicine Seoul South Korea J.Y. shin's current address is Biopharmaceutical Quality Management Division Ministry of Food and Drug Safety 187 Osongsaengmyeong2-ro Osong-eup Heungduk-gu Cheungju-si Chungbuk 363-700 South Korea J.H. Lim's current address is Department of Clinical Pathobiochemistry Faculty of Medicine Technische UniversitSt Dresden Dresden 01307 Germany Y.H. Kim's current address is Department of Microbiology Kyungpook National University School of Medicine 680 Gukchaebosang-ro Jung-gu Daegu 700-842 South Korea H.S. Cho's current address is Department of Pathology University of Massachusetts Medical School MA 01655 USA S.H. Hong's current address is Division of Immunology and Rheumatology Emory University School of MedicineGA 30322 USA

Regulatory T cells （Tregs） are a specialized subpopulation of T cells that control the immune response and thereby maintain immune system homeostasis and tolerance to self-antigens. Many subsets of CD4＋ Tregs have been identified, including Foxp3~, Trl, Th3, and Foxp3neg iT（R）35 cells. In this study, we identified a new subset of CD4＋VEGFR1high Tregs that have immunosuppressive capacity. CD4＋VEGFRlhigh T cells, which constitute approximately 1.0% of CD4＋ T cells, are hyporesponsive to T-cell antigen receptor stimulation. Surface marker and FoxP3 expression analysis revealed that CD4＋VEGFR1high T cells are distinct from known Tregs. CD4＋VEGFR1high T cells suppressed the proliferation of CD4＋CD25- T cell as efficiently as CD4＋CD25high natural Tregs in a contact-independent manner. Furthermore, adoptive transfer of CD4＋VEGFR1＋ T cells from wild type to RAG-2-deficient C57BL/6 mice inhibited effector T-cell-mediated inflammatory bowel disease. Thus, we report CD4＋ VEGFR1high T cells as a novel subset of Tregs that regulate the inflammatory response in the intestinal tract.

关键词： inflammatory bowel disease regulatory T cells suppression vascular endothelial growth factor receptor 1

Difficulties, strategies, and recent research and development of layered sodium transition metal oxide cathode materials for high-energy sodium-ion batteries

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Journal of Energy Chemistry 2024年第3期90卷 40-57,I0003页

作者： Kouthaman Mathiyalagan Dongwoo shin young-Chul Lee Department of Nano Science and Technology Convergence Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea Department of Bio Nano Technology Gachon University1342 Seongnam-DaeroSujeong-GuGyeonggi-DoSeongnam-Si 13120Republic of Korea

Energy-storage systems and their production have attracted significant interest for practical *** are the foundation of sustainable energy sources for electric vehicles(EVs),portable electronic devices(PEDs),*** recent decades,Lithium-ion batteries(LIBs) have been extensively utilized in largescale energy storage devices owing to their long cycle life and high energy ***,the high cost and limited availability of Li are the two main obstacles for *** this regard,sodium-ion batteries(SIBs) are attractive alternatives to LIBs for large-scale energy storage systems because of the abundance and low cost of sodium *** is one of the most important components in the battery,which limits cost and performance of a *** the classified cathode structures,layered structure materials have attracted attention because of their high ionic conductivity,fast diffusion rate,and high specific ***,we present a comprehensive review of the classification of layered structures and the preparation of layered ***,the review article discusses extensively about the issues of the layered materials,namely(1) electrochemical degradation,(2) irreversible structural changes,and(3) structural instability,and also it provides strategies to overcome the issues such as elemental phase composition,a small amount of elemental doping,structural design,and surface alteration for emerging *** addition,the article discusses about the recent research development on layered unary,binary,ternary,quaternary,quinary,and senary-based O3-and P2-type cathode materials for high-energy *** review article provides useful information for the development of high-energy layered sodium transition metal oxide P2 and O3-cathode materials for practical SIBs.

关键词： O3-type P2-type Cathode materials Sodium-ion batteries Layered structure

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Preparation of human decellularized peripheral nerve allograft using amphoteric detergent and nuclease

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Neural Regeneration Research 2021年第9期16卷 1890-1896页

作者： Joo-Yul Bae Suk young Park young Ho shin shin Woo Choi Jae Kwang Kim Department of Orthopedic Surgery University of Ulsan College of MedicineGangneung Asan HospitalGangneung-siKorea Department of Orthopedic Surgery University of Ulsan College of MedicineAsan Medical CenterSeoulKorea

Animal studies have shown that amphoteric detergent and nuclease(DNase I and ribonuclease A) is the most reliable decellularization method of the peripheral nerve. However, the optimal combination of chemical reagents for decellularization of human nerve allograft needs further investigation. To find the optimal protocol to remove the immunogenic cellular components of the nerve tissue and preserve the basal lamina and extracellular matrix and whether the optimal protocol can be applied to larger-diameter human peripheral nerves, in this study, we decellularized the median and sural nerves from the cadavers with two different methods: nonionic and anionic detergents(Triton X-100 and sodium deoxycholate) and amphoteric detergent and nuclease(3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate(CHAPS), deoxyribonuclease I, and ribonuclease A). All cellular components were successfully removed from the median and sural nerves by amphoteric detergent and nuclease. Not all cellular components were removed from the median nerve by nonionic and anionic detergent. Both median and sural nerves treated with amphoteric detergent and nuclease maintained a completely intact extracellular matrix. Treatment with nonionic and anionic detergent decreased collagen content in both median and sural nerves, while the amphoteric detergent and nuclease treatment did not reduce collagen content. In addition, a contact cytotoxicity assay revealed that the nerves decellularized by amphoteric detergent and nuclease was biocompatible. Strength failure testing demonstrated that the biomechanical properties of nerves decellularized with amphoteric detergent and nuclease were comparable to those of fresh controls. Decellularization with amphoteric detergent and nuclease better remove cellular components and better preserve extracellular matrix than decellularization with nonionic and anionic detergents, even in large-diameter human peripheral nerves. In Korea, cadaveric studies are not yet l

关键词： median nerve sural nerve nuclease detergent human decellularized nerve graft

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