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Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation

World Journal of Gastroenterology 2021年第21期27卷 2834-2849页

作者： Xin Wen Hong-Gang Wang Min-Na Zhang meng-hui Zhang Han Wang Xiao-Zhong Yang Department of Gastroenterology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai'an 223300Jiangsu ProvinceChina

BACKGROUND Emerging evidence has demonstrated that fecal microbiota transplantation(FMT)has a promising therapeutic effect on mice with experimental colitis and patients with ulcerative colitis(UC),although the mechanism of FMT is *** To evaluate the protective effect of FMT on UC and clarify its potential dependence on the gut microbiota,through association analysis of gut microbiota with colon transcriptome in *** Dextran sodium sulfate(DSS)-induced experimental colitis was established and fecal microbiota was transplanted by *** of colon inflammation was measured by body weight,disease activity index,colon length and histological *** microbiota alteration was analyzed through 16S ribosomal ribonucleic acid *** differentially expressed genes(DEGs)in the colon were obtained by transcriptome *** activation status of colonic T lymphocytes in the lamina propria was evaluated by flow *** Compared with the DSS group,the weight loss,colon length shortening and inflammation were significantly alleviated in the FMT *** scores of disease activity index and colon histology decreased obviously after *** restored the balance of gut microbiota,especially by upregulating the relative abundance of Lactobacillus and downregulating the relative abundance of Clostridium_sensu_stricto_1 and *** the transcriptomic analysis,128 DEGs intersected after DSS treatment and *** annotation analysis suggested that these DEGs were mainly involved in T-lymphocyte *** the DSS group,there was an increase in colonic T helper CD4^(+)and T cytotoxic CD8^(+)cells by flow *** selectively downregulated the ratio of colonic CD4^(+)and CD8^(+)T cells to maintain intestinal ***,Clostri dium_sensu_stricto_1 was significantly related to inflammation-related genes including REG3G,CCL8 and *** FMT ameliorated DSS-induced colitis in mice via regulating the g

关键词： Fecal microbiota transplantation Colitis Gut microbiota Transcriptome sequencing T lymphocyte

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Generic-Model-Based Description Scheme for MPEG-7

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Wuhan University Journal of Natural Sciences 2004年第3期9卷 283-287页

作者： DenqJuan Tanhui Chen.Xin-meng SchoolofComputer WuhanUniversityWuhan430072HubeiChina

We propose a new description scheme for MPEG-7:Generic-model-based Description Scheme to describe contents of audio, video, text and other sorts of multimedia. It uses a generic model as the description frame, which provides a simple but useful object\|based structure. The main components of the description scheme are generic model, objects and object features. The proposed description scheme is illustrated and exemplified by Extensible Markup Language. It aims at clarity and flexibility to support MPEG\|7 applications such as query and edit. We demonstrate its feasibility and efficiency by presenting applications: Digital Broadcasting and Edit System (DEBS) and Non\|linear Edit System (NLES) that already used the generic structure or will greatly benefit from it.

关键词： generic model object description scheme XML MPEG-7

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On the evolutionary trail of MagRs

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Zoological Research 2024年第4期45卷 821-830页

作者： Jing Zhang Yafei Chang Peng Zhang Yanqi Zhang mengke Wei Chenyang Han Shun Wang hui-meng Lu Tiantian Cai Can Xie High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui 230036China Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui 230039China School of Life Sciences Key Laboratory for Space Bioscience and BiotechnologyNorthwestern Polytechnical UniversityXi’anShaanxi 710072China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang 310027China

Magnetic sense,or termed magnetoreception,has evolved in a broad range of taxa within the animal kingdom to facilitate orientation and ***,highly conserved A-type iron-sulfur proteins,are widely distributed across all phyla and play essential roles in both magnetoreception and iron-sulfur cluster ***,the evolutionary origins and functional diversification of MagRs from their prokaryotic ancestor remain *** this study,MagR sequences from 131 species,ranging from bacteria to humans,were selected for analysis,with 23 representative sequences covering species from prokaryotes to Mollusca,Arthropoda,Osteichthyes,Reptilia,Aves,and mammals chosen for protein expression and *** studies revealed a gradual increase in total iron content in MagRs during *** types of MagRs were identified,each with distinct iron and/or iron-sulfur cluster binding capacity and protein stability,indicating continuous expansion of the functional roles of MagRs during speciation and *** evolutionary biochemical study provides valuable insights into how evolution shapes the physical and chemical properties of biological molecules such as MagRs and how these properties influence the evolutionary trajectories of MagRs.

关键词： Magnetoreception Magnetoreceptor(MagR) Iron-sulfur cluster Stability Evolutionary biochemistry

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Inducing Macrophages M2 Polarization by Dexamethasone Laden Mesoporous Silica Nanoparticles from Titanium Implant Surface for Enhanced Osteogenesis

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Acta Metallurgica Sinica(English Letters) 2019年第10期32卷 1253-1260页

作者： Jing Luo Xin Ding Wen Song Jian-Ying Bai Jing Liu Zhe Li Fan-hui meng Fang-Hao Chen Yu-Mei Zhang State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases Department of Prosthodontics School of Stomatology The Fourth Military Medical University Xi'an 710032 China Department of Stomatology General Hospital of Southern Theater Command of the Chinese People's Liberation Army Guangzhou 510010 China Huaian Stomatological Hospital Huaian 223001 China State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Key Laboratory of Oral Diseases Department of Dental Materials School of Stomatology The Fourth Military Medical University Xi'an 710032 China

The study conveys an idea to enhance the osseointegration of titanium implant (Ti) through modulating macrophages M2 polarization. The ?100 nm spherical mesoporous silica nanoparticles (MSN) that compromised of ~4-nm-diameter nano? tunnels were synthesized by the conventional "sol-gel" method, into which the dexamethasone (DEX) was loaded (DEX@ MSN). The DEX@MSN could consistently release DEX and showed favorable cytocompatibility in RAW264.7 cells. The arginase-1 expression, a specific marker for macrophages M2 polarization, was also enhanced by DEX @ MSN treatment. Then, the Ti was pre-treated with anodization under 5 V to generate the titania nanotubes with ?30 nm diameter (NT-30) and the DEX @ MSN was introduced onto NT-30 surface via electrophoretic deposition, with the aid of chitosan. After optimizing the deposition parameters, the supernatants of RAW264.7 from the decorated implant surface could significantly promote the osteogenic differentiation of murine primary bone marrow mesenchymal stem cells. These findings demonstrate that delivery of DEX from implant surface can modulate the macrophages M2 polarization and result in favorable osteogenesis.

关键词： Macrophages polarization Titanium implant Osteogenesis Dexamethasone Mesoporous silica nanoparticles Electrophoretic deposition

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Quantum block coherence with respect to projective measurements

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Chinese Physics B 2024年第8期33卷 213-220页

作者：王璞李忠艳孟会贤 School of Control and Computer Engineering North China Electric Power UniversityBeijing 102206China School of Mathematics and Physics North China Electric Power UniversityBeijing 102206China

Quantum coherence serves as a defining characteristic of quantum mechanics,finding extensive applications in quantum computing and quantum communication *** study explores quantum block coherence in the context of projective measurements,focusing on the quantification of such ***,we define the correlation function between the two general projective measurements P and Q,and analyze the connection between sets of block incoherent states related to two compatible projective measurements P and ***,we discuss the measure of quantum block coherence with respect to projective *** on a given measure of quantum block coherence,we characterize the existence of maximal block coherent states through projective *** research integrates the compatibility of projective measurements with the framework of quantum block coherence,contributing to the advancement of block coherence measurement theory.

关键词： quantum coherence compatibility projective measurement quantum block coherence

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Preparation and Tunable Luminescence of Eu Doped KNN Ceramics

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无机材料学报 2020年第2期35卷 236-242页

作者： WANG meng-hui SHEN hui TIAN Tian XIAN Qin XU Jia-Yue JIN Min JIA Run-Ping School of Materials Science and Engineering Shanghai Institute of TechnologyShanghai 201418China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China School of Materials Science and Engineering Shanghai Dianji UniversityShanghai 201306China

Rare-earth doped inorganic ferroelectrics are considered as novel photochromic materials,with potential applications for optical switch and information storage(K0.5Na0.5)1–xEuxNbO3(KNN:xEu)ceramics were prepared by high temperature calcination,with precursor powder obtained by hydrothermal *** red emission at 615 nm was observed which corresponds to the 5D0→7F2 transition of Eu3+under excitation of 465 *** UV light irradiation for 3 min,the color of the ceramics turned from milky white to dark *** colored samples returned to the original color when heated at 200℃for 10 min,showing strong photochromic ***,the luminescence intensity of Eu3+can be tuned without obvious degradation by alternating UV light and heat *** UV light irradiation,large luminescence modulation ratio(ΔRt)up to 83.9%was achieved for KNN:0.06Eu,indicating good luminescence switching behavior.A possible mechanism for non-radiative energy transfer from the luminescent center to the color center was proposed according to their luminescent behavior.

关键词： K0.5Na0.5NbO3(KNN) luminescence photochromism

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Dalbergia odorifera Essential Oil Protects against Myocardial Ischemia through Upregulating Nrf2 and Inhibiting Caspase Signaling Pathways in Isoproterenol-Induced Rats

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World Journal of Traditional Chinese Medicine 2023年第3期9卷 338-347页

作者： Can-Hong Wang Bao Gong hui meng Yu-Lan Wu Xiang-Sheng Zhao Jian-He Wei Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of State Administration of Traditional Chinese Medicine for Agarwood Sustainable Utilization Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikouChina Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical College Ministry of Education and National Engineering Laboratory for Breeding of Endangered Medicinal Materials Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Dalbergia odorifera has long been used as a Chinese herbal medicine for the treatment of cardiovascular and cerebrovascular *** study aimed to determine the potential myocardial protective effect and possible mechanism of action of *** ife ra essential oil(DOEO).Materials and Methods:The essential oil of *** was extracted by *** cardioprotective effects of DOEO were examined by histopathological observation,myocardial enzyme detection,peroxidation,anti-oxidant level detection,and related protein *** compounds in the blood were identified by gas chromatography-mass ***:These results showed that DOEO had significant myocardial cell protection,with IC50 values ranging from 17.64 to 24.78μg/mL in *** to the myocardial ischemia group,the DOEO pretreatment groups had lower levels of myocardial injury,creatinine kinase,lactate dehydrogenase,alanine transaminase,aspartate transaminase,hydrogen peroxide,and nitric oxide,and higher levels of glutathione and superoxide *** addition,DOEO pretreatment significantly increased Na+-K+-ATPase and Ca2+-ATPase *** r,immunohistochemical e xperiments showed that DOEO remarkably increased the protein levels of NF-E2-related nuclear factor 2(Nrf2)and heme oxygenase-1(HO-1)and reduced the expression of apoptotic caspases,including caspase 3 and caspase *** main components of the blood were transnerolidol and nerolidol ***,the study showed that DOEO displayed myocardial protection by upregulating the NF-E2-related nuclear factor-antioxidant response element(Nrf2-ARE)and caspase *** has a therapeutic effect on MI by inhibiting the oxidant and apoptotic ***:*** may be a potential candidate drug for treating myocardial ischemic injury.

关键词： Anti-apoptosis Anti-oxidation Dalbergia odorifera essential oil Isoproterenol Myocardial ischemia

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Fecal microbiota transplantation alleviates experimental colitis through the Toll-like receptor 4 signaling pathway

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World Journal of Gastroenterology 2023年第30期29卷 4657-4670页

作者： Xin Wen Rui Xie Hong-Gang Wang Min-Na Zhang Le He meng-hui Zhang Xiao-Zhong Yang Department of Gastroenterology The Affiliated Huaian No.1 People’s Hospital of Nanjing Medical UniversityHuai’an 223300Jiangsu ProvinceChina

BACKGROUND Fecal microbiota transplantation(FMT)has shown promising therapeutic effects on mice with experimental colitis and patients with ulcerative colitis(UC).FMT modulates the Toll-like receptor 4(TLR4)signaling pathway to treat some other ***,it remains unknown whether this modulation is also involved in the treatment of *** To clarify the necessity of TLR4 signaling pathway in FMT on dextran sodium sulphate(DSS)-induced mice and explain the mechanism of FMT on UC,through association analysis of gut microbiota with colon transcriptome in *** A mouse colitis model was constructed with wild-type(WT)and TLR4-knockout(KO)*** microbiota was transplanted by *** inflammation severity was measured by disease activity index(DAI)scoring and hematoxylin and eosin *** microbiota structure was analyzed through 16S ribosomal RNA *** expression in the mouse colon was obtained by transcriptome *** The KO(DSS+Water)and KO(DSS+FMT)groups displayed indistinguishable body weight loss,colon length,DAI score,and histology score,which showed that FMT could not inhibit the disease in KO *** mice treated with FMT,the relative abundance of Akkermansia decreased,and Lactobacillus became *** particular,compared with those in WT mice,the scores of DAI and colon histology were clearly decreased in the KO-DSS *** structure showed a significant difference between KO and WT *** were the dominant genus in healthy KO *** ineffectiveness of FMT in KO mice was related to the decreased abundance of *** Ontology enrichment analysis showed that differentially expressed genes between each group were mainly involved in cytoplasmic translation and cellular response to DNA damage *** top nine genes correlating with Akkermansia included Aqp4,Clca4a,Dpm3,Fau,Mcrip1,Meis3,Nupr1 L,Pank3,and Rps13(|R|>0.9,P<0.01).CONCLUSION FMT may ameliorate DSS-induced colitis by reg

关键词： Toll-like receptor 4 Fecal microbiota transplantation Colitis Akkermansia Lactobacillus Aquaporin 4 Transcriptome sequencing

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Effect of long-acting testosterone undecanoate treatment on quality of life in men with testosterone deficiency syndrome： a double blind randomized controlled trial

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Asian Journal of Andrology 2012年第4期14卷 604-611页

作者： Seng-Fah Tong Chirk-Jenn Ng Boon-Cheok Lee Verna-KM Lee Ee-Ming Khoo Eng-Giap Lee hui-meng Tan Universiti Kebangsaan Malaysia Kuala Lumpur 56000Malaysia University of Malaya Lumpur 56000Malaysia Sime Darby Medical Centre Selangor 47500Malaysia International Medical University Kuala Lumpur 57000Malaysia

This study aimed to investigate the effect of intramuscular injection of testosterone undecanoate on overall quality of life （QoL） in men with testosterone deficiency syndrome （TDS）. A randomized controlled trial over a 12-month period was carried out in 2009. One hundred and twenty men aged 40 years and above with a diagnosis of TDS （serum total testosterone 〈12 nmol 1-1 and total Aging Male Symptom （AMS） scores ≥ 27） were invited to participate. Interventions comprised intramuscular injection of either placebo or 1000 mg testosterone undecanoate, given at weeks O, 6, 18, 30 and 42. This paper presents the secondary analysis of QoL changes measured in the scores of Short-Form-12 （SF-12） scale at baseline, weeks 30 and 48 after the first injection. A total of 56/60 and 58/60 men from the active treatment and placebo group, respectively, completed the study. At week 48, before adjusting for baseline differences, the QoL of men in the treatment group improved significantly in five out of the eight domains on SF-12. The physical health composite scores improved 4.0 points from a baseline of 41.9±7.0 in the treatment group compared to 0.8 point from a baseline of 43.7--7.1 in the placebo group （F=3.652, P=0.027）. The mental health composite scores improved 4.4 points from a baseline of 37.1±9.0 in the treatment group compared to 1.0 points from a baseline of 37.6±7.9 in the placebo group （F=4.514, P=-0.018）. After adjusting for baseline differences, significant improvement was observed in mental health composite scores, but not in physical health composite scores. LQng-acting testosterone undecanoate significanUy improved the mental health component of QoL in men with TDS.

关键词： hypogonadism randomized controlled trial quality of life testosterone deficiency syndrome (TDS) testosterone therapy

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电解制备二氧化锰强酸性电解液中气体扩散电极的稳定性与失效行为

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物理化学学报 2013年第12期29卷 2558-2564页

作者：张慧孟惠民北京科技大学腐蚀和防护中心北京100083 北京科技大学北京市腐蚀、磨蚀与表面技术重点实验室北京100083

采用气体扩散电极(GDE)代替传统析氢阴极电解制备二氧化锰(EMD),重点研究了气体扩散电极在强酸性MnSO4-H2SO4电解液中的稳定性、寿命及失效行为.结果表明:气体扩散电极在MnSO4-H2SO4电解液中重现性好、具有一定的稳定性,寿命可达400 h;... 详细信息

采用气体扩散电极(GDE)代替传统析氢阴极电解制备二氧化锰(EMD),重点研究了气体扩散电极在强酸性MnSO4-H2SO4电解液中的稳定性、寿命及失效行为.结果表明:气体扩散电极在MnSO4-H2SO4电解液中重现性好、具有一定的稳定性,寿命可达400 h;平行实验表明,阳极沉积一定厚度的EMD是槽电压第一次升高的主要原因;电流密度为100 A m-2时,气体扩散电极失效前阴极过程的速度由氧的离子化反应和氧的扩散混合控制,失效后阴极过程由氧去极化和氢去极化共同组成,主要发生析氢反应;催化层聚四氟乙烯(PTFE)网络结构的破坏和镍网层的溶解是电极失效的原因之一;Pt的团聚降低了电极的电催化活性,是电极失效的主要原因;阴极失效是槽电压再次升高的主要原因.

关键词：气体扩散电极电解二氧化锰强酸性电解体系稳定性失效

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