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Process analytical technologies and self-optimization algorithms in automated pharmaceutical continuous manufacturing

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Chinese Chemical Letters 2024年第3期35卷 87-95页

作者： Peiwen Liu hui jin Yan Chen Derong Wang Haohui Yan Mingzhao Wu Fang Zhao Weiping Zhu State Key Laboratory of Bioreactor Engineering Shanghai Key Laboratory of Chemical BiologySchool of PharmacyEast China University of Science and TechnologyShanghai 200237China State Key Laboratory of Chemical Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China

The pharmaceutical industry is now paying increased attention to continuous manufacturing.While the revolution to continuous and automated manufacturing is deepening in most of the top pharma companies in the world,the advancement of automated pharmaceutical continuous manufacturing in China is relatively slow due to some key challenges including the lack of knowledge on the related technologies and shortage of qualified personnels.In this review,emphasis is given to two of the crucial technologies in automated pharmaceutical continuous manufacturing,i.e.,process analytical technology(PAT)and self-optimizing algorithm.Research work published in recent 5 years employing advanced PAT tools and self-optimization algorithms is introduced,which represents the great progress that has been made in automated pharmaceutical continuous manufacturing.

关键词： Pharmaceutical continuous manufacturing Automation Process analytical technology Self-optimization algorithm

Recent Progress in Fabrication and Structural Design of Thermal Conductive Polymer Composites

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Chinese Journal of Polymer Science 2024年第3期42卷 277-291,I0004页

作者： Yuan-Kai Du Zheng-Xue Shi Shan Dong hui jin Xue Ke Pei Zhao Bing-Bing Jiang Feng You Hubei Key Laboratory of Plasma Chemistry and Advanced Materials School of Material Science and EngineeringWuhan Institute of TechnologyWuhan 430205China Key Laboratory of Green Preparation and Application of Functional Materials Ministry of EducationHubei UniversityWuhan 430062China Institute of Molecular Aggregation Science Tianjin UniversityTianjin 300072China

In recent years, the demand direction for electronic equipment has expanded into embedded and miniaturized devices. The heat radiation problem has become one of the most significant factors for hindering the development of electronic devices. Since heat radiation material is one of the important components in electronic devices, the demand for enhancing thermal conductivity is also increasingly urgent. Research on thermal conductive polymer composites has become a major direction for developing functional composites. This work reviewed the recent progress in the fabrication of thermal conductive polymer composites. Five different structures are presented, including the using of single fillers,hybrid fillers, double threshold percolation structure, segregated structure and other complex multiphase structures. Specifically, the preparation of high-performance thermal conductive polymer composites was introduced through the combination of various thermal conductive fillers.Finally, the development direction of high thermal conductive polymer composites was briefly explored.

关键词： Thermal conductive polymer Hybrid fillers Polymer composite Thermal resistance

Modulating the alloying mode in the doping-induced synthesis of Au-Pd nanowires

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Nano Research 2024年第4期17卷 3334-3343页

作者： hui jin Xiaoliang Wei Lecheng Zhao Jialong Yu Qiao Pan Shumin Li Qian Wang Zhaotong Yuan Dan Yang Donghui Zhao Hongyu Chen Yawen Wang Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergistic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 211816China School of Science Westlake UniversityHangzhou 310064China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310064China

Heterogeneous doping is one effective strategy for synthesizing metal alloy nanowires.Herein,the heterogeneous doping processes of Pd on the ultrathin Au nanowires were systematically modulated and investigated.Au-Pd alloy nanowires with various morphologies and lattice structures can be obtained by adjusting the morphology of the precursor Au nanowires and the kinetics of the heterogeneous doping processes.The effects of the rate of Pd reduction and the concentration of the ligand oleylamine(OAm)on the Pd deposition and alloying mode were articulated.Generally,as the Pd deposition rate decreases,the Pd deposition and alloying mode switches from the island-forming Stransky–Krastanov(SK)mode to the epitaxial Frank-van der Merwe(FM)mode,and eventually to an unconventional twisting alloying mode,where the interdiffusion of Pd and Au causes drastic rearrangement of the lattice structure and formation of helical structures.The kinetics-related variation of alloying mode could also be observed in the Au-Ag nanowires,demonstrating a general design principle for the synthesis of alloy nanostructures.In addition,the electrocatalytic performance of various Au-Pd nanowires was evaluated,and the alloy nanowire formed via the SK mode was found to be an excellent electrocatalyst for oxygen reduction and ethanol oxidation.

关键词： gold nanowires Au-Pd alloy oleylamine post-synthetic modification

Vibration Suppression for Active Magnetic Bearings Using Adaptive Filter with Iterative Search Algorithm

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CES Transactions on Electrical Machines and Systems 2024年第1期8卷 61-71页

作者： jin-hui Ye Dan Shi Yue-Sheng Qi jin-hui Gao Jian-Xin Shen IEEE Department of Electrical Engineering Zhejiang UniversityHangzhou 310027China CES and IEEE

Active Magnetic Bearing(AMB) is a kind of electromagnetic support that makes the rotor movement frictionless and can suppress rotor vibration by controlling the magnetic force. The most common approach to restrain the rotor vibration in AMBs is to adopt a notch filter or adaptive filter in the AMB controller. However, these methods cannot obtain the precise amplitude and phase of the compensation current. Thus, they are not so effective in terms of suppressing the vibrations of the fundamental and other harmonic orders over the whole speed range. To improve the vibration suppression performance of AMBs,an adaptive filter based on Least Mean Square(LMS) is applied to extract the vibration signals from the rotor displacement signal. An Iterative Search Algorithm(ISA) is proposed in this paper to obtain the corresponding relationship between the compensation current and vibration signals. The ISA is responsible for searching the compensating amplitude and shifting phase online for the LMS filter, enabling the AMB controller to generate the corresponding compensation force for vibration suppression. The results of ISA are recorded to suppress vibration using the Look-Up Table(LUT) in variable speed range. Comprehensive simulations and experimental validations are carried out in fixed and variable speed range, and the results demonstrate that by employing the ISA, vibrations of the fundamental and other harmonic orders are suppressed effectively.

关键词： Active Magnetic Bearing(AMB) Adaptive filter Iterative search algorithm Least mean square(LMS) Vibration suppression

N-Heterocyclic carbene-catalyzed enantioselective(dynamic) kinetic resolutions and desymmetrizations

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Science China Chemistry 2024年第2期67卷 482-511页

作者： Yi Zhang hui Cai Xiuhai Gan Zhichao jin National Key Laboratory of Green Pesticide Key Laboratory of Green Pesticide and Agricultural BioengineeringMinistry of EducationGuizhou UniversityHuaxi DistrictGuiyang550025China

N-heterocyclic carbene-catalyzed enantioselective kinetic resolutions,dynamic kinetic resolutions,and desymmetrization reactions are systematically reviewed.The content is organized according to the activation modes involved in these transformations.Future advances within this highly active research field are discussed from our perspectives on the topic.

关键词： N-heterocyclic carbene kinetic resolution dynamic kinetic resolution desymmetrization organocatalysis

Recent progresses in thermal treatment of β-Ga_(2)O_(3) single crystals and devices

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1659-1677页

作者： Yuchao Yan Zhu jin hui Zhang Deren Yang State Key Laboratory of Silicon and Advanced Semiconductor Materials and School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027China Zhejiang Provincial Key Laboratory of Power Semiconductor Materials and Devices ZJU-Hangzhou Global Scientific and Technological Innovation CenterHangzhou 311200China

In recent years,ultra-wide bandgap β-Ga_(2)O_(3) has emerged as a fascinating semiconductor material due to its great potential in power and photoelectric devices.In semiconductor industrial,thermal treatment has been widely utilized as a convenient and effective approach for substrate property modulation and device fabrication.Thus,a thorough summary of β-Ga_(2)O_(3) substrates and devices behaviors after high-temperature treatment should be significant.In this review,we present the recent advances in modulating properties of β-Ga_(2)O_(3) substrates by thermal treatment,which include three major applications:(ⅰ)tuning surface electrical properties,(ⅱ)modifying surface morphology,and(ⅲ)oxidating films.Meanwhile,regulating electrical contacts and handling with radiation damage and ion implantation have also been discussed in device fabrication.In each category,universal annealing conditions were speculated to figure out the corresponding problems,and some unsolved questions were proposed clearly.This review could construct a systematic thermal treatment strategy for various purposes and applications of β-Ga_(2)O_(3).

关键词： β-gallium oxide thermal treatment substrates devices

Influence of crystal-transforming agent on the performance and mechanism ofα-high-strength gypsum prepared from FGD gypsum

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Particuology 2024年第4期87卷 37-45页

作者： Zhuoyue Xu Xiao Wang Biao jin Dawang Zhang hui Li College of Materials Science and Engineering Xi'an University of Architecture and TechnologyXi'an710055China Schoolof Materials and Chemical Engineering Henan University of Urban ConstructionPingdingshan46736China

This paper investigates the impact of flue gas desulfurization(FGD)gypsum's crystal modifier on the characteristics and microcosmic mechanism ofα-high strength gypsum.The results demonstrate that all three crystal modifiers can convert FGD gypsum toα-high-strength gypsum.Citric acid(CA)has the most significant influence onα-high-strength gypsum,and the preparedα-high-strength gypsum is short columnar,with an aspect ratio in the range of 1-3,and has a faster setting time,a larger specific surface area,and a smaller standard consistency,higher compressive strength,greater surface hardness,and smaller crystal particle size.The initial setting time of theα-high-strength gypsum manufactured with CA crystal modifier was decreased by 36%compared to the blank sample,the final setting time was lowered by 37.5%,and the water consumption of the standard consistency was reduced by 8%.The maximum strength is 32 MPa after 2 h,the absolute dry compressive strength is up to 38 MPa,and the surface hardness is improved by 24.43%.

关键词： Flue gas desulfurization gypsum Crystal modifier Microscopic mechanism α-high-strength gypsum

Electromagnetic fields in ultra-peripheral relativistic heavy-ion collisions

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Nuclear Science and Techniques 2024年第2期35卷 103-109页

作者： Jie Zhao jin-hui Chen Xu-Guang Huang Yu-Gang Ma Key Laboratory of Nuclear Physics and Ion-beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Theoretical Nuclear Physics NSFC and Fudan UniversityShanghai 200438China Physics Department and Center for Particle Physics and Field Theory Fudan UniversityShanghai 200438China

Ultra-peripheral heavy-ion collisions(UPCs)offer unique opportunities to study processes under strong electromagnetic fields.In these collisions,highly charged fast-moving ions carry strong electromagnetic fields that can be effectively treated as photon fluxes.The exchange of photons can induce photonuclear and two-photon interactions and excite ions.This excitation of the ions results in Coulomb dissociation with the emission of photons,neutrons,and other particles.Additionally,the electromagnetic fields generated by the ions can be sufficiently strong to enforce mutual interactions between the two colliding ions.Consequently,the two colliding ions experience an electromagnetic force that pushes them in opposite directions,causing a back-to-back correlation in the emitted neutrons.Using a Monte Carlo simulation,we qualitatively demonstrate that the above electromagnetic effect is large enough to be observed in UPCs,which would provide a clear means to study strong electromagnetic fields and their effects.

关键词： Electromagnetic fields Neutrons Ultra-peripheral relativistic heavy-ion collisions(UPC)

Enhanced Temporal Correlation for Universal Lesion Detection

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Computer Modeling in Engineering & Sciences 2024年第3期138卷 3051-3063页

作者： Muwei Jian Yue jin hui Yu School of Computer Science and Technology Shandong University of Finance and EconomicsJinanChina School of Information Science and Technology Linyi UniversityLinyiChina School of Creative Technologies University of PortsmouthPortsmouthUK

Universal lesion detection(ULD)methods for computed tomography(CT)images play a vital role in the modern clinical medicine and intelligent automation.It is well known that single 2D CT slices lack spatial-temporal characteristics and contextual information compared to 3D CT blocks.However,3D CT blocks necessitate significantly higher hardware resources during the learning phase.Therefore,efficiently exploiting temporal correlation and spatial-temporal features of 2D CT slices is crucial for ULD tasks.In this paper,we propose a ULD network with the enhanced temporal correlation for this purpose,named TCE-Net.The designed TCE module is applied to enrich the discriminate feature representation of multiple sequential CT slices.Besides,we employ multi-scale feature maps to facilitate the localization and detection of lesions in various sizes.Extensive experiments are conducted on the DeepLesion benchmark demonstrate that thismethod achieves 66.84%and 78.18%for FS@0.5 and FS@1.0,respectively,outperforming compared state-of-the-art methods.

关键词： Universal lesion detection computational biology medical computing deep learning enhanced temporal correlation