检索结果-南通市图书馆

Toll-like receptor 5-mediated signaling enhances liver regeneration in mice

Military Medical Research 2021年第4期8卷 490-502页

作者： Wen Zhang Lei Wang Xue-Hua Sun Xian Liu Yang Xiao Jie Zhang Ting Wang hui Chen Yi-Qun Zhan Miao Yu Chang-hui ge Chang-Yan Li Guang-Ming Ren Rong-Hua Yin Xiao-Ming Yang Department of Pharmaceutical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300072China. State Key Laboratory of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China. School of Basic Medical Sciences Anhui Medical UniversityHefei 230032Anhui ProvinceChina. Beijing Institute of Radiation Medicine Beijing 100850China.

Background:Toll-like receptor 5(TLR5)-mediated pathways play critical roles in regulating the hepatic immune response and show hepatoprotective effects in mouse models of hepatic ***,the role of TLR5 in experimental models of liver regeneration has not been *** study aimed to investigate the role of TLR5 in partial hepatectomy(PHx)-induced liver ***:We performed 2/3 PHx in wild-type(WT)mice,TLR5 knockout mice,or TLR5 agonist CBLB502 treated mice,as a model of liver *** flagellin content was measured with ELISA,and hepatic TLR5 expression was determined with quantitative PCR analyses and flow *** study the effects of TLR5 on hepatocyte proliferation,we analyzed bromodeoxyuridine(BrdU)incorporation and proliferating cell nuclear antigen(PCNA)expression with immunohistochemistry(IHC)*** effects of TLR5 during the priming phase of liver regeneration were examined with quantitative PCR analyses of immediate early gene mRNA levels,and with Western blotting analysis of hepatic NF-κB and STAT3 *** and growth factor production after PHx were detected with real-time PCR and cytometric bead array(CBA)*** Red O staining and hepatic lipid concentrations were analyzed to examine the effect of TLR5 on hepatic lipid accumulation after ***:The bacterial flagellin content in the serum and liver increased,and the hepatic TLR5 expression was significantly up-regulated in WT mice after ***5-deficient mice exhibited diminished numbers of BrdU-and PCNA-positive cells,suppressed immediate early gene expression,and decreased cytokine and growth factor ***,PHx-induced hepatic NF-κB and STAT3 activation was inhibited in Tlr5–/–mice,as compared with WT ***,the administration of CBLB502 significantly promoted PHx-mediated hepatocyte proliferation,which was correlated with enhanced production of proinflammatory cytokines and the recruitment of macrophages

关键词： Liver regeneration Partial hepatectomy Toll-like receptor 5 CBLB502 NF-κB

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Anatomical Study of the Intercostobrachial Nerve in Sprague-Dawlay Rats

引用

Chinese Journal of Clinical Oncology 2006年第2期3卷 118-120页

作者： Liansheng Ning Xin Wang Kai Zhao Zhenfong fang hui Sun Jie ge Department of Breast Tumors Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China.

OBJECTIVE The aim of the study was to explore the anatomy of the in-tercostobrachial nerve in rats. METHODS Dissections of 8 Sprague-dawley rats were performed to examine the intercostobrachial nerve. Fifteen dissections were successful. The position of the nerve, origin, termination, length and diameter were measured and recorded. RESULTS 1) 80% of the nerves originated from the second intercostal space and 20% from the first intercostal space; 2) 60% of the nerves terminated in the latissimus dorsi and 40% in the axillary skin 3) the branches of the nerves only were divided into 2 types, single and double; 4) the length of the nerves ranged from 2.4 to 3.4 cm with an average of 2.97±0.90 cm; 5) the diameter of the nerves was thicker at their origin compared to their termination. CONCLUSION The intercostobrachial nerve is simple in rats with 60% terminating in the latissimus dorsi.

关键词： SD rat intercostobrachial nerve anatomy.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Isochromophilones from an endophytic fungus Diaporthe sp.

引用

Natural Products and Bioprospecting 2012年第3期2卷 117-120页

作者： Le-Yun ZANG Wei WEI Ting WANG Ye GUO Ren-Xiang TAN hui-Ming ge Institute of Functional Biomolecules State Key Laboratory of Pharmaceutical BiotechnologySchool of Life ScienceNanjing UniversityNanjing 210093China

Three new azaphilone compounds,isochromophilones X-XII(1-3),together with two known ones sclerotioramine(4)and isochromophilone VI(5)were isolated from the cultures of an endophytic fungus Diaporthe *** structures were elucidated by extensive HRESIMS and NMR spectroscopic *** compounds were tested for their cytotoxicities against five human cancer cell lines by MTT method,among which compound 1 showed moderate inhibitory effects on these cell *** was the first report of azaphilones isolated from Diaporthe sp.

关键词： azaphilone endophyte Diaporthe sp. cytotoxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New antibacterial depsidones from an ant-derived fungus Spiromastix ***-1

引用

Chinese Journal of Natural Medicines 2022年第8期20卷 627-632页

作者： GUO Zhi-Kai HU Wen-Yong ZHAO Li-Xing CHEN Yan-Chi LI Sui-Jun CHENG Ping ge hui-Ming TAN Ren-Xiang JIAO Rui-Hua State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210093China Hainan Key Laboratory of Tropical Microbe Resources Institute of Tropical Bioscience and BiotechnologyChinese Academy of Tropical Agricultural SciencesHaikou 571101China Yunnan Key Laboratory of Vaccine Research&Development on Severe Infectious Diseases Institute of Medical BiologyChinese Academy of Medical SciencesKunming 650118China Yunnan Institute of Microbiology Yunnan UniversityKunming 650091China

Six new(1–6)and seven known depsidones(7–13)were isolated from the culture of an ant(Monomorium chinensis)-derived fungus Spiromastix *** structures were elucidated by extensive spectroscopic analysis including high resolution MS,1D and 2D NMR *** new bromide depsidones were obtained through supplementing potassium bromide in the fermentation medium of Spiromastix *** isolated compounds showed various bioactivities against the tested phytopathogenic ***,new bromide compound 4,named spiromastixone S,exhibited the strongest activity against Xanthomonas oryzae *** with a MIC value of 5.2μmol·^L(−1).

关键词： Fungus Spiromastix sp Depsidones Phytopathogenic bacteria Antibacterial

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Preparation and Magnetic Properties of Submicron CrO2 Thin Film on Poly-crystal TiO2 Film

引用

Chemical Research in Chinese Universities 2013年第3期29卷 600-602页

作者： YUAN Ju-jun WEN ge-hui ZHAO Qiang FAN Yin-bo ZHANG Cai-ping ZHANG Xian-ke YU Hua-jun XIE Ying-mao College of Physics and Electronics Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Superhard Materials Jilin University Changchun 130012 P. R. China Institute of Optoelectronic Materials and Technology Gannan Normal University Ganzhou 341000 P. R. China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Chengdu 610054 P. R. China

The submicron chromium dioxide（CrO2） thin film was fabricated on a poly-crystal titania（TiO2） film using Si wafers as substrates by atmospheric pressure chemical vapor deposition（CVD） method. X-Ray diffraction patterns show that the CrO2 films were pure rutile structure. Scanning electron microscopy（SEM） images indicate that the CrO2 films consisted of submicron grains with a grain size of 250--750 rim. The magnetic researches reveal that the magnetic easy axis is parallel to the films, and at room temperature, the CrO2 films show linear magnetoresistance.

关键词： CrO2 film TiO2 film Chemical vapor deposition(CVD) Magnetic property Half-metal ferromagnet

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on the secondary metabolites of grasshopper-derived fungi Arthrinium ***2410

引用

Chinese Journal of Natural Medicines 2020年第12期18卷 957-960页

作者： LI Wei WEI Jing CHEN Dao-Ying WANG Mei-Jing SUN Yang JIAO Fang-Wen JIAO Rui-Hua TAN Ren-Xiang ge hui-Ming State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory of Pharmaceutical Biotechnology Department of Biotechnology and Pharmaceutical SciencesSchool of Life ScienceNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China

Two new 2-carboxymethyl-3-hexyl-maleic anhydride derivatives,arthrianhydride A(1)and B(2),along with three known compounds 3-5,were isolated from the fermentation broth of a grasshopper-associated fungus Arthrinium *** structures of new compounds 1 and 2 were determined based on the analysis of the HR-ESI-MS and NMR spectroscopic ***,compounds 1 and 2 were evaluated on inhibitory activity against the enzyme SHP2 and both of them showed moderate inhibitory activity against SHP2.

关键词： Grasshopper-associated fungi Secondary metabolites Structure elucidation SHP2 Inhibitory activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Co-Harvest Phase-Change Enthalpy and Isomerization Energy for High-Energy Heat Output by Controlling Crystallization of Alkyl-Grafted Azobenzene Molecules

引用

Energy & Environmental Materials 2024年第3期7卷 415-424页

作者： Jian Gao Yiyu Feng Wenyu Fang hui Wang Jing ge Xiaoyu Yang huitao Yu Mengmeng Qin Wei Feng School of Materials Science and Engineering Tianjin UniversityTianjin 300350China Key Laboratory of Materials Processing and Mold Ministry of EducationZhengzhou UniversityZhengzhou 450002China

Photoisomerization-induced phase change are important for co-harvesting the latent heat and isomerization energy of azobenzene *** optimizing heat output and energy delivery at alternating temperatures are challenging because of the differences in crystallizability and *** article reports two series of asymmetrically alkyl-grafted azobenzene(Azo-g),with and without a methyl group,that have an optically triggered phase *** exothermic modes were designed to utilize crystallization enthalpy(△H_(c))and photothermal(isomerization)energy(△H_(p))at different temperatures determined by the ***-g has high heat output(275-303 J g^(-1))by synchronously releasing△H_(c)and△H_(p)over a wide temperature range(-79℃to 25℃).We fabricated a new distributed energy utilization and delivery system to realize a temperature increase of 6.6℃at a temperature of-8℃.The findings offer insight into selective utilization of latent heat and isomerization energy by molecular optimization of crystallization and isomerization processes.

关键词： crystallizability distributed energy utilization system energy density exothermic modes isomerization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

美国亚利桑那州立大学高水平篮球队球员招募对我国的启示

引用

北京体育大学学报 2018年第7期41卷 102-110页

作者：葛辉山西大学体育学院山西太原030006

运用文献资料法、访谈法和逻辑分析法等研究方法,调查访谈了美国亚利桑那州立大学篮球队的教练员、球队管理人员、体育部领导以及我国参加CUBA联赛的16位高校高水平篮球队教练员,就美国高校高水平篮球运动员招募对我国的启示这一问题进... 详细信息

运用文献资料法、访谈法和逻辑分析法等研究方法,调查访谈了美国亚利桑那州立大学篮球队的教练员、球队管理人员、体育部领导以及我国参加CUBA联赛的16位高校高水平篮球队教练员,就美国高校高水平篮球运动员招募对我国的启示这一问题进行了研究,旨在于为我国高校高水平篮球运动员的招生管理工作的优化提供一个理论参考和借鉴。研究认为:1)应建立一个独立、强大、完备的大学生高水平运动员组织管理机构;2)出台严格的法律法规为招生工作提供强有力的政策理论支持;3)严格控制招募流程和时间,使招募工作有序进行;4)逐渐取消各自学校的自行招考,建立制度明确、统一命题、统一考试、统一阅卷的文化课程考试方式;5)学校为招募球员提供适合球员发展的相关专业,提早做好未来职业规划;6)建立权威机构对青少年篮球大数据库及球员能力网络追踪平台;7)进一步优化篮球运动员等级划分的考核方式;8)科学细化招生名额限制,明确普通高中生源与其他渠道球员的招收名额。

关键词：美国亚利桑那州立大学高水平篮球运动员球员招募

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

国际法“碎片化”视角下的气候变化单边措施——以欧盟航空指令为例

引用

国际商务（对外经济贸易大学学报） 2015年第3期 121-130页

作者：葛辉南京大学法学院南京210093

在国际法"碎片化"的背景下,气候变化单边措施涉及不同类别的国际法与国际自足体制。在审查欧盟航空指令的有效性时,欧盟法和世贸组织法律制度有明显不同的利益偏好。为消除体制间的冲突,更为现实的态度是,应承认国际自足体制的多样性和... 详细信息

在国际法"碎片化"的背景下,气候变化单边措施涉及不同类别的国际法与国际自足体制。在审查欧盟航空指令的有效性时,欧盟法和世贸组织法律制度有明显不同的利益偏好。为消除体制间的冲突,更为现实的态度是,应承认国际自足体制的多样性和独立性。利用体制间的对话和相互适应来缓解贸易与环境之间的紧张关系。

关键词：国际法碎片化欧盟航空指令气候变化国际自足体制

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Berberine and Metformin in the Treatment of Type 2 Diabetes Mellitus: A Systemic Review and Meta-Analysis of Randomized Clinical Trials

引用

Health 2021年第11期13卷 1314-1329页

作者： Li Wang Donglan Liu Guohong Wei hui ge Department of Healthcare The First Affiliated Hospital Sun Yat-sen University Guangzhou China Outpatient Clinic of Internal Medicine Department The First Affiliated Hospital Sun Yat-sen University Guangzhou China Department of Endocrinology The First Affiliated Hospital Sun Yat-sen University Guangzhou China

Objective: To assess the effects of berberine and metformin on glucose in patients with type 2 diabets mellitus (T2DM) with a systematic review and meta-analysis. Methods: The databases including PubMed, Excerpta Medica Database (EMBase), Cochrane Library, Chinese National Knowledge Infrastructure database (CNKI), WanFang, the Chinese Scientific and Technical Journals database (VIP), China Doctor Dissertation Full-text Database (CDFD) and China Master Dissertation Full-text Database (CMFD) from the inception to April 2021 in Chinese or English language were searched. Randomized controlled trials (RCTs) of berberine only or combined with metformin versus metformin were included. Data extraction and paper quality assessment were conducted according to the Cochrane Handbook. RevMan 5.4 was used for the meta-analysis. Results: A total of thirteen studies were included, covering 1173 participants. The clinical heterogeneity of the included trials was relatively high. The methodological quality of most trials was generally low with bias in terms of random sequence generation, allocation concealment, blinding method, outcome data and selective reporting. Interventions were divided into two subgroups for analysis. Meta-analysis suggested that there was no statistical significance in the hypoglycemic effect between berberine and metformin for T2DM. However, berberine combined with metformin could reduce fasting plasma glucose (FPG) [MD = −1.49, 95% CI (−2.22, −0.76), P MD = −1.89, 95% CI (−2.94, −0.84), P = 0.0004], glycosylated hemoglobin A1c (HbA1c) [MD

关键词： Berberine Metformin Type 2 Diabetes Mellitus Efficacy Safety Meta-Analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：