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Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor

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Oncology Research 2024年第5期32卷 983-998页

作者： ANDI ZHAO YUE WANG ZIJIN WANG QING SHAO QI GONG hui ZHU SHIYA shen HU LIU XUEJUAN CHEN Department of Ophthalmology The First Affiliated Hospital with Nanjing Medical UniversityNanjing210029China The First Clinical Medical College Nanjing Medical UniversityNanjing211166China Department of Ophthalmology Nanjing First HospitalNanjing Medical UniversityNanjing210006China

Numerous studies have characterized the critical role of circular RNAs(circRNAs)as regulatory factors in the progression of multiple ***,the biological functions of circRNAs and their underlying molecular mechanisms in the progression of uveal melanoma(UM)remain *** this study,we identified a novel circRNA,circ_0053943,through re-analysis of UM microarray data and quantitative ***_0053943 was found to be upregulated in UM and to promote the proliferation and metastatic ability of UM cells in both in vitro and in vivo ***,circ_0053943 was observed to bind to the KH1 and KH2 domains of insulin-like growth factor 2 mRNA-binding protein 3(IGF2BP3),thereby enhancing the function of IGF2BP3 by stabilizing its target *** sequencing assays identified epidermal growth factor receptor(EGFR)as a target gene of circ_0053943 and IGF2BP3 at the transcriptional *** assays demonstrated that circ_0053943 exerts its biological function by stabilizing EGFR mRNA and regulating the downstream mitogen-activated protein kinase/extracellular signal-regulated kinase(MAPK/ERK)signaling ***,circ_0053943 may promote UM progression by stabilizing EGFR mRNA and activating the MAPK/ERK signaling pathway through the formation of a circ_0053943/IGF2BP3/EGFR RNA-protein ternary complex,thus providing a potential biomarker and therapeutic target for UM.

关键词： Uveal melanoma Hsa_circ_0053943 IGF2BP3 EGFR MAPK/ERK signaling pathway

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Will partial splenic embolization followed by splenectomy increase intraoperative bleeding?

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 318-330页

作者： Long Huang Qing-Lin Li Qing-sheng Yu hui Peng Zhou Zhen Yi shen Qi Zhang Department of No.1 Surgery The First Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230031Anhui ProvinceChina Anhui University of Traditional Chinese Medicine Anhui University of Traditional Chinese MedicineHefei 230038Anhui ProvinceChina Department of Surgery The Second Hospital Affiliated to Anhui University of Traditional Chinese MedicineHefei 230061Anhui ProvinceChina

BACKGROUND Partial splenic embolization(PSE)has been suggested as an alternative to splenectomy in the treatment of ***,some patients may experience recurrence of hypersplenism after PSE and require ***,there is a lack of evidence-based medical support regarding whether preoperative PSE followed by splenectomy can reduce the incidence of *** To investigate the safety and therapeutic efficacy of preoperative PSE followed by splenectomy in patients with cirrhosis and *** Between January 2010 and December 2021,321 consecutive patients with cirrhosis and hypersplenism underwent splenectomy at our *** on whether PSE was performed prior to splenectomy,the patients were divided into two groups:PSE group(n=40)and non-PSE group(n=281).Patient characteristics,postoperative complications,and follow-up data were compared between *** score matching(PSM)was conducted,and univariable and multivariable analyses were used to establish a nomogram predictive model for intraoperative bleeding(IB).The receiver operating characteristic curve,Hosmer-Lemeshow goodness-of-fit test,and decision curve analysis(DCA)were employed to evaluate the differentiation,calibration,and clinical performance of the *** After PSM,the non-PSE group showed significant reductions in hospital stay,intraoperative blood loss,and operation time(all P=0.00).Multivariate analysis revealed that spleen length,portal vein diameter,splenic vein diameter,and history of PSE were independent predictive factors for IB.A nomogram predictive model of IB was constructed,and DCA demonstrated the clinical utility of this *** groups exhibited similar results in terms of overall survival during the follow-up *** Preoperative PSE followed by splenectomy may increase the incidence of IB and a nomogram-based prediction model can predict the occurrence of IB.

关键词： Partial splenic embolization Splenectomy Hypertension,Portal Liver Cirrhosis Intraoperative bleeding

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The osteoclastic activity in apical distal region of molar mesial roots affects orthodontic tooth movement and root resorption in rats

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International Journal of Oral Science 2024年第2期16卷 322-332页

作者： Wenhao Zheng Xiaofeng Lu Guangjin Chen Yufeng shen Xiaofei Huang Jinfeng Peng Jiajia Wang ying yin Wencheng Song Mengru Xie Shaoling Yu Lili Chen Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina School of Stomatology Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration WuhanChina Department of Stomatology The First Affiliated HospitalSchool of MedicineShihezi UniversityShiheziChina

The utilization of optimal orthodontic force is crucial to prevent undesirable side effects and ensure efficient tooth movement during orthodontic ***,the sensitivity of existing detection techniques is not sufficient,and the criteria for evaluating optimal force have not been yet ***,by employing 3D finite element analysis methodology,we found that the apical distal region(A-D region)of mesial roots is particularly sensitive to orthodontic force in ***-resistant acidic phosphatase(TRAP)-positive osteoclasts began accumulating in the A-D region under the force of 40 grams(g),leading to alveolar bone resorption and tooth *** the force reached 80 g,TRAP-positive osteoclasts started appearing on the root surface in the A-D ***,micro-computed tomography revealed a significant root resorption at 80 ***,the A-D region was identified as a major contributor to whole root *** was determined that 40 g is the minimum effective force for tooth movement with minimal side effects according to the analysis of tooth movement,inclination,and *** findings suggest that the A-D region with its changes on the root surface is an important consideration and sensitive indicator when evaluating orthodontic forces for a rat ***,our investigations into this region would aid in offering valuable implications for preventing and minimizing root resorption during patients’orthodontic treatment.

关键词： movement roots offering

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Cardiac-Adaptive Conductive Hydrogel Patch Enabling Construction of Mechanical–Electrical Anisotropic Microenvironment for Heart Repair

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Research 2024年第1期2023卷 489-507页

作者： Xiaoping Song Jifeng Zhang Si shen Dan Liu Jie Zhang Wenming yin Genlan Ye Leyu Wang Liu Cai Honghao Hou Xiaozhong Qiu Central Laboratory The Fifth Affiliated HospitalSouthern Medical UniversityGuangzhouGuangdong 510910China Department of Anatomy Neuroscience Laboratory for Cognitive and Developmental DisordersMedical College of Jinan UniversityGuangzhou 510630China Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering School of Basic Medical ScienceBiomaterials Research CenterSchool of Biomedical EngineeringSouthern Medical UniversityGuangzhouGuangdong 510515China

The biomimetic construction of a microstructural–mechanical–electrical anisotropic microenvironment adaptive to the native cardiac tissue is essential to repair myocardial infarction(MI).Inspired by the 3D anisotropic characteristic of the natural fish swim bladder(FSB),a novel flexible,anisotropic,and conductive hydrogel was developed for tissue-specific adaptation to the anisotropic structural,conductive,and mechanical features of the native cardiac extracellular *** results revealed that the originally stiff,homogeneous FSB film was tailored to a highly flexible anisotropic hydrogel,enabling its potential as a functional engineered cardiac patch(ECP).In vitro and in vivo experiments demonstrated the enhanced electrophysiological activity,maturation,elongation,and orientation of cardiomyocytes(CMs),and marked MI repair performance with reduced CM apoptosis and myocardial fibrosis,thereby promoting cell retention,myogenesis,and vascularization,as well as improving electrical *** findings offer a potential strategy for functional ECP and provides a novel strategy to bionically simulate the complex cardiac repair environment.

关键词： bladder thereby patch

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Influence of erosion voids and traffic loads on buried large-diameter reinforced concrete pipes

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Underground Space 2024年第4期17卷 120-131页

作者： Ming Xu Dawei shen Department of Civil Engineering Tsinghua UniversityBeijing 100084China Beijing Institute of Technology Beijing 100081China

Geotechnical centrifuge tests were conducted to examine the influence of invert voids and surface traffic loads on 1400 mm diameter reinforced concrete pipes buried with a shallow soil cover depth of 700 *** formation beneath the pipe was simulated during centrifuge *** test results revealed that before void formation,the surface load directly above the middle of the pipe caused a significant increase in not only the circumferential bending moments but also the longitudinal bending moments,the latter of which was considerable and could not be *** formation beneath the middle of the pipe led to a reduction in both the circumferential bending moments and longitudinal bending moments at all measuring positions,i.e.,crown,springline,and *** most significant reduction occurred at the invert,and there was even a reversal in the sign of the invert longitudinal bending moment.A comparison was made between centrifuge tests with erosion voids and surface loads at different horizontal positions,which had a marked influence even when the positions differed by half a pipe *** rotation played an important role in relieving large bending moments of pipe barrels in a jointed pipeline when the void and surface load were located at the joint.

关键词： Centrifuge test Erosion void Reinforced concrete pipe Traffic loading Longitudinal bending moment Joint rotation

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Genetic basis of geographical differentiation,breeding selection,domestication effects,and breeding application for TaJAZ1 in wheat

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Journal of Genetics and Genomics 2024年第6期51卷 665-668页

作者： Botao Ye Yangyang Liu Ziying Wang Liping shen Changbin yin Kuocheng shen Jiaqiang Sun Xiaowan Xu Mengjing Sun Jianhui Wu Zhonghu He Xuchang Yu Fei Lu Yuanfeng Hao Zifeng Guo Key Laboratory of Plant Molecular Physiology Institute of BotanyChinese Academy of SciencesBeijing 100093China University of Chinese Academy of Sciences Beijing 100049China China National Botanical Garden Beijing 100093China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Institute of Crop Sciences Chinese Academy of Agricultural SciencesBeijing 100081China State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F UniversityYanglingShaanxi 712100China International Maize and Wheat Improvement Center China Office c/o CAASBeijing 100081China CAS-JIC Centre of Excellence for Plant and Microbial Science Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Common wheat(Triticum aestivum L.,2n=6x=42,AABBDD)is one of the most widely grown crops worldwide,providing about 20%of the daily calories and protein consumed by humans(Shiferaw et al.,2013).The world population is projected to reach 9.8 billion in 2050(https://***/en/desa/world-population-projectedreach-98-billion-2050-and-112-billion-2100);thus,to meet the challenges of global food and nutritional security,wheat yields must continue to be increased through breeding programs and improved agricultural techniques(Hunter et al.,2017).

关键词： breeding crops wheat

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Large reversible magnetocaloric effect in antiferromagnetic Er_(3)Si_(2)C_(2) compound

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Journal of Rare Earths 2024年第8期42卷 1555-1559,I0005页

作者： Hao Sun Lu Tian Xinqiang Gao Zhaojun Mo Jun shen Baogen shen School of Rare Earths University of Science and Technology of ChinaHefei230026China Ganjiang Innovation Academy Chinese Academy of SciencesGanzhou341000China Department of Energy and Power Engineering School of Mechanical EngineeringBeijing Institute of TechnologyBeijing100081China

The magnetic properties,magnetic phase transition and magnetocaloric effects(MCE) of Er_(3)Si_(2)C_(2) compound were investigated based on theoretical calculations and experimental *** on the first principles calculations,the antiferromagnetic(AFM) ground state type in Er_(3)Si_(2)C_(2) compound was predicted and its electronic structure was *** experimental results show that Ei_(3)Si_(2)C_(2) compound is an AFM compound with the Neel temperature(T_(N) of 7 K and undergoes a field-induced firstorder magnetic phase transition from AFM to ferromagnetic(FM) under magnetic fields exceeding 0.6 T at 2 *** magnetic transition process of Er_(3)Si_(2)C_(2) compound was investigated and *** values of the maximum magnetic entropy change(-ΔS_(M)^(max)) and the refrigeration capacity(RC) are 17 J/(kg·K)and 193 J/kg under changing magnetic fields of 0-5 T,*** a potential cryogenic magnetic refrigerant,the Er_(3)Si_(2)C_(2) compound also provides an interesting research medium to study the magnetic phase transition process.

关键词： Magnetic materials Magnetocaloric Metamagnetic transitions Magnetic phase transition Rare earths

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Polarization-dependent photoinduced metal–insulator transitions in manganites

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Science Bulletin 2024年第2期69卷 183-189页

作者： Lina Deng Weiye Zhang Hanxuan Lin Lifen Xiang ying Xu Yadi Wang Qiang Li yinyan Zhu Xiaodong Zhou Wenbin Wang Lifeng yin Hangwen Guo Chuanshan Tian Jian shen State Key Laboratory of Surface Physics Institute for Nanoelectronic Devices and Quantum Computingand Department of PhysicsFudan UniversityShanghai 200433China Shanghai Research Center for Quantum Sciences Shanghai 201315China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China Shanghai Branch CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum PhysicsShanghai 201315China

In correlated oxides,collaborative manipulation on light intensity,wavelength,pulse duration and polarization has yielded many exotic discoveries,such as phase transitions and novel quantum *** view of potential optoelectronic applications,tailoring long-lived static properties by light-induced effects is highly *** far,the polarization state of light has rarely been reported as a control parameter for this ***,we report polarization-dependent metal-to-insulator transition(MIT)in phaseseparated manganite thin films,introducing a new degree of freedom to control static ***,we observed giant photoinduced resistance jumps with striking features:(1)a single resistance jump occurs upon a linearly polarized light incident with a chosen polarization angle,and a second resistance jump occurs when the polarization angle changes;(2)the amplitude of the second resistance jump depends sensitively on the actual change of the polarization *** transmittance measurements reveal that the origin of the above phenomena is closely related to the coexistence of anisotropic *** results represent a first step to utilize light polarization as an active knob to manipulate static phase transitions,pointing towards new pathways for nonvolatile optoelectronic devices and sensors.

关键词： Metal-insulator phase transitions Polarization of light Electronic phase separation Selective domain controllability

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Oxygen vacancy promoting artificial atom(RuPd)by d-orbital coupling for efficient water dissociation

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Nano Research 2024年第8期17卷 7045-7052页

作者： Ruofan shen Yanyan Liu Shuling Liu Shuyan Guan Huanhuan Zhang Sehrish Mehdi Saima Ashraf Ting-hui Xiao Erjun Liang Jianchun Jiang Yongfeng Wang Baojun Li Laboratory of Zhongyuan Light School of PhysicsZhengzhou UniversityZhengzhou 450001China Key Laboratory of Materials Physics Ministry of EducationSchool of PhysicsZhengzhou UniversityZhengzhou 450001China College of Chemistry Zhengzhou UniversityZhengzhou 450001China College of Science Henan Agricultural UniversityZhengzhou 450002China Department of Chemistry Tsinghua UniversityBeijing 100084China National Engineering Lab.for Biomass Chemical Utilization Institute of Chemical Industry of Forest ProductsCAFNanjing 210042China Center for Carbon-based Electronics and Key Laboratory for the Physics and Chemistry of Nanodevices Department of ElectronicsPeking UniversityBeijing 100871China

Rational design of highly active catalysts for breaking hydrogen-oxygen bonds is of great significance in energy chemical reactions involving ***,an efficient strategy for the artificial atom(RuPd)established by d-orbital coupling and adjusted by oxygen vacancy(V_(O))is verified for water *** an experimental verification,the turnover frequency of RuPd-TiO_(2)-VO(RuPdTVO)catalyst in ammonia borane hydrolysis reaches up to 2750 min^(−1)(26,190 min−1 based on metal dispersion)in the absence of alkali,exceeding the highest active catalysts(Rh-based catalysts).The d-orbital coupling effect between Ru and Pd simulates the outer electronic structure of *** transfer from V_(O) to(RuPd)constructs an electron-rich state of active sites that further enhances the ability of the artificial atom to dissociate *** work provides an effective electronic regulation strategy from V_(O) and artificial atom constructed by d-orbital coupling effect for efficient water dissociation.

关键词： ammonia borane hydrolysis d-orbital coupling oxygen vacancy artificial atom water dissociation

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Identifying the enhancement mechanism of Al/MoO_(3) reactive multilayered films on the ignition ability of semiconductor bridge using a one-dimensional gas-solid two-phase flow model

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Defence Technology（防务技术） 2024年第3期33卷 168-179页

作者： Jianbing Xu Yuxuan Zhou Yun shen Yueting Wang yinghua Ye Ruiqi shen School of Chemistry and Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094China Micro-Nano Energetic Devices Key Laboratory of MIIT Nanjing 210094China Institute of Space Propulsion Nanjing University of Science and TechnologyNanjing 210094China

Energetic Semiconductor bridge(ESCB)based on reactive multilayered films(RMFs)has a promising application in the miniature and intelligence of initiator and pyrotechnics *** the ignition enhancement mechanism of RMFs on semiconductor bridge(SCB)during the ignition process is crucial for the engineering and practical application of advanced initiator and pyrotechnics *** this study,a one-dimensional(1D)gas-solid two-phase flow ignition model was established to study the ignition process of ESCB to charge particles based on the reactivity of Al/MoO_(3) *** order to fully consider the coupled exothermic between the RMFs and the SCB plasma during the ignition process,the heat release of chemical reaction in RMFs was used as an internal heat source in this *** is found that the exothermal reaction in RMFs improved the ignition performance of *** the process of plasma rapid condensation with heat release,the product of RMFs enhanced the heat transfer process between the gas phase and the solid charge particle,which accelerated the expansion of hot plasma,and heated the solid charge particle as well as gas phase region with low *** addition,it made up for pressure loss in the gas *** the plasma dissipation process,the exothermal chemical reaction in RMFs acted as the main heating source to heat the charge particle,making the surface temperature of the charge particle,gas pressure,and gas temperature rise *** result may yield significant advantages in providing a universal ignition model for miniaturized ignition devices.

关键词： Ignition enhancement mechanism 1D gas-solid two-phase flow Al/MoO_(3)reactive multilayered films Semiconductor bridge Miniaturized ignition device

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