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苏木酮A调控JNK通路减轻大鼠肾脏缺血再灌注损伤

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药学学报 2024年第6期59卷 1639-1646页

作者：金太伟高小宁宋文琳王妍妍孙琳陆玲红苏州市吴江区儿童医院江苏苏州215200

本研究旨在探讨苏木酮A(sappanone A,SA)调控大鼠肾脏缺血再灌注损伤(ischemia-reperfusion injury,IRI)的作用和机制。动物实验已获得苏州市吴江区儿童医院伦理委员会批准(批准号:2022010)。首先利用苏木精−伊红染色法(hematoxylin-eos... 详细信息

本研究旨在探讨苏木酮A(sappanone A,SA)调控大鼠肾脏缺血再灌注损伤(ischemia-reperfusion injury,IRI)的作用和机制。动物实验已获得苏州市吴江区儿童医院伦理委员会批准(批准号:2022010)。首先利用苏木精−伊红染色法(hematoxylin-eosin staining,H&E)观察大鼠肾组织形态学变化并进行肾损伤评分;提取血清检测肌酐(serum creatinine,SCr)、尿素氮(blood urea nitrogen,BUN)和胱抑素C(cystatin C,Cys C)的含量;通过TUNEL染色进一步分析苏木酮A对IRI引起的肾小管上皮细胞凋亡情况的影响;免疫印迹法(Western blot)检测肾组织中p-JNK/JNK、p-ERK/ERK、Bcl2、Bax和cleaved-caspase 3的蛋白表达水平。最后,通过以上研究方法明确JNK激活剂茴香霉素(anisomycin,Ani)是否可以逆转苏木酮A对大鼠IRI的保护作用。结果显示,苏木酮A明显减轻IRI引起的肾小管损伤,减少血清中SCr、BUN和Cys C的含量。TUNEL染色显示,苏木酮A明显减少IRI引起的肾小管上皮细胞凋亡。Western blot检测肾组织表明,苏木酮A明显促进凋亡抑制蛋白Bcl2的表达,抑制凋亡促进蛋白Bax和cleaved-caspase 3的表达,进一步分析显示苏木酮A不影响ERK的磷酸化,而抑制JNK的磷酸化。最后,通过H&E染色、血清学检测、TUNEL染色和免疫印迹法证实JNK激活剂茴香霉素可以逆转苏木酮A对大鼠IRI的保护作用。上述研究结果表明,苏木酮A通过抑制JNK磷酸化减轻大鼠肾脏缺血再灌注损伤。

关键词：苏木酮A 肾脏缺血再灌注损伤 p-JNK/JNK p-ERK/ERK 茴香霉素

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基于交通事故重建的行人过街安全岛高度设计

汽车安全与节能学报 2024年第2期15卷 178-184页

作者：张晨魏嵬陈家星马正伟深圳技术大学城市交通与物流学院深圳518118 应用生物力学实验室艾克斯-马赛大学和古斯塔沃-埃菲尔大学马赛13015法国

为了研究道路交通安全岛高度设计对于碰撞事故中行人和车内人员的防护效果,调研并选取典型的安全岛事故案例,运用PC-CRASH软件进行事故过程重建。在事故重建的基础上,基于LSDYNA软件,研究不同车辆碰撞速度、不同安全岛高度对行人和车内... 详细信息

为了研究道路交通安全岛高度设计对于碰撞事故中行人和车内人员的防护效果,调研并选取典型的安全岛事故案例,运用PC-CRASH软件进行事故过程重建。在事故重建的基础上,基于LSDYNA软件,研究不同车辆碰撞速度、不同安全岛高度对行人和车内人员安全防护的影响。结果表明:安全岛高度过低是导致汽车碰撞安全岛行人伤亡的主要原因。在城市道路的常见车速(30~50 km/h)范围内,350 mm以上的安全岛高度设计可以有效防止车辆驶上安全岛,起到行人保护效果;但车辆3 ms峰值减速度远超72 g,会导致较高的车内人员头部损伤风险。未来安全岛设计应兼顾岛内行人和车内人员的双重防护,可以考虑在提升安全岛高度的同时,通过安全岛外围设计吸能缓冲装置实现对车内人员的安全防护。

关键词：道路交通安全岛高度防护事故重建有限元仿真

Heavy ion energy influence on multiple-cell upsets in small sensitive volumes:from standard to high energies

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Nuclear Science and Techniques 2024年第5期35卷 109-121页

作者： Yang Jiao Li-Hua Mo Jin-Hu Yang Yu-Zhu Liu Ya-Nan Yin Liang Wang Qi-Yu Chen Xiao-Yu Yan Shi-wei Zhao Bo Li You-Mei Sun Pei-Xiong Zhao Jie Liu Institute of Modern Physics Chinese Academy of ScienceLanzhou 730000China University of Chinese Academy of Science Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China China Electronics Technology Group Corporation No.58 Research Institute Wuxi 214000China Beijing Microelectronics Technology Institute Beijing 100084China Institute of Microelectronics Chinese Academy of SciencesBeijing 100029China Key Laboratory of Science and Technology on Silicon Devices Chinese Academy of SciencesBeijing 100029China

The 28 nm process has a high cost-performance ratio and has gradually become the standard for the field of radiation-hardened ***,owing to the minimum physical gate length of only 35 nm,the physical area of a standard 6T SRAM unit is approximately 0.16μm^(2),resulting in a significant enhancement of multi-cell charge-sharing ***-cell upsets(MCUs)have become the primary physical mechanism behind single-event upsets(SEUs)in advanced nanometer node *** range of ionization track effects increases with higher ion energies,and spacecraft in orbit primarily experience SEUs caused by high-energy ***,ground accelerator experiments have mainly obtained low-energy ion irradiation ***,the impact of ion energy on the SEU cross section,charge collection mechanisms,and MCU patterns and quantities in advanced nanometer devices remains *** this study,based on the experimental platform of the Heavy Ion Research Facility in Lanzhou,low-and high-energy heavy-ion beams were used to study the SEUs of 28 nm SRAM *** influence of ion energy on the charge collection processes of small-sensitive-volume devices,MCU patterns,and upset cross sections was obtained,and the applicable range of the inverse cosine law was *** findings of this study are an important guide for the accurate evaluation of SEUs in advanced nanometer devices and for the development of radiation-hardening techniques.

关键词： 28 nm static random access memory(SRAM) Energy effects Heavy ion Multiple-cell upset(MCU) Charge collection Inverse cosine law

Opportunities for production and property research of neutron-rich nuclei around N=126 at HIAF

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Nuclear Science and Techniques 2024年第6期35卷 101-113页

作者： Shao-Bo Ma Li-Na Sheng Xue-Heng Zhang Shi-Tao Wang Kai-Long Wang Chun-Wang Ma Hool-Jin Ong Zhi-Yu Sun Shu-Wen Tang Yu-Hong Yu Xin-Tong Du Xiao-Bao wei Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China University of Chinese Academy of Sciences Beijing 100049China College of Physics Henan Normal UniversityXinxiang 453007China Institute of Nuclear Science and Technology Henan Academy of ScienceZhengzhou 450046China Joint-Department for Nuclear Physics Lanzhou University and Institute of Modern PhysicsLanzhou 730000China Research Center for Nuclear Physics Osaka UniversityOsaka 567-0047Japan RIKEN Nishina Center Saitama 351-0198Japan Northwest Normal University Lanzhou 730070China

The study of nuclide production and its properties in the N=126 neutron-rich region is prevalent in nuclear physics and astrophysics *** upcoming High-energy FRagment Separator(HFRS)at the High-Intensity heavy-ion Accelerator Facility(HIAF),an in-flight separator at relativistic energies,is characterized by high beam intensity,large ion-optical acceptance,high magnetic rigidity,and high momentum resolution *** provides an opportunity to study the production and properties of neutron-rich nuclei around N=*** this paper,an experimental scheme is proposed to produce neutron-rich nuclei around N=126 and simultaneously measure their mass and lifetime based on the HFRS separator;the feasibility of this scheme is evaluated through *** results show that under the high-resolution optical mode,many new neutron-rich nuclei approaching the r-process abundance peak around A=195 can be produced for the first time,and many nuclei with unknown masses and lifetimes can be produced with high *** the time-of-flight corrected by the measured dispersive position and energy loss information,the cocktails produced from 208 Pb fragmentation can be unambiguously ***,the masses of some neutron-rich nuclei near N=126 can be measured with high precision using the time-of-flight magnetic rigidity *** indicates that the HIAF-HFRS facility has the potential for the production and property research of neutron-rich nuclei around N=126,which is of great significance for expanding the chart of nuclides,developing nuclear theories,and understanding the origin of heavy elements in the universe.

关键词： HFRS Fragmentation Neutron-rich nuclei around N=126 Mass measurement Lifetime

一种面向限制性三体问题的轨道-姿态运动模态构建方法

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宇航学报 2024年第7期45卷 1078-1088页

作者：刘威罗建军西北工业大学航天学院西安710072 航天飞行动力技术重点实验室西安710072

针对平动点附近的具有强非线性和耦合性的轨道-姿态动力学机理分析,以及如何利用其动力学特性完成相关任务操作等问题,提出了基于Floquet理论的轨道-姿态运动模态构建方法,并探讨了所构建模态的典型应用。首先,在平动点轨道-姿态周期解... 详细信息

针对平动点附近的具有强非线性和耦合性的轨道-姿态动力学机理分析,以及如何利用其动力学特性完成相关任务操作等问题,提出了基于Floquet理论的轨道-姿态运动模态构建方法,并探讨了所构建模态的典型应用。首先,在平动点轨道-姿态周期解的基础上,对轨道-姿态状态转移矩阵进行分块,根据分块矩阵特征值特点,建立了姿态模态和姿轨耦合模态,与轨道模态共同构成完整的轨道-姿态运动模态。然后,对模态特性进行了相空间分析。最后,以平动点相对轨道-姿态运动解析、平动点轨道-姿态稳定性控制和平动点轨道附近姿轨编队设计为应用案例,相应数值仿真表明了所提出模态的正确性,以及在典型航天任务设计与控制中的应用价值。

关键词：圆型限制性三体问题轨道-姿态运动平动点 Floquet理论

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林业生态恢复与植树技术创新

林业科技情报 2024年第3期56卷 67-69页

作者：魏东琳甘肃省白银市靖远县林业和草原局

本文旨在深入探讨《林业生态恢复与植树技术创新》这一主题，强调其在当前环境保护和生态平衡中的关键性作用。研究的目的在于剖析现行植树技术在林业生态恢复中的局限性，提出创新性的技术解决方案，以实现更有效的生态修复。通过综合... 详细信息

本文旨在深入探讨《林业生态恢复与植树技术创新》这一主题，强调其在当前环境保护和生态平衡中的关键性作用。研究的目的在于剖析现行植树技术在林业生态恢复中的局限性，提出创新性的技术解决方案，以实现更有效的生态修复。通过综合分析先进的植树技术和生态学原理，本文在实地实施中验证了新技术的可行性，我们发现新技术的实施在植树过程中取得了积极的效果。传感、遥感、信息技术的有机结合，以及生态模型的应用，使植树技术更为科学、智能，为林业生态恢复提供了可持续的技术支持。

关键词：林业生态恢复植树技术创新环境保护生态平衡可持续发展

珠江口盆地惠北地区煤系烃源岩新认识与勘探实践

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中国海上油气 2024年第2期36卷 13-24页

作者：徐建永赵凯黄胜兵杨海长李楠王升兰柯岭崔维中海油研究总院有限责任公司北京100028

珠江口盆地恩平组煤系烃源岩因分布主控因素认识不清、发育规模不明确,导致勘探潜力被忽视。以煤系烃源岩发育区惠北地区作为研究靶区,利用地震、钻井和地化等资料,系统分析了煤系烃源岩分布主控因素,据此确定煤系烃源岩发育规模和资源... 详细信息

珠江口盆地恩平组煤系烃源岩因分布主控因素认识不清、发育规模不明确,导致勘探潜力被忽视。以煤系烃源岩发育区惠北地区作为研究靶区,利用地震、钻井和地化等资料,系统分析了煤系烃源岩分布主控因素,据此确定煤系烃源岩发育规模和资源潜力,从而有效指导勘探。研究表明:①纵向上,从恩四段到恩一二段沉积期,惠北地区古气候温暖湿润,古水深逐渐变浅,古构造活动强度逐渐减弱,恩一二段和恩三段有利于煤层的发育和聚集,恩四段沉积期煤层不发育;②横向上,受古沉积条件的控制,煤系烃源岩主要分布于惠州14洼北部缓坡带辫状河三角洲河道间的河漫沼泽和洼陷带滨浅湖内的湖沼范围内。基于煤系烃源岩分布规律,预测惠北地区煤系烃源岩资源量约2亿方油当量,带动了惠北地区周边勘探,也展示了珠江口盆地煤系烃源岩勘探前景。

关键词：煤系烃源岩分布规律主控因素恩平组惠北地区珠江口盆地

Prognostic relevance of ventricular arrhythmias in surgical patients with gastrointestinal tumors

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1787-1795页

作者： Jiao-Jie Xue Su-Tian Hu Chong-Chong Wang Zhi-Chong Chen Shi-Yao Cheng Shu-Qi Yu Hua-Jing Peng Yi-Tao Zhang wei-Jie Zeng Department of Cardiovascular Internal Medicine Sun Yat-sen University Sixth Affiliated HospitalGuangzhou 510655Guangdong ProvinceChina Department of Cardiovascular Internal Medicine The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700Guangdong ProvinceChina Department of Ultrasound Fuwai HospitalChinese Academy of Medical Sciences ShenzhenShenzhen 518052Guangdong ProvinceChina Department of Kidney Internal Medicine Sun Yat-sen University First Affiliated HospitalGuangzhou 510062Guangdong ProvinceChina

BACKGROUND Individuals diagnosed with gastrointestinal tumors are at an increased risk of developing cardiovascular *** which,ventricular arrhythmia is a prevalent clinical *** suggests that ventricular arrhythmias may have predictive value in the prognosis of patients with gastrointestinal *** To explore the prognostic value of ventricular arrhythmias in patients with gastrointestinal tumors receiving *** We retrospectively analyzed data from 130 patients undergoing gastrointestinal tumor *** patients were evaluated by a 24-h ambulatory electrocardiogram(ECG)at the Sixth Affiliated Hospital of Sun Yat-sen University from January 2018 to June ***,41 general healthy age-matched and sexmatched controls were *** were categorized into survival and non-survival *** primary endpoint was all-cause mortality,and secondary endpoints included major adverse cardiovascular events(MACEs).RESULTS Colorectal tumors comprised 90%of *** ambulatory ECG monitoring revealed that among the 130 patients with gastrointestinal tumors,100(76.92%)exhibited varying degrees of premature ventricular contractions(PVCs).Ten patients(7.69%)manifested non-sustained ventricular tachycardia(NSVT).The patients with gastrointestinal tumors exhibited higher PVCs compared to the healthy controls on both conventional ECG[27(21.3)vs 1(2.5),P=0.012]and 24-h ambulatory ECG[14(1.0,405)vs 1(0,6.5),P35/24 h to all-cause mortality,and NSVT was associated with ***,neither PVC burden nor NSVT independently predicted outcomes according to multivariate *** Patients with gastrointestinal tumors exhibited elevated ***>35/24 h and NSVT detected by 24-h ambulatory ECG were prognos

关键词： Ventricular arrhythmia Gastrointestinal tumor Major adverse cardiovascular events Prognostic Surgery

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酿酒污水资源化应用性能及风险分析

中国酿造 2024年第1期43卷 113-118页

作者：何静柏松谢光杰罗玲黄治国卫春会四川化工职业技术学院川酒学院四川泸州646300 四川化工职业技术学院党政办公室四川泸州646300 四川轻化工大学酿酒生物技术及应用四川省重点实验室四川宜宾643002

酿酒污水因其有机物浓度高而难以高效处理,但城镇污水处理厂面临着因有机物不足而导致的低碳氮比(C/N)污水反硝化效果差的问题。因此,该实验考察了以酿酒污水作为碳源强化低C/N污水的亚硝酸盐氮(NO3--N)去除效果,对水力停留时间(HRT)进... 详细信息

酿酒污水因其有机物浓度高而难以高效处理,但城镇污水处理厂面临着因有机物不足而导致的低碳氮比(C/N)污水反硝化效果差的问题。因此,该实验考察了以酿酒污水作为碳源强化低C/N污水的亚硝酸盐氮(NO3--N)去除效果,对水力停留时间(HRT)进行了优化,并对关键微生物和技术风险进行了分析。结果表明,在HRT为12~36 h、酿酒污水和低C/N污水体积比500∶1、进水总氮(TN)19.7 mg/L的条件下,处理后化学需氧量(COD)、TN、NO3--N浓度可以满足污水处理厂尾水排放标准。HRT优化过程造成了菌群差异,其中食酸菌属(Acidovorax)是同步去除COD和NO3--N的主要异养反硝化菌属。此外,致病和移动元件表型富集表明,在HRT为12 h时微生物致病和传播综合风险最低。综上,酿酒污水的资源化利用技术是可行的,并且HRT为12 h是最高效、安全的技术参数。研究可为酿酒污水处理提供理论指导和参考。

关键词：酿酒污水低C/N污水微生物特性风险分析