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Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond

Journal of Materials Science & Technology 2019年第5期35卷 817-823页

作者： Yixing Tian Huiling Liu Brian w.Sheldon Thomas J.webster Sichen Yang Huilin Yang Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 China School of Engineering Brown University Providence RI 02912 USA Department of Chemical Engineering Northeastern University Boston MA. 02115 USA International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou Jiangsu 215006 China UwC Changshu China Changshu Jiangsu 215500 China

Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface.

关键词： Nanostructure Diamond films Surface characteristics Protein adsorption Cell responses

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Effects of disturbance on small mammal community structure in the New Jersey Pinelands, usA

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Integrative Zoology 2012年第1期7卷 16-29页

作者： Alicia N.SHENKO walter F.BIEN James R.SPOtila Harold w.AVERY Department of Biology Drexel UniversityPhiladelphiaPennsylvaniaUSA

we compared small mammal community composition among undisturbed habitats and habitats disturbed by military operations on warren Grove Gunnery Range(wGR)in the New Jersey *** is one of the largest tracts of protected land within this globally rare *** in the form of fire,mowing,soil disruption and logging has had a large effect on small mammal occurrence and *** the 14 small mammal species that occur in the Pinelands,9 live on wGR,including large populations of the southern bog lemming(Synaptomys cooperi Baird,1858)and meadow jumping mouse[Zapus hudsonius(Zimmermann,1780)].Simpson’s Index of Diversity was 0 for most disturbed sites and was generally greater in wetlands than in ***-footed mouse[Peromyscus leucopus(Rafinesque,1818)]was the most common species on wGR and had a dominant effect on species diversity and community similarity *** dominated upland habitats and was the only species to occur in several disturbed habitats,whereas all 9 species occurred in *** components analysis indicated that most variation in species diversity was explained by disturbance and differences between upland and wetland habitats,due to presence of white-footed mice in disturbed and upland *** jumping mice,southern bog lemmings and red-back voles[Myodes gapperi(Vigors,1830)]were positively correlated with wetland habitats,and pine voles[Microtus pinetorum(Le Conte,1830)],short-tail shrews[Blarina brevicauda(Say,1823)]and eastern chipmunks[Tamias striatus(Linnaeus,1758)]were associated with *** heterogeneity at wGR,including extensive undisturbed wetlands and uplands supported a rich diversity of small mammal species.

关键词： disturbance mice military training Pine Barrens southern bog lemming

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The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000–2014)

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Infectious Diseases of Poverty 2016年第1期5卷 453-471页

作者： hugo C.Turner Alison A.Bettis Brian K.Chu Deborah A.McFarland Pamela J.Hooper Eric A.Ottesen Mark H.Bradley London Centre for Neglected Tropical Disease Research LondonUK Department of Infectious Disease Epidemiology School of Public HealthFaculty of MedicineSt Marys CampusImperial College LondonNorfolk PlaceLondon W21PGUK Neglected Tropical Diseases Support Center Task Force for Global HealthDecaturGAUSA Rollins School of Public Health Emory UniversityAtlantaGAUSA. Global Health Programs GlaxoSmithKlineLondonUK

Background:Lymphatic filariasis(LF),also known as elephantiasis,is a neglected tropical disease(NTD)targeted for elimination through a Global Programme to Eliminate LF(GPELF).Between 2000 and 2014,the GPELF has delivered 5.6 billion treatments to over 763 million *** the estimated health and economic benefits of this significant achievement is important in justifying the resources and investment needed for eliminating ***:we combined previously established models to estimate the number of clinical manifestations and disability-adjusted life years(DALYs)averted from three benefit cohorts(those protected from acquiring infection,those with subclinical morbidity prevented from progressing and those with clinical disease alleviated).The economic savings associated with this disease prevention was then analysed in the context of prevented medical expenses incurred by LF clinical patients,potential income loss through lost-labour,and prevented costs to the health system to care for affected *** indirect cost estimates were calculated using the human capital approach.A combination of four wage sources was used to estimate the fair market value of time for an agricultural worker with LF infection(to ensure a conservative estimate,the lowest wage value was used).Results:we projected that due to the first 15 years of the GPELF 36 million clinical cases and 175(116–250)million DALYs will potentially be *** was estimated that due to this notable health impact,us$100.5 billion will potentially be saved over the lifetimes of the benefit *** total amount results from summing the medical expenses incurred by LF patients(us$3 billion),potential income loss(us$94 billion),and costs to the health system(us$3.5 billion)that were projected to be *** results were subjected to sensitivity analysis and were most sensitive to the assumed percentage of work hours lost for those suffering from chronic disease(changing the total economic

关键词： Lymphatic filariasis DALYs averted Health impact Economic impact GPELF Programme evaluation

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从源头到海洋的全球水资源保护:从淡水到海洋连续体日益增长的氮磷双控需求

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Science Bulletin 2023年第1期68卷 21-24页

作者： Hans w.Paerl 许海 University of North Carolina at Chapel Hill Institute of Marine SciencesMorehead City NC 28557USA State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography&LimnologyChinese Academy of SciencesNanjing 210008China

we are entering a juncture of the Anthropocene and global climatic changes,with the combined impact being unprecedented pressures on our critical aquatic *** human nutrient(nitrogen and phosphorus)inputs are accelerat... 详细信息

关键词：全球水资源连续体双控

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Medical foods in usA at a glance

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Journal of Future Foods 2021年第2期1卷 141-145页

作者： Shiming Li Chi-Tang Ho Klaus w.Langec College of Life Sciences Huanggang Normal UniversityHuanggang 438000China Department of Food Science Rutgers UniversityNew Jersey 08901USA Department of Experimental Psychology University of RegensburgRegensburg 93040Germany

Increasing interest in attaining an optimal health have longstanding and are imperative for consumers,medical and health researchers and functional food scientists and producers among *** food is defi ned as foods that have a biological function with a very broad range of coverage including natural and conventional foods with reported bioactivities,dietary supplements and medical *** concept is inclusively broad and *** food is a specifi c class of functional foods with clear defi nition and limited coverage to guarantee its *** review introduced the defi nition of medical food by the us Food and Drug Administration,intended to clarify the differences among medical food,dietary supplements and conventional foods,and 1isted some examples of medical food products developed in the us.

关键词： Medical food Dietary supplement Functional food Nutraceuticals

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Directions in the Study of Richard wright

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山东外语教学 2011年第6期32卷 79-83页

作者： Jerry w.ward Dillard University 2601 Gentilly Blvd.

The increasing attention that contemporary scholars and students give to the concept of globalization and to new technologies should not lead them to minimize the importance of historical consciousness in the study of literature and *** the study of Richard wright(1908-1960),it is historical consciousness that enables us to distinguish between those of his works that have productive relevance(the potential to provoke synchronic thinking about contemporary human issues) and those which possess reflective relevance(the potential to invite diachronic thinking about change).This essay argues that new interdisciplinary directions in the study of wright can help us to balance a threatening "rhetoric of carelessness" with a desirable "rhetoric of genuine concern."

关键词： Richard wright globalization historical consciousness directions productive relevance reflective relevance rhetoric of carelessness rhetoric of genuine concern

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In-hospital outcomes of transapical versus surgical aortic valve replacement: from the U.S. national inpatient sample

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Journal of Geriatric Cardiology 2021年第9期18卷 702-710页

作者： Ashraf Abugroun Osama Hallak Ahmed Taha Alejandro Sanchez-Nadales Saria Awadalla Hussein Daoud Efehi Igbinomwanhia Lloyd w Klein Department of Internal Medicine Medical College of Wisconsin(MCW)WIUSA Division of Cardiology Ketter-ing Medical CenterOHUSA Department of Internal Medicine School of MedicineIndiana UniversityIndianapolisIndianaUSA Department of Cardiovascular Disease Cleveland Clinic FloridaFLUSA Division of Epidemiology&Biostatistics University of Illinois-ChicagoILUSA Division of Cardiology Creighton UniversityNEUSA Department of Cardiology Case Western Reserve University(MetroHealth)OHUSA University of California San Francisco(UCSF)San FranciscoCAUSA

OBJECTIVE To compare the outcomes of transapical transcatheter aortic valve replacement(TA-TAVR)and surgical aortic valve replacement(SAVR)using a large us population *** The *** Inpatient Sample was queried for all patients who underwent TA-TAVR or SAVR during the *** primary outcome was all-cause in-hospital *** outcomes were in-hospital stroke,pericardiocentesis,pacemaker insertion,mechanical ventilation,vascular complications,major bleeding,acute kidney injury,length of stay,and cost of *** were modeled using multi-variable logistic regression for binary outcomes and generalized linear models for continuous *** A total of 1560 TA-TAVR and 44,280 SAVR patients were *** who underwent TA-TAVR were older and *** to SAVR,TA-TAVR correlated with a higher mortality(4.5%vs.2.7%,effect size(SMD)=0.1)and higher periprocedural *** multivariable analysis,both TA-TAVR and SAVR had a similar adjusted risk for in-hospital ***-TAVR correlated with lower odds of bleeding with(adjusted OR(aOR)=0.26;95%CI:0.18-0.38;Pusted mean ratio(aMR)=0.77;95%CI:0.69-0.84;Pwith chronic lung disease had higher odds for mortality(aOR=3.11;95%CI:1.37-7.08;P=0.007).CONCLusION The risk-adjusted analysis showed that TA-TAVR has no advantage over SAVR except for patients with chronic lung disease where TA-TAVR has higher mortality.

关键词： logistic In-hospital outcomes of transapical versus surgical aortic valve replacement from the U.S national inpatient sample

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大剂量阿糖胞苷治疗高危急性髓细胞白血病优于中剂量阿糖胞苷:一项不同年龄组的前瞻性随机对比结果

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德国医学 2000年第1期17卷 13-15页

作者： w.Kern C.Aul G.Maschmeyer R.Schnrock-Nabulsi wDLudwig A.Bartholomus P.Bettelheim B.wrmann T.Büchner w.Hiddemann 曾慧兰 Georg-August-University Department of Hematology and OncologyRobert-Koch-Strasse 40 D-37075 Gttingen Germany 广州暨南大学医学院第一附属医院

阿糖胞苷(AraC)是白血病治疗中最古老的药物之一,至今成人急性髓细胞白血病(AML)大部分治疗方案仍以其为基本组成。大剂量阿糖胞苷(HD-AraC)对难治、复发 AML 有明显的抗白血病活性,增加 AraC 剂量的联合方案已被作为一线治疗。前瞻性... 详细信息

阿糖胞苷(AraC)是白血病治疗中最古老的药物之一,至今成人急性髓细胞白血病(AML)大部分治疗方案仍以其为基本组成。大剂量阿糖胞苷(HD-AraC)对难治、复发 AML 有明显的抗白血病活性,增加 AraC 剂量的联合方案已被作为一线治疗。前瞻性随机研究已证实诱导期或强化巩固期使用 HD-AraC 远期疗效佳,但相对于传统剂量(如100～200mg/m^2.次)AraC 最佳剂量多少为宜,目前仍未明了。

关键词：急性白血病髓细胞药物疗法阿糖胞苷

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Biochar applications influence soil physical and chemical properties,microbial diversity,and crop productivity:a meta-analysis

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Biochar 2022年第1期4卷 1055-1071页

作者： Hardeep Singh Brian K.Northup Charles w.Rice P.V.Vara Prasad Department of Agronomy Kansas State University2002 Throckmorton Plant Sciences Center1712 Claflin RoadManhattanKS 66506USA United States Department of Agriculture-Agricultural Research Service Grazinglands Research LaboratoryEl-RenoOK 73036USA

Biochar is a widely known soil *** we synthesize the available information on influence of biochar application on different soil properties and crop productivity using *** data on influence of biochar applications on different soil physical,chemical,microbial properties,and crop productivity were extracted from literature and statistically *** on selection criteria,59 studies from the literature published between 2012 and 2021 were selected for the *** were developed between effect size of biochar application on different soil properties and crop *** of biochar increased soil pH,cation exchange capacity,and organic carbon by 46%,20%,and 27%,respectively,with greater effects in coarse and fine-textured *** on chemical properties were variable among biochar prepared from different *** physical properties,biochar application reduced bulk densities by 29%and increased porosity by 59%.Biochar prepared at higher pyrolytic temperatures(>500℃)improved bulk density and porosity to greater extents(31%and 66%,respectively).Biochar prepared at lower pyrolytic temperatures(with more diverse bacterial populations in medium and coarse textured soils,while fungal diversity increased in fine textured *** applications increased crop productivity only in fine and coarse textured *** effect size of biochar application on crop productivity was correlated with responses to physical properties of *** meta-analysis highlighted the need to conduct long-term field experiments to provide better explanations for changes in biochar properties as it undergoes aging,its longer-term effects on soil properties,and timing of re-application of different biochars.

关键词： Biochar Crop productivity Microbial diversity Soil physical properties Soil chemical properties

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High throughput synthesis enabled exploration of CoCrFeNi-based high entropy alloys

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Journal of Materials Science & Technology 2022年第15期110卷 269-282页

作者： L.Zhao L.Jiang L.X.Yang H.wang w.Y.Zhang G.Y.Ji X.Zhou w.A.Curtin X.B.Chen P.K.Liaw S.Y.Chen H.Z.wang Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory of Metal Materials CharacterizationCentral Iron and Steel Research InstituteBeijing 100081China Institute for Advance Studies in Precision Materials Yantai UniversityYantai 264005China National Center for Materials Service Safety University of Science and Technology BeijingBeijing 100083China Laboratory for Multiscale Mechanics Modeling Ecole Polytechnique Federale de LausanneLausanne CH-1015Switzerland School of Engineering RMIT UniversityMelbourne 3046Australia Department of Materials Science and Engineering The University of Tennessee37996USA

To accelerate the exploration,screening,and discovery of structural high-entropy alloys with targeted properties,the newly developed High-Throughput Hot-Isostatic-Pressing based Micro-Synthesis Approach(HT-HIP-MSA)is employed to efficiently synthesize and characterize 85 combinatorial alloys in a 13-principal element alloying *** Co Cr Fe Ni-based high entropy alloys span 1 quaternary,9 quinary,and 36 senary alloy systems,and their composition-structure-property relationships are characterized and analyzed experimentally and *** the single-phase FCC CoCrFeNi alloy base,with Mn,Cu,Ti,Nb,Ta,Mo,w,Al,and Si as principal element alloying additions,we find(1)the extended Mn solubility in the single-phase FCC CoCrFeNi-Mn_(x) alloys,(2)the destabilizing behavior for most of the quinary and senary alloys,and(3)the distinctive solid-solution-strengthening effects in the *** combining the computational methods,the HT-HIP-MSA can be systematic and economic to explore and refine the compositions,structures,and properties of structural high-entropy alloys.

关键词： High-entropy alloys High-throughput Composition-structure-property

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