The health and economic benefits of the global programme to eliminate lymphatic filariasis (2000–2014)

作     者：Hugo C.Turner Alison A.Bettis Brian K.Chu Deborah A.McFarland Pamela J.Hooper Eric A.Ottesen Mark H.Bradley 

作者机构：London Centre for Neglected Tropical Disease ResearchLondonUK Department of Infectious Disease EpidemiologySchool of Public HealthFaculty of MedicineSt Marys CampusImperial College LondonNorfolk PlaceLondon W21PGUK Neglected Tropical Diseases Support CenterTask Force for Global HealthDecaturGAUSA Rollins School of Public HealthEmory UniversityAtlantaGAUSA. Global Health ProgramsGlaxoSmithKlineLondonUK 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2016年第5卷第1期

页      面：453-471页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：HCT and AAB are supported by London Centre for Neglected Tropical Disease Research(funded by GSK).MHB(employed by GSK)had a role in study design and preparation of the manuscript 

主　　题：Lymphatic filariasis DALYs averted Health impact Economic impact GPELF Programme evaluation 

摘      要：Background:Lymphatic filariasis(LF),also known as elephantiasis,is a neglected tropical disease(NTD)targeted for elimination through a Global Programme to Eliminate LF(GPELF).Between 2000 and 2014,the GPELF has delivered 5.6 billion treatments to over 763 million *** the estimated health and economic benefits of this significant achievement is important in justifying the resources and investment needed for eliminating ***:We combined previously established models to estimate the number of clinical manifestations and disability-adjusted life years(DALYs)averted from three benefit cohorts(those protected from acquiring infection,those with subclinical morbidity prevented from progressing and those with clinical disease alleviated).The economic savings associated with this disease prevention was then analysed in the context of prevented medical expenses incurred by LF clinical patients,potential income loss through lost-labour,and prevented costs to the health system to care for affected *** indirect cost estimates were calculated using the human capital approach.A combination of four wage sources was used to estimate the fair market value of time for an agricultural worker with LF infection(to ensure a conservative estimate,the lowest wage value was used).Results:We projected that due to the first 15 years of the GPELF 36 million clinical cases and 175(116–250)million DALYs will potentially be *** was estimated that due to this notable health impact,US$100.5 billion will potentially be saved over the lifetimes of the benefit *** total amount results from summing the medical expenses incurred by LF patients(US$3 billion),potential income loss(US$94 billion),and costs to the health system(US$3.5 billion)that were projected to be *** results were subjected to sensitivity analysis and were most sensitive to the assumed percentage of work hours lost for those suffering from chronic disease(changing the total economic