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Effecti.eness and safety of fi.st-generati.n protease i.hi.i.ors i. cli.i.al practi.e:Hepati.i. C vi.us pati.nts wi.h advanced fi.rosi.

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World Journal of Gastroenterology 2015年第30期21卷 9163-9174页

作者： Javi.r Salmeron carmen Vi.ai.a Ruben Berenguer Juan manuel Pascasi. Juan Jose Sanchez Ruano mi.uel angel Serra Ana Gi.a moi.es Di.go manuel Romero-Gomez Jose mari. Navarro mi.agros Testi.lano Conrado Fernandez Dolores Espi.osa i.abel Carmona Jose Antoni. Pons Franci.co Jorquera Franci.co Javi.r Rodri.uez Ramon Perez Jose Lui. montero Rafael Granados mi.uel Fernandez Ana Belen marti. Paloma munoz de Rueda Rosa Qui.es Ci.ERehd Instituto de Salud Carlos Ⅲ28029 MadridSpain Uni. for Cli.i.al management of Di.esti.e Di.eases Complejo Hospitalario Universitario de Granada i.sti.uto de i.vesti.aci.n Bi.sani.ari. de Granada Uni.ersi.y Hospi.al Poli.ecni.o La Fe Uni. for Cli.i.al management of Di.esti.e Di.eases University Hospital Virgen Del Rocio Hospi.al Toledo Uni.ersi.y Cli.i. Hospi.al of Valenci. Uni.ersi.y General Hospi.al of Valenci. Uni. for Cli.i.al management of Di.esti.e Di.eases University Hospital Nuestra Senora de Valme Department of Gastroenterology and Hepatology Agenci. Sani.ari. Costa del Sol Uni.ersi.y Hospi.al Cruces Gastroenterology Uni. University Hospital Fundacion Alcorcon Uni.ersi.y Hospi.al Vi.gen macarena Uni.ersi.y Hospi.al Vi.gen de la Arri.aca Hospi.al of Leon Uni.ersi.y General Hospi.al Rei.a Sofi. Department Gastroenterology and Hepatology University Hospital Central de Asturias Uni.ersi.y Hospi.al Rei.a Sofi. Uni.ersi.y Hospi.al De Gran Canari. Dr. Negri. Hospi.al San Pedro de Alcantara

Ai.:To evaluates the effecti.eness and safety of the fi.st generati.n,NS3/4A protease i.hi.i.ors(Pi.) i. cli.i.al practi.e agai.st chroni. C vi.us,especi.lly i. pati.nts wi.h advanced fi.rosi.. mETHODS:Prospecti.e study and non-experi.ental analysi. of a multi.entre cohort of 38 Spani.h hospi.als that i.cludes pati.nts wi.h chroni. hepati.i. C genotype 1,treatment-na?ve(TN) or treatment-experi.nced(TE),who underwent tri.le therapy wi.h the fi.st generati.n NS3/4A protease i.hi.i.ors,boceprevi.(BOC) and telaprevi.(TVR),i. combi.ati.n wi.h pegylated i.terferon and ri.avi.i.. The pati.nts were treatment i. routi.e practi.e setti.gs. Data on the study populati.n and on adverse cli.i.al and vi.ologi. effects were compi.ed duri.g the treatment peri.d and duri.g follow ***:One thousand and fi.ty seven pati.nts were i.cluded,405(38%) were treated wi.h BOC and 652(62%) wi.h TVR. Of thi. total,30%(n = 319) were TN and the remai.i.g were TE:28%(n = 298) relapsers,12%(n = 123) parti.l responders(PR),25%(n = 260) null-responders(NR) and for 5%(n = 57) wi.h pri.r response unknown. The rate of sustai.ed vi.ologi. response(SVR) by i.tenti.n-to-treatment(i.T) was greater i. those treated wi.h TVR(65%) than i. those treated wi.h BOC(52%)(P modi.i.d i.tenti.n-to-treatment(m i.T) no were found si.ni.i.ant di.ferences. By degree of fi.rosi.,56% of pati.nts were F4 and the hi.hest SVR rates were recorded i. the non-F4 pati.nts,both TN and TE. i. the analysi. by groups,the TN pati.nts treated wi.h TVR by i.T showed a hi.her SVR(P = 0.005). However,by m i.T there were no si.ni.i.ant di.ferences between BOC and TVR. i. the multi.ari.te analysi. by m i.T,the si.ni.i.ant SVR factors were relapsers,i.28 B CC and non-F4; the type of treatment(BOC or TVR) was not si.ni.i.ant. The lowest SVR values were presented by the F4-NR pati.nts,treated wi.h BOC(46%) or wi.h TVR(45%). 28% of the pati.nts i.terrupted the treatment,mai.ly by non-vi.al response(51%):thi. outcome was

关键词： Hepati.i. C Boceprevi. Telaprevi. Fi.st-generati.n protease i.hi.i.ors Advanced fi.rosi.

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Seroprevalence study of i.fecti.n wi.h i.fluenza A(H1N1)pdm09 vi.us i. San Feli.e Town, Chi.e

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World Journal of Cardi.vascular Di.eases 2013年第7期3卷 476-482页

作者： Olea Andrea Fasce Rodri.o Agui.era Xi.ena Oli.a Otavi. munoz Sergi. Garci. mari.za Pedroni.Elena Najera manuel Guerrero Andrea Bustos Patri.i. mora Judi.h Vega Jeanette cerda Jai.e Abarca Kati. mcCarron meg Wi.dowson marc-Alai. Casti.lo Ernesto Alvarado Sergi. Qui.ada Sandra Gallegos Dori. Gonzalez Claudi. Center of Epi.emi.logy and Health Poli.i.s Department Faculty of MedicineUniversidad del DesarrolloConcepcionChile Secti.n of Respi.atory and Exanthematous vi.uses Sub-Department of Clinical VirologyInstitute of Public HealthMinistry of HealthSantiagoChile Center of Epi.emi.logy and Health Poli.i.s of the Uni.ersi.ad del Desarrollo ConcepcionChile Panameri.an Health Organi.ati.n Washington DCUSA Publi. Health Department and Pedi.tri.s Di.i.i.n Faculty of MedicinePontifical Catholic University of ChileSantiagoChile Centers for Di.eases Control and Preventi.n AtlantaUSA Center for mi.ro Data Economics DepartmentUniversity of ChileSantiagoChile Epi.emi.logy and Health Poli.i.s Department Universidad del DesarrolloConcepcionChile

Objecti.e: To know the natural hi.tory of the fi.st wave of pandemi. i.fluenza A(H1N1)pdm09 i. the Southern hemi.phere, through the detecti.n of anti.odi.s agai.st i.fluenza A(H1N1)pdm09 i. a selected communi.y, to esti.ate the populati.n attack rate and i.s vari.ti.ns, the consultati.n rates, hospi.alli.ati.n and mortali.y rates. methodology: A representati.e random sample of the populati.n of a commune i. Chi.e (San Feli.e) was i.tervi.wed and taken blood samples between January and march 2010. A study agai.st the anti.odi.s of the i.fluenza A(H1N1) pdm09 vi.us was conducted, by the techni.ue of the Hemagluti.ati.n i.hi.i.i.n (HAi. accordi.g to standardi.ed methodology. Subjects wi.h anti.ody ti.ers ≥1:40 were consi.ered posi.i.e. Results: 13.5% of the populati.n of San Feli.e had anti.odi.s agai.st i.fluenza A(H1N1)pdm09;thi. percentage reached 30% of the populati.n between 0 and 18 years and 6.1% among those over 19 years. The age vari.ble was the only factor that evi.enced si.ni.i.ant di.ferences i. the prevalence of anti.odi.s. There were no si.ni.i.ant di.ferences related to gender, vacci.ati.n hi.tory agai.st seasonal i.luenza, or comorbi.i.y. 51% of people wi.h posi.i.e serology showed i.-FLUENZA-Li.E SYmPTOmS. Conclusi.ns: A relevant percentage of subcli.i.al di.ease was detected i. the fi.st pandemi. wave i. Chi.e and the proporti.n of people wi.h SARi.and deaths was small. Data from epi.emi.logi.al survei.lance were useful to esti.ate the trend of TSi.but not i.s magni.ude.

关键词： i.fluenza A(H1N1)pdm09 i.fluenza Seroprevalence

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Di.esti.e and breast cancer pati.nts managed duri.g the fi.st wave of COVi.-19 pandemi.:Short and mi.dle term outcomes

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World Journal of methodology 2024年第2期14卷 107-126页

作者： Jacobo Trébol Ana Carabi.s-Orgaz maría carmen Esteban-Velasco Asunci.n García-Plaza Juan i.naci. González-munoz Ana Belén Sánchez-Casado Feli.e Carlos Parreno-manchado marta Eguía-Larrea José Antoni. Alcázar-montero Ci.ugía General y del Aparato Di.esti.o Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain Ci.ugía Universidad de SalamancaSalamanca 37007SalamancaSpain Oftalmología Complejo Asistencial Universitario de SalamancaSalamanca 37007SalamancaSpain

BACKGROUND The fi.st wave of coronavi.us di.ease 2019(COVi.-19)pandemi. i. Spai. lasted from mi.dle march to the end of June *** populati.n was subjected to lockdown peri.ds and scheduled surgeri.s were di.conti.ued or reduced duri.g vari.ble *** our centre,we managed pati.nts previ.usly and newly di.gnosed wi.h *** establi.hed a strategy based on li.i.i.g peri.perati.e soci.l contacts,preoperati.e screeni.g(symptoms and reverse transcri.ti.npolymerase chai. reacti.n)and creati.g separated i.-hospi.al COVi.-19-free pathways for non-i.fected *** also adopted some practi.e modi.i.ati.ns(surgery i. di.ferent faci.i.i.s,changes i. staff and gui.eli.es,usi.g conti.uously changi.g personal protecti.e equi.ment…),that supposed new *** To analyse cancer pati.nts wi.h a deci.i.n for surgery managed duri.g the fi.st wave,focali.i.g on outcomes and pandemi.-related *** We prospecti.ely i.cluded adults wi.h a confi.med di.gnosi. of colorectal,oesophago-gastri.,li.er-pancreati. or breast cancer wi.h a deci.i.n for surgery,regardless of whether they ulti.ately underwent *** analysed short-term outcomes[30-d postoperati.e morbi.ortali.y and severe acute respi.atory syndrome coronavi.us 2(SARS-CoV-2)i.fecti.n]and outcomes after 3 years(adjuvant therapi.s,oncologi.al events,death,SARS-CoV-2 i.fecti.n and vacci.ati.n).We also i.vesti.ated modi.i.ati.ns to usual *** From 96 i.cluded pati.nts,seven di.n’t recei.e treatment that peri.d and four never(3 due to COVi.-19).Operated pati.nts:28 colon and 21 rectal cancers;laparoscopy 53.6%/90.0%,mortali.y 3.57%/0%,major compli.ati.ns 7.04%/25.00%,anastomoti. leaks 0%/5.00%,3-years di.ease-free survi.al(DFS)82.14%/52.4%and overall survi.al(OS)78.57%/76.2%.Si. li.er metastases and si. pancreati. cancers:no mortali.y,one major compli.ati.n,three grade A/B li.er fai.ures,one bi.e leak;3-year DFS 0%/33.3%and OS 50.0%/33.3%(li.er metastases/pancreati. carci.oma).5 g

关键词： COVi.-19 SARS-CoV-2 Colon cancer Rectal cancer Breast cancer Li.er cancer Pancreati. cancer Gastri. cancer Oesophageal cancer Surgery

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星形胶质细胞对维持成年小鼠脑血脑屏障是必需的

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神经损伤与功能重建 2021年第11期16卷 F0003-F0003页

作者： Benjami. P Hei.hoff Ki.ana K George Aubrey N Phares i.an A Zui.hoek carmen munoz-Ballester Stefani. Robel 杜一星(编译) Frali. Bi.medi.al Research i.sti.ute at Vi.gi.i. Tech Cari.i.n RoanokeVirginiaUSA. Department of Bi.logi.al Sci.nces Virginia TechBlacksburgVirginiaUSA. Graduate Program i. Translati.nal Bi.logy Medicineand HealthVirginia TechRoanokeVirginiaUSA. School of Neurosci.nce Virginia TechBlacksburgVirginiaUSA. 不详

已知在成年大脑中多种细胞类型会产生调节血脑屏障(BBB)特性的因子,包括星形胶质细胞。然而,最近的几项研究对成熟星形胶质细胞在BBB中的作用提出了质疑。我们使用他莫昔芬诱导的星形胶质细胞消融小鼠模型,以确定星形胶质细胞在维持成年... 详细信息

已知在成年大脑中多种细胞类型会产生调节血脑屏障(BBB)特性的因子,包括星形胶质细胞。然而,最近的几项研究对成熟星形胶质细胞在BBB中的作用提出了质疑。我们使用他莫昔芬诱导的星形胶质细胞消融小鼠模型,以确定星形胶质细胞在维持成年BBB中是否有有着非冗余和必要功能。在成年小鼠中,他莫昔芬诱导在2 h内导致星形胶质细胞稀疏的凋亡性死亡。早在星形胶质细胞消融出现时即可检测到小分子尸胺的渗漏和进入脑实质的大血浆蛋白纤维蛋白原等表明BBB损伤的迹象。在星形胶质细胞丢失区域内和邻近的血管,紧密连接蛋白zonula occludens-1的表达降低,而内皮葡萄糖转运蛋白1的表达不受干扰。尸胺渗漏持续数周,表明缺乏BBB的修复。这与消融的星形胶质细胞未被替换的发现一致。相邻的星形胶质细胞出现部分非增殖性胶质细胞增生,其特征是形态变化和STAT3的延迟磷酸化。这使泄漏入脑内的染料在消融1月后仍局限于缺乏星形胶质细胞覆盖的血管表面区域。总之,星形胶质细胞是维持成年大脑BBB完整性所必需的。其他细胞类型(如周细胞)分泌的BBB调节因子不足以补偿星形胶质细胞的缺失的影响。

关键词：星形胶质细胞增生接触抑制胶质疤痕胶质血管单位紧密连接

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