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Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling

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Genes & Diseases 2023年第3期10卷 679-682页

作者： Yoon Seok Jung Yong-Hoon Kim Kamalakannan Radhakrishnan Jung-Ran Noh Jung Hyeon choi Hyo-Jin Kim Jae-Ho Jeong Steven Dooley Chul-Ho Lee hueng-sik choi School of Biological Sciences and Technology Chonnam National UniversityGwangju 61186Republic of Korea Laboratory Animal Resource Center Korea Research Institute of Bioscience and Biotechnology125 Gwahak-roYuseong-guDaejeon 34141Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon 34113Republic of Korea Combinatorial Tumor Immunotherapy MRC Chonnam National University Medical SchoolHwasun-gunJeonnam 58128Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju 61186Republic of Korea Molecular Hepatology Section Medical Faculty MannheimHeidelberg University69117 HeidelbergGermany

Fibroblast growth factor 23(FGF23)is an osteocyte-and osteoblast-derived hormone that primarily regulates phosphate and vitamin D *** FGF23 levels are abnormally increased in pathological conditions like acute or chronic kidney injury,resulting in disease progression as well as increased rates of morbidity and mortality.^(1) However,FGF23 production in acute liver injury is not fully *** this study.

关键词： FGF23 acute vitamin

Therapeutic strategy targeting host lipolysis limits infection by SARS-CoV-2 and influenza A virus

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4223-4234页

作者： Yeong-Bin Baek Hyung-Jun Kwon Muhammad Sharif Jeongah Lim In-Chul Lee Young Bae Ryu Jae-In Lee Ji-Sun Kim Young-Seung Lee Dong-Hoon Kim Sang-Ik Park Don-Kyu Kim Jeong-Sun Kim Hyon EChoy Sunwoo Lee hueng-sik choi Timothy FOsborne Tae-Il Jeon Kyoung-Oh Cho Laboratory of Veterinary Pathology College of Veterinary MedicineChonnam National UniversityGwangju61186Republic of Korea Functional Biomaterial Research Center Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Chemistry Chonnam National UniversityGwangju61186Republic of Korea Korean Collection for Type Cultures Korea Research Institute of Bioscience&BiotechnologyJeongeup-siJeollabuk-do56212Republic of Korea Department of Animal Science Chonnam National UniversityGwangju61186Republic of Korea Department of Pharmacology Korea University College of MedicineSeoul02841Republic of Korea Department of Integrative Food Bioscience and BiotechnologyChonnam National UniversityGwangju61186Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju61486Republic of Korea School of Biological Sciences and Technology Chonnam National UniversityGwangju61186Republic of Korea Institute for Fundamental Biomedical Research Department of Medicine and Biological ChemistryJohns Hopkins University School of MedicineSt.PetersburgFL33701USA

The biosynthesis of host lipids and/or lipid droplets(LDs)has been studied extensively as a putative therapeutic target in diverse viral ***,directly targeting the LD lipolytic catabolism in virus-infected cells has not been widely ***,we show the linkage of the LD-associated lipase activation to the breakdown of LDs for the generation of free fatty acids(FFAs)at the late stage of diverse RNA viral infections,which represents a broad-spectrum antiviral *** of membrane transporter systems due to virus-induced cell injury results in intracellular malnutrition at the late stage of infection,thereby making the virus more dependent on the FFAs generated from LD storage for viral morphogenesis and as a source of *** replication of SARS-CoV-2 and influenza A virus(IAV),which is suppressed by the treatment with LD-associated lipases inhibitors,is rescued by supplementation with *** administration of lipase inhibitors,either individually or in a combination with virus-targeting drugs,protects mice from lethal IAV infection and mitigates severe lung lesions in SARS-CoV-2-infected ***,the lipase inhibitors significantly reduce proinflammatory cytokine levels in the lungs of SARS-CoV-2-and IAV-challenged animals,a cause of a cytokine storm important for the critical infection or mortality of COVID-19 and IAV *** conclusion,the results reveal that lipase-mediated intracellular LD lipolysis is commonly exploited to facilitate RNA virus replication and furthermore suggest that pharmacological inhibitors of LD-associated lipases could be used to curb current COVID-19-and future pandemic outbreaks of potentially troublesome RNA virus infection in humans.

关键词： linkage furthermore thereby

Ex situ aging effect on sulfonated poly(ether ether ketone) membrane:Hydration-dehydration cycling and hydrothermal treatment

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Journal of Energy Chemistry 2022年第7期31卷 583-592,I0014页

作者： Seung-Young choi Kyeong sik Jin Polymer&Materials Chemistry Department of ChemistryLund UniversitySE-22100Sweden Center for Hydrogen·Fuel Cell Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)PohangKyungbuk 37673Republic of Korea

Prolonged hydrothermal treatment for sulfonated poly(ether ether ketone) membranes induces mechanical degradation and developing hydrophilic-hydrophobic phase separation, simultaneously. The enhanced phase separation provides incremental proton conductivity to the membranes, whereas mechanical degradation drastically reduces device stability. On this basis, we describe here the effects of two different ex situ aging processes on sulfonated poly(ether ether ketone) membranes: hydrationdehydration cycling and prolonged hydrothermal treatment. Both aged membranes exhibited enhanced phase separation under the hydrated conditions, as characterized by small angle X-ray ***, when the aged membranes were dried again, the nanostructure of the membranes aged via the hydration-dehydration cycling was recoverable, whereas that of the membranes aged via prolonged hydrothermal treatment was irreversible. Furthermore, the two differently aged membranes showed clear differences in thermal, mechanical, and electrochemical properties. Finally, we implemented both aged membranes in fuel cell application. The sample aged via hydration-dehydration cycling maintained its improved cell performance, whereas the sample aged via hydrothermal treatment showed drastically reduced cell performance after durability test for 50 h.

关键词： Sulfonated poly(ether ether ketone) Humidity cycle test Ex situ aging Proton exchange membrane Fuel cell

Meso-porous silicon-coated carbon nanotube as an anode for lithium-ion battery

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Nano Research 2016年第7期9卷 2174-2181页

作者： Won-sik Kim Jonghyun choi Seong-Hyeon Hong Department of Materials Science and Engineering and Research Institute of Advanced Materials Seoul National University Seoul 151-744 Republic of Korea

Meso-porous Si-coated carbon nanotube （CNT） composite powders were prepared by combining a sol-gel method and the magnesiothermic reduction process. Meso-porous Si-coated CNT electrodes exhibit excellent cycle and rate performances as anodes in Li-ion batteries （LIBs）, which can be attributed to the efficient accommodation of volume change from meso-porous Si structure and the enhanced electrical conductivity from CNT core. This simple synthesis and subsequent reduction process provide a scalable route for the large-scale production of Si-C composite nanostructures, which can be utilized in a variety of applications, such as in photocatalysis, photoelectrochemical cells （PECs）, and LIBs.

关键词： meso-porous carbon nanotube (CNT) magnesiothermic reduction battery

Modeling asymmetric fracture mechanics of Mg alloy wire in drawing process

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Journal of Magnesium and Alloys 2024年第5期12卷 2057-2069页

作者： Sunghoon choi Jongwon Shin Joung sik Suh Dongchoul Kim Department of Mechanical Engineering Sogang UniversitySeoul04107Republic of Korea Advanced Metals Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study,a numerical analysis was conducted on the ductile fracture of a 2-mm diameter Mg-1Zn-0.5Mn-0.5Sr-0.1Ca alloy wire during *** hexagonally close-packed crystal structure of Mg alloys causes asymmetric fracture behavior,especially in the compression *** aim of this study is to develop a comprehensive damage model for Mg alloy wire that accurately predicts ductile fracture,with a focus on the compression region.A novel experimental method was introduced to measure the ductile fracture of Mg alloy wires under different stress *** wire drawing process was simulated using the Generalized Incremental Stress-State dependent damage(GISSMO)Model and the Semi-Analytical Model for Polymers(SAMP)*** damage model's prediction and the experimental results were found to be in excellent agreement,especially in determining crack *** analysis established a safe zone diagram for die angle and reduction ratio,and experimental validation confirmed the feasibility of this *** proposed damage model can provide a practical and reliable analysis for optimizing the drawing process of Mg alloy wire.

关键词： Mg alloy Wire drawing Finite element method Damage model Safe zone diagram

Protein and energy concentrations of meat meal and meat and bone meal fed to pigs based on in vitro assays

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Animal Nutrition 2021年第1期7卷 252-257页

作者： Hyunjun choi Chang sik Won Beob Gyun Kim Department of Animal Science and Technology Konkuk UniversitySeoul 05029Republic of Korea

The objective of this study was to develop equations for estimating ileal digestible crude protein(CP)and metabolizable energy(ME)contents of meat meal(MM)and meat and bone meal(MBM)as feed in-gredients for pigs based on in vitro *** ingredients were 4 sources of MM and 3 sources of *** and CP contents of the ingredients ranged from 3.8%to 33.1%and 46.8%to 82.9%(as-is basis),*** vitro ileal disappearance(IVID)of CP was determined and ileal digestible CP content was calculated by multiplying CP content by IVID of *** vitro total tract disappearance(IVTTD)of dry matter(DM)was determined and ME was calculated using gross energy,CP contents,and IVTTD of *** IVID of CP and IVTTD of DM ranged from 77.2%to 88.7%and from 82.7%to 92.4%,*** ileal digestible CP and ME contents ranged from 37.8%to 73.5%DM and 2,405 to 3,905 kcal/kg DM,*** contents were negatively correlated(P<0.001)with CP(r=-0.99),in vitro ileal digestible CP(r=-0.97),gross energy(r-1.00),in vitro digestible energy(r=-0.97),and adjusted ME(r=-0.97).The most fitting equations for ileal digestible CP and adjusted ME were:ileal digestible CP(%DM)=11.91-0.90×Ash(%DM)+0.74×IVID of CP(%)(R2=0.99)and adjusted ME(kcal/kg DM)=130.85-50.90×ash(%DM)+47.06×IVTTD of DM(%)(R2=0.99).To validate the accuracy of the prediction equations for ME,mean bias and linear bias were determined using a regression *** ME values of MM and MBM were in a good agreement with data obtained from animal ex-periments based on a statistically insignificant bias in the *** conclusion,ME concentrations of MM and MBM as swine feed ingredients can be calculated using ash concentration and in vitro disap-pearance of dry matter.

关键词： Animal offal Energy In vitro disappearance method Protein

Single-atom Pd catalyst anchored on Zr-based metal-organic polyhedra for Suzuki-Miyaura cross coupling reactions in aqueous media

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Nano Research 2021年第2期14卷 486-492页

作者： Seongsoo Kim Seohyeon Jee Kyung Min choi Dong-sik Shin Division of Chemical and Bioengineering Kangwon National UniversityGangwon-do 24341Republic of Korea Department of Chemical and Biological Engineering Sookmyung Womens University100 Cheongpa-ro 47-gilYongsan-guSeoul 04310Republic of Korea

The challenge for single-atom catalysts in various C-C cross coupling reaction exists in the development of solid supporting *** has been desired tofind a supporting material designed in molecular level to anchor a single-atom catalyst and provide high degree of dispersion and substrate access in aqueous ***,we prepared discrete cages of metal-organic polyhedra anchoring single Pd atom(MOP-BPY(Pd))and successfully performed a Suzuki-Miyaura cross coupling reaction with various substrates in aqueous *** was revealed that each tetrahedral cage of MOP-BPY(Pd)has 4.5 Pd atoms on average and retained its high degree of dispersion up to 3 months in *** coupling efficiencies of the Suzuki-Miyaura cross coupling reaction exhibited more than 90.0%for various substrates we have tested in the aqueous media,which is superior to those of the molecular Pd complex and metal-organic framework(MOF)anchoring Pd ***,MOP-BPY(Pd)was successfully recovered and recycled without performance degradation.

关键词： metal-organic polyhedra Suzuki-Miyaura cross coupling reaction structure characterization aqueous phase reaction high-degree of dispersion

Gradient Si-and Ti-doped Fe_(2)O_(3) hierarchical homojunction photoanode for efficient solar water splitting:Effect of facile microwave-assisted growth of Si-FeOOH on Ti-FeOOH nanocorals

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Journal of Energy Chemistry 2023年第2期77卷 27-37,I0002页

作者： Tae sik Koh Periyasamy Anushkkaran Weon-sik Chae Hyun Hwi Lee Sun Hee choi Jum Suk Jang Division of Biotechnology College of Environmental and Bioresource SciencesJeonbuk National UniversityIksan 54596Republic of Korea Daegu Center Korea Basic Science InstituteDaegu 41566Republic of Korea Pohang Accelerator Laboratory Pohang University of Science and Technology(POSTECH)Pohang 37673Republic of Korea

The construction of a homojunction is an effective approach for addressing issues such as slow charge separation and charge-transfer kinetics in *** the present work,we designed a gradient Si-and Ti-doped Fe_(2)O_(3) homojunction photoanode to improve the photoelectrochemical(PEC)performance of a Ti-doped Fe_(2)O_(3) ***-FeOOH nanocorals were synthesized using a hydrothermal process,and Si-FeOOH was grown on Ti-FeOOH nanocorals using a rapid and facile microwaveassisted(MW)*** varying the MW irradiation time,the thickness of the Si/Ti:Fe_(2)O_(3) photoanode was adjusted and an optimized 3-Si/Ti:Fe_(2)O_(3) photoelectrode was achieved with a significantly enhanced photocurrent density(1.37 mA cm^(-2) at 1.23 V ***)and a cathodic shift of the onset potential(150 mV)compared with that of bare Ti-Fe_(2)O_(3).This enhanced PEC performance can be ascribed to homojunction formation and Si gradient *** Si dopant increased the donor concentration and the formation of a homojunction improved the intrinsic built-in electric field,thereby promoting charge separation and charge ***,the as-formed homojunction passivated the surfacetrapping states,consequently improving the charge transfer efficiency(60%at 1.23 VRHE)at the photoanode/electrolyte *** findings could pave the way for the microwave-assisted fabrication of diverse efficient homojunction photoanodes for PEC water splitting applications.

关键词： Homojunction Microwave-assisted Hematite Gradient doping PEC water splitting

An Experimental Study on the Behavior of Square Concrete-Filled High Strength Steel Tube Columns

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Journal of Iron and Steel Research International 2011年第S1期18卷 878-882页

作者： Hyung-suk Jung Chang-sik choi Department of sustainable architectural engineering Hanyang UniversitySeoulKorea Department of architectural engineering Hanyang UniversitySeoulKorea

The paper presents an experimental study on the behavior of square concrete-filled high strength steel tube columns until *** specimens were tested to investigate the effect of high strength steel and plain strength concrete on the load carrying capacity of the square concrete-filled steel tube *** effect of the concrete which filled in the steel tube was also ***,the effect of high strength steel and the presence of concrete were also *** main parameters in the tests were:(1) the ultimate strength of steel (800 Mpa),(2) the presence of concrete in steel tube (hollow steel tube and concrete-filled steel tube),and (3) slender *** main objectives of these tests were three-step:(1) to describe a series of tests on composite columns,(2) to analyze the influence of several parameters,and (3) to compare the accuracy of the predictions by using the specifications in the code (AISC-LRFD,EC4 and AIJ etc.) for the design of high-strength composite *** results indicate that the ultimate strength of steel and presence of concrete had significant influence on both the axial compressive load capacity and the ductile of the square steel tube.

关键词： square concrete-filled steel tubes high strength steel axial compression