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Euphorbia factor L2 induces apoptosis in A549 cells through the mitochondrial pathway

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Acta Pharmaceutica Sinica B 2017年第1期7卷 59-64页

作者： Minting Lin Sili Tang Chao Zhang hubiao Chen Wenjing Huang Yun Liu Jianye Zhang School of Pharmaceutical Sciences Guangzhou Medical University School of Chinese Medicine Hong Kong Baptist University

Euphorbia factor L2, a lathyrane diterpenoid isolated from caper euphorbia seed(the seeds of Euphorbia lathyris L.), has been traditionally applied to treat cancer. This article focuses on the cytotoxic activity of Euphorbia factor L2 against lung carcinoma A549 cells and the mechanism by which apoptosis is induced. We analyzed the cytotoxicity and related mechanism of Euphorbia factor L2 with an MTT assay, an annexin V-FITC/PI test, a colorimetric assay, and immunoblotting. Euphorbia factor L2 showed potent cytotoxicity to A549 cells. Euphorbia factor L2 led to an increase in reactive oxygen species(ROS) generation,a loss of mitochondrial electrochemical potential, release of cytochrome c, activation of caspase-9 and caspase-3, and cleavage of poly(ADP-ribose) polymerase, suggesting that Euphorbia factor L2 induced apoptosis through a mitochondrial pathway. The cytotoxic activity of Euphorbia factor L2 in A549 cells and the related mechanisms of apoptotic induction provide support for the further investigation of caper euphorbia seeds.

关键词： Euphorbia Factor L2 Caper euphorbia seed Euphorbia lathyris L Anticancer agent Apoptosis Mitochondrial pathway

Measurement of the Newtonian gravitational constant based on the principle of free fall

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Chinese Science Bulletin 2009年第6期54卷 1019-1025页

作者： WANG Yong KE XiaoPing ZHANG WeiMin XU HouZe WANG hubiao CHAI Hua Institute of Geodesy and Geophysics Chinese Academy of Sciences Wuhan 430077 China

The Newtonian gravitational constant (G) is one of the fundamental physical constants. This paper in-troduces a method to determine the Newtonian gravitational constant based on the principle of free fall, through measuring the change of gravity from the disturbed mass with an FG5/112 absolute gravimeter. This method has good repeatability. The measurement precision can be improved by error control and a large number of experiments. The constant G is obtained by two experiments, and the measured value is (6.6665±0.0554)×10-11 m3/(kg·s2).

关键词：牛顿万有引力常数测量精度跌落自由基础绝对重力仪基本物理常数可重复性

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现浇箱梁施工技术在桥梁施工中的应用研究

工程技术研究 2023年第14期8卷 64-66页

作者：田虎彪中铁二十二局集团第四工程有限公司天津301700

为优化市政桥梁施工质量,延长桥梁使用寿命,文章结合某市政桥梁工程项目,阐述了现浇箱梁的主要特点,深入研究了现浇箱梁基础处理、支架安装、支架预压、模板安装、钢筋制安、箱梁现浇施工、预应力张拉和孔道压浆等工序施工技术要点,旨... 详细信息

为优化市政桥梁施工质量,延长桥梁使用寿命,文章结合某市政桥梁工程项目,阐述了现浇箱梁的主要特点,深入研究了现浇箱梁基础处理、支架安装、支架预压、模板安装、钢筋制安、箱梁现浇施工、预应力张拉和孔道压浆等工序施工技术要点,旨在分享现浇箱梁的实践经验与施工方法,为现浇箱梁施工提供有益参考和借鉴,为我国公路桥梁事业壮大发展作出贡献。

关键词：市政桥梁现浇箱梁预应力张拉孔道压浆

联合多种测高数据确定中国边缘海及全球海域的垂线偏差

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武汉大学学报（信息科学版） 2007年第9期32卷 770-773页

作者：王虎彪王勇陆洋中国科学院测量与地球物理研究所动力大地测量学重点实验室

联合多种测高资料,基于EIGEN_CG01C重力场模型,采用沿轨迹加权最小二乘方法确定了中国边缘海和全球海域格网垂线偏差(IGG2006_DOV),中国海域整体精度优于1.2″,满足了反演高分辨率、高精度海洋重力场对测高垂线偏差的精度要求。在南海海... 详细信息

联合多种测高资料,基于EIGEN_CG01C重力场模型,采用沿轨迹加权最小二乘方法确定了中国边缘海和全球海域格网垂线偏差(IGG2006_DOV),中国海域整体精度优于1.2″,满足了反演高分辨率、高精度海洋重力场对测高垂线偏差的精度要求。在南海海域,基于测高垂线偏差解算的重力异常与船测重力进行了外部检核,精度达到7.75 mGal。

关键词：卫星测高沿轨迹加权最小二乘垂线偏差

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阳辿煤矿浅埋三软煤层首采面切眼支护实践

山西焦煤科技 2023年第12期47卷 46-49页

作者：石虎彪山西阳辿煤业有限公司山西长治046000

以阳辿煤矿三软煤层首采面开切眼为研究对象,运用数值模拟分析了不同锚杆支护参数对3#煤层浅部围岩的压应力场影响规律,并以此作为理论依据制定了有效的开切眼锚杆支护方案。经过理论分析、数值模拟以及工程试验等验证,表明所提锚杆支... 详细信息

以阳辿煤矿三软煤层首采面开切眼为研究对象,运用数值模拟分析了不同锚杆支护参数对3#煤层浅部围岩的压应力场影响规律,并以此作为理论依据制定了有效的开切眼锚杆支护方案。经过理论分析、数值模拟以及工程试验等验证,表明所提锚杆支护方案使阳辿煤业三软煤层大断面切眼巷道围岩变形可控制,围岩变形较小,满足了正常的生产需求。

关键词：三软煤层开切眼锚杆支护

大颗粒物料组合称重系统的冲击干扰分析与优化

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包装与食品机械 2023年第3期41卷 32-36,64页

作者：申阳程苏华陈琪胡虎标张超周明刚湖北工业大学农机工程研究设计院武汉430068 湖北省农机装备智能化工程技术研究中心武汉430068

针对智能组合秤称重土豆等较大果蔬产生较大冲击干扰,影响称重精度和速度的问题,对单组称重系统3种工况干扰信号进行试验分析,通过对采集的振动信号进行时域和频域分析,建立数学模型分析响应影响。增大称重系统阻尼比和折弯以增大称重... 详细信息

针对智能组合秤称重土豆等较大果蔬产生较大冲击干扰,影响称重精度和速度的问题,对单组称重系统3种工况干扰信号进行试验分析,通过对采集的振动信号进行时域和频域分析,建立数学模型分析响应影响。增大称重系统阻尼比和折弯以增大称重斗刚度,提高模态频率。优化后对500 g物料称重100次,每分钟称重次数/平均绝对误差/最大短缺量分别从15/35.06 g/20.7 g优化到18/21.41 g/12.7 g,实现提高称重精度与速度目的,达到标准要求。研究结果可为智能组合秤称重系统设计提供理论依据。

关键词：冲击干扰称重信号冲击响应信号处理

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模糊特征目标的相对熵识别法

北京航空航天大学学报 2023年第12期49卷 3547-3558页

作者：张虎彪王星徐宇恒吴笑天胡文辉空军工程大学航空工程学院西安710038 中国人民解放军95174部队武汉430000

针对模糊特征的目标识别问题,提出了一种结合模糊建模和改进CRITIC方法的相对熵识别方法。计算多个时刻观测值的统计特征,通过模糊建模将观测值转化为模糊数;基于模糊数距离测度,定义并计算目标特征值和观测值之间的相似度;对CRITIC方... 详细信息

针对模糊特征的目标识别问题,提出了一种结合模糊建模和改进CRITIC方法的相对熵识别方法。计算多个时刻观测值的统计特征,通过模糊建模将观测值转化为模糊数;基于模糊数距离测度,定义并计算目标特征值和观测值之间的相似度;对CRITIC方法进行改进,提出一种目标特征客观权重的求解方法;根据相似度和特征权重,使用相对熵排序法得到识别结果。仿真结果显示:模糊特征能够更好地体现识别中的不确定性,所提方法对模糊特征的目标识别率高,实时性和鲁棒性好,具有一定的应用价值。

关键词：相对熵模糊数 CRITIC 多属性决策目标识别

Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2006-2018页

作者： Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang Guangdong Provincial Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical Sciences and the Fifth Affiliated HospitalGuangzhou Medical University511436 GuangzhouGuangdongP.R.China Institute of Respiratory and Occupational Diseases Collaborative Innovation Center for CancerMedical CollegeShanxi Datong University037009 DatongP.R.China School of Chinese Medicine Hong Kong Baptist UniversityHong KongP.R.China College of Public Health Guangzhou Medical University511436 GuangzhouGuangdongP.R.China Cancer Center of Datong the Second People’s Hospital of Datong037005 ShanxiP.R.China GZMU-GIBH School of Life Sciences Guangzhou Medical University511436 GuangzhouGuangdongP.R.China Xinjiang Institute of Materia Medica 830004 UrumqiP.R.China Department of Pathology Shanxi Provincial People’s Hospital030012 TaiyuanP.R.China Key Laboratory of Tropical Translational Medicine of Ministry of Education Hainan Medical University571199 HaikouP.R.China

Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and *** studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor ***,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well ***,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC *** results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC *** analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in *** shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in *** data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β***-34c-3p can be a diagnostic and prognostic marker for *** expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells.

关键词： invasion Exosomes cancer

Optimization Design of the Conductor Section Selection in the Transmission Line

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Optimization Design of the Conductor Section Selection in th...